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Ryeong Ha Kwon,Heon-Woong Kim,Suji Lee,So-Jeong Lee,Hyemin Na,Ju Hyung Kim,Chi-Do Wee,Seon Mi Yoo,Sang Hoon Lee 한국식품영양과학회 2021 한국식품영양과학회 학술대회발표집 Vol.2021 No.10
In this study, shoots and leaves of Acanthopanax senticosus (AST) were analyzed to identify triterpenoid saponins using UPLC-DAD-QToF/MS. The forty-three of saponins were isolated and identified by six standard compounds and published data (library) and the seventeen of saponins were tentatively confirmed for the first time as new compounds. According to aglycone types, triterpenoid saponins in shoots and leaves were classified to oleanane (mesembryanthemoidigenic acid, echinocystic acid, hederagenin, oleanolic acid), noroleanane (akebonic acid), lupane (chiisanogenin) classes. These saponins possessed structures in which arabinose (Ara, m/z 132), rhamnose (Rham, m/z 146), glucose and galactose (Glu and Gal, respectively, m/z 162) were bonded to C-3 of each aglycone and Rham-2Glu (m/z 470) or Rham-(acetyl)Glu-Glu (m/z 512) were bonded to C-28. The MS fragment pattern and intensity of the compounds were the crucial factors that tentatively identified to sugar type and position. It was the fundamental data that the result of composition of AST saponins support in future activity research and functional product development.
P234 : Efficacy and safety of cyclosporine in patients with chronic urticaria
( Ha Ryeong Ryu ),( Chul Hyun Yun ),( Ji Hoon Kim ),( Joon Seok Choi ),( Jin Ok Baek ),( Jong Rok Lee ),( Joo Young Roh ) 대한피부과학회 2014 대한피부과학회 학술발표대회집 Vol.66 No.2
Background: Chronic urticaria (CU) can be resistant to higher dose of antihistamines. When first-line therapy fails, patients are often treated with alternative therapies that either have serious side effect profile or little evidence to support effectiveness. Objectives: This study was done to evaluate clinical response and safety of cyclosporine in patients with CU resistant to antihistamine. Methods: A retrospective study was done in 35 adult CU patients treated with cyclosporine. Elements of the history, physical examination, diagnostic testing, efficacy, and side effects were extracted. Results: Thirty-two patients (18 male, 14 female) with CU resistant to high dose of antihistamines were enrolled. The mean age of patients was 38.5 years (aged 16-60 years), and the median age was 37 years. The mean duration of CU was 3.4 years (0.2-12 years). After taking cyclosporine at an average dose of 4-5 mg/kg/day, 25 patients (78.1%) attained complete remission defined as ≤ 1 day of hives per month. Mean duration of complete remission was 14.5 weeks (2-36 weeks). Two patients (6.3%) had a partial response and 5 patients (15.6%) had no response. Mean duration of treatment was 18.7 weeks (2-48 weeks) in 32 patients. Side effects were seen in 6 patients (18.8%); gastrointestinal upset (n=2), hypertension (n=2) and hypertrichosis (n=2), all were reversible by dose reduction. Conclusion: Cyclosporine is an effective and safe treatment option for CU resistant to high dose of antihistamine treatment.
