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Ha-ri Cha(차하리),Byoung-Kwon Lee(이병권),Dong-Kwon Seo(서동권) 한국산학기술학회 2021 한국산학기술학회논문지 Vol.22 No.2
이 연구는 정상 성인에서 머리-목 굽힘 운동 시 시선의 각도와 압력이 깊은목굽힘근의 두께변화에 미치는 영향을 알아보고자 하였다. 본 연구에는 27명이 참여하였다. 머리-목굽힘 운동하는 동안 4가지(0°, 20°, 40°, 60°)의 시선과 5가지(20mmHg, 22mmHg, 24mmHg, 26mmHg, 28mmHg)의 압력에서 목긴근과 목빗근의 근 두께는 초음파 영상을 이용해 측정하였다. 시선 각도 및 압력변화에 따른 목긴근과 목빗근의 두께 변화를 비교 분석하기 위하여 반복측정분산분석을 수행하였다. 본 연구결과, 목긴근은 20과 22mmHg에서 0°와 20°, 0°와 40°, 0°와 60°은 유의한 차이를 보였으며, 20°에서 가장 근활성도가 높았다(p<.05). 목빗근은 28mmHg에서 0°와 20°, 20°와 40°, 40°와 60°은 유의한 차이를 보였으며, 20°에서 가장 낮은 근활성도를 보였다(p<.05). 본 연구에서 머리-목 굽힘 운동 시에는 시선의 방향을 20°로 설정하는 것이 목긴근의 활성화를 높이고, 목빗근의 근활성도를 낮추어 운동의 효과를 얻을 수 있다는 것을 찾았다. 본 연구의 결과를 바탕으로 임상환경에서 머리-목 굽힘 운동시에 시선 방향을 설정하여 운동의 효과를 증대시키길 바란다. This study aimed to investigate the effect of changes in pressure levels and gaze directions on deep neck flexor muscle thickness. Twenty-seven subjects participated in this study. Ultrasound imaging of the longus colli (LC) and sternocleidomastoid (SCM) were measured in four gaze directions (0°, 20°, 40°, 60°) and five pressure levels (20 mmHg, 22 mmHg, 24 mmHg, 26 mmHg, 28 mmHg) during cranial-cervical flexor (CCF) exercises. Repeated ANOVA was performed for analysis of muscle thickness difference according to gaze direction and pressure levels in LC and SCM. Results: LC showed a significant difference between 0° and 20°, 0° and 40°, and 0° and 60° at pressures of 20 mmHg and 22 mmHg (p<.05). SCM displayed a significant difference between 0° and 20°, 20° and 40°, and 40° and 60° at 28 mmHg (p<.05). In this study, it was found that setting the gaze direction to 20° for the CCF exercise can increase the activation of LC and lower the activity of SCM to obtain the effect of exercise. Based on the results of this study, it is hoped that the beneficial effects of the CCF exercise can be increased by setting an optimal gaze direction in a clinical environment.
Ha, You-Ri,Choi, Myeon-Cheon,Jo, Nam-Ju,Kim, Il,Ha, Chang-Sik,Han, Dong-Hee,Han, Se-Won,Han, Mi-Jeong The Polymer Society of Korea 2008 Macromolecular Research Vol.16 No.8
Polyimide (PI) multilayer thin films were prepared by spin-coating from a poly(amic acid) (PAA) and poly(amic acid) ammonium salt (PAAS). PI was prepared from pyromellitic dianhydride (PMDA) and 4,4'-oxydianiline (ODA) PAA. Different compositions of PAAS were prepared by incorporating triethylamine (TEA) into PMDA-ODA PAA in dimethylacetamide. PI multilayer thin films were spin-coated from PMDA-ODA PAA and PAAS. The PAAS comprising cationic and anionic moieties were spherical with a particle size of $20{\sim}40\;nm$. Some particles showed layers with ammonium salts, despite poor ordering. Too much salt obstructed the interaction between the polymer chains and caused phase separation. A small amount of salt did not affect the interactions of the interlayer structure but did interrupt the stacking between chains. Thermogravimetric analysis (TGA) showed that the average decomposition temperature of the thin films was $611^{\circ}C$. All the films showed almost single-step, thermal decomposition behavior. The nanostructure of the multilayer thin films was confirmed by X -ray reflectivity (XRR). The LF 43 film, which was prepared with a 4:3 molar ratio of PMDA and ODA, was comprised of uniformly spherical PAAS particles that influenced the nanostructure of the interlayer by increasing the interaction forces. This result was supported by the atomic force microscopy (AFM) data. It was concluded that the relationship between the uniformity of the PAAS particle shapes and the interaction between the layers affected the optical and thermal properties of PI layered films.
Ha-Ri Lee,Joon Min Jung,Ji-Yeon Seo,Sung Eun Chang,Youngsup Song 고려인삼학회 2021 Journal of Ginseng Research Vol.45 No.5
Background: Ginsenosides of Panax ginseng are used to enhance skin health and beauty. The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from Panax ginseng as a new anti-pigmentation agent. Methods: The anti-melanogenic effects of Rf were explored. The transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated ex vivo human skin. Results: Rf significantly inhibited Forskolin (FSK) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by FSK or CREB-regulated transcription coactivator 3 (CRTC3) overexpression. Increased CREB phosphorylation and protein kinase A (PKA) activity induced by FSK were also mitigated in the presence of Rf. Conclusion: Rf can be used as a reliable anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway.
