Prednislolne이 골조직에 미치는 영향에 관한 형태학적 연구

송혜정,김무강,김원식,이영호 충남대학교 의과대학 지역사회의학연구소 1988 충남의대잡지 Vol.15 No.1

To study the effects of corticosteroids to the bone tissues, author grouped young(3 weeks affter birth) and adult ICR mouse by dosage, injected intramusculaily prednisolone, a series of corticosteroids, to posterior leg during 6 weeks per day, obtained femurs and tibias, measured the lengths of tibias and femurs. The portions of the distal end of tibial crests were cross-sectioned, general H-E stain was perpormed. The adjacent distal portions of femoral neck were sectioned longitudinally, observed endosteal surface by scanning electron micrscope The results were followings: 1. The adult group injected by large dosage (0.56mg/100g body weight/day) and the young group injected by small dosage(0.14mg/100g body weight/day) from 3 weeks after birth were significantly shorter than the normal group according to statistics. And the adult group injected by small dosage (0.14mg/100g body weight/day) was not different from normal group according to statistics. 2. In the light microscopic sutdy, the adult group injected by large dosage decreased in bone mass of compact bone severely, the adult group injected by small dosage changed a little grade. The young group injected by small dosage from 3 weeks after birth was not severe in bone change, but bone thickness decreased. 3. In the scanning elctron microscopic study, the adult group injected by large dosage and the young group iniected by small dosage from 3 weeks after birth decreased in trabeculae. The trabeculae of the adult group injected by small dosage were decreased slightly. 4. Integrating above all, the changes by prednisolone injection osteoporosis, of young period were more severe than those of adult, too.

주의력 결함 과잉행동 아동의 문제행동 치료 사례 연구

황혜자,김옥정 東亞大學校 學生生活硏究所 1998 學生硏究 Vol.17 No.-

Children with ADHD experience numerous difficulties that go beyond the first symptoms(inattention, impulsive responding, and overactivity). Although these problems are not related to the diagnosis of ADHD, the fact that children with ADHD present these added difficulties(conduct disorder, peer rejection, underachievement, low self-esteern) accounts for the extreme heterogeneity among ADHD cases. In this study, attention and social skill training program is applied to modify difficulties of children with ADHD(ADD). The program contains social entry skills, conversational skills, attention trianing and willingness to practice. The three cases are ADHD, mild conduct disorder, low IQ ; ADHD, mild conduct disorder, High IQ ; ADD(-H) low IQ, mild social withdrawal. The follow conclusions were obtained from the results of this study. First, the three children gradually improved through the attention and social skill training, increasing attention, decreasing impulsive and hyperactivity. Parents rating scales of inattention showed decreasing at home. Second, consideration and self-control were increasing. The children with conduct disorder improved reducing on the three behavior problems of delinquent, aggressive, and hyperactive. For the children with ADHD or ADD(-H), 'think aloud' and' self instruction' helps to solve academic problems. The cognitive behavioral strategies in anger control-namely, an emphasis on "stopping and thinking" before acting and the reflective sequence for approaching conflicts was efficient. Third, low self-esteem, especially social-peer self was improved. And mild social withdrawal behavior was disappeared. And self-assertion was elevated, and the children showed prosocial behavior in the classroom.

RP 조형용 삼각형 평면 CAD 모델의 생성

池海成,鄭海鎔 弘益大學校 科學技術硏究所 2000 科學技術硏究論文集 Vol.11 No.-

Rapid prototyping (RP) technologies have an ability of creating a physical part directly from its computer model by adding material on a layer by layer basis. Since actual production of a physical model using traditional techniques has been quite expensive, a prototyping apparatus like Stereolithography can recently be used to get physical verification of a product design rapid and economic. In spite of this tremendous progress in fabrication, many problems remain unsolved including several geometric issues that must be resolved in coming years before these technologies are in common use. The biggest problem lies in their standard file format for CAD data exchange. Current method using the de facto industry standard STL data format have at times resulted in problems such as accuracy, redundancy, and integrity in its representing CAD models. In this paper, a general explanation about why a next generation of data exchange standard for RP technologies is needed, why it must be based on a solid model, and what its major advantages are given.

