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      • Suppressive effects of three diketopiperzines from marine-derived bacteria on TGFBIp-mediated septic responese in human endothelial cells and mice

        ( Byeongjin Jung ),( Sae Kwang Ku ),( Ming Gao ),( Kyung Min Kim ),( Min Su Han ),( Hyukjae Choi ),( Jong Sup Bae ) 영남대학교 약품개발연구소 2016 영남대학교 약품개발연구소 연구업적집 Vol.26 No.-

        Diketopiperazine is a naturally occurring cyclic dipeptide found from diverse living organisma. The com-pounds in this structure class have been known with a broad spectrum of bioactivities including anti-inflamma-tory activities. Transforming growth factor β-induced protein (TGFBIp) is an extracellular matrix protein whose expression in several cell types is greatly increased by TGB- β. TGFBIp is released by human umbilical vein endothelica cells and functions as a mediator of experi-mental sepsis. Here, three (1-3) of diketopiperazines were isolated from two strains of marine-derived bacteria and we hypothesized that 1-3 could reduce TGFBIp-mediated severe inflammatory responses in human endothelial cells and mice. Here, we investigated the anti-septic effects and underlying mechanisms of 1-3 effectively inhibited lipopolysac-charide-induced release of TGFBIp and suppressed TGFBIp-mediated septic responses. In addition, 1-3 sup-pressed cecal ligation and puncture (CLP)-induced sepsis lethality and pulmonary injury. In conclusion, 1-3 sup-pressed TGFBIp-mediated and CLP-induced septic response. Therefore, 1-3 could be a potential therapeutic agent for treatment of various severe vascular inflamma-tory diseases inhibition of the TGFBIp signaling pathway.

      • 人文系 高等學校 (男,女)學生의 體育成積, 身體 充實指數, 體力章과의 相關關係 調査

        金漢燮 관동대학교 1984 關大論文集 Vol.12 No.2

        It is a matter of course that our wish to be more healthy has been, and is enshrined in heart. Physical power has been improved owing to the highly-developed science and technology, moreover, middle and high school student's physical fitness has made a remarkable progress. This can be attributed the systematic training and normalized school education in gymanastics. The purpose of this paper is to prove the correlationship between Physical Fitness Test, physique index and physical achievement. 1. The correlation rate between Physical Fitness Test and Physique Index is 0.20∼0.40, being little significant. 2. The correlation rate between student's physical Achievement records and Physical Fitness Test 0.40∼0.60 (both male and female), proving to be clearly significant. 3. It has turned out that there is a noticeable relationship between physical achievement records and physique Index. This research shouss that middle and high school student's physical grouth can be achieved by performing student's physical check-up two times rather than just once a year. A more accurate measurement of student's physical conditions will be helpful their growth.

      • KCI등재
      • 2¼Cr-1Mo강 압력용기 용접이음부의 재열균열에 관한 역학적 연구

        권영섭,노찬승,방한서 朝鮮大學校 機械技術硏究所 1999 機械技術硏究 Vol.2 No.2

        구조물에 사용되는 각종 압력용기들의 재질은 고온 및 고압에 견딜 수 있도록 요구되고 있다. 따라서, 내열, 내압 및 내부식성이 뛰어난 2¼Cr-1Mo강의 수요가 향후 증대될 전망이다 용접잔류응력은 일반적으로 응접구조물에 각종 악영향을 미치는 것으로 알려져 있다. 이 때문에 용접잔류응력. 확산성 수소제거 및 용접 열영향부의 연화등을 목적으로 용접후열처리(PWHT)를 수행하나, PWHT를 행하면 사용 강재의 종류에 따라 재열균열이 발생하고 있다. 본 연구에서는 2¼Cr-1Mo강에 대하여 실험과 수치해석 기법을 통하여 용접이음부의 재열균열 감수성평가 및 상당크리프 변형율의 재열균열 발생에 판정에 대한 역학적 지표로서의 적용성을 검토하였다. 2¼Cr-1Mo steels are widely used to fabricate pressure vessels. Residual stresses, in general, are known to be harmful to the soundness of the welded structures. PWHT is release residual stresses, which may cause cracks. But, in those PWHT process, 2¼Cr-1Mo steels are apt to occur reheat crack frequently. In this reason, it is strongly needed to analysis and examine the mechanical behavior of welded joints through welding to PWHT process. So, in this study, welded nozzle parts of pressure vessel where reheat cracks are frequently occur are selected for examine the crack-occurrence mechanism.

