한옥의 특징기반 형상모델링 및 매개변수형 BIM 라이브러리 브라우저 개발에 관한 연구

김인한(Kim In-Han),박승화(Park Seung-Hwa),이지아(Lee Ji-Ah) 대한건축학회 2012 대한건축학회논문집 Vol.28 No.5

Since Han-ok, the traditional Korean-style house, is composed with combinations of complex components in various shapes and sizes, it is essential to categorize the components into several types for digitalization of Han-ok information. This study applied feature-based classification using BIM parametric modelling methods. After investigating ‘Parameter and Formula relations’, ‘Parametric description’ and ‘Instance diagram’ of Han-ok components, the study established XML libraries for the parametric modelling of open BIM. The IFC-XML libraries include parametric and properties information as well as the geometric information of Han-ok. For the combination of parametric and non-parametric geometry, the study also suggested a new methodology of using ‘comments’ inside IFC, which enabled interworking between IFC and XML. A prototype of BIM browsing module was developed in the last phase of this study to validate the conformance of the IFC-XML libraries. This integrated browser for Han-ok allows the users, both experts and non-experts, to check and manipulate Han-ok component fabrication by changing specific parameters promptly. The browser successfully showed automatic changes of all related Han-ok elements in accordance with the parameters, relationships and formulas of components.

Amino-Functionalized Mesoporous Silica Particles for Ocular Delivery of Brimonidine

Kim, Se-Na,Ko, Song Ah,Park, Chun Gwon,Lee, Seung Ho,Huh, Beom Kang,Park, Yoh Han,Kim, Young Kook,Ha, Ahnul,Park, Ki Ho,Choy, Young Bin American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.8

<P>To treat glaucoma, conventional eye drops are often prescribed. However, the eye drops have limited effectiveness as a result of low drug bioavailability due to their rapid clearance from the preocular space. To resolve this, we proposed amino-functionalized mesoporous silica (AMS) particles as delivery carriers of the glaucoma drug, brimonidine. Because of the presence of mesopores, brimonidine (BMD) could be encapsulated in the AMS with a loading amount of 41.73 μg/mg (i.e., drug loading capacity of about 4.17%) to give the BMD-AMS, which could release the drug in a sustained manner over 8 h. BMD-AMS was also shown to be mucoadhesive due to the presence of both hydroxyl and amino groups in the surface, allowing for formation of hydrogen bonds and an ionic complex with the mucin, respectively. Therefore, when topically administered to rabbit eyes in vivo, BMD-AMS could reside in the preocular space for up to 12 h because of its adherence to the mucous layer. To assess in vivo efficacy, we examined the variance in intraocular pressure (IOP) and brimonidine concentration in the aqueous humor (AH) after applying BMD-AMS to the eye, which was compared with that induced by Alphagan P, the marketed brimonidine eye drops. For BMD-AMS, the duration in the decrease in IOP and the area under the drug concentration in the AH-time curve (AUC) were 12 h and 2.68 μg·h/mL, respectively, which were about twice as large as those obtained with Alphagan P; this finding indicated enhanced ocular bioavailability of brimonidine with BMD-AMS.</P> [FIG OMISSION]</BR>

In vivo study for the hemostatic efficacy and foreign body reaction of a new powder-type polysaccharide hemostatic agent

Yoonhyeong Byun,Eun Jin Kim,Areum Lee,Young-Ah Suh,Hee Ju Sohn,Jung Min Lee,Jae Seung Kang,Yoo Jin Choi,Youngmin Han,Hongbeom Kim,Wooil Kwon,Jin-Young Jang 대한외과학회 2022 Annals of Surgical Treatment and Research(ASRT) Vol.102 No.2

