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이순철,이수정,정경수,유관희,김학성 충남대학교 약학대학 의약품개발연구소 1995 藥學論文集 Vol.11 No.-
The present study was undertaken to elucidate the characteristics of red ginseng total saponin in behavioral changes on ambulation, forced swim test and convulsion in mice. The ambulation and the duration of immobility on forced swim test were not affected by red ginseng total sapinin. On the other hand, the duration of immobility induced by DMI, PGL but not CIP was significantly decreased, and the onset of convulsion induced by pentylenetetrazole was significantly shortened by preadminstration of red ginseng total saponin. These results suggest that red ginseng total saponin component may play an important role in modulation synergism with drugs acting on depression and convulsion, and that the characteristics of synergetic effect induced by red ginseng total saponin potentiate the central norepinephrine neuron activity.
Hack Seang Kim,Myung Koo Lee,Dong Yoon Baek,Seong Lok Hwang,Kang Ju Choi,Suk Chang Kim 한국생약학회 1989 생약학회지 Vol.20 No.2
The effects of ginsenosides on the development of morphine induced tolerance and physical dependence were investigated. Rb₁, Rb₂, Rg₁ and Re inhibited significantly the development of morphine induced tolerance but Rb₁ and Rg₁ showed significant inhibitory effect on the naloxone induced withdrawal jumping response. Ginsenosides inhibited the body weight decrease in physically dependent mice during multiple injection of morphine.
Effects of Ginseng Saponins on the Development and Loss of Morphine Tolerance and Dependence
Hack Seang Kim,Sei Kwan Oh,Kang Ju Choi,Jung Sup Park 한국생약학회 1986 생약학회지 Vol.17 No.2
Ginseng saponins(GS), protopanaxadiol saponins(PD) and protopanaxatriol saponins (PT) were tested for the inhibition of the development of morphine tolerance and dependence antagonism of morphine analgesia and the loss of morphine tolerance and dependence in mice The results were as follows: 1. Inhibition of the development of morphine tolerance and dependence. 2. Antagonism of morphine analgesia. 3. Increase in the loss of morphine tolerance and dependence. Antagonism of morphine by ginseng saponins and its reversal by L-DOPA and 5-HTP suggest some possibility that catecholamines and serotonin levels might be associated with the results.