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Haseong Song 한국공공정책학회 2005 공공정책연구 Vol.19 No.-
The National Intelligence Agency confessed its wrongdoing and openly apologized to the country. Furthermore, including unprecedented response to subpoena, it fully cooperated with the Public Prosecutors Office's investigation. Given the nature of an intelligence agency that highly values secrecy, this certainly was a surprising turn of event. The agency itself is trying to transform itself. Therefore, we should commend the National Intelligence Agency for its efforts at reform and further encourage it so as to avoid yet another X-File scandal.
S-188 Incidental pulmonary thromboembolism in malignancy: Clinical characteristics and outcome
( Haseong Chang ),( Eun Kyung Kim ),( Duk-kyung Kim ) 대한내과학회 2016 대한내과학회 추계학술대회 Vol.2016 No.1
Background:?Incidental pulmonary thromboembolism (PTE) is defined as PTE diagnosed on routine computed tomography (CT) without clinical suspicion of PTE. It is a relatively frequent finding occurring 2 to 4% in cancer patients undergoing CT scans for staging work up or treatment response evaluation. Nevertheless, the optimal management of the incidental PTE remains unknown and current treatment choices largely depend on individual clinician’s preference rather than established guidelines. We aim to evaluate clinical characteristics of incidental PTE and its impact on overall survival with or without treatment. Patients and Methods:?We performed a retrospective review of electronic medical records in a single cancer center to identify cancer patients with PTE. We used Cox’s proportional hazard model to assess effect of anticoagulation treatment on incidental PTE. Subgroup analysis was performed to determine whether the effect of treatment was consistent across patients with different embolic burden. Results:?Among 704 cancer patients diagnosed with pulmonary thromboembolism, incidental PTE was identified in 474(67.3%) patients. Compared to symptomatic patients, they tend to have less embolic burden represented by lower rate of both lung involvement and RV dysfunction on echocardiography. Only 52.5% of patients with incidental PTE were treated with anticoagulation for differing duration. While symptomatic PTE showed improved survival with anticoagulation treatment (median survival 6.0 vs 17.3 months, p=0.003), anticoagulation did not result in significant survival benefit in incidental PTE (median survival 15.1 vs 22.1, p=0.205). However, in subgroup analysis, significant survival improvement by anticoagulation was found in proximal incidental PTE (median survival 12.2 vs 23.4 months, p=0.020), but not in distal incidental PTE (15.1 vs 21.2, p=0.906).?Conclusions:?Benefits of anticoagulation treatment differs according to embolic burden in cancer patients with incidental PTE. Proximal incidental PTE warrants anticoagulation treatment while distal incidental PTE may not. Prospective study is needed to confirm this finding.
Distributed CRC scheme for low-complexity successive cancellation flip decoding of polar codes
Haseong Kim,Hyunjee Lee,박호성 한국통신학회 2022 ICT Express Vol.8 No.3
In this paper, we propose a novel successive cancellation flip (SCF) decoding to reduce the computational complexity compared to the conventional SCF decoding by using distributed CRC bits. The proposed decoding reduces the number of estimations for information bits by early termination of decodings for failed frames of the first SC decoding, while trying to minimize the additional sorting operations. Simulation results show that the proposed SCF decoding reduces the computational complexity of repeated SC decoding at least 27% compared to the conventional SCF decoding.
High-throughput part characterization tools with a long-read sequencing technique
Haseong KIM 한국생물공학회 2021 한국생물공학회 학술대회 Vol.2021 No.10
It is known that the optimal performance of a metabolic pathway is achieved by the appropriate expression balance among genes. However, investigating each DNA part that controls the expression of the genes requires time-consuming cloning experiments along with high-cost equipment measuring single-cell fluoresce. This study presents a high-throughput part characterizing technique that increases cloning throughput by combinatorial DNA part assembly approach and quantifies the part characteristics with High-reproducibility plate based image analysis. The PCR based long-read sequencing technique allows us fast identification of part combinations and their genotypes regardless relatively low base-calling accuracy of the long-read sequencing technique. We confirmed the ratios of the part combinations were constantly remained in each assembly step and the fluorescent intensities of the colonies on plates were comparable to the single-cell level fluorescence from a high-end flowcytometry device. Quantitative values of twenty DNA parts (23 promoters and 23 RBSs) were successfully obtained in 1 week without any automated and expensive devices. We anticipate that this high-throughput and easy-to-use part characterization technique will contribute to increase the available parts in the synthetic biology community.