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Improving Outcome of Capd: Twenty-Five Years’ Experience in a Single Korean Center
Han, Seung Hyeok,Lee, Sang Choel,Ahn, Song Vogue,Lee, Jung Eun,Choi, Hoon Young,Kim, Beom Seok,Kang, Shin-Wook,Choi, Kyu Hun,Han, Dae Suk,Lee, Ho Yung SAGE Publications 2007 Peritoneal dialysis international Vol.27 No.4
<B>Background</B><P> Continuous ambulatory peritoneal dialysis (CAPD) is an established treatment for end-stage renal disease (ESRD). We investigated the outcome of CAPD over a period of 25 years at our institution. </P><B>Methods</B><P> CAPD has been performed in 2301 patients in 25 years. After excluding patients with less than 3 months of follow-up and missing data, we evaluated 1656 patients who started peritoneal dialysis between November 1981 and December 2005. Data for sex, age, primary disease, co-morbidities, follow-up duration, cause of death, and cause of technique failure were collected. We also examined data for urea kinetic modeling (UKM), beginning in 1990, and peritonitis episodes, including causative organisms, starting in 1992. </P><B>Results</B><P> Compared to incident patients from 1981 - 1992, mean age and incidence of ESRD caused by diabetic nephropathy increased in patients from 1993 to 2005. Technique survival after 5 and 10 years was 71.9% and 48.1% respectively. Technique survival was significantly higher in patients who started CAPD after 1992 than in those who started before 1992. Peritonitis was the main reason for technique failure. Overall peritonitis rate was 0.38 episodes per patient-year, with a significant downward trend to 0.29 per patient-year over 10 years, corresponding to a decrease in gram-positive peritonitis. Patient survival after 5 and 10 years was 69.8% and 51.8% respectively. Patient survival improved significantly during 1992 - 2005 compared to 1981 - 1992 after adjustment for age, gender, diabetes, and cardiovascular comorbidities [hazard ratio (HR) 0.68, p @@<@@ 0.01]. Subgroup analysis based on UKM revealed that dialysis adequacy did not affect patient survival. However, diabetes (HR 2.78, p @@<@@ 0.001), older age (per 1 year: HR 1.06; p @@<@@ 0.001), serum albumin level (per 1 g/dL: increase, HR 0.52; p @@<@@ 0.05), and cardiovascular comorbidities (HR 2.32, p @@<@@ 0.01) were identified as significant risk factors. </P><B>Conclusion</B><P> Technique survival has improved due partly to a decrease in peritonitis, which was attributed to a decrease in gram-positive peritonitis. Patient survival has also improved considering increases in aged patients and ESRD caused by diabetes. The mortality rate of CAPD is still high in older, diabetic, malnourished, and cardiovascular diseased patients. A more careful management of higher risk groups will be needed to improve the outcome of CAPD patients in the future. </P>
Han, Seung Hyeok,Lee, Sang Choel,Kang, Ea Wha,Park, Jung Kyung,Yoon, Hyang Sook,Yoo, Tae-Hyun,Choi, Kyu Hun,Han, Dae-Suk,Kang, Shin-Wook SAGE Publications 2012 Peritoneal dialysis international Vol.32 No.2
<B>♦Background</B><P> Endothelial dysfunction, which contributes to atherosclerosis and arteriosclerosis, commonly accompanies end-stage renal disease (ESRD). However, little is known about the role of residual renal function (RRF) in endothelial protection in ESRD patients. This study aimed to investigate the relationship between endothelial function and RRF in patients undergoing peritoneal dialysis (PD). </P><B>♦Methods</B><P> This was a cross-sectional study involving 72 prevalent PD patients. Demographic and clinical data were recorded and residual glomerular filtration rate (GFR), Kt/V urea, and serum concentrations of inflammatory markers were measured. Endothelial function was assessed by brachial artery endothelium-dependent vasodilation [flow-mediated dilation (FMD)] to reactive hyperemia following 5 minutes of forearm ischemia. </P><B>♦Results</B><P> In patients with FMD% above the median value (FMD @@>@@ 2.41%), residual GFR was significantly higher compared to that in patients with FMD% below the median [1.50 (0 - 9.64) vs 0.48 (0 - 3.89) mL/min/1.73 m<SUP> 2</SUP>, P = 0.026]. Correlation analyses revealed that residual GFR (p = 0.381, P = 0.001) and total Kt/V urea (γ= 0.408, P @@<@@ 0.001) were positively correlated with FMD%, whereas PD duration (γ = -0.351, P = 0.003), high-sensitivity C-reactive protein (p = -0.345, P = 0.003), pulse pressure (γ = -0.341, P = 0.003), and age (γ = -0.403, P @@<@@ 0.001) were inversely correlated with FMD%. In contrast, there was no correlation between peritoneal Kt/V urea and FMD%. In multivariate linear regression analysis adjusted for these factors, residual GFR was found to be an independent determinant of FMD% (β = 0.317, P = 0.017). </P><B>♦ Conclusion</B><P> This study shows that RRF is independently associated with endothelial dysfunction in ESRD patients on PD, suggesting that RRF may contribute to endothelial protection in these patients. </P>
Induction of heme oxygenase-1 protects against podocyte apoptosis under diabetic conditions
Lee, Sang Choel,Han, Seung Hyeok,Li, Jin Ji,Lee, Sun Ha,Jung, Dong-Sub,Kwak, Seung-Jae,Kim, Seung Hye,Kim, Dong Ki,Yoo, Tae-Hyun,Kim, Jin Hyun,Chang, Se-Ho,Han, Dae Suk,Kang, Shin-Wook International Society of Nephrology 2009 Kidney international Vol.76 No.8
Heme oxygenase-1 (HO-1) is an anti-oxidant enzyme normally upregulated in response to oxidant injury. Here we determined the role of HO-1 in podocyte apoptosis in glomeruli of streptozotocin-treated rats and in immortalized mouse podocytes cultured in media containing normal or high glucose. HO-1 expression, its activity, the ratio of Bax/Bcl-2 protein, and active caspase-3 fragments were all significantly higher in isolated glomeruli of diabetic rats and in high glucose–treated podocytes. These increases were inhibited by zinc protoporphyrin treatment of the rats or by HO-1 siRNA treatment of the podocytes in culture. The number of apoptotic cells was also significantly increased in the glomeruli of diabetic rats and in high glucose–treated podocytes. Inhibition of HO-1 accentuated the increase in apoptotic cells both in vivo and in vitro. Our findings suggest that HO-1 expression protects against podocyte apoptosis under diabetic conditions.
