Synthesis and Anti-inflammatory Activity of Certain Piperazinylthienylpyridazine Derivatives

Hanan M. Refaat,Omneya M. Khalil,Hanan H. Kadry 대한약학회 2007 Archives of Pharmacal Research Vol.30 No.7

In this study, a novel series of 2-(4-substituted piperazin-l-ylmethyl)-6-(thien-2-yl)-2H-pyridazin- 3-ones (3a-f), 2-(4-substituted piperazin-l-yl carbonylmethyl)-6-(thien-2-yl)-2H-pyridazin-3-ones (4a-c) and 2-[2-(4-substituted piperazin-l-ylcarbonylethyl)]-6-(thien-2-yl)-2H-pyridazin-3-ones (5a,b) were prepared from 6-(thien-2-yl)-2H- pyridazin-3-one (1). In addition, 3-(4-substituted piperazin-l-ylcarbonyl methyl thio)-6-(thien-2-yl) pyridazines (6a-c) and 3-[2-(4-substitutedpiperazin- l-ylcarbonyl ethylthio]-6-(thien-2-yl) pyridazines (7a,b) were synthesized. Furthermore, 5-(4-substituted piperazin-l-ylmethyl)-6-(thien-2-yl)-2H-pyridazin-3-ones (12a,b) were prepared. The structures of the new compounds were confirmed by elemental analysis as well as by 1H-NMR, IR and MS data. Some of the newly prepared compounds were subjected to evaluation for their anti-inflammatory activity against carrageenan-induced paw edema at a dose of 10 mg/kg using indomethacin as the reference standard.

Herbal Drug Loaded Poly(D,L-lactide-co-glycolide) Ultrafine Fibers: Interaction with Pathogenic Bacteria

Hanan M. Al-Youssef,Musarat Amina,Shamshi Hassan,TOUSEEFAMNA,정진원,남기택,김학용 한국고분자학회 2013 Macromolecular Research Vol.21 No.6

This study investigated for the first time the antimicrobial effect of methanolic extract of Grewia mollis Juss (mGM) against Staphylococcus aureus KCCM 11256 (Gram positive) and Escherichia coli KCCM 11234(Gram negative). The minimum inhibitory concentration (MIC) values for each bacterial strain were recorded in a liquid medium. In addition, ultrafine poly(D,L-lactide-co-glycolide) (PLGA) fiber mats containing a methanolic crude extract (7.5 wt%) of Grewia mollis (mGM) were fabricated from the neat PLGA solution by electrospinning. The PLGA ultrafine fiber mat containing mGM were characterized by SEM, FE-SEM, Bio-TEM, TGA, and EDX analyses. Our findings indicate that the incorporation of mGM in the polymer media affected both the morphology and size of the mGM-loaded PLGA ultrafine fibers (UFs). SEM-EDX results confirmed well oriented ultrafine fibers with good incorporation of mGM. Results of the structure characterization indicated that the incorporated mGM interacted strongly with the PLGA matrix and the mechanical properties were effectively improved. Moreover,mGM loaded PLGA ultrafine fiber mats were able to inhibit the growth of the bacterial strains, which indicate that mGM blended PLGA fibers could be used as a potential effective antimicrobial agent for many biomedical applications including wound dressing.

e-SYMMETRIC MODULES

( Hanan Abd-elmalk ) 호남수학회 2021 호남수학학술지 Vol.43 No.2

In this paper we introduce two classes of modules namely e-symmetric and e-reduced. Also, we study the characterizations of e-symmetric and e-reduced modules and their related properties.

Perioperative effects of various anesthetic adjuvants with TIVA guided by bispectral index

Hanan F. Khafagy,,Reeham S. Ebied,Emad S. Osman,Mohamed Z. Ali,Yasser M. Samhan 대한마취통증의학회 2012 Korean Journal of Anesthesiology Vol.63 No.2

