ORiginal Article : Ischemia-Modified Albumin: Could It Be a New Oxidative Stress Biomarker for Colorectal Carcinoma?

( Hamit Yasar Ellidag ),( Nurullah Bulbuller ),( Esin Eren ),( Sedat Abusoglu ),( Evren Akgol ),( Mustafa Cetiner ),( Necat Yilma ) The Editorial Office of Gut and Liver 2013 Gut and Liver Vol.7 No.6

Background/Aims: An impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases, including cancer. The aim of this study was to evaluate the levels of the novel marker ischemia-modified al-bumin (IMA) and albumin-adjusted IMA (Adj-IMA) in patients with colorectal cancer (CRC) and look for the associations of these with the total antioxidant status (TAS), total oxidant status (TOS), and oxidative stress index (OSI). Methods: Forty patients with CRC (19 females and 21 males; mean age, 56.5±2.1 years) and 39 age- and sex-matched healthy peo-ple (22 females and 17 males; mean age, 56.0±1.7 years) were included in this study. Serum levels of IMA, TAS, and TOS were analyzed, and the OSI was calculated. Results: Serum IMA, TOS, and OSI levels were significantly higher in patients with CRC than in controls (p<0.0001), whereas TAS levels were significantly lower in CRC patients (p=0.03). There was no significant difference in serum Adj-IMA levels between groups (p=0.32). Conclusions: In this study, the oxidative/antioxidant status was impaired in favor of oxida-tive stress in CRC patients. This observation was not con-firmed by IMA measurement. Further studies are needed to establish the relationship between IMA and oxidative stress parameters in CRC and other cancers. (Gut Liver 2013;7:675-680)

A mathematical model to investigate the effects of misfire and cyclic variations on crankshaft speed fluctuations in internal combustion engines

Hamit Solmaz,Halit Karabulut 대한기계학회 2015 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.29 No.4

In internal combustion engines the engine vibrations come up as block vibrations and crankshaft speed fluctuations. Crankshaft speedfluctuations indicate the unstable running of the engine. Crankshaft speed fluctuations are caused by several sources. Main factor affectingthe crankshaft speed fluctuations is in-cylinder pressure. Changes in-cylinder pressure caused by cyclic variations and misfire resultas speed fluctuations on a crankshaft. In this study the effects of the cyclic variations and misfire problem on the engine crankshaft speedfluctuations have been investigated. A mathematical model including engine kinematics has been developed for a four cylinder dieselengine. In-cylinder pressure profiles used in the mathematic model were obtained experimentally. Two pressure profiles including 11cycles and averages of these cycles were used in analysis. Pressure profiles were expressed mathematically by Fourier series having 1001term. Although the indicated mean effective pressure values of pressure profiles were stable, the crankshaft speed fluctuations were determinedas 5.5% and 11.1% at 230 rad/s for 5.15% and 12.92% imep COV values. When single misfire take place in the third cylinder,average crankshaft speed decreased 6.6 rad/s. Also, in case of continuous misfire the crankshaft speed fluctuations increased from 4.3%to 8%.

Evaluation of Molecular Weight Distribution, Pasting and Functional Properties, and Enzyme Resistant Starch Content of Acid-modified Corn Starches

Hamit Koksel,Serpil Ozturk,Kevser Kahraman,Arzu Basman,Ozen Ozboy Ozbas,Gi-Hyung Ryu 한국식품과학회 2008 Food Science and Biotechnology Vol.17 No.4

The aim of this study was to produce resistant starch preparations from acid-modified corn starches prepared at various hydrolysis levels (0.5-4.0 hr). Effect of autoclaving cycles on resistant starch (RS) formation was investigated. Molecular weight distribution, pasting and functional properties of acid-modified corn starches were determined. For RS formation native and acid-modified starch samples were gelatinized and autoclaved (1 or 2 cycles). While native and acid-modified starches did not contain any RS, the levels increased to 9.0-13.5% as a result of storage at 95℃ after first autoclaving cycle. Second autoclaving cycle together with storage at 95℃ brought final RS contents of the samples incubated at 4 and 95℃ after the first cycle to comparable level. As acid modification level increased, the amount of high molecular weight fractions decreased, resulting in significant decreases in viscosities (p<0.05). The samples produced in this study had low emulsion stability and capacity values.

