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Guolin Zhou,Xia Li,Aihua Wang,Feng Zu,Zhenhua Hu,Jiazao Lin,Jinxing Tu 한국유전학회 2016 Genes & Genomics Vol.38 No.12
WS24-3 is a newly bred recessive genic male sterility line of the non-heading Chinese cabbage (Brassica rapa ssp. chinensis). Here, an F2 population was produced from the cross between WS24-3 and a male-fertile breeding line (WS135). The Illumina Brassica 60 K single nucleotide polymorphism (SNP) array was used for SNPs detecting between sterile and fertile bulks from the F2 population, and 62 SNPs were identified. BLAST analysis of the 62 SNPs revealed that the A2 chromosome of Brassica rapa genome contained 22 SNPs, whereas the other chromosomes did not contain more than 6 SNPs each. These data indicated that the potential target gene locus, named Bra2Ms, might be located on A2. Based on 10 of the 22 SNPs, allele-specific-polymerase chain reaction (AS-PCR) primers and single sequence repeat (SSR) primers were designed, 5 AS-PCR primers and 9 SSR primers showed difference between the bulks in electrophoretic determination. Analysis of these markers in F2 population revealed that Bra2Ms was genetically delimited to a region of 1.2 cM. We also detected two co-segregated markers SSRa2-951 and SSRa2-960 in this region. The markers identified in our study might facilitate the transfer of recessive genic male sterility alleles to other favorable genetic backgrounds. Furthermore, these markers will support a map-based clone of Bra2Ms.
( Guolin Sun ),( Gordon Owusu Boateng ),( Hu Huang ),( Wei Jiang ) 한국인터넷정보학회 2019 KSII Transactions on Internet and Information Syst Vol.13 No.8
Cloud radio access networks (C-RANs) have been regarded in recent times as a promising concept in future 5G technologies where all DSP processors are moved into a central base band unit (BBU) pool in the cloud, and distributed remote radio heads (RRHs) compress and forward received radio signals from mobile users to the BBUs through radio links. In such dynamic environment, automatic decision-making approaches, such as artificial intelligence based deep reinforcement learning (DRL), become imperative in designing new solutions. In this paper, we propose a generic framework of autonomous cell activation and customized physical resource allocation schemes for energy consumption and QoS optimization in wireless networks. We formulate the problem as fractional power control with bandwidth adaptation and full power control and bandwidth allocation models and set up a Q-learning model to satisfy the QoS requirements of users and to achieve low energy consumption with the minimum number of active RRHs under varying traffic demand and network densities. Extensive simulations are conducted to show the effectiveness of our proposed solution compared to existing schemes.
CXCL-13 Regulates Resistance to 5-Fluorouracil in Colorectal Cancer
Guolin Zhang,Xin Luo,Wei Zhang,Engeng Chen,Jianbin Xu,Fei Wang,Gaoyang Cao,Zhenyu Ju,Dongai Jin,Xuefeng Huang,Wei Zhou,Zhangfa Song 대한암학회 2020 Cancer Research and Treatment Vol.52 No.2
Purpose 5-Fluorouracil (5-Fu) is used as a conventional chemotherapy drug in chemotherapy for patients with advanced colorectal cancer, but many patients still suffer from treatment failure due to 5-Fu resistance. Emerging observations revealed the important role of chemokine (C-X-C motif) ligand 13 (CXCL-13) in tumor microenvironment and its relationship with prognosis in patients with colorectal cancer. This study is designed to reveal the important role of CXCL-13 in causing colorectal cancer resistance to 5-Fu. Materials and Methods CXCL-13 levels of patient's serum or cell culture supernatants were measured separately by enzyme-linked immunosorbent assay. In cell assays, cell viability is detected by Cell Counting Kit-8. Therefore, the recombinant human CXCL-13 was used to simulate its high expression in cells while its antibody and siRNA were used to reduce CXCL-13 expression in cells. Results In this study, we demonstrated that CXCL-13 is associated with 5-Fu resistance by culture medium exchange experiments and cytokine arrays of colorectal cancer resistant and nonresistant cells. Clinical studies showed that CXCL-13 is highly expressed in the serum of 5-Fu–resistant patients. High levels of serum CXCL-13 also predict a worse clinical outcome. The addition of recombinant CXCL-13 cytokine resulted in 5-Fu resistance, while its antibody overcame 5-Fu resistance, and knockdown of CXCL-13 expression by siRNA also reduced 5-Fu resistance, which can be saved by added recombination CXCL-13. Conclusion These results not only identify a CXCL-13 mediated 5-Fu resistance mechanism but also provide a novel target for 5-Fu–resistant colorectal cancer in prevention and treatment strategies.
Reservation based Resource Management for SDN-based UE Cloud
( Guolin Sun ),( Dawit Kefyalew ),( Guisong Liu ) 한국인터넷정보학회 2016 KSII Transactions on Internet and Information Syst Vol.10 No.12
Recent years have witnessed an explosive growth of mobile devices, mobile cloud computing services offered by these devices and the remote clouds behind them. In this paper, we noticed ultra-low latency service, as a type of mobile cloud computing service, requires extremely short delay constraints. Hence, such delay-sensitive applications should be satisfied with strong QoS guarantee. Existing solutions regarding this problem have poor performance in terms of throughput. In this paper, we propose an end-to-end bandwidth resource reservation via software defined scheduling inspired by the famous SDN framework. The main contribution of this paper is the end-to-end resource reservation and flow scheduling algorithm, which always gives priority to delay sensitive flows. Simulation results confirm the advantage of the proposed solution, which improves the average throughput of ultra-low latency flows.
( Guolin Sun ),( Li Lu ),( Daniel Ayepah-mensah ),( Xiufen Fang ),( Wei Jiang ) 한국인터넷정보학회 2018 KSII Transactions on Internet and Information Syst Vol.12 No.10
In recent years, dense small cell network has been deployed to address the challenge that has resulted from the unprecendented growth of mobile data traffic and users. It has proven to be a cost efficeient solution to offload traffic from macro-cells. Software defined heterogeneous wireless network can decouple the control plane from the data plane. The control signal goes through the macro-cell while the data traffic can be offloaded by small cells. In this paper, we propose a framework for cell virtualization and user association in order to satisfy versatile requirements of multiple tenants. In the proposed framework, we propose an interference graph partioning based virtual-cell association and customized physical-cell association for multi-homed users in a software defined small cell network. The proposed user association scheme includes 3 steps: initialization, virtual-cell association and physical-cell association. Simulation results show that the proposed virtual-cell association outperforms the other schemes. For physical-cell association, the results on resource utilization and user fairness are examined for mobile users and infrastructure providers.
An effective process for removing organic compounds from oily sludge using soluble metallic salt
Guolin Jing,Mingming Luan,Chunjie Han,Tingting Chen,Huaiyuan Wang 한국공업화학회 2012 Journal of Industrial and Engineering Chemistry Vol.18 No.4
This study evaluates the application of wet oxidation for the treatment of oily sludge by using hydrogen peroxide as oxidant instead of air at high temperature in a batch reactor. The experimental results show that the quantity of oxidant with 250% to theoretical oxygen demand of oily sludge is comparatively effective and economica1. Adding a catalyst, Fe3+, significantly improved the COD removal. Reaction mechanism for WO of oily sludge is analyzed. Oxidation of intermediate for oily sludge is a rate-limiting step for further oxidation of oily sludge.