알레르기성 소인이 없는 정상인에서 특이 알레르겐항체 양성율

남해선,안현철,박준수,황규윤,박춘식 순천향의학연구소 2001 Journal of Soonchunhyang Medical Science Vol.7 No.2

This study was designed to evaluate prevalence of allergen-specific antibodies in healthy adults. During Mar. ~ Aug. 2001, 1,925 subjects visited for medical check-up, were inquired to fill out a standardized questionnaire. Among them, 200 subjects who had no current and past allergic disorders were randomly selected for rhe current study and examined for allergen-specific antibodies using Korean inhalant panel of MAST-CLA allergen-specific IgE assay. Among them, 170 persons (85.0%) did not have any positive allergen-specific antibody. Each positive rate of 35 allergen specific antibodies was usually less than 3%, except Cockroach Mix (3.5%), Dermatophagoides farinae(8.5%), Dermatophagoides pteronyssinus(6.0%). Among 30 positive subjects, 19(63.3%) showed one or two allergen-specific antibodies. Although atopic subjects in non-allergic population were not common, few of them showed allergen-specific antibodies in Korean inhalant panel of MAST-CLA. Our results suggested that the standardized questionnaire and MAST-CLA could be an useful tool of a screening test for allergy, showing high specificity and sensitivity.

Prednislolne이 골조직에 미치는 영향에 관한 형태학적 연구

송혜정,김무강,김원식,이영호 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To study the effects of corticosteroids to the bone tissues, author grouped young(3 weeks affter birth) and adult ICR mouse by dosage, injected intramusculaily prednisolone, a series of corticosteroids, to posterior leg during 6 weeks per day, obtained femurs and tibias, measured the lengths of tibias and femurs. The portions of the distal end of tibial crests were cross-sectioned, general H-E stain was perpormed. The adjacent distal portions of femoral neck were sectioned longitudinally, observed endosteal surface by scanning electron micrscope The results were followings: 1. The adult group injected by large dosage (0.56mg/100g body weight/day) and the young group injected by small dosage(0.14mg/100g body weight/day) from 3 weeks after birth were significantly shorter than the normal group according to statistics. And the adult group injected by small dosage (0.14mg/100g body weight/day) was not different from normal group according to statistics. 2. In the light microscopic sutdy, the adult group injected by large dosage decreased in bone mass of compact bone severely, the adult group injected by small dosage changed a little grade. The young group injected by small dosage from 3 weeks after birth was not severe in bone change, but bone thickness decreased. 3. In the scanning elctron microscopic study, the adult group injected by large dosage and the young group iniected by small dosage from 3 weeks after birth decreased in trabeculae. The trabeculae of the adult group injected by small dosage were decreased slightly. 4. Integrating above all, the changes by prednisolone injection osteoporosis, of young period were more severe than those of adult, too.

포플라 Callus의 배양환경에 따른 Anthocyanin 생합성

방혜진,이승우,최근원,정인식,설일환 경희대학교 생명자원과학연구원 1997 遺傳工學論文集 Vol.9 No.-

Studies were carried out to investigate the effects of various cultural and environmental conditions on callus growth and anthocyanin biosynthesis of the callus derived from the leaf discs of the Populus hybrid (Populus nigra × Populus maximowiczii cv. Yanghwangchul). Even though the largest amount of anthocyanin was obtained from the calli grown in the vessels illuminated with white fluorescent light, no significant differences in callus growth could be obtained among other vessels illuminated with different light qualities, i.e., red, yellow, blue, green and dark. Callus growth and anthocyanin biosynthesis were promoted by long-day conditions (16-hour photoperiod or longer). The calli grown in Schenk & Hildebrandt (SH) medium continuously (SH→SH) showed the best growth whereas the highest amount of anthocyanin biosynthesis was obtained in the calli grown in SH→SH or SH→White media.

수정 몬테칼로법에 의한 鐵筋콘크리트 보의 離散形 最適設計

김유식,이해은,박경현 大田産業大學校 1999 한밭대학교 논문집 Vol.16 No.1

In this study, our effort has been made to review the economics design for the discrete optimum design of the R. C. beam section by modified Monte carlo method. In this discrete optimum formulation, the design variables are the overall depth, width and effective depth of beams and area of longitudinal reinforcement. Total weight has been used as the objective function. The constraints include the code requirements such as flexural strength and steel ratio. The proposed algorithm is applied to a test problem for reliability, and the results are compared with the Monte carlo optimum design and the modified Monte carlo optimum design by strength design method As a result of calculation, In the optimum convergence by the each method, it was very earlist on the case of 5cm unit. Optimum weight was very light in the case of 2cm unit. In the study, Our know to possible of design by the optimum design based on modified Monte carlo method.

