http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Effect of Serum Perampanel Concentration on Sporadic Amyotrophic Lateral Sclerosis Progression
Haruhisa Kato,Makiko Naito,Tomoko Saito,Takuto Hideyama,Hiroo Terashi,Shin Kwak,Hitoshi Aizawa 대한신경과학회 2023 Journal of Clinical Neurology Vol.19 No.3
Background and Purpose To clarify the effect of perampanel (PER) on sporadic amyotrophic lateral sclerosis (sALS) progression, the relationship between the changes in Revised Amyotrophic Lateral Sclerosis Functional Rating Scale (ALSFRS-R) scores and serum PER concentrations was investigated. Methods 12 patients with sALS from our hospital who agreed to participate and completed the PER for sALS randomized phase 2 study were included. After completing the study, we retrospectively obtained serum PER concentration data from the patients. Based on their mean PER concentrations, we divided the patients who had been taking PER into two groups: four patients with a mean PER concentration of ≥400 ng/mL were assigned to the H group, and three with a mean PER concentration of <400 ng/mL were assigned to the L group. The control group consisted of five patients who had been taking a placebo. We obtained the ALSFRS-R scores of each patient at 36 and 48 weeks after randomization. The differences in ALSFRS-R scores at baseline (0 weeks) and each subsequent week were used in the analysis. Results At 48 weeks, there were no differences in the degree of deterioration of the bulbar, upper and lower limb, and respiratory ALSFRS-R subscores and total ALSFRS-R score. However, at 36 weeks, the bulbar subscore was significantly lower in the H group than in the control group (p=0.032). Conclusions Because high PER concentrations may exacerbate bulbar symptoms in patients with sALS, serum PER measurements may be beneficial when patients with sALS are taking PER.
Haruhisa Kato,Makiko Naito,Tomoko Saito,Takuto Hideyama,Yasuhiro Suzuki,Takashi Kimura,Shin Kwak,Hitoshi Aizawa 대한신경과학회 2022 Journal of Clinical Neurology Vol.18 No.4
Background and Purpose Amyotrophic lateral sclerosis (ALS) is a fatal motor neuron disease. Selective deficiency of edited adenosine deaminase acting on RNA 2 (ADAR2), a key molecule in the acquisition of Ca2+ resistance in motor neurons, has been reported in sporadic ALS (sALS) spinal motor neurons. Since ADAR2 activity is positively regulated by prolyl isomerase Protein never in mitosis gene A interacting-1 (Pin1), a known phosphorylation-dependent peptidyl-prolyl cis/trans isomerase, we investigated Pin1 expression in spinal motor neurons in sALS. Methods Specimens of the spinal cord were obtained from the lumbar region in eight sALS patients and age-matched five controls after postmortem examinations. The specimens were double stained with anti-Pin1 and anti-TAR DNA-binding protein of 43 kDa (TDP-43) antibodies, and examined under a fluorescence microscope. Results This study analyzed 254 and 422 spinal motor neurons from 8 sALS patients and 5 control subjects, respectively. The frequency of motor neurons with high cytoplasmic Pin1 expression from the spinal cord did not differ significantly between sALS specimens without cytoplasmic TDP-43 inclusions and control specimens. However, in sALS specimens, neurons for which the Pin1 immunoluminescence intensity in the cytoplasm was at least twice that in the background were more common in specimens with cytoplasmic TDP-43 inclusions (p<0.05 in χ2 test). Conclusions In sALS, neurons with higher expression levels of Pin1 levels had more TDP-43 inclusions. Despite the feedback mechanism between Pin1 and ADAR2 being unclear, since Pin1 positively regulates ADAR2, our results suggest that higher Pin1 expression levels in motor neurons with TDP-43 pathology from sALS patients represent a compensatory mechanism
Local Anesthesia in Dental Practice -New Methods of Local Anesthesia
Haruhisa Fukayama 대한치과마취과학회 2003 Journal of Dental Anesthesia and Pain Medicine Vol.3 No.2
Almost all the dental procedures are done under local anesthesia. Local anesthesia is inevitable in dental practice. First of all, the dentists should have the same understanding that local anesthesia is straightly leads to great pain sensation. It derives from needle injection of sensitive oral mucosa, poor technique and incomplete topical anesthesia. Dental anesthesia itself has a contradiction because it gives intolerable pain before painless practice. Almost all the dental procedures are done under local anesthesia. Local anesthesia is inevitable in dental practice. First of all, the dentists should have the same understanding that local anesthesia is straightly leads to great pain sensation. It derives from needle injection of sensitive oral mucosa, poor technique and incomplete topical anesthesia. Dental anesthesia itself has a contradiction because it gives intolerable pain before painless practice.
한문(漢文)과 진실(眞實) -『조선(朝鮮)(코리아)한문(漢文)』을 실례(實例)로-
소천청구 ( Ogawa Haruhisa ) 한국한문교육학회 2009 한문교육논집 Vol.33 No.-
This paper reviewed Chosun Classical Chinese in writings of Siseup Kim, of Sunshin Lee, of daughter of Changhyeop Kim, and in Daeyong Hong`s Euisan-Mundap, Jiweon Park`s The Story of Heo-Saeng, and Yakyong Jeong`s letters, which Jeong sent his two suns at the penal colony. As a result, we found that we should learn truth in both areas of historical facts and human issues. This paper, in order to attain this aim efficiently, insists we make good use of Classical Chinese textbooks of Korean colleges and gradually expand textbooks of high school and middle school, in understanding history and culture of Chosun, which have been unknown to Japanese learned circles.
오가와하루히사 ( Ogawa Haruhisa ) 한국실학학회 2016 한국실학연구 Vol.0 No.31
There are two "real learning(實學)in the history of east asia. The one is the modern "real learning"meant as useful learning. It is consisted of technique. The other is the pre-modern "real learning" meant as Confucianism(儒學). Confucianism is explained as the learning of the self-disciplined governmental method(修已治人之學). It contains the element of mind. The modern real leaning has lost the element of mind. So we must learn it from the pre-modern real learning. Especially the pre-modern real learning of 17-18century has a broad view to the nature and the universe. I esteem it high. The concept of pre-modern real learning is regulated "real learning for life". But I have come to know that this regulation has the universal character. The element of mind means the philosophy or the thought or the moral of the learning.