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Lee, Haeshin,Jeong, Ji-Hoon,Lee, Je-Hoon,Park, Tae-Gwan The Korean Society for Biotechnology and Bioengine 2001 Biotechnology and Bioprocess Engineering Vol.6 No.4
This study presents a new formulation method for improving DNA transfection effi-ciency using a fusogenic peptide and polyethylene glycol-grafted polyethylenimine. Succinimidyls succinate polyethylene glycol (PEG-SSA) was conjugated with polyethylenimine(PEL). PEL is well known for a good endosomal escaping and DNA condensign agent. The positively charged syn-thetic fusogenic peptide, KALA was coated on the negatively charged PEG-g-PEI/DNA and PEI/DNA complexes. The KALA/PEI/ DNA complexes exhibited aggregation behavior at higher KALA coating amount with an effective diameter of around 1,000 nm. However, the LALA/PEG-g-PEI/DNA complexes were 100-300 nm in size with a surface zeta-potential (ζ)value of about +20mV. The conjugated PEG molecules suppressed any KALA-mediated inter-particle aggregation, and thereby improved the transfection efficiency, Consequently, the transfection efficiency of the KALA/PEG-g-PEI/DNA complexes was obtained by utilizing both the fusogenic activity of KALA and the steric repulsion effect of PEC.
Kim, Bong Hoon,Lee, Duck Hyun,Kim, Ju Young,Shin, Dong Ok,Jeong, Hu Young,Hong, Seonki,Yun, Je Moon,Koo, Chong Min,Lee, Haeshin,Kim, Sang Ouk WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.47
<P>Mussel‐inspired block copolymer lithography is reported on page 5618 by Haeshin Lee, Sang Ouk Kim, and co‐workers. Mussel‐inspired poly‐dopamine coating enables the organic surface energy modification of low surface energy materials, such as Teflon, graphene, and gold, which is required for block copolymer lithography. Further pattern transfer generates unconventional nano structures, such as Teflon nanowires, nano‐patterned graphene, and vertical carbon nanotubes directly grown on Au substrates. The image shows an uncoated (left) and a polydopamine‐coated (right) cherry tomato. </P>
Ryu, Seongwoo,Lee, Yuhan,Hwang, Jae‐,Won,Hong, Seonki,Kim, Chunsoo,Park, Tae Gwan,Lee, Haeshin,Hong, Soon Hyung WILEY‐VCH Verlag 2011 Advanced Materials Vol.23 No.17
<P>Super‐strong carbon nanotube fibers can be fabricated by infiltration of poly(ethylenimine)‐catechols (PEI‐Cs), report Tae Gwan Park, Haeshin Lee, Soon Hyung Hong, and co‐workers on p. 1971. PEI‐C mimics the amino acid sequence of mussel adhesive proteins in which catechols from 3,4‐dihydroxyl‐l‐phenylalanine and amines from lysine are found. Weak interactions between CNTs are overcome by heat‐induced, metal‐catalyzed chemical crosslinking of catechol, resulting in high‐strength CNT fibers. </P>
Chung, Hyun Jung,Lee, Haeshin,Bae, Ki Hyun,Lee, Yuhan,Park, Jongnam,Cho, Seung-Woo,Hwang, Jin Young,Park, Hyunwook,Langer, Robert,Anderson, Daniel,Park, Tae Gwan American Chemical Society 2011 ACS NANO Vol.5 No.6
<P>Currently available methods to stably disperse iron oxide nanoparticles (IONPs) in aqueous solution need to be improved due to potential aggregation, reduction of superparamagnetism, and the use of toxic reagents. Herein, we present a facile strategy for aqueous transfer and dispersion of organic-synthesized IONPs using only polyethylene glycol (PEG), a biocompatible polymer. A library of PEG derivatives was screened, and it was determined that amine-functionalized six-armed PEG, 6(PEG-NH<SUB>2</SUB>), was the most effective dispersion agent. The 6(PEG-NH<SUB>2</SUB>)-modified IONPs (IONP-6PEG) were stable after extensive washing, exhibited high superparamagnetism, and could be used as a platform material for secondary surface functionalization with bioactive polymers. IONP-6PEG biofunctionalized with hyaluronic acid (IONP-6PEG-HA) was shown to specifically label mesenchymal stem cells and demonstrate MR contrast potential with high <I>r</I><SUB>2</SUB> relaxivity (442.7 s<SUP>–1</SUP>mM<SUP>–1</SUP>) compared to the commercially available Feridex (182.1 s<SUP>–1</SUP>mM<SUP>–1</SUP>).</P><P><B>Graphic Abstract</B> <IMG SRC='http://pubs.acs.org/appl/literatum/publisher/achs/journals/content/ancac3/2011/ancac3.2011.5.issue-6/nn201198f/production/images/medium/nn-2011-01198f_0005.gif'></P><P><A href='http://pubs.acs.org/doi/suppl/10.1021/nn201198f'>ACS Electronic Supporting Info</A></P>
Kang, Sung Min,Lee, Haeshin American Scientific Publishers 2015 Journal of nanoscience and nanotechnology Vol.15 No.2
<P>We report a facile method for surface-initiated ring opening polymerization (ROP) and atom transfer radical polymerization (ATRP) via a poly(norepinephrine) coating. Solid substrates were modified by poly(norepinephrine) under alkaline conditions, with concurrent co-adsorption of an ATRP initiator. The poly(norepinephrine) layer acted as a ROP initiator due to the presence of hydroxyl groups in its side chain, resulting in a surface that was able to initiate ATRP and ROP simultaneously. 관-Caprolactone (관-CL) and 2-(dimethylamino)ethyl methacrylate (DMAEMA) were grafted onto the surface via ROP and ATRP, respectively, and the polymers subsequently grown from the surfaces were characterized in detail using Fourier transform infrared (FT-IR) spectroscopy, X-ray photoelectron spectroscopy (XPS), contact angle goniometry, and atomic force microscopy (AFM).</P>