Anti-inflammatory and Anti-oxidant Effects of PHBV/Collagen (PHCP) on Lipopolysaccharide-Induced Skin Inflammation

Jin-Yi Han3*, Xu Zi Guang, Jyung-Sik Kwak, Ki-Wan Oh, Han-Ik Bae 충북대학교 동물의학연구소 2012 Journal of Biomedical and Translational Research Vol.13 No.1

The anti-inflammatory effect of PHBV/Collagen (PHCP) was examined in a mouse model of lipopolysaccharide (LPS)-induced skin inflammation. Vascular permeability on the back skin was measured by the local accumulation of Evan’s blue dye after subcutaneous injection of LPS (30 μg site-1). Dye leakage in the skin showed a significant increase at 2 h after injection of LPS. This LPS-induced dye leakage was also completely inhibited by HO-1 inhibitor, ZnPP, and antioxidants, including methyl gallate, trolox, and mannitol. To study the possible mechanisms underlying the in vivo anti-inflammatory effect of PHCP against LPS-induced inflammation, we also examined the effects of PHCP on malondialdehyde (MDA) and glutathione levels in skin tissues and found that pretreatment with PHCP resulted in inhibited MDA elevation and a remarkable reduction of glutathione level. In addition, similar results were obtained after pretreatment with antioxidants, including trolox and mannitol, and HO-1 inhibitor, ZnPP. Histopathologically, an influx of neutrophils into the skin dermis was detected between 24 h and 72 h after LPS injection (30, 100 μg site-1), compared to control animals after injection of saline. This increase was greater in mice treated with 100 μg of LPS than in those treated with 30 μg of LPS and was significantly suppressed by pretreatment with PHCP, antioxidants, and HO-1 inhibitor. These results collectively suggest that PHCP has an anti-inflammatory effect against LPS-induced inflammation model in vivo and may be a good candidate for the skin tissue engineering biomedical application primarily through manipulation of the redox state.

수축저감제 혼입률 변화에 따른 콘크리트의 공학적 특성에 관한 연구

한민철,金光華,정규문,정평유,윤성노,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In this paper, tests are carried out using concrete incorporating shrinkage reducing agent(SR) in order to investigate the engineering properties of concrete. The contents of SR and W/C are varied. According to test results, as for fresh concrete, as SR content increases, slump and air content shows decline tendency, and setting time is accelerated with increase of SR content and decrease of W/C. As for compressive strength, as SR contents increases compressive strength shows to be decreased. As for the effect of SR on drying shrinkage, it shows to be reduced with increase of SR content. This is due to the reduced surface tensile strength of water and tensile strength of capillary pore in concrete.

시멘트 제조사 및 W/C 변화에 따른 콘크리트의 초기 강도발현 특성

金光華,裵正烈,김규도,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

This study is to investigate the influence of cement manufacturing company and W/C on the properties of fresh concrete, strength of hardened concrete and rebound value of P type Schmidt hammer. According to the result, setting time of concrete is shortened with and increase of W/C, and when cement made in A and B corporation is used in concrete, the final setting time is measured at about 10 hours and 13 hours. Compressive strength increases with elapse of time and decrease of W/C, and concrete using cement made in A corporation shows higher compressive strength and rebound value until 24 hours, but from 3rd day, the contrary tendency is shown. As for the properties of early strength, the strength develop fast with decrease of W/C, and the time when compressive strength of 5MPa is gained and the form can be removed, is about 15, 18, 21 hours and 20, 22, 27 hours at the W/C 40, 45, 50% in concrete using cement made in A and B Co. respectively. The correlativity between compressive strength and the rebound value, which a coefficient of correlation is over 0.97, is very favorable. Therefore this method is effective to estimate the strength of removing the form.

수축저감제와 혼화재를 병용한 콘크리트의 공학적 특성

金光華,김종,한민철,정평유,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

The objective of this paper is to investigate the physical and mechanical properties of concrete incorporating shrinkage reducing admixture(SRA) and mineral admixture(MA) such as fly ash and blast furnace slag powder. According to results, for fresh concrete properties, increase of SRA content leaded to reduce the fluidity and air content sharply. For setting time, use of SRA caused concrete to accelerate setting time, and compared with plain concrete it retarded by incorporating MA. Compressive strength decreased with an increase in SRA content, and when incorporating MA, compared with plain concrete, it shows lower compressive strength in early age but similar or increase by the elapse of age due to the pozzolanic and latent hydration reaction. For drying shrinkage, concrete shows decline tendency with an increase in SRA content due to the relaxation effect at the capillary tension in concrete by SRA. In the scope of this paper, it is found that the use of SRA with 1.0% has optimum effects on the various properties of concrete, and the combinations of SRA and fly ash will ensure the stability for drying shrinkage.

회수수 안정화제를 사용한 콘크리트의 공학적 특성에 관한 연구

김기정,金光華,이문환,이세현,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.2

In this study is investigated the engineering properties of concrete using stabilizing agent of recycling water in order to suggest a practical use of recycling water. According to the results. as stabilizing agent is added. fluidity and air content varies slightly with W/C, but does not make a big difference. Bleeding is reduced by adding stabilizing agent, and so it decreases by about 40% at the adding ratio of 0.15%. When stabilizing agent is not added, compressive strength decreases in comparison with plain concrete, but increases by adding stabilizing agent, so it is largest at adding ratio of 0.30%(W/C 30%) and 0.15%(W/C 40, 50%). Length change by drying shrinkage is larger than plain concrete in the case of no adding of stabilizing agent, but decreases by the use of stabilizing agent. Therefore, it is thought that when stabilizing agent is added to recycling water, quality deterioration of concrete is prevented, moreover, quality of concrete can be improved.