【영아보육프로그램】자료 개발 연구

황해익,임재택,김정신,송연숙,이경화,김남희 부산대학교 영유아보육연구소 1998 영유아보육연구 Vol.4 No.-

This study aimed to develop Materials for (The Infant Educare Program) (Dept. of Health & Welfare, 1996). Infant educare Materials were developed through following procedures: 1) analysis of reference and other educare materials 2) content analysis of (The Infant Educare Program) 3) developing materials and 4)testing and revising materials by professionals. Infant educare Materials that developed in this study were constituted of 12 kinds in 5 areas - Materials for management of daycare center, the nursery stories for infants, musical materials for infants, play things for infants, and educational materials for parents. First, materials for management of daycare center were considered various conditions whithin daycare centers and were compased of 2 kinds - diary for educare plan and diskettes for documents. Second, the nursery stories for infants were compased of materials for 3 stages-the weaning stage, the toddling stage, and the independent stage. Similarly, musical materials for infants were composed of 3 stages. And play things for infants were composed of 2 kinds - play things to be easily founded and easily making play things. Finally, educational materials for parents were composed of 2 kinds - guide book for parents education and diskettes for communication with parents. It is needed that persistent attention from professionals in developing and testing materials for infant educare. Also, further educational implications were discussed

반정량 식품섭취빈도조사지를 이용한 한국노인의 영양섭취 실태조사

이해정,박선주,김정희,김초일,장경자,임경숙,김경원,최혜미 대한지역사회영양학회 2003 대한지역사회영양학회지 Vol.8 No.3

The aim of this study was to assess the nutrient intakes of the elderly subjects in Korea. Dietary assessment was carried out using a semi-quantitative food frequency questionnaire (SQFFQ) developed by our laboratory, which included 98 commonly consumed food items selected from 1998 National Health and Nutritional Survey for Korean population. Subjects (n = 2,660) aged 50yr and over were recruited in Seoul, 6 metropolitan cities, and 8 mid-size cities. Calcium and riboflavin intakes of the elderly subjects aged 65 yr and over (n = 1,974) were much lower compared with Korean RDA. Nutrient intakes of the three age group (50 - 64 yr, 65 - 74 yr, 75 yr and over) were decreased as age increased in male and female elderly. Nutrient intakes of male elderly, 75 yr and over, were significantly decreased while in female elderly nutrient intakes were gradually decreased as age increased. Over 30% of the elderly subjects did not meet 75% RDA for calcium, iron, vitamin A, and riboflavin. The proportion of the elderly subjects whose intakes were below 75% RDA was much higher than the elderly whose intakes were above 125% RDA, especially among the elderly aged 75 yr and over. This study revealed that the Korean elderly had inadequate intakes for many nutrients. This will cause a serious nutritional problem for the elderly.

