카뮈의 《표리》에 나타난 「유년시절」연구

이해방 상명대학교 논문집 1986 상명대학교논문집 Vol.17 No.-

Notre travail consiste a` examiner,en analysant les images concernant l'enfance, le rapport entre l'homme et le monde,et a` expliquer leur signification dans cet ouvrage. D'apre`s Gaston Bachelard, l'enfance est comme un ve´ritable arche´type du bonheur qui est une ouverture au monde et une invitation au monde. Dans ce petit cahier, nous constaterons que l'enfance est en effet la cle´ nous permettant de nous rouvrir le monde myste´rieiux et qu'elle se re´ve`le comme une source du bonheur de vivre et le facteur de l'accord poe´tique entre la vie d'homme et l'univers.

플래쉬형 A/D 변환기를 위한 간단한 구조의 고속 비교기 설계

潘在景,方駿鎬,曺海豊 全北大學校 1992 論文集 Vol.34 No.-

A Flash A/D converter has many comparators for the high speed conversion operation, and its high performance can be achieved by the comparator with good characteristics. When the comparator is used in Flash A/D converter, the improved characteristics of the comparator are restrained by its size and power consumption. In this paper, a high speed CMOS comparator with simple architecture has been designed and simulated using a standard 1.5[㎛] processing parameter for the Flash A/D converter. The characteristics of the designed comparator are improved by using internal biasing circuits and the CMOS complementary gain stage. This comparator can be operated in a few nano second and have a small size achitecture.

혈부축어탕의 고지혈증 유발 생쥐 신장내 지방 축적 감소효과

김호현,강윤호,방혜정,김진택,박인식,안상현,이해풍 世明대학교 한의학연구소 1998 韓醫學硏究所 論文集 Vol.1 No.-

Renal tissues of ICR mouse were intraperitoneally injected with Hyulboochucketang(HCE;1.28g/kg/day) after Triton WR-1339(TX;600mg/kg) injection were observed to investigate the lipid accumulation suppressive effect of HCE. The renal tissues were obtained at hour 24,48 and 72 after TX injection that were fixed in fromol-calcium solution and were cryocut. The tissue stained by H&E for general morphology, sudan black B for lipid and perchloric acid-naphthoquinone method for cholesterol. The parietal layer of Bowman's capsule is swelled as cuboidal type at hour 48 after TX injection and the lipid blot and cholesterol particle were noticeably increased in glomerulus than control group. But the parietal layer of Bowman's capsule in HCE treated group was shaped as squamous type that was looked like as normal morphology and the lipid blot and cholesterol particle w3ere considerably decreased in glomerulus than TX group. As results indicated that the accumulation of lipid including cholesterol caused by TX injection were mitigated in renal tissues by the antihyperlipidermic effect of HCE.

불어권 카나다 연구

원윤수,한명수,이인성,이해방 서울대학교 국제지역원 1992 국제지역연구 Vol.1 No.2

본 연구의 목적은 카나다 불어권 지역, 즉 퀘벡의 문화에 대한 포괄적이고 기초적인 지식을 확립하는 데 있다. 퀘벡은 주변 영어문화권으로부터 받는 끊임없는 동화의 위협에도 불구하고 자신들 고유의 불어권 문화를 형성, 발전시킴으로써 세계 문화 구도 속에서 독특한 위치를 차지하고 있으며, 퀘벡의 역사는 문화적, 사회적, 정치적 변화 속에서 자신들만의 독특한 정체성을 형성하기 위한 퀘벡인들의 노력이 어떠한 것이었던가를 잘 보여준다. 따라서 본 연구는 카나다 불어권을 역사, 정치, 경제, 예술, 언어의 다섯 분야로 나누어 탐구함으로써 이 지역이 갖는 특수성을 보다 잘 이애하고자 하였다. 특히 다음의 사항이 주된 연구 대상이 되었다. 주요 연구대상은 카나다 불어의 역사, 문화 생활에 불어의 사용이 끼친 영향, 이중언어주의, 현재의 퀘벡의 경제상항, 다원문화주의, 문화의식과 정치의식과의 상관성, 카나다의 미래 등이었다. 이러한 연구들 통해 우리는 퀘벡이 다른 문화권들과의 관계 속에서 자신의 독자성을 잃지 않으려는 끊임없는 노력을 보여주는 동시에 '다양성 속의 통일성'이라는 자신의 궁극적 목표에 다가서려는 노력도 잃지 않는 독자적인 문화권임을 알 수 있었다. Le but de cette etude est d'etablir les connaissances preliminaires et globales sur la culture du Quebec, region francophone du Canada. Cette region a un statut particulier dans la culture mondiale; comme un petit ilot francophone entoure d'une mer anglophone, le Quebec a toujours eu la volonte de sauvegarder son identite specifique, a travers les aleas d'une histoire agitee, parfois perilleuse meme. Portant notre attension sur cette specificite, nous avons essaye d'examiner la francophonie canadienne en cinq domaines : celui de l'histoire, de la politique, de l'economie, de l'art et de la langue. Notre reflexion s'est penchee surtout sur les questions suivantes: - l'evolution du francaise au Canada a travers les siecles - l'impact de l'usage du francais sur la vie culturelle - la situation actuelle du bilinguisme canadien - la conscience identitaire des francophones canadiens - la situation actuelle economique du Quebec - Le pluriculturalisme et le modele canadien par rapport au modele americain - leur resonnance dans la conscience cuturelle et politique - l'impasse constitutionnelle et la conscience politique des Canadiens - le Canada, quel avenir? Ce faisant, nous avons pu constater que le Quebec est une region culturelle independante s'efforcant a maintenir son identite specifique dans les relations complexes avec les autre communautes culturelles et a atteindre son but essentiel : "la diversite dans l'unit".