      • KCI등재
      • 인터넷을 통해서 본 미국 고등학교의 생물교육 내용 분석

        윤한선,김종균,김현섭 공주대학교 사범대학 과학교육연구소 1999 과학교육연구 Vol.30 No.1

        컴퓨터 통신과 인터넷에 힘입어 앞으로의 교육은 온라인 교육이 보편화될 것이다. 생물 교육에도 온라인 교육이 교육의 한 형태로 자리매김할 것으로 예상되므로 인터넷상의 학습 정보가 어느 정도인가를 파악하는 것은 매우 의미있는 일이라 생각된다. 따라서, 본 연구는 우리 나라보다 인터넷이 먼저 도입되고 또 많은 정보가 실려 있는 미국 고등학교 홈페이지의 생물 교과 내용을 조사 및 분석하여 우리 나라 고등학교의 생물 교과 온라인 교육 자료 제작에 참고할 수 있도록 함으로써 생물 교과의 수업에 조금이나마 도움을 주는 데 목적을 두고 수행되었다. 생물 교과 내용이 우수한 고등학교를 선정하기 위해서 미국에서 일반적으로 많이 적용하고 있는 4개의 홈페이지에 실린 19개 Topic을 기준으로 삼았다. 미국의 고등학교 홈페이지에 실린 내용이 그 기준에 어느 정도 접근하였는지를 조사하여, 접근률이 가장 큰 것에서부터 10개의 홈페이지를 선정, 그 내용을 분석하였다. 그 결과는 다음과 같다. 1. 미국 고등학교 훔페이지에는 학생들이 스스로 공부할 수 있는 생물 교과 내용이 충분히 있었고, 각 Topic에는 관련 사이트들이 많이 연결되어 있어서 각자의 능력에 맞는 내용을 선택하여 이용할 수 있게 되어 있었다. 2. 또한 전자우편을 통하여 질문과 답변뿐만 아니라 시험문항에 대한 답을 교환할 수도 있었다. 3. 표준으로 삼은 4개의 홈페이지와 상위 10개 홈페이지에 주로 소개되는 Topic은 Classical Genetics, The Cell, Biological Evolution, Chemistry of Life, Plants, Molecular Basis of Heredity, Energy, Diversity of Organisms, Behavior of Organisms, Cellular Respiration의 순서로 나타났는데, 이들 내용은 우리 나라 고등학교의 생물 교과 온라인 수업에 이용될 내용을 선정하는 데 참고로 삼을 만하였다. The continuous development of internet makes us not only use many types of information such as letters, pictures, sounds, animations and video-visions synthetically, but ?? communicate with each other. In a short time, we will make use of the computer with multimedia instead of the blackboard in education. And the on-line education will be world-wide by the help of telecommunication and internet. Naturally, it also will be applied to biology education. The purpose of this study is to analyze the homepages of the United States high school in order to help building up the data-base for high school biology curriculum of our country. For this study, we first investigated the references. Next, we classified and standardized the curriculums of the United States high school. After that, we searched for the high school home pages in the registered engine. Finally, we selected and analyzed the home pages close to the standard biology curriculum of them. The analyzed results were as follows. 1. The homepages of the United States high school were contained much biology related contents, and linked to various related topic sites including many animations to stimulate interest of students. It means that United States high school make good use of internet for the biology learning. 2. The homepags of the United States high school were also contained the teaching plan, the informations and questions for examination so that students may catch the way of learning. 3. It may be possible that students self-study using them. because the homepages were composed of the simple and systematic structure.

      • 활성탄을 이용한 휘발성 유기화합물(VOCs-BTX)의 흡착특성

        김한수,장효섭,박영성 大田大學校 環境問題硏究所 1998 환경문제연구소 논문집 Vol.3 No.-

        Adsorption characteristics of volatile organic compounds(VOC) by activated carbon were investigated using a continuous generation system for VOC. As samples of VOC, benzene, toluene, and xylene were adopted. The pelletized activated carbon prepared by Hanil Green Tech. Company was used as a adsorbent. As operating variables, adsorption temperature(25∼45℃) and partial pressure of VOC(0.25∼22.5mmHg) were applied. Adsorption characteristics such as adsorption rate, adsorption equilibrium capacity, and breakthrough curve were studied. The experimental results show that the adsorption rate increases with increasing temperature and partial pressure. Also, the adsorption equilibrium capacity increases with increasing pressure. and decreases with increasing temperature.

      • 在庫管理를 위한 資材所要計劃技法 (MRP) 活用에 관한 硏究

        李漢燮 大田大學校 1983 論文集 Vol.2 No.1

        Material requirements planning ( MRP ) is probably the most rapidly growing system area in operations today. The term “Inventory” indicates a static state at a certain point in the systemetic areas of production and marketing. In the light of that type of plan, with the introduction of the concepts of average inventory, present existing techniques of inventory management must prepare a way to minimize the inventory costs by diminishing the trends for surplus inventory and for inventory deficiency. The purpose of this study is designed simply to provide a necessary input into emerging businesses and entrepreneur to enhance the value of marketing and inventory practices. The models in this study can decide the planned lead time through the simulation.

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