Helicobacter pylori의 생육에 영향을 미치는 성분과 식품첨가물에 관한 연구

송재철,정혜진,박현정,조은경,신완철 한국식품영양학회 1999 韓國食品營養學會誌 Vol.12 No.5

본 연구에서는 일반적으로 섭취하고 있는 식품재료나 음식 중에 공통적으로 함유한 성분 또는 가공중에 많이 첨가되는 성분을 선정하여 이들이 Helicobacter pylori 생육에 어떤 영향을 미치는지를 검토하였다. 첫째, 일반식품의 주요 성분인 탄소원, 질소원, 무기질을 대상으로 Helicobacter pylori 생육에 미치는 영향을 검토하였다. 그 결과 식품성분 중 탄소원의 종류에 따라 균일 생육활성은 다르게 나타났다. 우선 단당류가 이당류나 다당류에 비교하여 생육을 촉진하였고 특히 단당류 중 포도당은 가장 균의 생육에 큰 영향을 미치는 것으로 나타났다. 그러나 만노오스는 균의 생육을 오히려 억제시키는 것으로 나타났다. 당알코올류인 솔비톨, 만니톨, 말티톨, 크리시톨 등은 균의 생육에 아무런 영향을 미치지 않은 것으로 나타났다. 질소원과 Helicobacter pylori의 생육과의 관계는 평소 식생활에서 많이 섭취된다고 생각되는 일반 음식에 많이 함유되어 있는 유기형 아미노산 성분고 무기형 질소화합물을 대상으로 균의 생육 정도를 비교하였다. 리신, 메티오닌, 시스테인, 트립토판 등은 균의 생육을 촉진하고 아르기닌, 황산암모늄, 염화암모늄 등은 균의 생육에 도움이 되지 않고 암노니아, 요소등은 균의 생육에 도움이 되지 않고 암모니아, 요소 등은 균의 생육에 조금 영향을 미침을 관찰할 수 있었다. 특히 리신과 메티오닌은 가장 균의 생육에 영향을 미치는 것으로 나타났다. 무기염류의 영향에서는 황산마그네슘, KH-2PO_4, 염화마그네슘 등은 큰 영향을 미치지 못하였고 황산철, 염화제일철, 염화제이철은 생육을 억제하는 것으로 나타났다. 식품첨가물의 Helicobacter pylori의 생육 정도를 검토한 것으로, 그 다음이 질화나트륨, 염화나트륨 순이었으며 토코페롤은 전혀 생육에 영향을 미치지 못하였다. The purpose of this study was to choose principal food components contained in diet foods and food additives used for manufacturing processed foods, and elucidate their in vivo effects on the growth pattern of Helicobacter pylori. To do this, the antibacterial effects of various sources of carbon, nitrogen and mineral as an effect agent on Helicobacter pylori were first assessed based upon bacterial growth degree. Results show that the source of carbon tested had different effects on bacterial growth of Helicobacter pylori. It was revealed that a promotional effect of monosaccharides resulted in enhanced growth of Helicobacter pylori compared with disaccharides and polysaccharides. In particular, glucose was observed to be most effective in growth of Helicobacter pylori among monosaccharides tested, whereas mannose to hinder the growth of Helicobacter pylori. Polyols such as sorbitol, mannitol, maltitol and xylitol was, however, observed to show no promotion or suppression effect on growth of Helicobacter pylori. Apart from these, the sources of amino acid and inorganic nitrogen were chosen and tested to assess the promotion or suppression effect of nitrogen sources on growth of Helicobacter pylori. It was found that amino acid such as lysine showed its promotion effect on the growth of Helicobacter pylori, while arginine, (NH_1)_2SO_4 and NH_4Cl showed no effect on its growth. Ammonia and urea were, however, observed to have a positive effect on the growth of Helicobacter pylori. Among these effect agents, lysine and methionine were revealed to show the most positive effect on growth of Helicobacter pylori. Minerals such as MgSO_4, KH_2PO_4, and MgCl_2 appeared to exert their positive growth effects, whereas CaCl_2, and CaSO_4 had a little effect. In addition FeSO_4, FeCl_2, and FeCl_3 brought suppression on the growth of Helicobacter Pylori. In studies of the growth of Helicobacter pylori by food additives, ascorbic acid showed extreme suppression on its growth. Sodium nitrate and sodium chloride were also found to be of negative effect on the growth of Helicobacter pylori in order of degree, whereas tocopherol had nothing to do with microbial growth.

1-Bromoacetylpyrene 誘導體化劑를 利用한 Carboxyl基 含有成分의 分析에 관한 硏究(Ⅲ) : 生藥成分의 HPLC에 依한 定量 Determination of Carboxylic acids in Crude drugs by HPLC

李允中,曺正吉,丁海秀,嚴東玉 成均館大學校 科學技術硏究所 1988 論文集 Vol.39 No.2

A highly sensitive and selective fluoresence high-performance liquid chromatography using 1-bromoace-tylpyrene as a pre-labelling reagent was applied to the determination of cinnamic acid and glycyrrhetic acid at p mol level. The optimum conditions for the derivatization such as concentrations of KOH, 18-crown-6, and 1-bromoacetylpyrene, reaction temperature and reaction time were investigated. The derivatives were separated on a reversed phase column using the mixture of acetonitrile, methanol and water as the mobile phase. The effluent was menitored by fluorometer. Linearities of calibration curve were obtained between 0.5 p mol and 2.0 p mol. The detection limit of cinnamic acid and glycyrrhetic acid was 0.05 p mol in a 20 ㎕ of injection volume.