이혁주 ( Lee Hyuk-ju ),한준희 ( Han Jun-hui ),이재진 ( Lee Jae-jin ),한동엽 ( Han Dong-yeop ),한인덕 ( Han In-duck ),한민철 ( Han Min-choel ) 한국건축시공학회 2018 한국건축시공학회 학술발표대회 논문집 Vol.18 No.1
There are three types of high fluidity concrete: powder based, VMA based, and combined. In the case of the powder based high fluidity concrete mixture, according to the textbook, increased viscosity due to the replaced fly ash can prevent segregation of coarse aggregate. On the other hand, decreased density of the powder due to the fly ash replacement can causes segregation but there is no report on this issue. Therefore, in this research, the segregation resistance and segregation evaluation method for powder based high fluid concrete mixture are evaluated. As a result, with increased replacing ration of supplementary materials, EIS value was decreased and apparently segregation resistance was increased. However, from the compressive strength evaluation depending on height of the cylindrical specimen, it was confirmed that the different of strength difference between top and bottom part of the specimen. Thus, following research regarding vertical segregation should be studied.
20℃ 조건에서 초지연제 혼입율 변화에 따른 응결지연 성능 변화 분석
임군수 ( Lim Gun-su ),한수환 ( Han Soo-hwan ),현승용 ( Hyun Seung-yong ),김종 ( Kim Jong ),한민철 ( Han Min-choel ),한천구 ( Han Cheon-goo ) 한국건축시공학회 2020 한국건축시공학회 학술발표대회 논문집 Vol.20 No.2
This research is part of the research for unifying the mass concrete and utilizing the rate of super retarding agent. We analyzed the performance of super retarding agent 20℃ conditions. It was found that there was no deterioration in fluidity and air quality due to the change in the super retarding agent mixing rate. It was found that when super retarding agent was mixed up to 0.5 %, it was delayed for 22.3 hours at 20℃. Therefore in order to ensure the performance required at the site, the super retarding agent mixing rate must be determined by fully considering the situation at the site. In addition it will be analyzed that super retarding agent performance analysis at high temperature will be required in subsequent studies.
CGS 잔골재를 사용한 콘크리트의 응결시간 추정시 듀로미터 사용 가능성 분석
이혁주 ( Lee Hyuk-ju ),한준희 ( Han Jun-hui ),백승복 ( Baek Seung-bok ),신용섭 ( Shin Yong-sub ),한민철 ( Han Min-choel ),한천구 ( Han Cheon-goo ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2
In this study, we compared the proctor penetration resistance test value of the concrete using CGS for Fine Aggregate and the hardness value of the Durometer. The results are summarized as follows. 1) Surface finish The Durometer C type setting time measurement value was about 45 HD, and the hardness value of the Durometer D type was about 5 HD. 2) The proctor penetration resistance test value and the hardness value of the Durometer are highly correlated and are expected to be easy to use.
CGS를 잔골재로 활용하는 콘크리트의 응결시간 추정시 고무경도계 A타입 사용 가능성 분석
이혁주 ( Lee Hyuk-ju ),한준희 ( Han Jun-hui ),백승복 ( Baek Seung-bok ),신용섭 ( Shin Yong-sub ),한민철 ( Han Min-choel ),한천구 ( Han Cheon-goo ) 한국건축시공학회 2019 한국건축시공학회 학술발표대회 논문집 Vol.19 No.2
In this research, Proctor insertion resistance test values and Durometer A type hardness values were compared and analyzed between the setting times of the concrete using CGS for Fine Aggregate, and the results are summarized as follows. 1) The Proctor penetration resistance test value and the hardness value of Durometer A type showed a high correlation in the form of a curve. 2) About surface finish The resolution exceeding the hardness value of the Durometer A type uses about 25 HD, and in the case of termination, about 35 HD, and is considered to be effective for determining the surface finishing work time. The possibility to do is expected.