Increased Bladder Wall Thickness in Diabetic and Nondiabetic Women With Overactive Bladder

Hakkı Uzun,Sabri Ogullar,Serap Baydur Şahin,Orhan Ünal Zorba,Görkem Akça,Fatih Sümer,Ülkü Mete Güney,Gülşah Balık 대한배뇨장애요실금학회 2013 International Neurourology Journal Vol.17 No.2

Purpose: Bladder wall thickness has been reported to be associated with overactive bladder (OAB) in women. Diabetic women have an increased risk for OAB syndrome and may have an increased risk for bladder wall thickness. Methods: A total of 235 female patients aged 40 to 75 years were categorized into four groups. The first group consisted of women free of urgency or urge urinary incontinence. The second group included nondiabetic women with idiopathic OAB. The third group consisted of women with diabetes and clinical OAB, and women with diabetes but without OAB constituted the fourth group. Bladder wall thickness at the anterior wall was measured by ultrasound by the suprapubic approach with bladder filling over 250 mL. Results: The diabetic (third group) and nondiabetic (second group) women with OAB had significantly greater bladder wall thickness at the anterior bladder wall than did the controls. However, the difference was not significant between the diabetic (third group) and the nondiabetic (second group) women with OAB. Women with diabetes but without OAB (fourth group) had greater bladder wall thickness than did the controls but this difference was not significant. Additionally, the difference in bladder wall thickness between diabetic women with (third group) and without (fourth group) OAB was not significant. Conclusions: This is the first study to show that bladder wall thickness is increased in diabetic women with and without OAB. Additionally, nondiabetic women with OAB had increased bladder wall thickness. Further studies may provide additional information for diabetic and nondiabetic women with OAB, in whom the etiopathogenesis of the disease may be similar.

Treatment of wastewater containing organic pollutants in the presence of N‑doped graphitic carbon and Co3O4/ peroxymonosulfate

Hakkı T?rker Ak?ay,Adem Demir,Zehra ?z?if?i,Tu?rul Yumak,Turgut Kele? 한국탄소학회 2023 Carbon Letters Vol.33 No.5

The disposal of organic pollutants is one of the important research topics. Some of the studies in this field are based on the degradation of organic pollutants with a catalytic agent. The cobalt tetraoxide/peroxymonosulfate system is an important catalytic system used for the radical degradation of organic pollutants. To increase the catalytic efficiency of such reactions, graphitization of activated carbon used as a support solid and nitrogen doping to the carbon structure are commonly used methods. In this study, cobalt tetraoxide production, N-doping and graphitization were carried out in a single step by heat treatment of activated carbon doped with the phthlocyanine cobalt (II) complex. The catalytic performance of the catalyst/ peroxymonosulfate system was investigated by changing the pH, catalyst, and PMS concentration parameters on rhodamine B and 1,3,5 trichlorophenol, which were used as models. It was seen that the catalysts had 97% activity on rhodamine B in 16 min and 100% on 1,3,5 trichlorophenol in 6 min. It was observed that the catalysts continued to show high catalytic activity for five cycles in reusability studies and had a very low cobalt leaching rate. These results are in good agreement with previously published studies. In line with these results, the synthesized N-doped graphitic carbon/Co3O4 catalyst can be used as an effective catalyst for wastewater treatments.

Examination of Gusset Plate Modeling via Nonlinear Dynamic Analysis

Hakkı Deniz Gül,Kıvanç Taşkın 한국강구조학회 2023 International Journal of Steel Structures Vol.23 No.2

The connection of the braces of special concentrically braced steel frames to the adjoining frames is usually modeled as a pin connection in practice. However, in the actual case, stiff gusset plates settle in brace-ends to provide the connection of brace elements to the structural system. In this study, gusset plates are modeled as the semi-rigid and pin connection to investigate the modeling effects on the structural responses on both member and global levels. The finite element model of a single brace element is calibrated according to previous experimental work to provide reliable analytical work. The two analytical steel frame models of a fictitious office building are created to perform the nonlinear response history analysis. Analysis results showed that the pin connection assumption for the brace-ends could not reflect the buckling behavior of the brace member with sufficient accuracy. Gusset plates should be designed as a structural element, and their mechanical properties should be implemented into the analytical model to accurately simulate the buckling and the post-buckling behavior of brace members.