CO₂아크 용접 근로자의 뇌 MRI 고신호강도 3례

홍영습,정해관,김준연,이용희,김지용,사공준,임현술,이중정,임명아 동아대학교 부설 산업의학연구소 1999 산업의학연구소 논총 Vol.- No.4

We experienced three cases of high signal intensity observed by Brain Magnetic Resonance Imaging in CO₂ are welders of steel-frame manufacturing industry. Case 1 was a 35 years old man who has been an CO₂ arc welder for 10 years, admitted a sudden onset of tonic clonic seizure. He complained fever, chilling and myalgia since 3 days before admission. On admission, in the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 5.17 ㎍/dl, 22.00 ㎍/l and 31.25 ppm respectively. Case 2 was a 35 years old man who has been an CO₂ arc welder for 20 years. On admission, He complained fatigue, numbness and weakness of extremities, and decrease of libido. In the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 6.34 ㎍/㎗, 14.62 ㎍/l and 57.87 ppm respectively. In neurologic examination, Palmo-mentle reflex and Myerson sign were observed. Case 3 was a 33 years old man who has been an CO₂ arc welder for 16 years. On admission, He complained loss of appetite, numbness of extremities, fatigue and decrease of attention. In the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 5.14 ㎍/㎗, 13.79 ㎍/l and 50.08 ppm respectively. In neurologic examination, Myerson sign was observed. In brain magnetic resonance imaging, T1WI showed symmetrical high signal intensity in basal ganglia and midbrain of three cases. Authors argued that they were developed by manganese exposure, and we considered that follow up study would be necessary.

CO₂아크 용접 근로자의 뇌 MRI 고신호강도 3례

김준연,임현술,정해관,홍영습,이용희,임명아,이중정,김지용,사공준 大韓産業醫學會 1998 대한직업환경의학회지 Vol.10 No.2

We experienced three cases of high signal intensity observed by Brain Magnetic Resonance Imaging in CO₂arc welders of steel-frame manufacturing industry. Case 1 was a 35 years old man who has been an CO₂arc welder for 10 years, admitted a sudden onset of tonic clonic seizure. He complained fever, chilling and myalgia since 3 days before admission. On admission, in the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 5.17μg/dl, 22.00μg/l and 31.25ppm respectively. Case 2 was a 35 years old man who has been an CO₂arc welder for 20 years. On admission, he complained fatigue, numbness and weakness of extremities, and decrease of libido. In the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 6.34μg/dl, 14.62μg/l and 57.87 ppm respectively. In neurologic examination, Palmo-mentle reflex and Myerson sign were observed. Case 3 was a 33 years old man who has been an CO₂arc welder for 16 years. On admission, He complained loss of appetite, numbness of extremities, fatigue and decrease of attention. In the test of manganese exposure indices, manganese concentrations of blood, urine and scalp hair were 5.14μg/dl, 13.79μg/l and 50.08 ppm respectively. In neurologic examination, Myerson sign was observed. In brain magnetic resonance imaging. TIWI showed symmetrical high signal intensity in basal ganglia and midbrain of three cases. Authors argued that they were developed by manganese exposure, and we considered that follow up study would be necessary.

三日酒와 三日 基以內로 빚어지는 우리나라의 速成酒 : Ⅱ. 찹쌀로 빚은 速成酒 Ⅱ. About Brewing from Glutinous Rice

錢精日,申敏子,崔榮辰,金賢淑,李惠靜,鄭在洪,白淑殷 동아시아식생활학회 1999 東아시아食生活學會誌 Vol.9 No.3

This study was carried out to understand the brewing and processing methods of rapid-brew alcoholic beverage. In the contents of 45 classical records, there were 68 items about rapid-brew alcoholic beverage and single and double brew alcoholic beverage. Those alcoholic beverage of 68 items above, were made from green grown at that time-rice, glutinous rice, regular rice. Selected 38 items among those brewages, alcoholics from glutinous rice, were distributed into 4 patterns. Four patterns, grounded on rapid-brewing and processing methods, were set one thing to another and analyzed.