Preoperative Levels of Matrix Metalloproteinase-7 and -9 and Tissue Inhibitor of Matrix Metalloproteinase-1 Relation to Pathologic Parameters in Bladder Carcinoma Patients

Gunes, Mustafa,Kemik, Ahu Serap,Pirincci, Necip,Gecit, Ilhan,Taken, Kerem,Yuksel, Mehmet Bilgehan,Kaba, Mehmet,Eryilmaz, Recep Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.2

Our aim was to test the hypothesis that preoperative serum levels of matrix metalloproteinase-7 (MMP-7) and -9 (MMP-9) and tissue inhibitor of matrix metalloproteinase (TIMP-1) levels correlate with pathological features. Serum levels of MMP-7, and MMP-9 and TIMP-1 were determined in 90 bladder cancer patients and 40 healthy controls using an enzyme linked immunosorbent assay. Preoperative serum MMP-7 and MMP-9 levels were significantly higher in cancer patients than control groups (p<0.001). In contast, serum TIMP-1 levels were lower (p<0.001). Alteration in MMP-7, and MMP-9, and TIMP-1 production may contribute to tumor angiogenesis and be associated with clinic-pathological features.

DSM Quality of Korean Satellite KOMPSAT-3 in Comparison to AW3D30 and Sentinel-1A in respect of Airborne Laser Scanning

Umut Gunes Sefercik,Gurcan Buyuksalih,Karsten Jacobsen,Serdar Bayburt 대한토목학회 2019 KSCE JOURNAL OF CIVIL ENGINEERING Vol.23 No.7

With significant technological improvements on earth observation instruments, three dimensional space-borne remote sensing data became indispensable for modelling large areas and continents. To acquire high resolution 3D earth data, actual optical and synthetic aperture radar (SAR) satellite missions are launched frequently. Korean Multi-Purpose Satellite 3 (KOMPSAT-3), which was launched in May, 2012 by Korea Aerospace Research Institute (KARI), is a high-resolution optical observation mission. The 0.7 m ground sampling distance (GSD) and stereo imaging capability of the satellite enables to derive qualified digital surface models (DSM). We generated a 5 m spacing KOMPSAT-3 DSM in Istanbul historic peninsula and estimated its quality by comprehensively analysing the absolute and relative accuracies and the morphological detail description capability. In the analysis, 1 m spacing airborne laser scanning (ALS) DSM was used as reference. Additionally, the ALOS (Advanced Land Observation Satellite) World 3D 30 m (AW3D30) and Sentinel-1A (S-1A) DSMs have been used in comparison with the KOMPSAT-3 DSM. As accuracy metrics, standard deviation (SZ) and normalized median absolute deviation (NMAD) of height differences between KOMPSAT-3, AW3D30, S-1A and ALS reference DSM were used. The results demonstrated that KOMPSAT-3 DEM quality is better than AW3D30 and S-1A both in accuracy and morphologic detail analysis.

The change of metal pollution in the water and sediment of the Bartın River in rainy and dry seasons

Gulten Gunes 대한환경공학회 2022 Environmental Engineering Research Vol.27 No.2

In this study, it was aimed to determine the heavy metal pollution and the factors causing this pollution in the water and sediment of the Bartın River during rainy and dry periods. Concentrations of Co, Cr, Cu, Fe, Mn, Ni, Pb, Zn, As and some other metals in water and sediment samples collected from 4 different points during rainy and dry periods were investigated. It has been determined that both natural sources (soil erosion) and anthropogenic sources (runoff in urban and agricultural areas) affect metal concentrations in water and sediment during the rainy period. Heavy metal accumulation was less at the point with the least water depth (≈ 2 m). Higher concentrations were determined at the point where soil transport was highest during the rainy period. Since EF values of As, Pb, Zn and Li were greater than two in both periods, it was determined that they were affected by anthropogenic sources (wastewater discharges, agricultural and urban activities). EF values less than one showed that Co, Cr, Ba, Ni, Mn were related to lithogenic actions and riverbank runoff. Non-carcinogenic effects caused by metals did not pose a risk to adults and children.

