http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
Hydrochlorothiazide의 microcapsule 제조와 평가
남상철,박목순,나성범,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 1990 藥學論文集 Vol.6 No.-
The microcapsules of hydrochlorothiazide using Eudragit RL were prepared by the solvent evaporation process in liquid paraffin phase, and the microcapsules of hydrochlorothiazide using Ethylcellulose were prepared by the solvent evaporation process in water phases. The size distribution, drug content, interaction between the drug and the polymer, dissolution test, observation of SEM were investigated. The results are summarized as belows. The Eudragit RL microcapsules and Ethylcellulose microcapsules obtained were spherical, uniform and free flowing particles. As the dispersing agents (Eudragit RL-magnesium stearate, Ethylcellulose-sod, lauryl sulfate) were fixed, the preparation of microcapsules showed constant in particle size distribution. The actual drug contents of the Eudragit RL microcpasules were lower than theoretical drug contents, but the actural drug contents of the Ethylcellulose were higher than those. No interaction between the polymer and the drug was observed from the results of TLC, UV, IR, DSC. The release of hydrochlorothiazide from the Eudragit RL microcapsules except for the release in pH 8.0 phosphate buffer solution was not increased when the drug: polymer ratio was increased. The dissolution rate of hydrochlorothiazide from Ethylcellulose microcapsules increased with increasing drug: polymer ratio. Scanning electron micrograph study revealed that microcapsules prepared by this method showed comparatively rough surface when drug: polymer ratio was decreased.
ZVS를 이용한 풀 브릿지 단일 전력단 고주파 공진 AC-DC 컨버터의 특성해석
남승식,황계호,오경섭,원재선,조규판,김동희 嶺南大學校 工業技術硏究所 2003 工業技術硏究所論文集 Vol.31 No.2
This paper proposes a single-stage high frequency resonant AC-DC converter using zero voltage switching with high input power factor. The proposed high frequency resonant converter ingegrates a half bridge boost rectifier as power factor corrector(PFC) and half resonant converter into a single stage. The input stage of the half bridge boost converter is working in discontinuous conduction mode(DCM) with constant duty cycle and variable switching frequency. Therefore, high power factor is achieved naturally. The results of simulation using the Pspice have demonstrated the feasibility of the proposed AC-DC converter. The proposed converter will be able to be practically used as power supply.
META분석을 이용한 유산소운동의 생리적변인에 관한 연구
남덕현,김규수,박찬웅 龍仁大學校 1998 용인대학교 논문집 Vol.16 No.-
The purpose of this study was to analyze the effects of regular aerobic exercise on physiological variable. The results of 145 training studies, conducted of the last 30 years(1966-1996), involving the measurement of % body fat, RHR, VO2max, VE were collected and statistically analyzed using META-analysis method. The major results were as follows, ① physiological effect As aerobic excercise had a significant effect on physiological variables(% body fat, RHR, VO2max, VE), it directed to positive effects. And the specific character variables effecting on physiological variable by aerobic exercise were initial level, exercise duration, weight, age, exercise time and exercise intensity. ② The characteristic variables effecting on physiological variables had on different influence by the sex and subject state.
제산제 탄산수산화마그네슘의 최적 제조조건 추구 및 분체학적 성질
남진경,이계주 충남대학교 약학대학 의약품개발연구소 1999 藥學論文集 Vol.15 No.-
Magnesium carbonate hydroxide (hydrotalcite) was synthesized to pursue the optimum conditions having the highest acid consuming capacity by a Box-Wilson experimental design, and micromeritical properties of samples were evaluated by laser particle size analyzer, SRD, BET system, mercury porosimeter, and several adsorption capacity test. The optimum preparation conditions for hydrotalcite were as followwws: concentration of aluminum hydroxide and magnesium hydroxide 1.17mole, reaction temp. 82.6℃, reaction time 2.32hr, ratio of (Al(OH)_3/Mg(OH)_2 4.25, drying temperature 93.2℃ respectively, and its acid consuming capacity was 286ml/g. the neutralization curve shows that sample whose acid consuming capacity was the highest has the best neutralizing capacity and duration capacity. The crystalline form of the synthesized hydrotalcite was identified with a hexagonal system, and the d (003) spacing value of three samples was large. a part of alumina crystal form was shown at 2θ=18°, 38° in sample 3. The micromeritical properties of the synthesized hydrotalcite has no relation with an acid consuming capacity, and there was a tendency that the higher the acid consuming capacity is the larger the particle size and the narrower the size distribution. The values of pore invasive volume, pore area and specific surface area of sample 1 were small among three samples. Isotherm by BET system forms hyteresis loop and it shows the synthesized hydrotacite was porous. the pore diameter was about 10Å and it verifies mesopore. The adsorption capacity measured by methylene blue has no relation with acid consuming capacity. The adsorption of quinine sulfate in aqueous solutuion was identical with the Langmuir isotherm.
