http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Haroon,Li Yu‐Xin,Ye Chen‐Xu,Ma Xiao‐Qin,Su Jian,Su Xiao‐Hong,Xing Lian‐Xi 한국곤충학회 2021 Entomological Research Vol.51 No.9
Aging and longevity is a dynamic, chronological process assumed to originate from several hallmarks causing archetypal and beguiling cycles with incredible natural diversity. This phenomenon is widely observed in different animals, and the estimated age of Drosophila melanogaster, Caenorhabditis elegans, Daphnia longispina are a few days to weeks. Reproductive termites live for 30 years, although the root cause of longevity in termite castes is still debated for molecular and cellular changes. Insulin and insulin signaling pathway-related (IIS) genes are important metabolic factors (glucose) highly conserved in lower to higher organisms. Therefore, in this study, we pooled Reticulitermes chinensis castes as primary king (PK), primary queen (PQ), ergatoid king “SWRK” and queen “SWRQ”,male (WM), and female (WF) workers. We determined transcriptome sequencing of R. chinensis castes as a model organism for longevity to investigate the insulin signaling pathway and longevity genes. Through RNA-sequencing, we identified 35 IIS- pathway-related genes out of 343 to the KEGG pathway in ergatoid king and queen, PK, PQ, WM, and WF. Among these genes, Ts c 2 , akt2-a, mTOR, EIF4E, Pdk1,and RPS expressed highly in ergatoid king and queen, PK, and PQ. However, a significant cornerstone tradeoff between reproductive and non-reproductive efforts for early life is essential for evolutionary longevity. The present study concludes that a highly conserved IIS-pathway is evidence for the prolonged termite reproductive life span. We recommended devoting insulin signaling pathway genes to their biological function for termite survival and new insights into the maintenance and relationships between biomolecular homeostasis and remarkable longevity.
Haroon,Ahsan M.A.H. 한국물리학회 2023 Current Applied Physics Vol.56 No.-
The T-shaped double quantum dot system with single-walled metallic armchair carbon nanotube leads has been studied using Green functions obtained by the equation of motion method. The effect of relative spacing between the energy levels of the dots, interdot tunneling matrix-element, interdot Coulomb interaction, and van-Hove singularities in density of states characteristics of quasi-one-dimensional carbon nanotube leads on the conductance of the double quantum dot system has been studied. The conductance and dot occupancies are calculated at finite temperatures. The density of states of the carbon nanotube leads is observed to play a significant role in determining the conductance profile. In particular, whenever the chemical potential of the isolated double quantum dot system is aligned with the position of a van-Hove singularity in the density of states of armchair carbon nanotube leads, the height of the corresponding conductance peak falls considerably. It is further observed that the suppression in the heights of the alternate peaks depends on the relative positions of the energy levels of the dots and their magnitude of separation.
Modeling and Simulation of an EPPR Valve Coupled with a Spool Valve
Haroon Ahmad Khan,윤소남 사단법인 유공압건설기계학회 2019 드라이브·컨트롤 Vol.16 No.2
EPPR (Electro-hydraulic Proportional Pressure Reducing) valves are pressure control valves. In this study, an independent metering valve (IMV), which is a combination of a spool valve opened and closed with the help of an EPPR valve, was discussed. The overall performance of the valve (IMV) was obtained by the respective modeling and simulation of the system. The valve investigated in this study is to be used for independent metering of hydraulic excavator actuator e.g. boom, arm, bucket etc. To design the model, continuity equations and force balance equations were used. The set of differential equations were then simulated in Simulink using ODE45 option in the configuration toolbox. The valve has to be able to control the flow rate going in and out of the cylinder separately, which is why the particular configuration was needed and selected.