트리에탄올아민의 혼입률 변화에 따른 콘크리트의 초기 강도발현 특성

황인성,金光華,김규동,이승훈,한천구 대한건축학회 2003 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.23 No.1(구조계)

In this study, the influence of TEA on early strength development of concrete is discussed in order to reduce a construction period in RC structure by early removal of forms. According to the results, as for the properties of fresh concrete, fluidity of concrete shows no difference, and air content increases with an increase of the mixing ratio of TEA. Setting time is shortened upto mixing ratio of 0.025%, but is retarded above the mixing ratio of 0.025%. The time when compressive strength gains 5MPa is fast in about 2 hours in the case of the mixing ratio of 0.05%, but it is retarded above the mixing ratio of 0.05%. The relativity between compressive strength and the rebound value of P-type Schmidt hammer is also favorable at early age, and compressive strength of 5MPa, which the side forms can be removed, is estimated at the rebound value of 23.

국내 레미콘사의 부순모래 사용실태 조사

김기훈,金虎林,金光華,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

Crushed sand is made by crushing the rock artificially. With the wide shortage of natural fine aggregates at all regions in Korea. crushed sand has been increasingly consumed as a alternative aggreagtes of natural sand. But there is insufficient information related to the actual situation on the produce. quality and manufacturing company of crushed sand. In this paper. survey is performed in order to know actual consumption situation of crushed sand through ready mixed concrete company in domestic. The remicon companies using crushed sand were estimated with 55%. According to the using method of crushed sand. most remicon company used fine aggregates by mixing natural sand and crushed sand. It is found that natural sand is replaced by crushed sand by about 20~50%. For quality problems in using crushed sand. grain shape. grade and fine particles shall be improved to meet the quality requirement of remicon and wide application. Therefore. it is found that quality improvement of crushed sand is required.

Systematic Review on Epstein-Barr Virus (EBV) DNA in Diagnosis of Nasopharyngeal Carcinoma in Asian Populations

Han, Bao-Lin,Xu, Xiang-Ying,Zhang, Chun-Zhi,Wu, Jian-Juan,Han, Chun-Feng,Wang, Hui,Wang, Xuan,Wang, Guang-Shun,Yang, Shu-Juan,Xie, Yao Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.6

Objective: To conduct a meta-analysis to investigate the value of EBV DNA in diagnosis of nasopharyngeal cancer (NPC) in Asian populations, and provide important evidence for screening. Methods: Prospective or respective case-control or cohort studies regarding the detection role of EBV DNA for NPC were included in our study. We conducted a comprehensive literature search in PubMed, EMBASE, and the Chinese Biomedical Database (CBM database between January 1980 and March 2012. Results: A total of 18 studies with 1492 NPC cases and 2641 health controls were included. Almost of the included studies were conducted in China, and only one other conducted in Thailand. The overall results demonstrated that the pooled sensitivity, specificity, positive likelihood (+LR) and negative likelihood (-LR) were 0.73 (0.71-0.75), 0.89 (0.88-0.90), 8.84 (5.65-13.84) and 0.19(0.11-0.32), respectively. The overall EBV DNA detection showed the largest area of 0.932 under the summary receiver operator curve (SROC). The accuracy of detection by plasma for NPC (0.86) was higher than in serum (0.81), with largest areas under the SROC of 0.97 and 0.91, respectively. Conclusion: Our results demonstrated the EBV DNA detection in plasma or serum has high sensitivity and specificity in diagnosis of NPC, especially in Chinese populations with a high risk of cancer.

Multiconsensus of Second Order Multiagent Systems with Directed Topologies

Guang-Song Han,Zhi-Hong Guan,Xin-Ming Cheng,Yonghong Wu,Feng Liu 제어·로봇·시스템학회 2013 International Journal of Control, Automation, and Vol.11 No.6

A novel multiconsensus problem is introduced in multiagent systems. The states of multiple agents in each subnetwork asymptotically converge to a consistent value with information exchanges among subnetworks. The multiconsensus problem of second order multiagent systems with directed topologies is studied. Three linear protocols are proposed to solve the multiconsensus problem. Necessary and sufficient conditions are derived based on matrix theory. Simulations are provided to demonstrate the effectiveness of the theoretical results.

A method based on Multi-Convolution layers Joint and Generative Adversarial Networks for Vehicle Detection

( Guang Han ),( Jinpeng Su ),( Chengwei Zhang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.4

In order to achieve rapid and accurate detection of vehicle objects in complex traffic conditions, we propose a novel vehicle detection method. Firstly, more contextual and small-object vehicle information can be obtained by our Joint Feature Network (JFN). Secondly, our Evolved Region Proposal Network (EPRN) generates initial anchor boxes by adding an improved version of the region proposal network in this network, and at the same time filters out a large number of false vehicle boxes by soft-Non Maximum Suppression (NMS). Then, our Mask Network (MaskN) generates an example that includes the vehicle occlusion, the generator and discriminator can learn from each other in order to further improve the vehicle object detection capability. Finally, these candidate vehicle detection boxes are optimized to obtain the final vehicle detection boxes by the Fine-Tuning Network(FTN). Through the evaluation experiment on the DETRAC benchmark dataset, we find that in terms of mAP, our method exceeds Faster-RCNN by 11.15%, YOLO by 11.88%, and EB by 1.64%. Besides, our algorithm also has achieved top2 comaring with MS-CNN, YOLO-v3, RefineNet, RetinaNet, Faster-rcnn, DSSD and YOLO-v2 of vehicle category in KITTI dataset.