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Türkoğlu Aras,Tosun Metin,Haliloğlu Kamil 한국작물학회 2023 Journal of crop science and biotechnology Vol.26 No.2
Wheat (Triticum aestivum L.) is highly rich in nutrients and is an important staple food for humankind. Mutation breeding ofers a relatively quick method for crop improvement and it provides variation for selective breeding programs and functional gene studies. In vitro mutagenesis, coupled with in vitro regeneration procedure, can ofer a wide variety of plant materials for mutagenesis; enable generation of large mutant populations in a relatively short period. Present experiments were conducted to investigate potential use of conventional chemical mutagenesis technique through ethyl methanesulfonate (EMS) for mature embryo culture in wheat. EMS mutagenesis was experimented with 4 treatment durations (2, 4, 6, and 8 h) and 5 treatment concentrations (0, 0.1, 0.2, 0.3, and 0.4%). Mature embryos were treated to detect optimum doses of mutagenesis and to estimate polymorphism and genomic instability. First of all, 50% reduction in number of regenerated plants as compared to the control (LD50) was adopted as the optimum dose. Treated and untreated mature embryos were transferred to callus induction media. EMS mutagens at diferent duration and concentration had signifcant efects on callus formation rate (%), embryogenic callus formation rate (%), responded embryogenic callus rate (%), regeneration efciency and number of plants parameters. Based on LD50 criterion, the optimum value was achieved at 8 h duration of 0.1% EMS concentration. Secondly, inter-primer binding site (iPBS) markers was applied to investigate insertion polymorphism and genomic instability in the regenerated plants. EMS mutagenic treatments had signifcant efects on diferent efects on polymorphism and genomic instability of regenerated plants. Present fndings revealed that in vitro mutagenesis might be a useful approach for accelerating breeding strategies to create enough genetic variation in wheat populations. Besides, an integrated approach can be used to carry out mutation-assisted breeding and subsequent selection of desired mutants using molecular markers in wheat.
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Ömer Gülpınar,Ahmet Hakan Haliloğlu,Mehmet İlker Gökce,Nihat Arıkan 대한비뇨의학회 2014 Investigative and Clinical Urology Vol.55 No.5
Purpose: In the treatment of interstitial cystitis, intravesical hyaluronic acid application may be suggested as a treatment option. In this randomized prospective study, the authors aimed to identify whether instilling the hyaluronic acid with electromotive drug administration (EMDA) would increase the tissue uptake and improve the efficacy. Materials and Methods: The data of 31 patients who had been diagnosed with bladder pain syndrome/interstitial cystitis (BPS/IC) between 2004 and 2005 were examined. The patients were randomized to two groups: patients in group A received hyaluronic acid directly with a catheter and patients in group B received hyaluronic acid with EMDA. The patients were followed for 24 months and the two groups were compared at certain time intervals. The primary end points of the study were visual analogue scale (VAS) score, global response assessment, and micturition frequency in 24 hours. Results: There were 6 males and 25 females. The two groups were similar in baseline parameters. The decrease in VAS score and the micturition frequency in 24 hours were significantly lower with EMDA at months 6 and 12. The difference between the two groups was not significant at months 1 and 24. Also, treatment with EMDA, positive KCl test, and pretreatment voiding frequency >17 were associated with higher response rates. Conclusions: Hyaluronic acid installation is an effective glycosaminoglycan substitution therapy in patients with BPS/IC. Instillation of hyaluronic acid via EMDA can improve the efficacy of the treatment; however, lack of long-term efficacy is the major problem with this glycosaminoglycan substitution therapy.
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Raif Alan,İsmail Marakoğlu,Seyfullah Haliloğlu 대한치주과학회 2015 Journal of Periodontal & Implant Science Vol.45 No.5
Purpose: Despite the high success rates of endosseous dental implants, their placement is restricted according to the height and volume of bone available. The use of short or mini dental implants could be one way to overcome this limitation. Thus, this study aimed to compare standard, short, and mini dental implants with regard to associated clinical pa¬rameters and peri-implant crevicular fluid (PICF) levels of cathepsin-K (CTSK), RANK ligand (RANKL), and osteoprotegerin (OPG), after prosthodontic loading. Methods: A total of 78 non-submerged implants (Euroteknika, Aesthetica+2, Sallanches, France) were installed in 30 subjects (13 male, 17 female; range, 26–62 years) who visited the clinic of the Periodontology Department, Faculty of Dentistry, Selcuk University. Sam¬pling and measurements were performed on the loading date (baseline) and 2, 14, and 90 days after loading. Assessment of the peri-implant status for the implant sites was per¬formed using the pocket probing depth (PPD), modified plaque index, modified gingival in¬dex, modified sulcular bleeding index, and radiographic signs of bone loss. PICF samples collected from each implant were evaluated for CTSK, RANKL, and OPG levels using the ELISA method. Keratinized tissue and marginal bone loss (MBL) were also noted. Results: Clinical parameters statistically significantly increased in each group but did not show statistical differences between groups without PPD. Although implant groups showed a higher MBL in the upper jaw, only the standard dental group demonstrated a statistically significant difference. At 90 days, the OPG:sRANKL ratio and total amounts of CTSK for each group did not differ from baseline. Conclusions: Within the limitations of this study, both short and mini dental implants were achieving the same outcomes as the standard dental implants in the early period after loading.
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Ömer Gülpınar,Evren Süer,Mehmet İlker Gökce,Ahmet Hakan Haliloğlu,Erdem Öztürk,Nihat Arıkan 대한비뇨의학회 2013 Investigative and Clinical Urology Vol.54 No.6
Purpose: To evaluate the long-term outcomes of artificial urinary sphincter (AUS) implantation and to report the complication rates, including mechanical failure, erosion,and infection. Materials and Methods: From June 1990 to May 2011, AUS (AMS 800) implantations were performed in 56 adult males by one surgeon. Various demographic and preoperative variables, surgical variables, and postoperative outcomes, including success and complication rates with a median follow-up of 96 months, were recorded retrospectively. Results: The mean age of the patients at the time of AUS implantation was 61.8 (±14.2)years. During the follow-up period, the total complication rate was 41.1% (23 patients). The incidence of complications was significantly lower during the follow-up period after 48 months (p<0.05). Kaplan-Meier analysis revealed that 5- and 10-year failure-free rates were 50.3% and 45.2%, respectively. Conclusions: Long-term durability and functional outcomes are achievable for the AMS 800, but there are appreciable complication rates for erosion, mechanical failure, and infection of up to 30%.
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