Prediction of concrete compressive strength using non-destructive test results

Hamit Erdal,Mürsel Erdal,Osman Şimşek,Halil İbrahim Erdal 사단법인 한국계산역학회 2018 Computers and Concrete, An International Journal Vol.21 No.4

Concrete which is a composite material is one of the most important construction materials. Compressive strength is a commonly used parameter for the assessment of concrete quality. Accurate prediction of concrete compressive strength is an important issue. In this study, we utilized an experimental procedure for the assessment of concrete quality. Firstly, the concrete mix was prepared according to C 20 type concrete, and slump of fresh concrete was about 20 cm. After the placement of fresh concrete to formworks, compaction was achieved using a vibrating screed. After 28 day period, a total of 100 core samples having 75 mm diameter were extracted. On the core samples pulse velocity determination tests and compressive strength tests were performed. Besides, Windsor probe penetration tests and Schmidt hammer tests were also performed. After setting up the data set, twelve artificial intelligence (AI) models compared for predicting the concrete compressive strength. These models can be divided into three categories (i) Functions (i.e., Linear Regression, Simple Linear Regression, Multilayer Perceptron, Support Vector Regression), (ii) Lazy-Learning Algorithms (i.e., IBk Linear NN Search, KStar, Locally Weighted Learning) (iii) Tree- Based Learning Algorithms (i.e., Decision Stump, Model Trees Regression, Random Forest, Random Tree, Reduced Error Pruning Tree). Four evaluation processes, four validation implements (i.e., 10-fold cross validation, 5-fold cross validation, 10% split sample validation & 20% split sample validation) are used to examine the performance of predictive models. This study shows that machine learning regression techniques are promising tools for predicting compressive strength of concrete.

A linear variation of the thermal expansivity with the isothermal compressibility for ammonia solid III near the melting point

Hamit Yurtseven,Önder Ça lar 한국화학공학회 2010 Korean Journal of Chemical Engineering Vol.27 No.1

The thermal expansivity αp is related to isothermal compressibility κT at various pressures for constant temperatures of 254.6, 274 and 297.5 K close to the melting pressure in ammonia solid III. By analyzing the experimental data for κT according to a power-law formula, a linear variation of αp with the κT is established here close to the solid-liquid transition in ammonia. Anomalous behavior of thermal expansivity αp and the isothermal compressibility κT near the melting pressure is indicative of the λ-type transition in ammonia solid III.

Analysis of the Orientational Order Parameter and the Magnetic Field as Functions of Temperature for p-anisaldazine

Hamit Yurtseven,Ethem Kaya 한국물리학회 2016 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.68 No.11

We analyze in this study the orientational order parameter and the magnetic field as functions of temperature close to the nematic-isotropic liquid (NI) transition in anisaldazine. The experimental data from the literature are analyzed by using a power-law formula for both the orientational order parameter and the magnetic field, and the critical exponents are deduced. In particular, the mean field value of = 0.5 for the critical exponent of the orientational order parameter is used, and the power-law formula is fitted to the experimental data. Our fits and the values of the critical exponents for the temperature dependence of the orientational order parameter and the magnetic field indicate weak first-order transition, and they adequately describe the observed behavior of the nematic-isotropic liquid transition in anisaldazine.

Strength and failure analysis of inverse Z joints bonded with Vinylester Atlac 580and Flexo Tix adhesives

Hamit Adin,Aydın Turgut 대한기계학회 2012 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.26 No.11

In this study, the tensile strength and failure loads of the inverse Z joints were analyzed both experimentally and numerically by using two adhesives with different properties under a tensile load. Vinylester Atlac 580 and Flexo Tix were used as adhesives and the joints were prepared with two different composite materials. Initially, the mechanical properties of the adhesives were specified using bulk specimens. Then, the stress analyses were performed using three-dimensional finite element method (3-D FEM) via Ansys (V.10.0.1). The experimental results were compared with the numerical results and they were found quite reasonable. According to the test results, it can be seen that when the adherend thickness is increased, the stress increases as well. The most appropriate value of the adherend thickness is identified as t = 5 mm. Furthermore, it was observed that the lowest failure load was obtained at t = 3 mm the thickness for each specimen.