Effects of Coenzyme Q10 Supplementation on Plasma Adiponectin, Interleukin-6, and Tumor Necrosis Factor-α Levels in Men

Hakkı Gökbel,Serdar Gergerliog˘lu,Nilsel Okudan,Ibrahim Gu,Sadık Bu¨yu¨kbas,Muaz Belviranlı 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.1

The aim of the study was to determine the effects of coenzyme Q10 supplementation on plasma adiponectin, interleukin (IL)-6, and tumor necrosis factor (TNF)-α levels in sedentary men. Fourteen healthy, nonsmoking, sedentary men participated in the study. The protocol was approved by the Ethical Committee of our institution. This study was a randomized, double-blind, crossover trial. Blood samples were collected from all participants before coenzyme Q10 or placebo supplementation. The participants were randomly allocated to two groups. Seven participants received oral coenzyme Q10 (100mg/day) supplementation, and seven participants received placebo (glucose) for 8 weeks. At the end of the 8 weeks, a second blood sampling was performed. After a 4-week washout period, placebo was given to the participants who used coenzyme Q10 the first time, and vice versa, and blood sampling was repeated. Plasma was stored at −80°C until the time of analysis for adiponectin, IL-6, and TNF-α. Both CoQ10 and placebo supplementation did not affect plasma adiponectin and TNF-α levels. IL-6 level increased with coenzyme Q10 supplementation, but this increase did not differ from that seen with placebo supplementation. Coenzyme Q10 supplementation did not affect plasma adiponectin, IL-6, and TNF-α levels in sedentary men.

3D micro-CT analysis of void formations and push-out bonding strength of resin cements used for fiber post cementation

İsmail Hakkı Uzun,Meral Arslan Malkoç,Ali Keleş,Ayşe Tuba Öğreten 대한치과보철학회 2016 The Journal of Advanced Prosthodontics Vol.8 No.2

PURPOSE To investigate the void parameters within the resin cements used for fiber post cementation by micro-CT (µCT) and regional push-out bonding strength. MATERIALS AND METHODS Twenty-one, single and round shaped roots were enlarged with a low-speed drill following by endodontic treatment. The roots were divided into three groups (n=7) and fiber posts were cemented with Maxcem Elite, Multilink N and Superbond C&B resin cements. Specimens were scanned using µCT scanner at resolution of 13.7 µm. The number, area, and volume of voids between dentin and post were evaluated. A method of analysis based on the post segmentation was used, and coronal, middle and apical thirds considered separately. After the µCT analysis, roots were embedded in epoxy resin and sectioned into 2 mm thick slices (63 sections in total). Push-out testing was performed with universal testing device at 0.5 mm/min cross-head speed. Data were analyzed with Kruskal–Wallis and Mann–Whitney U tests (α=.05). RESULTS Overall, significant differences between the resin cements and the post level were observed in the void number, area, and volume (P<.05). Super-Bond C&B showed the most void formation (44.86 ± 22.71). Multilink N showed the least void surface (3.51 ± 2.24 mm2) and volume (0.01 ± 0.01 mm3). Regional push-out bond strength of the cements was not different (P>.05). CONCLUSION µCT proved to be a powerful non-destructive 3D analysis tool for visualizing the void parameters. Multilink N had the lowest void parameters. When efficiency of all cements was evaluated, direct relationship between the post region and push-out bonding strength was not observed.