Purpose: Various hemostatic agents have been introduced in therapy as postoperative bleeding is a poor prognostic factor for postoperative outcomes. These products can be divided into those that directly promote the hemostatic cascade and those that physically form a barrier by absorbing blood. The latter, powder-type hemostatic agents have the advantages of being inexpensive and more absorbable with less foreign body reactions (FBRs) and are applicable to a relatively wide area. This study was conducted to verify the safety and efficacy of a newly invented polysaccharide product (OOZFIX, Theracion Biomedical), which improves blood absorption and hemostatic effects. Methods: Two separate animal experiments were performed. The first evaluated FBRs histologically at 3 days, 2 weeks, and 4 weeks, after implantation of OOZFIX in rats, and the second compared hemostatic performance of OOZFIX and Arista AH (Bard) in the porcine liver punch biopsy model. Results: We found minimal FBRs in the 3-day group and no reactions in both the 2-week and 4-week groups after implantation of hemostatic agents. The time to hemostasis of OOZFIX was not significantly different from that of Arista AH (median [interquartile range]: 9 [6–10] minutes vs. 8 [6–10] minutes, respectively; P = 0.522). When comparing the serial bleeding grade tendency, there was no statistical difference between OOZFIX and Arista AH (P = 0.656). Conclusion: OOZFIX caused a minimal FBR that disappeared within 2 weeks in vivo, and its hemostatic performance was comparable with that of an existing agent, Arista AH. Further clinical studies are required in the future.

건축디자인과정에서 스케치와 창조적 디자인 행위의 인지적 상호작용분석을 위한 기초연구

최현아,전한종 대한건축학회 2004 대한건축학회논문집 Vol.20 No.7

One of characteristics of the design process in the area of architectural design is the use of a number of different types of sketches. Designers place great emphasis on the sketch often because it is thought to be associated with innovation and creativity. Because of this emphasis researchers have also begun to focus on the sketch and its role of design. Especially emergent shapes through the sketches plays a significant role in the creative design. The first aim of this paper is to collect together and review the results closely related researches that have looked at the role of sketches in design process. The second aim of this paper is to review analogy and emergence that can be effective in facilitating creative design. At last the mutational emergent shapes are introduced.

진달래 꽃에 의한 Grayanotoxin 중독 3 례

김아진,김준식,신동운,백광제,한승백,이용주 대한응급의학회 2000 대한응급의학회지 Vol.11 No.3

Traditionally, the Rhododendron species has been used in gastrointestinal disorder or hypertension. Grayanotoxin exists in honey, flowers, pollen, and the nectar of the Rhododenron species. We experienced 3 cases of Grayanotoxin intoxication. The symptoms of intoxication were nausea, vomiting, hypotension, bradycardia, diplopia, dizziness, and chest discomfort. Generally, the treatment for Grayanotoxin intoxication is fluid resuscitation and injection of atropine sulfate. The patients who were intoxicated with Grayanotoxin were discharged without complication after supportive care.