Calculation of thermodynamic quantities for carbon tetrachloride (CCl_4) close to the III-IV phase transition

Hamit Yurtseven,Ye in Dildar 한국화학공학회 2011 Korean Journal of Chemical Engineering Vol.28 No.1

We calculate the thermal expansion α_p , isothermal compressibility κ_T and the specific heat, C_p-C_v, as a function of pressure using the observed V-P data at room temperature close to the III-IV phase transition in CCl_4. Calculated κ_T , α_p and Cp-Cv decrease as the pressure increases from phase III to phase IV in this molecular crystal system,as expected. On the basis of our calculations of the κ_T, α_p and C_p-C_v, the Pippard relations are established close to the III-IV phase transition in CCl_4, which can be verified experimentally.

Ischemia Modified Albumin Levels and Oxidative Stress in Patients with Bladder Cancer

Ellidag, Hamit Yasar,Eren, Esin,Aydin, Ozgur,Akgol, Evren,Yalcinkaya, Soner,Sezer, Cem,Yilmaz, Necat Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.5

Background: Impaired oxidative/antioxidative status plays an important role in the pathogenesis of many diseases like cancer. The aim of this study was to evaluate the levels of the novel marker ischemia modified albumin (IMA) and albumin adjusted-IMA (Adj-IMA) in patients with bladder cancer (BC) as well as its association with total antioxidant status (TAS), total oxidant status (TOS) and oxidative stress index (OSI). Materials and Methods: Forty male patients with BC (mean age, $67.4{\pm}12$ years) and forty age-sex matched healthy persons (mean age $56.0{\pm}1.7$ years) were included in this study. Serum levels of IMA, TAS, TOS were analyzed and Adj- IMA and OSI was calculated. Results: Serum IMA, TOS and OSI values were significantly higher in patients with BC compared to controls (p<0.0001, p=0.01 and p=0.01, respectively), whereas TAS was significantly lower in BC patients (p=0.04). There was no significant difference for serum albumin-adjusted IMA levels between groups (p=0.4). Conclusions: In this study, it was found that there was an impaired oxidative/antioxidant status in favor of oxidative stress in BC patients. This observation was not confirmed by Adj-IMA calculation. There is no published report about serum concentrations of IMA in patients with BC. Further studies are needed to establish the relationship of IMA and oxidative stress parameters in BC and the significance of IMA to other cancers.

Treatment Outcomes and Survival Study of Gastric Cancer Patients: A Retrospective Analysis in an Endemic Region

Basaran, Hamit,Koca, Timur,Cerkesli, Arda Kaymak,Arslan, Deniz,Karaca, Sibel Asian Pacific Journal of Cancer Prevention 2015 Asian Pacific journal of cancer prevention Vol.16 No.5

Purpose: To present information about prognostic factors of gastric cancer patients treated in our Erzurum center including age, gender, tumour location, pathological grade, stage and the effect of treatment on survival. Materials and Methods: This retrospective study was performed on patients who applied to our clinic and diagnosed as gastric cancer. Age and gender of the patients, primary location, histopathological characteristics, TNM stage of the gastric cancers (GCs), treatment applied, oncological treatment modalities and survival outcomes were studied. A univariate analysis of potential prognostic factors was performed with the log-rank test for categorical factors and parameters with a p value < 0.05 at the univariate step were included in the multivariate regression. Results: A total of 228 patients with a confirmed diagnosis of gastric cancer were included in the study with a male/female ratio of 1.47. Median follow-up period was estimated as 22.3 (range, 3 to 96) months. When diagnosis of the patients at admission was analysed, stage III patients were most frequently encountered (n=147; 64.5%). One hundred and twenty-six (55.3%) underwent surgical treatment, while 117 (51.3%) were given adjuvant chemotherapy. Median overall survival time was 18.0 (${\pm}1.19$) months. Mean overall survival rates for 1, 2, 3 and 5 years were $68{\pm}0.031%$, $36{\pm}0.033%$, $24{\pm}0.031%$and $15.5{\pm}0.036%$, respectively. Univariate variables found to be significant for median OS in the multivariate analysis were evaluated with Cox regression analysis. A significant difference was found among TNM stage groups, location of the tumour and postoperative adjuvant treatment receivers (p values were 0.011, 0.025 and 0.001, respectively). Conclusions: This study revealed that it is possible to achieve long-term survival of gastric cancer with early diagnosis. Besides, in locally advanced GC patients, curative resection followed by adjuvant concomitant chemoradiotherapy based on the McDonald regimen was an independent prognostic factor for survival.