Background: This prospective, randomized, double blinded, controlled study was designed to compare effects of intravenous co-administration of clonidine, magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics, postoperative analgesia and recovery indices during Bispectral Index (BIS) guided total intravenous anesthesia (TIVA). Methods: After ethical committee approval and written informed consent, 120 adult patients ASA I and II scheduled for open cholecystectomy were randomly assigned to one of 4 equal groups. Group CL received clonidine 3 μg/kg and maintained by 2 μg/kg/h. Group MG received magnesium sulphate 50 mg/kg and maintained by 8 mg/kg/h. Group KET received racemic ketamine 0.4 mg/kg and maintained by 0.2 mg/kg/h. Control group (CT) received the same volume of isotonic saline. Anesthesia was induced and maintained by fentanyl, propofol and rocuronium. Propofol infusion was adjusted to keep the BIS value between 45-55. Intraoperative hemodynamics, induction time, anesthetic consumption, recovery indices, and PACU discharge were recorded. Results: Induction time, propofol requirements for induction and maintenance of anesthesia, intraoperative fentanyl and hemodynamic values were significantly lower with Groups CL and MG compared to Groups KET and CT (P < 0.05). Patients in Group MG showed significantly lower muscle relaxant consumption, delayed recovery and PACU discharge than other groups (P < 0.05). First, analgesic requirement was significantly longer and total postoperative analgesic consumption was significantly lower in the adjuvant groups versus Group CT (P < 0.05). Conclusions: Clonidine, magnesium, and ketamine can be useful adjuvant agents to BIS- guided TIVA. Pharmacokinetic studies of such drug combinations were recommended to investigate their interaction. Background: This prospective, randomized, double blinded, controlled study was designed to compare effects of intravenous co-administration of clonidine, magnesium, or ketamine on anesthetic consumption, intraoperative hemodynamics, postoperative analgesia and recovery indices during Bispectral Index (BIS) guided total intravenous anesthesia (TIVA). Methods: After ethical committee approval and written informed consent, 120 adult patients ASA I and II scheduled for open cholecystectomy were randomly assigned to one of 4 equal groups. Group CL received clonidine 3 μg/kg and maintained by 2 μg/kg/h. Group MG received magnesium sulphate 50 mg/kg and maintained by 8 mg/kg/h. Group KET received racemic ketamine 0.4 mg/kg and maintained by 0.2 mg/kg/h. Control group (CT) received the same volume of isotonic saline. Anesthesia was induced and maintained by fentanyl, propofol and rocuronium. Propofol infusion was adjusted to keep the BIS value between 45-55. Intraoperative hemodynamics, induction time, anesthetic consumption, recovery indices, and PACU discharge were recorded. Results: Induction time, propofol requirements for induction and maintenance of anesthesia, intraoperative fentanyl and hemodynamic values were significantly lower with Groups CL and MG compared to Groups KET and CT (P < 0.05). Patients in Group MG showed significantly lower muscle relaxant consumption, delayed recovery and PACU discharge than other groups (P < 0.05). First, analgesic requirement was significantly longer and total postoperative analgesic consumption was significantly lower in the adjuvant groups versus Group CT (P < 0.05). Conclusions: Clonidine, magnesium, and ketamine can be useful adjuvant agents to BIS- guided TIVA. Pharmacokinetic studies of such drug combinations were recommended to investigate their interaction.

Modeling and Code Generation of Android Applications Using Acceleo

Hanane BENOUDA,Redouane ESSBAI,Mostafa AZIZI,Mimoun MOUSSAOUI 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.3

The development of mobile applications becomes increasingly popular in our daily life due to the intensive use of applications in mobile devices like smartphones and tablets. The diversity and variety of mobile operating systems (Android, iOS, Black Berry, Windows Phone, etc.) make software engineers in front of a big challenge to develop the same application for these different platforms. This paper presents a methodology based on the Model Driven Architecture (MDA) to develop mobile applications according to the principle “develops once, use everywhere”. Our approach exploits UML modeling and Acceleo to generate specific code in order to accelerate and facilitate the development of mobile applications.

Axial.Flexural Interaction in FRP-Wrapped RC Columns

Hanan Suliman Al-Nimry,Rabi Amer Al-Rabadi 한국콘크리트학회 2019 International Journal of Concrete Structures and M Vol.13 No.7

The study reported herein aims at investigating the behavior of medium-scale circular reinforced concrete columns wrapped with fiber reinforced polymer (FRP) sheets under concentric and eccentric axial loads. The experimental program was devised to assess the effects of loading conditions, absence/presence of an FRP jacket as well as the FRP wrapping system. To achieve the study objectives, four column groups were tested under axial compression at 0, 25, 50 and 65 mm loading eccentricities corresponding to eccentricity-to-diameter ratios of 0, 0.13, 0.26 and 0.34, respectively. Specimens in a fifth group were tested in pure bending simulating axial compression at infinite loading eccentricities. Three column subcategories were tested under each of the 5 loading eccentricities: unwrapped; wrapped with one ply of hoop FRP sheets; and wrapped with two FRP plies with fibers oriented at 0 and 90° to the longitudinal column axis thereby providing externally-bonded longitudinal reinforcement and hoop confinement, respectively. Tests confirmed that FRP confinement enhances the axial–flexural column resistance even at large eccentricities that exceed the balanced state of unconfined columns. Although axial column resistance decreased with increasing bending moments, relative enhancements (25–35%) in axial resistance provided by FRP confinement were found to be more significant under eccentric loading than in pure compression. Compared to hoop FRP-confined columns, using additional longitudinal sheets resulted in minor (7–9%) but stable enhancements in axial resistance that were unaffected by the increase in loading eccentricity. The FRP hoop wraps had a minor effect on the flexural resistance of specimens tested in pure bending but managed to double their resistance when combined with the externallybonded longitudinal FRP sheets. Finally, three stress–strain models of FRP-confined concrete were used in conventional section analysis to assess the axial–flexural interaction in the FRP-jacketed columns. Strength predictions made using the stress–strain model proposed in ACI 440.2R-17 design guidelines did not agree with the test results of the eccentrically-loaded columns and underestimated the moment resistance at a given axial force even when considering higher confinement ratios than those permitted by the guidelines. Strength predictions made using eccentricitydependent stress–strain models showed better results especially when accounting for the increase in ultimate axial strains under eccentric loading.

