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A. Selen Gurkan-Alp,Hakan Go¨ker,Mehmet Alp,Tulin Ozkan,Asuman Sunguroglu 대한약학회 2015 Archives of Pharmacal Research Vol.38 No.5
A series of novel 2-(4-phenoxyphenyl)-1Hbenzimidazolederivatives was synthesized and testedin vitro on human chronic myelogenous leukemia (CML)cell line K562. Benzimidazoles containing 5-amidino (10),5-N-isopropylamidino (11), 5-bromo (13), and 5,6-dimethyl(14) derivatives exhibited remarkable cytotoxicactivity. The quantitative analysis of apoptosis by flowcytometrydemonstrated that the percentages of early andlate apoptotic K562 cells treated with these compoundswere significantly higher than cells without treatment. Wealso investigated the effects of these compounds on theexpression of apoptosis-related genes BAX, BCL-2, BADand BIM. Treatment of K562 cells wih compounds 10–14significantly increased the expression levels of the proapoptoticgenes BAX, BAD and BIM, whereas compound20 increased BAX and BAD.