Determination of Ethanol in Blood Samples Using Partial Least Square Regression Applied to Surface Enhanced Raman Spectroscopy

Acikgoz, Gunes,Hamamci, Berna,Yildiz, Abdulkadir Korean Society of ToxicologyKorea Environmental Mu 2018 Toxicological Research Vol.34 No.2

Alcohol consumption triggers toxic effect to organs and tissues in the human body. The risks are essentially thought to be related to ethanol content in alcoholic beverages. The identification of ethanol in blood samples requires rapid, minimal sample handling, and non-destructive analysis, such as Raman Spectroscopy. This study aims to apply Raman Spectroscopy for identification of ethanol in blood samples. Silver nanoparticles were synthesized to obtain Surface Enhanced Raman Spectroscopy (SERS) spectra of blood samples. The SERS spectra were used for Partial Least Square (PLS) for determining ethanol quantitatively. To apply PLS method, $920{\sim}820cm^{-1}$ band interval was chosen and the spectral changes of the observed concentrations statistically associated with each other. The blood samples were examined according to this model and the quantity of ethanol was determined as that: first a calibration method was established. A strong relationship was observed between known concentration values and the values obtained by PLS method ($R^2=1$). Second instead of then, quantities of ethanol in 40 blood samples were predicted according to the calibration method. Quantitative analysis of the ethanol in the blood was done by analyzing the data obtained by Raman spectroscopy and the PLS method.

Is Retinal Nerve Fiber Layer Thickness Change Related to Headache Lateralization in Migraine?

Alime Gunes,Seden Demirci,Levent Tok,Ozlem Tok,Serpil Demirci,Sü,leyman Kutluhan 대한안과학회 2016 Korean Journal of Ophthalmology Vol.30 No.2

Purpose: To evaluate retinal nerve fiber layer (RNFL) thickness in migraine patients with unilateral headache. Methods: A total of 58 patients diagnosed with migraine headache consistently occurring on the same side and 58 age- and sex-matched healthy subjects were evaluated in this cross-sectional study. RNFL thickness was measured using spectral-domain optical coherence tomography, and the side with the headache was compared with the contralateral side as well as with the results of healthy subjects. Results: The mean patient age was 33.05 ± 8.83 years, and that of the healthy subjects was 31.44 ± 8.64 years (p = 0.32). The mean duration of disease was 10.29 ± 9.03 years. The average and nasal RNFL thicknesses were significantly thinner on the side of headache and on the contralateral side compared to control eyes (p< 0.05, for all). Thinning was higher on the side of the headache compared to the contralateral side; however, this difference was not statistically significant. Conclusions: The RNFL thicknesses were thinner on the side of the headache compared to the contralateral side in the migraine patients with unilateral headache, but this difference was not statistically significant.

Microtubular Dysfunction and Male Infertility

Sezgin Gunes,Pallav Sengupta,Ralf Henkel,Aabed Alguraigar,Mariana Marques Sinigaglia,Malik Kayal,Ahmad Joumah,Ashok Agarwal 대한남성과학회 2020 The World Journal of Men's Health Vol.38 No.1

Microtubules are the prime component of the cytoskeleton along with microfilaments. Being vital for organelle transport and cellular divisions during spermatogenesis and sperm motility process, microtubules ascertain functional capacity of sperm. Also, microtubule based structures such as axoneme and manchette are crucial for sperm head and tail formation. This review (a) presents a concise, yet detailed structural overview of the microtubules, (b) analyses the role of microtubule structures in various male reproductive functions, and (c) presents the association of microtubular dysfunctions with male infertility. Considering the immense importance of microtubule structures in the formation and maintenance of physiological functions of sperm cells, this review serves as a scientific trigger in stimulating further male infertility research in this direction.

Nature of Lesions Undergoing Radical Nephrectomy for Renal Cancer

Mustafa, Gunes,Ilhan, Gecit,Necip, Pirincci,Kerem, Taken,Kadir, Ceylan Asian Pacific Journal of Cancer Prevention 2012 Asian Pacific journal of cancer prevention Vol.13 No.9

Aim: The aim of the present study was to evaluate retrospectively histopathologically-diagnosed lesions that were detected in the kidney after radical nephrectomy for a preoperative diagnosis of kidney cancer. Methods: The medical records of 83 patients (51 male, 32 female) were included. Preoperative staging was accomplished by various methods including physical examination, blood hemography and biochemistry, abdominal ultrasonography (US), chest x-ray, abdominal computed tomography (CT) and abdominal magnetic resonance imaging (MRI). Results: Totals of 70 patients underwent radical nephrectomy and 13 nephron sparing surgery. Of the 83 patients, 70 had malignant lesions (renal cell carcinoma, squamous cell carcinoma or other malignancies) 13 had a variety of benign lesions, the most frequently detected being oncoytoma (6), angiomyolipoma (3), xanthogranulamatous pyelonephritis (2), cortical cyst (1) and chronic pyelonephritic change (1). Conclusion: It was concluded that in spite of great technological developments regarding radiological imaging modalities such as US, CT and MRI, benign lesions might still be detected pathologically in patients who undergo radical nephrectomy with the preoperative diagnosis of renal cancer. But, all renal masses should be regarded as malignant and should be managed surgically otherwise proven benign.