Cyst Fluid Carcinoembryonic Antigen Level Difference between Mucinous Cystic Neoplasms and Intraductal Papillary Mucinous Neoplasms

Ibrahim Hakkı Köker,Nurcan Ünver,Fatma Ümit Malya,Ömer Uysal,Elmas Biberci Keskin,Hakan Şentürk 대한소화기내시경학회 2021 Clinical Endoscopy Vol.54 No.1

Background/Aims: The role of cyst fluid carcinoembryonic antigen (CEA) level in differentiating mucinous pancreatic cystic lesions(PCLs) is controversial. We investigated the role of cyst fluid CEA in differentiating low-risk (LR)-intraductal papillary mucinousneoplasms (IPMNs) from high-risk (HR)-IPMNs and LR-mucinous cystic neoplasms (MCNs). Methods: This was a retrospective study of 466 patients with PCLs who underwent endoscopic ultrasound-guided fine-needleaspirationover a 7-year period. On histology, low-grade dysplasia and intermediate-grade dysplasia were considered LR, whereashigh-grade dysplasia and invasive carcinoma were considered HR. Results: Data on cyst fluid CEA levels were available for 50/102 mucinous PCLs with definitive diagnoses. The median CEA (range)levels were significantly higher in HR cysts than in LR cysts (2,624 [0.5–266,510] ng/mL vs. 100 [16.8–53,445] ng/mL, p=0.0012). The area under the receiver operating characteristic curve (AUROC) was 0.930 (95% confidence interval [CI], 0.5–0.8; p<0.001) fordifferentiating LR-IPMNs from LR-MCNs. The AUROC was 0.921 (95% CI, 0.823–1.000; p<0.001) for differentiating LR-IPMNsfrom HR-IPMNs. Both had a CEA cutoff level of >100 ng/mL, with a negative predictive value (NPV) of 100%. Conclusions: Cyst fluid CEA levels significantly vary between LR-IPMNs, LR-MCNs, and HR-IPMNs. A CEA cutoff level of>100 ng/mL had a 100% NPV in differentiating LR-IPMNs from LR-MCNs and HR-IPMNs.

Phenytoin Induced Erythema Multiforme after Cranial Radiation Therapy

Atilla Kazanci,Ismail Hakkı Tekkök 대한신경외과학회 2015 Journal of Korean neurosurgical society Vol.58 No.2

The prophylactic use of phenytoin during and after brain surgery and cranial irradiation is a common measure in brain tumor therapy. Phenytoin has been associated with variety of adverse skin reactions including urticaria, erythroderma, erythema multiforme (EM), Stevens-Johnson syndrome, and toxic epidermal necrolysis. EM associated with phenytoin and cranial radiation therapy (EMPACT) is a rare specific entity among patients with brain tumors receiving radiation therapy while on prophylactic anti-convulsive therapy. Herein we report a 41-year-old female patient with left temporal glial tumor who underwent surgery and then received whole brain radiation therapy and chemotherapy. After 24 days of continous prophylactic phenytoin therapy the patient developed minor skin reactions and 2 days later the patient returned with generalized erythamatous and itchy maculopapuler rash involving neck, chest, face, trunk, extremities. There was significant periorbital and perioral edema. Painful mucosal lesions consisting of oral and platal erosions also occurred and prevented oral intake significantly. Phenytoin was discontinued gradually. Systemic admistration of corticosteroids combined with topical usage of steroids for oral lesions resulted in complete resolution of eruptions in 3 weeks. All cutaneous lesions in patients with phenytoin usage with the radiotherapy must be evoluated with suspicion for EM.