에타놀 投與 흰쥐의 血中 에타놀 濃度와 ADH의 變化

朴載植,朴海根 충남대학교 의과대학 지역사회의학연구소 1987 충남의대잡지 Vol.14 No.1

It is generally accepted that ethanol has the diuretic action in the human beings by the inhibition of ADH(antidiuretic hormone) secretion. However, contribution of ethanol to body fluid change and blood ethanol curve in the rat has not been studied satisfactorily. Thus, the following experiment was performed to examine the change of blood ethanol concentration and the body fluid after ethanol administration in the Sprague Dawley female rats which were divided into 2 groups: control and ethanol-administered group. A single dose of one ml of 25% ethanol (ethanol group) or water(control group) per 100gm body weight was administered. On the day of experiment, the rat was anesthetized with ether and catheterized in the femoral artery for sampling of arterial blood. The catheter was filled with heparin solution. Blood sampling was done at least 3 hours after the surgery. Blood ethanol concentration was measured by the alcohol dehydrogenase enzyme method and ADH by radioimmunoassay. The results obtained are summarized as follows. The formula representing the blood ethanol concentration, C(mg/dl), after ethanol administration as a function of time, t(hour), was C=126.57(1-e^-2l.036t)-16.59t and showed more rapid absorption and metabolism of ethanol in the rats than in human beings. Plasma ADH concentration was 3.4±0.4pg/ml at rest but was decreased significantly at 30 and 120 minutes after ethanol administration. A gradual decrease in hematocrit was produced by continuous blood sampling but ethanol group showed higher hematocrit values than control. A significant increase of corrected osmolality was observed compared with the control, particularly at 30 and 60 min after ethanol administration and urine volume was also increased in the first 2 hours. From these results it was concluded that in the rats the rates of ethanol absorption and metabolism was rapid and ADH secretion was decreased for 2 hours after ethanol administration. Subsequently, the solute free urine volume and corrected osmolality was increased followed by plasma volume shift from the vessel. After 2 hours, though blood ethanol concentration was still high, corrected osmolality and urine volume was recovered to the original value.

자본주의사회에서의 대중매체의 위상과 기능에 대한 이론적 고찰

김해식 서울대학교 사회과학연구소 1991 社會科學과政策硏究 Vol.13 No.2

머리염색이 인체에 미치는 영향

윤형식,황성호,이현륭,김수호,박연석,권낙현,정호진,김동훈,노현주,홍성호,박병찬,이관,정해관 東國大學校醫學硏究所 2002 東國醫學 Vol.9 No.1

일상생활에서 모발염색은 흔히 접할 수 있는 미용의 한 종류로 특히 젊은층을 중심으로 폭발적으로 유행하고 있다. 염색을 위항 사용하는 약제는 표백제와 발색제 등 각종 화학약품이 사용되고 있으나 이로 인한 건강장해에 대한 연구는 그리 많지 않다. 저자들은 염색이 인체의 모발건강에 미치는 영향을 파악하기 위하여 염색과 관련된 주관적 증상과 모발의 변화에 대한 실험적 연구를 시행하였다. 동국대학교 경주 캠퍼스 재학생 80명을 대상으로 설문조사를 시행하여 염색 유 ·무 및 염색 후에 경험한 증상에 대해 설문 조사하였고, 의과대학 재학생 46명을 대상으로 피부 반응 테스트를 실시하였다. 또한 염색 전후의 모발 탄성도를 측정하였고 모발의 상태를 파악하기 위해 전자 현미경검사를 실시하였다. 설문조사 결과 염색 전에 비하여 염색 후 안구혼탁, 안구건조, 시력저하, 발진 및 접촉성 피부염, 모발손상, 모근손상 등의 증상을 더 많이 경험한다고 호소하였다(p<0.05). 모발손상과 모근손상은 헤어드라이어 사용 빈도에 따라 증가하는 것으로 조사되었다(p<0.05). 피부반응검사에서 가려움증이 가장 많은 증상이었으며 이는 여성보다는 남성에서 높은 것으로 조사되었다. 염색 전후의 모발장력은 염색 전 134.5±10.37g, 염색 128.0±30.69g, 염색 이틀 후 112.5±19.69g으로 나타났다. 염색 전후의 모발의 전자현미경 케라틴 층이 현저히 감소하고 모발이 가늘어지는 차이를 보였다. 염색은 모발손상, 모발 케라틴 손상 및 모근 손상, 발진 및 접촉성 피부반응, 안구혼탁, 안구건조, 시력 저하를 유발한다. 따라서 염색약으로 인한 손상에 대한 주의와 예방이 필요하다고 생각한다. 예방대책으로 염색 전 피부테스트를 통한 적합성 여부를 판단하는 것이 필요하며 가급적 염색을 피하는 것이 좋을 것이다. 염색약에 발암물질이 포함되어있다는 보고도 있어 염색 제조사의 철저한 실험과 염색 물질의 선별이 염색으로 인한 부작용을 최소화하는데 중요한 역할을 할 것이다. Hair coloring has became one of the most popular cosmetic activities to younger generations during last decade. However, there are few studies on the health effect of widespread use of chemical dyes. This study was conducted to study the effects of hair coloring dye on hair and other systems. We conducted a questionnaire survey of 80 persons in Kyongju campus, Dongguk University. We have done open patch skin test on 46 medical students. We also conducted scanning electron microscopy to examine the hair strength and structure before and after hair coloring process. Injury of hair and hair bulb, contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity were the main symptoms complained after hair coloring (p<0.05). Injury of hair and hair bulb were increased by frequency of hair-dryer use(p<0.05). In open patch test, pruritus was complanined by more than half of the subjects. Mean strength of hairs before and after hair coloring was as follows; 134.5 (SD 10.37)g before hair coloring, 128.0 (SD 30.69)g immediately after hair coloring, and 112.5 (SD 19.69)g after two days. The scanning electron microscopic findings of hair surface before and after hair coloring showed decreased keratin layer and thinning of the hair. Hair coloring induces injury to hair, its keratin layer, and hair bulb as well as contact dermatitis, turbid eyes, xerophthalmia, and poor visual acuity. Therefore, we think that precaution is needed in use of hair coloring dye. To prevent complications induced by hair coloring dye, it is necessary, especially to those with allergy or skin disorders, to perform skin test before action and avoid hair coloring whenever possible. Longterm health effects of hairdye should be studied and manufacturing companies should try to minimize complications induced by hair coloring dye.

