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A comprehensive review of techniques for biofunctionalization of titanium
Hanawa, Takao Korean Academy of Periodontology 2011 Journal of Periodontal & Implant Science Vol.41 No.6
A number of surface modification techniques using immobilization of biofunctional molecules of Titanium (Ti) for dental implants as well as surface properties of Ti and Ti alloys have been developed. The method using passive surface oxide film on titanium takes advantage of the fact that the surface film on Ti consists mainly of amorphous or low-crystalline and nonstoichiometric $TiO_2$. In another method, the reconstruction of passive films, calcium phosphate naturally forms on Ti and its alloys, which is characteristic of Ti. A third method uses the surface active hydroxyl group. The oxide surface immediately reacts with water molecules and hydroxyl groups are formed. The hydroxyl groups dissociate in aqueous solutions and show acidic and basic properties. Several additional methods are also possible, including surface modification techniques, immobilization of poly(ethylene glycol), and immobilization of biomolecules such as bone morphogenetic protein, peptide, collagen, hydrogel, and gelatin.
A comprehensive review of techniques for biofunctionalization of titanium
Takao Hanawa 대한치주과학회 2011 Journal of Periodontal & Implant Science Vol.41 No.6
A number of surface modification techniques using immobilization of biofunctional molecules of Titanium (Ti) for dental implants as well as surface properties of Ti and Ti alloys have been developed. The method using passive surface oxide film on titanium takes advantage of the fact that the surface film on Ti consists mainly of amorphous or low-crystalline and nonstoichiometric TiO2. In another method, the reconstruction of passive films, calcium phosphate naturally forms on Ti and its alloys, which is characteristic of Ti. A third method uses the surface active hydroxyl group. The oxide surface immediately reacts with water molecules and hydroxyl groups are formed. The hydroxyl groups dissociate in aqueous solutions and show acidic and basic properties. Several additional methods are also possible, including surface modification techniques, immobilization of poly(ethylene glycol), and immobilization of biomolecules such as bone morphogenetic protein, peptide, collagen,hydrogel, and gelatin.
Park, Jin-Woo,Kim, Eun-Suk,Jang, Je-Hee,Suh, Jo-Young,Park, Kwang-Bum,Hanawa, Takao Blackwell Publishing Ltd 2010 Clinical oral implants research Vol.21 No.3
<P>Abstract</P><P>Objectives</P><P>This study investigated the efficacy of new bone graft substitutes – biphasic calcium phosphates (BCP) made of submicron-sized grains with fully interconnected wide-range micron-scale pores in two different macrodesigns: donut shaped with a 300–400 μm central macropore (n-BCP-1) or rod-shaped (n-BCP-2) – in the healing of rabbit calvarial defects, and compared their bone-healing properties with those of various commercial bone substitutes, which included substitutes with similar BCP composition (MBCP and Osteon), anorganic bovine bone (Bio-Oss), and β-TCP (Cerasorb).</P><P>Material and methods</P><P>The surface morphology of the bone substitutes was investigated using scanning electron microscopy (SEM). Defects 8 mm in diameter were created in the calvaria of 30 adult male New Zealand White rabbits and were filled with six types of bone substitutes. The percentage of newly formed bone (NB%) was evaluated histomorphometrically 4 and 8 weeks after implantation.</P><P>Results</P><P>SEM observation showed submicron-sized grains with fully interconnected micropore structures in the n-BCP-1 and n-BCP-2 groups; these groups also showed considerable new bone formation in inner micropores as well as on the outer surfaces. The n-BCP-1 group exhibited enhanced new bone formation and direct ingrowth of bone tissue with blood vessels into central pores. Histomorphometric analysis showed significantly greater NB% in the n-BCP-1 group when compared with the other groups at 4 and 8 weeks (<I>P</I><0.05).</P><P>Conclusion</P><P>A new BCP ceramics made of submicron-sized grains with a hierarchical pore structure was an effective osteoconductive material for the treatment of osseous defects of rabbit calvaria.</P><P><B>To cite this article:</B>Park J-W, Kim E-S, Jang J-H, Suh J-Y, Park K-B, Hanawa T. Healing of rabbit calvarial bone defects using biphasic calcium phosphate ceramics made of submicron-sized grains with a hierarchical pore structure.<I>Clin. Oral Impl. Res</I>. <B>21</B>, 2010; 268–276.doi: 10.1111/j.1600-0501.2009.01846.x</P>
EBUCHI, NAOTO,HANAWA, KIMIO 대한원격탐사학회 2001 International Symposium on Remote Sensing Vol.17 No.1
Mesoscale eddies in the Kuroshio recirculation region south of Japan have been investigated by using surface current data measured by an Acoustic Doppler Current Profiler (ADCP) installed on a regular ferry shuttling between Tokyo and Chichijima, Bonin Islands, and sea surface height (SSH) anomaly derived from the TOPEX/POSEIDON altimeter. Many cyclonic and anticyclonic eddies were observed in the region. Spatial and temporal scales of the eddies were determined by lag-correlation analyses in space and time. The frequency of occurrence, temporal and spatial scales, and intensity are all nearly the same for the cyclonic and anticyclonic eddies. Phase speed of westward propagation of the eddies is estimated as 6.8 cm/s, which is faster than a theoretical estimate based on the baroclinic first-mode Rossby wave with or without a mean current. Trajectories of the eddies were also traced using SSH maps observed by the TOPER/ POSEIDON and ERS altimeters. Both the cyclozic and anticyclonic eddies propagate westward in the Kuroshio recirculation region from a region south of the Kuroshio Extension. In the region south of Shikoku and east of Kyushu, some of the eddies coalesce with the Kuroshio. It is suggested that this coalescence may trigger the path variations of the Kuroshio in the sea south of Japan.