Optimizing a Submerged Monascus cultivation for Production of Red Pigment with Bug Damaged Wheat using Artificial Neural Networks

Serap Duraklı-Velioğlu,İsmail Hakkı Boyacı,Osman Şimşek,Tuncay Gümüş 한국식품과학회 2013 Food Science and Biotechnology Vol.22 No.6

The combined effect of temperature, agitationspeed, and light on red pigment production by Monascuspurpureus (M. purpureus) Went DSM 1604 using bugdamaged wheat was studied using an artificial neuralnetwork (ANN). Information retrieved from the ANN wasused to determine the optimal operating conditions forpigment production by M. purpureus using bug damagedwheat meal. The developed ANN had R2 values fortraining, validation, and testing data sets of 0.993, 0.961,and 0.944, respectively. According to the model, thehighest pigment production of 1.874 absorbance units at510 nm (A510 nm) would be achieved at 29oC and 150 rpmunder light conditions. The mean value of the experimentalresults obtained under these optimum conditions was1.787±0.072 A510 nm, corresponding to a pigment yield of35.740 A510 nm/g. The study showed that bug damagedwheat can be used as a substrate for red pigment productionby M. purpureus.

Influence of different universal adhesives on the repair performance of hybrid CAD-CAM materials

Gülbike Demirel,İsmail Hakkı Baltacıoğlu 대한치과보존학회 2019 Restorative Dentistry & Endodontics Vol.44 No.3

Objectives: The aim of this study was to investigate the microshear bond strength (μSBS) of different universal adhesive systems applied to hybrid computer-aided design/computeraided manufacturing (CAD-CAM) restorative materials repaired with a composite resin. Materials and Methods: Four types of CAD-CAM hybrid block materials—Lava Ultimate (LA), Vita Enamic (VE), CeraSmart (CS), and Shofu Block HC (SH)—were used in this study, in combination with the following four adhesive protocols: 1) control: porcelain primer + total etch adhesive (CO), 2) Single Bond Universal (SB), 3) All Bond Universal (AB), and 4) Clearfil Universal Bond (CU). The μSBS of the composite resin (Clearfil Majesty Esthetic) was measured and the data were analyzed using two-way analysis of variance and the Tukey test, with the level of significance set at p < 0.05. Results: The CAD-CAM block type and block-adhesive combination had significant effects on the bond strength values (p < 0.05). Significant differences were found between the following pairs of groups: VE/CO and VE/AB, CS/CO and CS/AB, VE/CU and CS/CU, and VE/ AB and CS/AB (p < 0.05). Conclusions: The μSBS values were affected by hybrid block type. All tested universal adhesive treatments can be used as an alternative to the control treatment for repair, except the AB system on VE blocks (the VE/AB group). The μSBS values showed variation across different adhesive treatments on different hybrid CAD-CAM block types.

The Effect of Grape Seed Extracts on Serum Paraoxonase Activities in Streptozotocin-Induced Diabetic Rats

Aysel Kıyıcı,Nilsel Okudan,Hakkı Gokbel,Muaz Belviranlı 한국식품영양과학회 2010 Journal of medicinal food Vol.13 No.3

Procyanidins, a group of flavonoids, are oligomeric forms of catechins that are abundant in red wine, grapes, cocoa, and apples. Paraoxonase acts as an antioxidant enzyme and protects low-density lipoprotein-cholesterol against oxidation. In our study we aimed to evaluate the effects of grape seed extract (GSE) on paraoxonase activities in streptozotocin-induced diabetic rats. Our study included four groups of rats: Group I (n=8), control; Group II (n=10), GSE-supplemented; Group III (n=6), streptozotocin-induced diabetic; and Group IV (n=7), GSE-supplemented diabetic rats. Serum paraoxonase activities were determined with a spectrophotometric method. Paraoxonase activities in Group III were significantly lower than in the other three groups (P<.001, P<.001, and P=.005 for Groups I, II, and IV, respectively), and Group IV showed increased paraoxonase activities compared to Group III (P=.005). This is the first study to show an association between paraoxonase status and GSE supplementation and demonstrated that GSE increased paraoxonase activities. This beneficial effect of GSE was more obvious in the diabetic group, which was more prone to atherosclerotic events compared to the healthy population.