Controlled Drug Delivery Technologies

Hai Bang Lee,Moon Suk Kim,Ju Young Lee,Je Kyo Jeong,Sei-il Sohn,Yongro Byun,Min Hyo Ki,Jung-Ki Seo 한국생물공학회 2009 한국생물공학회 학술대회 Vol.2009 No.10

약물전달과 재생의학 기술

이해방 ( Hai Bang Lee ),정제교 ( Je Kyo Jeong ),손세일 ( Se Il Sohn ),변영로 ( Young Ro Byun ),기민효 ( Min Hyo Ki ),서중기 ( Jung Ki Seo ) 한국조직공학과 재생의학회 2009 조직공학과 재생의학 Vol.6 No.4

Drug delivery system(DDS) has been extensively applied the various areas as (1) novel methods for drug administration through several route, (2) development of novel polymeric carrier, and (3) tissue engineering and regenerative medicine. The aim of this review is to report the recent progress of "Development of controlled drug delivery system" supported by Korean Intellectual and Economy(KOIE) for 2004~2009. This project is composed by 5 subproject as (1) development of novel osmotic pump, (2) development of liposome delivery system, (3) development of DDS by bile acid transporter, (4) protein drug delivery system using thermo-sensitive hydrogel, and (5) development of novel transdermal drug delivery system. DDS system might be the core and platform technology for the application of diagnosis, bioinstrument, tissue engineering, regenerative medicine and pharmaceutical industries.

Visible light-activated degradation of natural organic matter (NOM) using zinc-bismuth oxides-graphitic carbon nitride (ZBO-CN) photocatalyst: Mechanistic insights from EEM-PARAFAC

Truong, Hai Bang,Huy, Bui The,Ly, Quang Viet,Lee, Yong-Ill,Hur, Jin Elsevier 2019 CHEMOSPHERE - Vol.224 No.-

<P><B>Abstract</B></P> <P>In this study, the complex degradation behavior of natural organic matter (NOM) was explored using photocatalytic oxidation systems with a novel catalyst based on a hybrid composite of zinc-bismuth oxides and g-C<SUB>3</SUB>N<SUB>4</SUB> (ZBO-CN). The photooxidation system demonstrated the effective removal of NOM under low-intensity visible light irradiation, presenting removal rates of 53–74% and 65–88% on the basis of dissolved organic carbon (DOC) and the UV absorption coefficient (UV<SUB>254</SUB>), respectively, at 1.5 g/L of the catalyst. The NOM removal showed an increasing trend with a higher ZBO-CN dose. Comparative experiments with the hole and <SUP> </SUP>OH radical scavengers revealed that the direct oxidation occurring on the catalyst's surface might be the governing photocatalytic mechanism. Fluorescence excitation emission matrix-parallel factor analysis (EEM-PARAFAC) revealed the individual removal behavior of the different constituents in bulk NOM. Different tendencies towards preferential adsorption and subsequent oxidative removal were found among dissimilar fluorescent components within a bulk terrestrial NOM, following the order of terrestrial humic-like (C1) > humic-like (C2) > microbial humic-like (C3) components. The result suggests the dominant operation of π-π and/or hydrophobic interactions between the NOM and the catalyst. The discriminative removal behavior was more pronounced in visible light versus UV-activated systems, probably due to the incapability of visible light to excite è - h<SUP>+</SUP> pairs of ZnO and the triplet state of NOM. The high photoactivity and structural stability of ZBO-CN under visible light implies its potential for an effective, low-cost and energy-saving treatment technology to selectively remove large sized humic-like substances from water.</P> <P><B>Highlights</B></P> <P> <UL> <LI> A novel photocatalyst, ZBO-CN, showed a good performance in NOM removal. </LI> <LI> First study of NOM removal using g-C<SUB>3</SUB>N<SUB>4</SUB>-based photocatalyst under visible light. </LI> <LI> Direct oxidation on the catalyst operates as a dominant removal mechanism. </LI> <LI> Selective removal is more pronounced for visible light vs. UV-activated systems. </LI> <LI> ZBO-CN system can be an effective energy-saving technology for NOM removal. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

고분자 구배표면 제조와 생체의료학적 응용

이해방(Hai Bang Lee),김문석(Moon Suk Kim),조영호(Young Ho Cho),강길선(Gil Son Khang),이진호(Jin Ho Lee) 한국고분자학회 2005 폴리머 Vol.29 No.5