분무건조법을 이용한 방출 제어형 케토로락 고형지질마이크로스피어의 제제설계
윤재남,이은미,김동우,박용근,전일순,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-
Ketorolac (KA) and ketorolac tromethamine (KT) is the nonsteroidal anti-inflammatory drugs (NSAIDs) and has been used widely. To improve its frequent administration by control of drug release. we prepared SLM of KA and KT using Mirj 45 and 52 as surfactants and tripalmitin and tristearin as lipids by spry drying method SLM, as a disperse system for injection, were evaluated by measurement of particle sizes. SEM and drug release pattern As a result. spherical SLM were prepared and their particle size were in the range of 25-125 μm, which were dependant on the types and contents of lipid and sururfactants. Their dissolution rate were decreased as increasing lipid contents.
崔桂浩,南洋洙 대구산업정보대학 1992 논문집 Vol.6 No.-
Coporation of the Korea has been maintaining by dint of the low-wage labor power and unlimited supply until 1970, the shortage of the labor is raising a great of bottleneck according to the deadlock of laborpower supply. As such phenomena prospect are prospected more deepen resulting to the fore casting of the manpower demand and supply. Accordingly, diversified counter plan are needed to the coporation which in the improvement of wage and working condition in addition to oldman power and acceleration of the female power and abroad lowwage labor power.
[논문]지진격리교량의 내진설계를 위한 표준 인공지진파 생성
김남식,김재민,이계희,강형택 釜山大學校生産技術硏究所 2007 生産技術硏究所論文集 Vol.66 No.-
본 연구에서는 지진격리교량의 내진설계에 사용할 수 있는 인공지진파의 생성기법을 제시하였다. 또한,생성한 지진파가 적절한지 조사하였으며,지진격리교량의 내진설계기준(안)을 토대로 인공지진파 작성을 수행하였다. 설계지반응답스펙트럼을 만족시키기 위하여 22개의 가속도시간이력을 작성하였다. 얻어진 인공지진파는 (1) 통제진동수에서 인공지진파의 평균응답스펙트럼 평가, (2) EPGA(유효최대지반가속도) 평가,(3) 인공지반가속도 사이의 상관계수 평가, 동으로 적합성을 평가하였다. 최종적으로 생성된 인공지진파를 이용하여 4쌍의 지진파를 사용한 최대응답과 7쌍의 지진파를 사용한 평균 응답을 계산하여 제안된 인공지진파 시간이력의 타당성을 제시하였다.
폴리메타크릴레이트를 이용한 케토로락 트로메타민 서방성 정제의 제조와 용출평가
전일순,윤재남,이은미,박용근,김동우,이계원,지웅길 충남대학교 약학대학 의약품개발연구소 2003 藥學論文集 Vol.18 No.-
To improve administration of ketolorac tromethamine, we prepared matrix tablets with Eudragit (RS 100 or 30D), diluents (avicel:lactose=l:l or Ca phosphate) and Mg stearate using wet-granulation method. Sustained release matrix tablets using Eudragit® RS 100 7 and 10% decreased dissolution rate at pH 1.2 and 68 Ca. phosphate as diluents showed more decreased dissolution rate than that of avicel:lactose (1:l). Sustained release matrix tablets using Eudragit® RS 30D also showed very effective sustained release of KT.