Fabrication of an Enzymatic Biofuel Cell with Electrodes on Both Sides of a Microfluidic Channel
Haroon Khan,김철민,Sung Yeol Kim,Sanket Goel,Prabhat K. Dwivedi,Ashutosh Sharma,김영호,Gyu Man Kim 한국정밀공학회 2019 International Journal of Precision Engineering and Vol.6 No.3
Enzymatic biofuel cells (EBFCs) that utilize glucose as fuel in a human body to produce electricity are being explored as promising alternatives to power implantable devices. However, some limitations need to be overcome to render such micro-electronic devices practically applicable. Here, we propose a microfluidic EBFC architecture with electrodes on both sides of the microchannel and its fabrication via stencil method. Multiwalled carbon nanotube (MWCNT) electrodes are fabricated on both sides of a Y-shaped microfluidic channel to reduce the effect of the depletion boundary layer and cross-diffusional mixing of the fuel and oxidant, which are functions of the distance from the microchannel inlet. Therefore, the microchannel length is reduced by half, while maintaining the same MWCNT electrode area. The microchannel is produced by polydimethylsiloxane (PDMS) casting whereas the electrodes are fabricated by a PDMS stencil, using MWCNT patterned on etched indium tin oxide glass. The electrodes are modified with glucose oxidase and laccase via direct covalent bonding. The cell performance is studied at different microchannel heights and flow rates, obtaining a maximum power and current density of 153 µW cm−2 and 450 µA cm−2, respectively, at a microchannel height of 450 µm and flow rate of 25 mL h−1. The double-layer EBFC shows a 23% improvement in the performance compared to a single-layer EBFC.
Producing Micro-Power with Microfluidic Enzymatic Biofuel Cells: A Comprehensive Review
Haroon Khan,Muhammad Tanveer,Cheol Woo Park,Gyu Man Kim 한국정밀공학회 2023 International Journal of Precision Engineering and Vol.10 No.2
Enzymatic biofuel cells (EBFCs) use enzymes as biocatalysts to produce clean energy. They have attracted much attention owing to several interesting features, such as the use of cheap and renewable biocatalysts, utilization of abundantly available high-energy–density biofuels, and their capability to operate under mild temperature and pH conditions. The integration of EBFCs into microfluidic architecture enables their application as small-scale power sources for portable, implantable, and wearable microelectronics. However, despite extensive research over the last two decades, this technology is still in the early stages of development owing to critical challenges, such as inefficient fuel oxidation, short lifetimes, and limited power density. This review paper broadly discusses various attributes of microfluidic EBFCs, focusing on the different microfabrication techniques employed to date because miniaturization is considered a promising approach for developing this technology. A short history and evolution of EBFCs are presented, after which fundamentals of the chemistry of EBFCs are briefly discussed to clarify the basic terms. In addition, various microfabrication techniques for manufacturing microfluidic EBFCs, which have been practiced over the last two decades, are reviewed thoroughly and compared according to resolution quality, fabrication convenience, and cost-effectiveness. Furthermore, potential applications of EBFCs and various obstacles to the realization of these applications are reviewed. Finally, the key challenges in producing practical and commercialized EBFCs and different approaches to overcome these challenges are discussed. This review article provides insight into the past, present, and future of this rapidly emerging microscale EBFC-based green technology.
Celastrol-mediated autophagy regulation in cancer
Haroon Muhammad,Kang Sun Chul 한국응용생명화학회 2020 Applied Biological Chemistry (Appl Biol Chem) Vol.63 No.6
In the last few decades, studies on autophagy regulation and its potential role in cancer therapeutics have expanded to include detailed mechanisms. Since apoptosis exhibits drug resistance in some cancers, eforts have focused on searching for compounds with autophagy modulating properties. Numerous natural compounds have been used in cancer treatment and are considered a signifcant research area due to their remarkable anti-cancer properties. Celastrol, a quinone methide triterpene, derived from Tripterygium wilfordii, has recently drawn much attention because of its anticancer potential. It enhances tumor suppression and induces autophagy in cancer cells by regulating signaling pathways such as Beclin-1, Akt/mTOR, ROS, NF-κB, MAPK, HSP90, and the proteasome. In the current study, we address the anticancer potential of celastrol, its efect on various cellular pathways, and describe how it functions as an autophagy modulator in cancer therapeutics and helps diminish multidrug resistance in cancer cells.