A Survey on Concepts, Applications, and Challenges in Cyber-Physical Systems

( Volkan Gunes ),( Steffen Peter ),( Tony Givargis ),( Frank Vahid ) 한국인터넷정보학회 2014 KSII Transactions on Internet and Information Syst Vol.8 No.12

The Cyber-Physical System (CPS) is a term describing a broad range of complex, multi-disciplinary, physically-aware next generation engineered system that integrates embedded computing technologies (cyber part) into the physical world. In order to define and understand CPS more precisely, this article presents a detailed survey of the related work, discussing the origin of CPS, the relations to other research fields, prevalent concepts, and practical applications. Further, this article enumerates an extensive set of technical challenges and uses specific applications to elaborate and provide insight into each specific concept. CPS is a very broad research area and therefore has diverse applications spanning different scales. Additionally, the next generation technologies are expected to play an important role on CPS research. All of CPS applications need to be designed considering the cutting-edge technologies, necessary system-level requirements, and overall impact on the real world.

Evaluation of Anterior Segment Parameters in Obesity

Alime Gunes,Feyzahan Uzun,Emine Esra Karaca,Mustafa Kalaycı 대한안과학회 2015 Korean Journal of Ophthalmology Vol.29 No.4

Purpose: To investigate anterior segment parameters in obese patients in comparison to healthy individuals. Methods: Thirty-four obese subjects and 34 age-sex-matched healthy subjects were enrolled in this prospective cross-sectional study. Ophthalmological examinations including intraocular pressure (IOP), central corneal thickness (CCT), anterior chamber depth (ACD), anterior chamber volume (ACV), anterior chamber angle (ACA), and axial length (AL) measurements were performed on each subject. Height and weight of all subjects were recorded and body mass index (BMI) was calculated. Results: IOP was significantly higher in the obese group (p = 0.003). The mean ACD in obese subjects was significantly lower than that in control subjects (p = 0.036). AL, ACV, ACA and CCT were not significantly different between the groups. There was a positive correlation between BMI and IOP (r = 0.404, p < 0.001). ACD and ACA were negatively correlated with BMI. Conclusions: IOP was significantly higher and ACD was significantly lower in obese subjects. AL, ACV, ACA and CCT were not significantly different between the groups. The impact of obesity on anterior chamber parameters should be further investigated.

Neutrophil to Lymphocyte Ratio in Patients with Nonarteritic Anterior Ischemic Optic Neuropathy

Alime Gunes,Musa Yigit,Levent Tok,Ozlem Tok 대한안과학회 2017 Korean Journal of Ophthalmology Vol.31 No.2

Purpose: To evaluate the neutrophil to lymphocyte ratio (NLR) in patients with nonarteritic anterior ischemic opticneuropathy (NAION). Methods: We investigated 112 subjects comprising 56 patients with NAION and 56 healthy controls at SüleymanDemirel University. Complete blood count, demographic, and clinic data from NAION patients were evaluatedin this study. The NLR was calculated in all individuals and compared between the patient and controlgroups. Cut-off values were also determined. Then, the relationship between NLR and visual outcomes wasinvestigated. Results: The cut-off value for NLR was 1.64. NLR values were significantly higher in NAION patients than inhealthy subjects (p < 0.001) and were directly correlated with erythrocyte sedimentation rate levels (r = 0.263,p = 0.006). Also, the NLR value was associated with visual outcomes. Receiver operator characteristic curveanalysis revealed a 0.63 area under the curve (confidence interval, 53.7% to 74.1%), 85% sensitivity and 41%specificity at the cut-off NLR value. Conclusions: The NLR may be a biomarker with good sensitivity that is quick, cost effective and easily detectedin serum. It can be used in clinical practice to predict a NAION patient’s prognosis in terms of visual outcomes.