기술역량, 혁신성, 관리역량이 구매IOS성과에 미치는 영향

박해철,김기윤,나관식 한국정보사회진흥원 2006 정보화정책 Vol.13 No.2

IOS(Inter-Organizational Information Systems)는 전통적인 제조업을 비롯한 모든 산업분야에서 폭넓게 활용되고 있으며, 광범위하게 흩어져 있는 공급자, 유통망, 고객들을 연결해 주는 주문시스템이 일반적이다. 실무적으로는 EDI나 SCM 등과 같은 형태로 구현되고 있는 이 IOS가 최근 들어 이들 조직 간의 거래활동을 혁신적으로 변화시키고 있지만, 실제 적용에 도움을 줄 수 있는 구매성과에 관련된 연구는 거의 이루어지지 않고 있다. 따라서 본 논문의 연구목적은 기술역량, 혁신성, 관리역량이 구매IOS 성과에 미치는 영향을 검정하고자 하는 것이다. 이를 위해서 기존 연구로부터 네 개의 가설을 도출하여 연구모형을 수립하였고, 구조방정식모형으로 이를 검정하였다. 검정결과 혁신성과 관리역량은 구매IOS품질에 직접적으로 관련이 되어 있으며, 이 구매IOS품질은 구매성과를 향상시키는 것으로 나타났다. 하지만 기술역량과 구매IOS품질과의 관계에서는 기업 규모에 따라 상이한 결과를 보였다. 이 결과에 의하면 대기업의 경우 중소기업과는 달리 기술역량이 중요한 요인인 것으로 검정되었으므로, 개별기업이나 관련기관에서 IOS 구축을 위한 정보기술 투자정책 수립 시에는 기업규모에 따라 차별화된 접근방법이 요구된다.

요통환자의 외래 진료양상에 대한 조사

조무식,김선주,원혜윤,고정관,이경석 순천향의학연구소 1997 Journal of Soonchunhyang Medical Science Vol.3 No.2

We report a series of 220 patients with low back pain who visited through neurosurgical out-patient department(OPD) from January 1994 to June 1994. We investigated how they were treated and what was the outcome on December 1995 by telephone interview. During the study period, 176 patients (80%) visited our OPD not more than twice. Frequency of OPD visit was single in 138 patients (62.7%), twice in 38 patients (17.3%), and over twice in 44 patients (20.0%). Twenty six patients (11.8%) were admitted, and 16 patients (7.3%) underwent an operation. Sixteen patients underwent surgery in this hospital, and the other 12 patients underwent surgery in any other hospitals. The rate of revisit was relatively high in patients who had a special study (58.1%), whose impression was herniated lumbar disc (41.2%) or degenerative spondylosis (55.6%), and who received prescriptions for drug (42.1%) or underwent an operation(87.5%). The rate of special study, prescriptions and/or operations of was relatively low in this hospital, which seems to lessen the rate of revisit. More active management seems to be necessary for the patient' satisfaction.

다중매체와 여가생활의 변동

김해식,이종구 경상대학교 사회과학연구소 2000 사회과학연구 Vol.18 No.1