Serum macrophage-derived chemokine (MDC) levels are elevated from patients with atopic dermatitis
( Ha Ryeong Ryu ),( Jeong Soo Kim ),( Chul Hyun Yun ),( Ji Hoon Kim ),( Jin Ok Baek ),( Joo Young Roh ),( Jong Rok Lee ) 대한피부과학회 2015 대한피부과학회 학술발표대회집 Vol.67 No.2
Background: Atopic dermatitis(AD) is a chronic inflammatory skin disease characterized by the predominant infiltration of T cells, eosinophils and macrophages in lesional skin. Recently, MDC/CCL22, a CC chemokine, wasidentified as a selective chemoattractant for CC chemokine receptor 4 (CCR4)-expressing cells, in addition to thymus and activation-regulated chemokine (TARC).Objectives: The purpose of this study was to investigate serum levels of Th2 chemokine MDC from patients with AD and their clinical correlation. Methods: Serum chemokine levels in patients with AD (n=21), chronic urticaria (n=6), and normal controls (n=4) were examined by ELISA. The clinical severity of AD assessed using SCORAD index. Results: Serum MDC levels in patients with AD were significantly higher than those found in normal controlsubjects (2012.80【1341.78pg/ml versus 665.29【178.39pg/ml, P<0.05). MDC levels were significantly elevated in patients with chronic urticaria subjects (2010.92【 1376.61pg/ml versus 615.22【167.45pg/ml, P<0.01). MDC levels correlated significantly with eosinophil numbers inperipheral blood (r=0.362, P<0.05) and total serum IgE levels (r=0.447, P<0.05) in patients with AD. Patients with severe AD (3044.25【1621.60pg/ml) showed significantly increased MDC levels when compared with those with mild AD (1061【401.48pg/ml, P<0.01). Conclusion: Our study strongly suggests that serum MDC levels have a notable correlation with disease activity and that MDC may be involved in the pathogenesis of AD.
( Ha Ryeong Ryu ),( Seul Ki Lee ),( Jeong Su Kim ),( Chul Hyun Yun ),( Joo Young Rho ),( Jong Rok Lee ),( Jin Ok Baek ) 대한피부과학회 2016 대한피부과학회 학술발표대회집 Vol.68 No.2
Background: Rosacea is a common chronic inflammatory cutaneous disorder of unclear origin. It has been associated with systemic comorbidities, but studies addressing rosacea’s association with systemic comorbidities are scarce. Objectives: This study aimed to elucidate the clinical manifestations of rosacea and the association between rosacea and systemic comorbidities. Methods: We performed a prospective analysis of 17 patients with rosacea. A structured interviewer administered questionnaire collected detailed medical history and current comorbidities, and information on demographics and lifestyle factors. Results: The ratio of males to females was 1:3.3. The mean age at the time of diagnosis was 47.4 ±10.8 years. Patients presented with erythematotelangiectatic (94.1%), papulopustular (64.7%), and phymatous (23.5%) changes, and nearly half (52.9%) had ocular involvement. Aggravating factors included stress, hot/cold weather, alcohol, sun expose and hot baths. We observed a significant association between rosacea and gastroesophageal reflux disease (35.3%), other gastrointestinal disease (29.4%), hypertension and metabolic disease (23.5%), female hormone imbalance (23.5%), migraine and other recurrent headaches (23.5%) and allergies (air borne, food) (11.8%). Conclusion: Rosacea is associated with numerous systemic comorbid diseases. Physicians should be aware of these associations to provide comprehensive care to patients with rosacea, especially to those with more severe disease.
A Study on the Improvement Plan of Business District Information System
Ha-Ryeong Song,Young-Ki Kim,Seung-Hee Kim 한국유통과학회 2016 유통과학연구 Vol.14 No.6
Purpose – This study aims to suggest a developmental direction to small enterprisers who start their business. The developmental direction makes the small enterprisers more stable with providing the Business District Information System service, which offers the location and business area's information aimed at pre-enterprisers after analyzing its overcrowded index's current state and problems. Research design, data, and methodology – This research proposes the developmental direction for helping the pre-small enterprisers to have more stability through examining the Business District Information System'sㅡoperated by Small Enterprise and Market Serviceㅡovercrowded index's current state and problems. Results – This system has drawbacks about giving the start-up overcrowded index as follows: ① non-accurate consultative group for sharing the DB ② providing analysis information, not evaluation information ③ not to anticipate the changes of business types & the flow of business district and perceive the symptom data with providing predictive information. Conclusions – This system should be more publicized through the mass media for making it approachable with collecting the user's opinion and investigating customer satisfaction & the level of awareness.