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Hương Giang Lê,Tuấn Cường Võ,강정미,Thu Hằng Nguyễn,황병수,오영택,나병국 대한기생충학ㆍ열대의학회 2023 The Korean Journal of Parasitology Vol.61 No.4
Free-living amoebae (FLA) rarely cause human infections but can invoke fatal infections in the central nervous system (CNS). No consensus treatment has been established for FLA infections of the CNS, emphasizing the urgent need to discover or develop safe and effective drugs. Flavonoids, natural compounds from plants and plant-derived products, are known to have antiprotozoan activities against several pathogenic protozoa parasites. The anti-FLA activity of flavonoids has also been proposed, while their antiamoebic activity for FLA needs to be emperically determined. We herein evaluated the antiamoebic activities of 18 flavonoids against Naegleria fowleri and Acanthamoeba species which included A. castellanii and A. polyphaga. These flavonoids showed different profiles of antiamoebic activity against N. fowleri and Acanthamoeba species. Demethoxycurcumin, kaempferol, resveratrol, and silybin (A+B) showed in vitro antiamoebic activity against both N. fowleri and Acanthamoeba species. Apigenin, costunolide, (‒)-epicatechin, (‒)-epigallocatechin, rosmarinic acid, and (‒)-trans-caryophyllene showed selective antiamoebic activity for Acanthamoeba species. Luteolin was more effective for N. fowleri. However, afzelin, berberine, (±)-catechin, chelerythrine, genistein, (+)-pinostrobin, and quercetin did not exhibit antiamoebic activity against the amoeba species. They neither showed selective antiamoebic activity with significant cytotoxicity to C6 glial cells. Our results provide a basis for the anti-FLA activity of flavonoids, which can be applied to develope alternative or supplemental therapeutic agents for FLA infections of the CNS.
Bản chất văn hóa của tục ngữ Việt
Nguyễn Việt Hương 한국외국어대학교 동남아연구소 2011 東南亞硏究 Vol.21 No.1
Proverb is the treasure where stores people’s folk knowledge, summarized from the general experiences about the nature and social relations. Proverb expressed in focus the way of living, the features of thinking, expressing the thought, it means the way of speaking and thinking of people. Therefore, it is a synthetical phenomenon where the cultural hallmark quite obviously. In that way, we can assert surely that there is the cultural nature inside the proverb. With the linguistic essence and artistic essence, the cultural nature contributes to enhance strength of proverb in folklore in general and genres of literature in particular. This paper reconfirms the range of proverb notion and the line to distinguish proverb from several genres of folk literature. After that, the paper analyzes aspects of content in proverb to enhance the cultural nature of this genre. Proverb is a vivid picture about Vietnamese culture. The paper mentiones on the aspects of material life and the social life that expressed through the topics about the custom in Viet proverb. Particularly, the paper emphasizes and analyses the advantages of proverb in representing conceptions, the way of assessment, philosophy of human life, expressing the ability in thinking and reflecting the psychological life and spirit of Vietnamese. This is the most typical character for nature of proverb in general and being a specific characteristics to distinguish proverb’s cultural essence, making cultral characteristic of proverb is more original than if comparing with the other genres in folklore. The paper indicates that using proverb in the life being an original characteristic in treatment culture of Vietnamese people. For that reason, the paper demonstrates that Viet proverb contains all cultural hallmark of traditional Vietnamese society.
Mapping of the Complement C9 Binding Region on Clonorchis sinensis Paramyosin
강정미,Hương Giang Lê,Tuấn Cường Võ,유원기,손운목,나병국 대한기생충학ㆍ열대의학회 2022 The Korean Journal of Parasitology Vol.60 No.4
Heliminthic paramyosin is a multifunctional protein that not only acts as a structural protein in muscle layers but as an immune-modulatory molecule interacting with the host immune system. Previously, we found that paramyosin from Clonorchis sinensis (CsPmy) is bound to human complement C9 protein (C9). To analyze the C9 binding region on CsPmy, overlapping recombinant fragments of CsPmy were produced and their binding activity to human C9 was investigated. The fragmental expression of CsPmy and C9 binding assays revealed that the C9 binding region was located at the C-terminus of CsPmy. Further analysis of the C-terminus of CsPmy to narrow the C9 binding region on CsPmy indicated that the region flanking 731Leu–780Leu was a potent C9 binding region. The CsPmy fragments corresponding to the region effectively inhibited human C9 polymerization. These results provide a precise molecular basis for CsPmy as a potent immunomodulator to evade host immune defenses by inhibiting complement attack.
Thị Lam Thái,Hojong Jun,Seo Hye Park,Hương Giang Lê,이진영,안성규,강정미,Moe Kyaw Myint,Khin Lin,손운목,남호우,나병국,Tong-Soo Kim 대한기생충학ㆍ열대의학회 2019 The Korean Journal of Parasitology Vol.57 No.3
Toxoplasma gondii is an apicomplexan parasite that can cause toxoplasmosis in a wide range of warm-blood- ed animals including humans. In this study, we analyzed seroprevalence of T. gondii among 467 school children living in the rural areas of Pyin Oo Lwin and Naung Cho, Myanmar. The overall seroprevalence of T. gondii among school children was 23.5%; 22.5% of children were positive for T. gondii IgG, 0.4% of children were positive for T. gondii IgM, and 0.6% of children were positive for both T. gondii IgG and IgM. Geographical factors did not significantly affect the seropreva- lence frequency between Pyin Oo Lwin and Naung Cho, Myanmar. No significant difference was found between males (22.2%) and females (25.0%). The overall seroprevalence among school children differed by ages (10 years old [13.6%], 11-12 years old [19.8%], 13-14 years old [24.6%], and 15-16 years old [28.0%]), however, the result was not significant. Polymerase chain reaction analysis for T. gondii B1 gene for IgG-positive and IgM-positive blood samples were negative, indicating no direct evidence of active infection. These results collectively suggest that T. gondii infection among school children in Myanmar was relatively high. Integrated and improved strategies including reinforced education on toxoplas- mosis should be implemented to prevent and control T. gondii infection among school children in Myanmar.