Polyethyleneimine modification of activated fly ash and biochar for enhanced removal of natural organic matter from water via adsorption

Truong, Hai Bang,Ike, Ikechukwu A.,Ok, Yong Sik,Hur, Jin Elsevier 2020 CHEMOSPHERE - Vol.243 No.-

<P><B>Abstract</B></P> <P>In this study, fly ash (FA) and biochar (BC), two common industrial byproducts, were activated and surface-modified with polyethyleneimine (PEI) to enhance their capacities to remove natural organic matter (NOM) from water via adsorption. Different fluorescent components were identified using fluorescence excitation-emission matrix coupled with parallel factor analysis (EEM-PARAFAC) to explore the individual adsorption behaviors of different organic constituents in a bulk NOM. The NOM adsorption was quantitatively examined via adsorption isotherm and kinetics models. Compared to the pristine adsorbents, the functionalized adsorbent with increased surface area and positive surface charge achieved higher NOM adsorption. By evaluating the adsorptive behaviors of UV-absorbing and fluorescent moieties, it was concluded that the operative mechanism of adsorption included electrostatic attraction, hydrogen bonding, and π-π interaction. At the optimal pH of 3, the surface-modified FA and BC (i.e., FA-PEI and BC-PEI) had adsorption capacities for NOM that were ∼3 times higher than the capacities of the pristine materials. Due to its aromatic features, π-π interaction may have enhanced BC and BC-PEI selective adsorption of aromatic NOM components compared to FA and FA-PEI. Kinetic modelling showed that the mesopores of FA-PEI were available for NOM adsorption and diffusion of NOM molecules into the mesoporous structures was rate-limiting. On the other hand, PEI-modification may have further reduced NOM diffusion through the narrow micropores in BC such that external adsorption primarily occurred on BC-PEI. The modified adsorbents showed a faster adsorption kinetics than the pristine counterparts and a high durability in repeated adsorption-desorption cycles.</P> <P><B>Highlights</B></P> <P> <UL> <LI> Two industrial by-products are activated and surface-modified for NOM removal. </LI> <LI> FA-PEI and BC-PEI showed enhanced adsorption for NOM than the pristine ones. </LI> <LI> PEI-modification increased surface areas and positive surface charges of adsorbents. </LI> <LI> Preferential adsorption of aromatic molecules may occur through π-π interaction. </LI> <LI> Reduced NOM diffusion through micropores led to fast adsorption onto BC-PEI. </LI> </UL> </P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>

고지방 식이로 유도된 비만 쥐에서 HPJ 추출물의 항비만 효과

원해단(Hai-Dan Yuan),임방호(Bang-Ho Lim),김성집(Sung-Jib Kim),권해연(Hai-Yan Quan),장아(Ya Zhang),신대희(Dae-Hee Shin),정성현(Sung-Hyun Chung) 대한약학회 2009 약학회지 Vol.53 No.5

In this study, we investigated the anti-obese activity of HPJ extract in C57BL/6J mice. The C57BL/6J mice were randomly divided into five groups: normal control group (Con), high fat diet control group (HFD), treatment groups with HPJ at 125 mg/kg (HPJ125), 250 mg/kg (HPJ250), or 500 mg/kg (HPJ500). To induce an obesity, mice were fed by a high fat diet for 6 weeks, and mice were administered with HPJ extract once a day for 8 weeks. At the end of treatment, we examined the effect of HPJ extract on body weight, plasma lipid, and lipogenic enzymes. HPJ extract was found to lower whole body and epididymal adipose tissue weights and lowered plasma levels of glucose, insulin, triglyceride (TG), total cholesterol (TC), non-esterified fatty acid (NEFA) and leptin, compared to those in HFD group. Histological analyses of the liver and fat tissues of mice treated with HPJ extract revealed significantly decreased number of lipid droplets and decreased size of adipocytes compared to the HFD group. In addition, HPJ extract preserved the morphological integrity of pancreatic islets. To elucidate an action mechanism of HPJ extract, Western blot and RT-PCR were performed using epididymal adipose tissues. HPJ extract up-regulated the levels of phosphorylated adenosine monophosphate-activated protein kinase (AMPK) and its substrate, acetyl-CoA carboxylasse (ACC). HPJ extract also attenuated lipogenic gene expressions of sterol regulatory element-binding protein 1α (SREBP1α), fatty acid synthase (FAS), sterol-CoA desaturase 1 (SCD1) and glycerol-3-phosphate acyltransferase (GPAT) in dose-dependent manners. In contrast, expressions of lipolytic genes such as peroxisome proliferator-activated receptor-α (PPAR-α) and CD36, and fatty acid β-oxidation gene, carnitine palmitoyltransferase-1 (CPT-1) were increased. These results suggest that HPJ extract ameliorates obesity through inhibiting synthesis of lipogenic enzymes as well as stimulating fatty acid oxidation resulting from activation of AMPK, and HPJ extract could be developed as a potential therapeutic agent for obese patients.