On Soft Generalized Closed Sets in a Soft Topological Space with a Soft Weak Structure

Hanan S. Al-Saadi,Won Keun Min 한국지능시스템학회 2017 INTERNATIONAL JOURNAL of FUZZY LOGIC and INTELLIGE Vol.17 No.4

In this work, we introduce the notion of generalized ω-closed set in a soft topological space with a soft weak structure. And some basic properties of this new class are investigated by using the concept of weak structure. Moreover, we study soft ω-T1/2-spaces defined by soft gω-closed sets and study some properties of it by using g!-open sets.

Structural design of steel fibre reinforced concrete in-filled steel circular columns

Hanan H. Eltobgy 국제구조공학회 2013 Steel and Composite Structures, An International J Vol.14 No.3

This paper presents the behavior and design of axially loaded normal and steel fiber reinforced concrete in-filled steel tube (SFRCFT) columns, to examine the contribution of steel fibers on the compressive strength of the composite columns. Non-linear finite element analysis model (FEA) using ANSYS software has been developed and used in the analysis. The confinement effect provided by the steel tube is considered in the analysis. Comparisons of the analytical model results, along with other available experimental outputs from literature have been done to verify the structural model. The compressive strength and stiffness of SFRC composite columns were discussed, and the interpretation of the FEA model results has indicated that, the use of SFRC as infill material has a considerable effect on the strength and stiffness of the composite column. The analytical model results were compared with the existing design methods of composite columns – (EC4, AISC/LRFD and the Egyptian code of Practice for Steel Construction, ECPSC/LRFD). The comparison indicated that, the results of the FEA model were evaluated to an acceptable limit of accuracy. The code design equations were modified to introduce the steel fiber effect and compared with the results of the FEA model for verification.

Integrating Entrepreneurship in Translator Training : A Project-Based Case Study

Hanan Sharaf,Dine M. Ahmed 한국외국어대학교 통번역연구소 2022 한국외국어대학교 통번역연구소 학술대회 Vol.2022 No.01

In contemporary research on translator training and education, emphasis is largely placed on the translation process and translation competence acquisition. A broader social constructivist approach to translator training is needed to pay more attention towards strengthening the social connections within which translators are embedded and towards addressing a multi-dimensional translator competence rather than translation competence (Kiraly, 2013). Thus, shifting the initial traditional focus on linguistic skills to a more comprehensive set of competencies that can better prepare the freshly graduated translators to venture confidently into the Language Service Providers market is needed. Entrepreneurial skills are among the most significant skills translators should acquire in the 21st Century. The 2030 Agenda for Sustainable Development pays close attention to entrepreneurship as a means for creating decent work opportunities, improving the quality of life, promoting sustainable economic development, and fostering innovation. While the UN 2018 World Youth Report commends efforts for introducing entrepreneurship to educational programs in both developed and developing countries, it still calls for further studies to evaluate the effectiveness and value of such programs. Although there is a growing interest among institutions of higher education in Egypt to integrate entrepreneurship education in their programs, in fulfillment of the Egypt Vision 2030 and consequently the global SDGs, this interest remains confined mostly to the science majors like engineering, computer science, or even pharmacy and dentistry. Translator training in Egypt mostly focuses on developing the linguistic skills of translators and in best cases their technology and soft skills. To introduce entrepreneurship into translator training, it is not just enough to combine specific skills of business planning and management to linguistic and soft skills, there should be a shift in the teaching and learning methodologies and the roles assumed by students and instructors (Lackeus, 2015). This article presents a case study of a project that integrates entrepreneurship education in a quasi-professional practice setting within a legal translation course for senior students of the translation minor, at an Egyptian private university. The study adopts a post-modern relativistic qualitative methodology as advocated by Kiraly (2013, 2014) to investigate the newly emerging translator competence. Interviews are also conducted to further consolidate the research findings. The study aims to provide insights into curriculum development for translation undergraduate programs promoting entrepreneurship education and student-centered learning. In addition, the study proposes a model of translator competence that befits the new changes in the LSP market and contributes to the 2030 Agenda.

The Helicobacter pylori Ferric Uptake Regulator (Fur) Is Essential for Growth Under Sodium Chloride Stress

Hanan Gancz,D. Scott Merrell 한국미생물학회 2011 The journal of microbiology Vol.49 No.2

Epidemiological data and animal models indicate that Helicobacter pylori and dietary NaCl have a synergistic ill effect on gastric maladies. Here we show that the Ferric Uptake Regulator (Fur), which is a crucial regulatory factor required for H. pylori colonization, is essential for growth in the presence of high NaCl concentrations. Moreover, we demonstrate that the transcriptional response induced by sodium chloride stress exhibits similarities to that seen under iron depletion.