Miniscrew implant를 이용한 상악 구치부 압하와 개방교합 치료의 효과 및 안정성

이한아,박영철 대한치과교정학회 2008 대한치과교정학회지 Vol.38 No.1

최근 절대적인 고정원의 등장으로 다른 부작용 없이 구치부 압하 치료를 가능하게 하였고, 비수술적으로 개방교합의 심미적인 치료를 가능하게 하였다. 그러나, 이러한 치료법의 장기적인 안정성에 대한 연구는 많이 부족한 실정이다. 이에 본 연구에서는 miniscrew implant를 이용하여 상악 구치를 압하시켜 치료한 성인 개방교합 환자 11명 (남자 1명, 여자 10명)을 대상으로 치료 전후, 그리고 유지기의 골격성, 치아 치조성 변화를 측모 두부 방사선사진을 이용하여 평가하였으며 계측치의 치료 전후 변화량간의 상관관계와 치료에 의한 변화량과 재발량과의 상관관계를 규명하여 상악구치의 압하를 통해서 개방교합을 치료할 때의 안정성을 평가하였다. 그 결과로 상악 구치는 2.22mm 압하(P < 0.001)가 일어났고, 평균 17.4개월 유지 후 0.23 mm의 정출(P = 0.359)이 나타났으며, 재발율은 10.36%로 나타났다. 전치부의 수직피개는 평균 5.47 mm의 증가(P < 0.01)가 나타났고 평균 17.4개월 유지 후 0.99 mm의 감소(P < 0.05)가 나타나서, 재발량은 18.10%로 계산되었다. 치료 전후 수치 변화량의 상관분석을 통해 상악구치 압하량과 하악 평면각 변화량이 상관관계(P < 0.05)가 있었다. 치료 전의 개방교합량, 하악 평면각, 전하안면고경과 치료 후의 수직피개 재발량과는 상관관계가 없었다. 상악 구치 압하량과 수직피개 개선량에서 치료에 의한 변화량과 재발량이 통계적으로 유의한 상관관계를 보였고, 이를 토대로 재발량을 예측할 수 있었다. 이상의 결과를 통하여 성인 개방교합 환자에서 miniscrew implant를 이용한 상악구치부의 압하는 비수술, 심미적 접근방법으로 효율적이고 안정적인 치료방법으로 유용하게 사용할 수 있을 것으로 생각된다. Objective: This study investigated the skeletal and dentoalveolar changes after intrusion of maxillary posterior teeth using miniscrew implants during the treatment and posttreatment period. Method: The subjects consisted of 11 adults (1 male, 10 females) whose open bites were treated by posterior teeth intrusion with miniscrew. The lateral cephalometric x-rays of pre-treatment, post-treatment, and the retention period were evaluated. Results: The average intrusion of maxillary posterior teeth at the end of the treatment period was 2.22 mm (P < 0.001) and the average extrusion of maxillary posterior teeth at the end of the 17.4 month retention period was 0.23 mm (P = 0.359). The relapse rate was calculated at 10.36%. A decrease in overbite after the 17.4 month retention period was 0.99 mm (p < 0.05). The relapse rate was calculated at 18.10%. The skeletal changes and vertical height change of maxillary posterior teeth during the retention period was statistically insignificant, but there was a significant decrease in overbite (mean 0.99 mm, P < 0.05). The amount of intrusion and the overbite improvement from treatment significantly correlates to the degree of relapse. Conclusions: The results indicate that intrusion of the maxillary posterior teeth using miniscrews is an effective, non-surgical treatment modality which can reasonably be used to address adult open bite.

경기 일부지역 육용 양돈작업장의 분진 및 내독소 농도

유동호,김형아,허용,성재혁,이한기,박용규 한국산업위생학회 2003 한국산업보건학회지 Vol.13 No.1

The aim of this study was to evaluate exposure to dust and endotoxin produced while working at swine confinement buildings. The dusts and endotoxin may cause adverse health effects on humans. Fourteen swine farms located at Yong-In, I-Cheon and Yeo-Ju of onggi-do were investigated. Husbandry workers form the farms were requested to wear personal sampler to measure respirable dust levels. Area samplings for total and respirable dust were also conducted at swine confinements buildings by season (summer under window open, winter under window close.) Gravimetric analyses and Limulus Amebocyte Lysate assay for measu- rement of dust level and endotoxin, respectively. The highest geometric mean (GM) concentration of airbome dusts was 7.47mg/㎡ for area respirable dust. and 10.35mg/㎡ for personal respirable dust. For respirable dust levels, seven farmers exceeded level of ACGIH, 3mg/㎥. The highest GM of endo- toxin was 5745.40 EU/㎥ for personal respirable dust. Significantly increased level of total dust (p〈0.001) and endotoxin in area total dust was observe with winter samples compared with those of summer. Area total dust and area respirable dust (r-0.622, p〈0.0001) was very significantly correlated in winter. Swine husbandry worker may have a considerable risk of ill health whenexposed to level of dust or endotoxin demonstrated at this study.

침 시술로 발생한 Non-O1, Non-O139 Vibrio cholerae에 의한 패혈증

임태섭,지아영,이중희,장수연,김인수,김영주,김범경,김승업,박준용,안상훈,한광협,김도영 Ewha Womans University School of Medicine 2013 EMJ (Ewha medical journal) Vol.36 No.S

Vibrio cholerae is mainly known to cause gastrointestinal infection after seawater exposure or raw seafood intake. It is rarely reported to cause cellulitis or sepsis, but threre has been no known case after acupuncture. Herein, We report a 56-year-old cirrhotic patient of non-O1, non-O139 Vibrio cholerae septicemia caused by cellulitis of both lower extremities after acupuncture.