( Ha-ri Lee ),( Joon Min Jung ),( Mi Young Lee ),( Ji-yeon Seo ),( Sung Eun Chang ),( Youngsup Song ) 대한피부과학회 2020 대한피부과학회 학술발표대회집 Vol.72 No.1
Background: Ginsenosides of Panax ginseng are used to enhance skin health and beauty through their anti-oxidative, anti-inflammatory, and pigment-modulating effects. Objectives: The present study aimed to investigate the potential use of ginsenoside Rf (Rf) from P. ginseng as a new anti-pigmentation agent (as a cosmetic ingredient or a functional food). Methods: The anti-melanogenic effects of Rf were explored. For mechanistic pathways, the transcriptional activity of the cyclic adenosine monophosphate (cAMP) response element binding protein (CREB) and the expression levels of tyrosinase, microphthalmia-associated transcription factor (MITF), and tyrosinase-related proteins (Tyrps) were evaluated in melanocytes and UV-irradiated ex vivo human skin. Results: Rf significantly inhibited cAMP (forskolin) or UV-stimulated melanogenesis. Consistently, cellular tyrosinase activity and levels of MITF, tyrosinase, and Tyrps were downregulated. Furthermore, Rf suppressed MITF promoter activity, which was stimulated by forskolin or CREBregulated transcription coactivator 3 overexpression. Increased CREB phosphorylation and protein kinase A activity induced by forskolin were also mitigated in the presence of Rf. Conclusion: Rf can be used as a reliable promising anti-pigmentation agent, which has a scientifically confirmed and reproducible action mechanism, via inhibition of CREB/MITF pathway.
Ha, Na-Ri,Hong, Eui-Ju,Ryu, Si-Yun,Sim, Cheolho,Chae, Joon-Seok,Kim, Hyeon-Cheol,Park, Jinho,Choi, Kyoung-Seong,Yu, Do-Hyeon,Park, Bae-Keun The Korean Society of Veterinary Service 2017 韓國家畜衛生學會誌 Vol.40 No.3
Acanthocephalan worms were harvested from the posterior intestines of the cultured marine fishes from January to July 2016 in a fish market located in Daejeon metropolitan city, Republic of Korea. Totally 450 cultured fishes (rock fish 100, olive flounder 250, red sea bream 100) were surveyed. Of the 100 red sea bream fish, 37 fishes (37%) were diagnosed as positive for Longicollum pagrosomi by light, electron microscopic and molecular examination. The number of worm was 25~78 (mean $51{\pm}13$). However, we can't found any worm from the cultured rock fish and olive flounder. After sequencing, none of Pomphorhynchidae family are not identical based on 18S rRNA gene, and this data were identified with the first report for 18S rRNA gene sequence of L. pagrosomi. Furthermore, we confirmed that L. pagrosomi of the cultured red sea bream in Republic of Korea is very common parasite.
Flavobacterium jocheonensis sp. nov., Isolated from Marine Green Alga Ulva pertusa
( Ha Ri Choi ),( So Hyun Park ),( Moon Soo Heo ) 한국미생물생명공학회(구 한국산업미생물학회) 2019 Journal of microbiology and biotechnology Vol.29 No.8
A bacterial strain, labeled UR11<sup>T</sup>, was isolated from green alga Ulva pertusa collected from Jeju Island, Korea. UR11<sup>T</sup> was identified as a gram-negative, rod-shaped, motile by gliding and aerobic bacterial strain with yellow colonies on R2A plates. The strain UR11<sup>T</sup> grew over at a temperature range of 10°C to 30°C (optimally at 25°C), a pH range of 6.0-11 (optimally at pH 7.0) and a Nacl range of 0.5-5% Nacl (w/v). Phylogenetic analysis based on 16S rRNA gene sequences revealed that strain UR11<sup>T</sup> was a member of the genus Flavobacterium. Strain UR11<sup>T</sup> shared close similarity with F. jejuensis EC11<sup>T</sup> (98.0%) F. jumunjinense HME7102T (96.1%), F. haoranii LQY-7<sup>T</sup> (95.3%), F. dongtanense LW30<sup>T</sup> (95.1%), and F. ahnfeltiae 10Alg 130<sup>T</sup> (94.9%). The major fatty acids (>5%) were iso-C<sub>15:0</sub> (33.9%), iso-C<sub>15:1</sub> G (12.4%), iso-C<sub>17:0</sub> 3-OH (9.0%), iso- C<sub>16:0</sub> (7.0%) and iso-C<sub>15:0</sub> 3-OH (6.3%). The major polar lipids were phosphatidylethanolamine, seven unknown aminolipids, two unknown aminopolarlipids and two unknown lipids. DNADNA hybridization value was 58% at strain UR11<sup>T</sup> w ith F. jejuensis EC11<sup>T</sup>. Based on phenotypic, chemotaxonomic and phylogenetic evidence, strain UR11<sup>T</sup> represents a novel species of the genus Flavobacterium, for which the name Flavobacterium jocheonensis sp. nov. is proposed. The type strain is Flavobacterium jocheonensis is UR11<sup>T</sup> (=KCTC 52377 <sup>T</sup> =JCM 31512 <sup>T</sup>).