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Toyota Kazuhiro,Mori Masayuki,Hirahara Satoshi,Yoshioka Shoko,Kubota Haruna,Yano Raita,Kobayashi Hironori,Hashimoto Yasushi,Sakashita Yoshihiro,Yokoyama Yujiro,Murakami Yoshiaki,Miyamoto Katsunari 대한위암학회 2022 Journal of gastric cancer Vol.22 No.1
Purpose: Nutritional problems after gastrectomy affect continuation of postoperative chemotherapy. There have been no studies limited to total gastrectomy, which is particularly prone to nutritional problems. In this study, we aimed to investigate the factors that predict the continuation of postoperative chemotherapy. Materials and Methods: We included 101 patients who underwent curative total gastrectomy and postoperative chemotherapy at Hiroshima Memorial Hospital. The effects of 37 factors, including perioperative inflammatory, nutritional, and tumor status, on the persistence of postoperative chemotherapy were analyzed. Results: In univariate analysis of preoperative factors, age, carbohydrate antigen 19-9, platelet-to-neutrophil ratio, Onodera's prognostic nutritional index (PNI), controlling nutritional status score, and nutritional risk screening (NRS-2002) score were significantly associated with the duration of postoperative chemotherapy. In multivariate analysis of preoperative factors, age (≥74 years) was an independent factor for a shorter duration of postoperative chemotherapy (hazard ratio [HR], 5.24; 95% confidence interval [CI], 2.19–12.96; P<0.01). In univariate analysis of factors before postoperative chemotherapy, intraoperative blood loss, perioperative weight loss rate, postoperative performance status, PNI, albumin-to-bilirubin index, and NRS-2002 score were significantly associated with the duration of postoperative chemotherapy. In multivariate analysis of factors before postoperative therapy, age (≥74 years) (HR, 5.75; 95% CI, 1.90–19.49; P<0.01) and PNI (<39) (HR, 3.29; 95% CI, 1.26–8.56; P=0.02) were independent factors for a shorter duration of postoperative chemotherapy. Conclusions: Age and PNI are useful predictors of postoperative chemotherapy intolerance after total gastrectomy and may determine the treatment strategy and timing of chemotherapy initiation.
A Study on the Process of Low-Frequency Noise Generation in A Multi-Blade Centrifugal Fan
Masatoshi Kawasaki,Hiroyuki Hirahara,Donghyuk Kang 한국유체기계학회 2020 International journal of fluid machinery and syste Vol.13 No.2
This study numerically investigates the flow characteristics of a multi-blade centrifugal fan in order to identify the process of low-frequency aerodynamic noise generation. Computational analysis has been carried out using the large eddy simulation (LES) model. In the preliminary study, it was confirmed that the present computational fluid dynamics simulation using LES shows good agreement with the experimental results of the performance curve, sound pressure spectra, and the flow field obtained by using a time-resolved particle image velocimetry (PIV) system. Consequently, it was found that the appearance of an unexpected significant flow, which recirculated from the scroll casing, passed through the impeller, and returned to the scroll casing again to exit the scroll casing in a specific region, was similar to the flow suggested in the experimental results, which were obtained utilizing PIV measurement. The fluid flow related to the fluctuation, which was remarkably not included in the impeller main flow, existed beside the outer main flow. A certain amount of fluctuated flow bifurcated near the scroll end, one regurgitating into the impeller, and another colliding with the tongue. The former became a driving source of noise and the latter a direct noise-generating factor. Consequently, it was demonstrated that a significant fluctuation owing to flow collision with the tongue propagated through the impeller and formed a loop.