X-linked recessive myotubular myopathy with MTM1 mutations

Han, Young-Mi,Kwon, Kyoung-Ah,Lee, Yun-Jin,Nam, Sang-Ook,Park, Kyung-Hee,Byun, Shin-Yun,Kim, Gu-Hwan,Yoo, Han-Wook The Korean Pediatric Society 2013 Clinical and Experimental Pediatrics (CEP) Vol.56 No.3

X-linked recessive myotubular myopathy (XLMTM) is a severe congenital muscle disorder caused by mutations in the MTM1 gene and characterized by severe hypotonia and generalized muscle weakness in affected males. It is generally a fatal disorder during the neonatal period and early infancy. The diagnosis is based on typical histopathological findings on muscle biopsy, combined with suggestive clinical features. We experienced a case of a newborn who required intubation and ventilator care because of profound hypotonia and respiratory difficulty. The preliminary diagnosis at the time of request for retrieval was hypoxic ischemic encephalopathy, but the infant was clinically reevaluated for generalized weakness and muscle atrophy. Muscle biopsies showed variability in fiber size and centrally located nuclei in nearly all the fibers. We detected an MTM1 gene mutation of c.1261-1C>A in the intron 10 region, and diagnosed the neonate with myotubular myopathy. The same mutation was detected in his mother.

Evaluation of Treatment Response after Endoscopic Variceal Obturation with Abdominal Computed Tomography

( Han Ah Lee ),( Hyun Gil Goh ),( Tae Hyung Kim ),( Sun Young Yim ),( Young-sun Lee ),( Sang Jun Suh ),( Young Kul Jung ),( Ji Hoon Kim ),( Yeon Seok Seo ),( Hyung Joon Yim ),( Sung Bum Cho ),( Jong E 대한간학회 2018 춘·추계 학술대회 (KASL) Vol.2018 No.1

Aims: Current guidelines recommend endoscopic variceal obturation (EVO) as the treatment of choice for the management of bleeding from gastric varices (GV). This study was performed to evaluate the usefulness of CT for the prediction of rebleeding after EVO for GV bleeding. Methods: Patients who were treated with EVO for GV bleeding and performed CT before and after EVO were included. Those with a previous history of endoscopic treatment for bleeding from GVs (n=4) and those with accompanying portal vein invasion by hepatocellular carcinoma (HCC) (n=9) or other malignancy (n=7) were excluded. Results: Fifty-three patients were included. Age was 60.6±11.6 years and 40 patients (75.5%) were men. Alcoholic liver disease was the most frequent underlying liver disease (24 patients, 45.3%). Complete impaction of cyanoacrylate in GVs and in the feeding vessels were achieved in 40 (75.5%) and 24 (45.3%) of patients, respectively. During the follow-up, GV rebleeding occurred in 9 patients and the cumulative incidences of GV rebleeding at 3, 6, and 12 months were 11.8%, 18.9%, and 18.9%, respectively. GV rebleeding rate did not differ significantly according to the complete cyanoacrylate impaction in GV, while it differed significantly according to the complete cyanoacrylate impaction in feeding vessels: the cumulative incidences of GV rebleeding at 3, 6, and 12 months were 22.3%, 35.2%, and 35.2%, respectively, in patients with incomplete cyanoacrylate impaction in feeding vessels and there was no rebleeding during the follow-up period in patients with complete cyanoacrylate impaction in feeding vessels (P=0.002) Conclusions: Abdominal CT was useful in evaluation of treatment response after EVO for GV bleeding. Because incomplete cyanoacrylate impaction in feeding vessels is the risk factor of GV rebleeding, detailed evaluation of feeding vessels on CT after EVO and determination of additional treatment is needed.