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Recent developments in cancer therapy and diagnosis
Atlihan-Gundogdu Evren,Ilem-Ozdemir Derya,Ekinci Meliha,Ozgenc Emre,Demir Emine Selin,Sánchez-Dengra Bárbara,González-Alvárez Isabel 한국약제학회 2020 Journal of Pharmaceutical Investigation Vol.50 No.4
Background The cancer is serious health problem and leading cause of death in the world. Area covered There have intensively studied for diagnosis and therapy of this disease and these studies provided important insights into their mechanism of action and therapeutic/diagnostic effects. The accurence rates of cancer has dramatic increase, particularly in the developed countries. Although there are many different strategies about diagnosis and treatment for cancer, more effective new approaches are needed. Expert opinion In this review, we summarize recent developments on cancer diagnosis, radiopharmaceuticals in cancer diagnosis, nanoparticulate systems in cancer diagnosis, T cells in cancer diagnosis, cancer therapy and pharmacokinetic of anticancer drugs. We thought that while there are some current limitations such as clinical studies, ranging from diagnosis to theraphy, future improvements in cancer diagnosis and treatment will meet the most relevant issues required for the eventual approval of nano-drugs, radiopharmaceuticals, T cells in clinical practice.
Voices of home and school on democracy and human rights education at the primary level: a case study
Kerim Gundogdu 서울대학교 교육연구소 2010 Asia Pacific Education Review Vol.11 No.4
The purpose of this research was to investigate the perceptions of home and school concerning ideally implemented primary democracy and human rights education. In this qualitative study, data were collected from six voluntary classroom teachers and 16 parents in a selected school through interviews. The results of the interview yielded five major themes: physical and environmental issues, instructional process, teacher characteristics, assessment practices, and communication patterns for teaching democracy and human rights ideally. Most of the participants also indicated the lack of partnership between home and school. The results showed that there are gaps between the existing and desired conditions of democracy and human rights education in schools.
Goseki Grade and Tumour Location Influence Survival of Patients with Gastric Cancer
Calik, Muhammet,Calik, Ilknur,Demirci, Elif,Altun, Eren,Gundogdu, Betul,Sipal, Sare,Gundogdu, Cemal Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.3
Background: Owing to the variability of histopathological features and biological behaviour in gastric carcinoma, a great number of categorisation methods such as classical histopathologic grading, Lauren classification, the TNM staging system and the newly presented Goseki grading method are used by pathologists and other scientists. In our study, we aimed to investigate whether Goseki grade and tumour location have an effects on survival of gastric cancer cases. Materials and Methods: Eighty-four patients with gastric adenocarcinoma were covered in the investigation. The importance of Goseki grading system and tumour location were analysed in addition to the TNM staging and other conventional prognostic parameters. Results: The median survival time in our patients was 35 months (minimum: 5, maximum: 116). According to our findings, there was no relation between survival and tumour size (p=0.192) or classical histological type (p=0.270). In contrast, the Goseki grade and tumour location significantly correlated with survival (p=0.007 and p<0.001, respectively). Additionally, tumours of the intestinal type had a longer median survival time (60.0 months) than diffuse tumours (24.0 months). Conclusions: In addition to the TNM staging system, tumour location and the Goseki grading system may be used as significant prognostic parameters in patients with gastric cancer.
Analysis of conventional drag and lift models for multiphase CFD modeling of blood flow
Yilmaz, Fuat,Gundogdu, Mehmet Yasar The Korean Society of Rheology 2009 Korea-Australia rheology journal Vol.21 No.3
This study analyzes especially drag and lift models recently developed for fluid-solid, fluid-fluid or liquid-liquid two-phase flows to understand their applicability on the computational fluid dynamics, CFD modeling of pulsatile blood flow. Virtual mass effect and the effect of red blood cells, RBCs aggregation on CFD modeling of blood flow are also shortly reviewed to recognize future tendencies in this field. Recent studies on two-phase flows are found as very useful to develop more powerful drag-lift models that reflect the effects of blood cell's shape, deformation, concentration, and aggregation.
Synthesis and Antifungal Activities of Some Aryl (3-Methyl-Benzofuran-2-yl) Ketoximes
Benkli, Kadriye,Gundogdu-Karaburun, Nalan,Karaburun, Ahmet-Cagrl,Ucucu, Umit,Demirayak, Seref,Kiraz, Nuri The Pharmaceutical Society of Korea 2003 Archives of Pharmacal Research Vol.26 No.3
In this study, some aryl (3-methyl-benzofuran-2-yl) ketoximes and their ethers and esters were synthesised. The structure elucidation of the compounds was performed by IR, $^1H-NMR$, MASS spectroscopy and elemental analyses. Antifungal activities of the compounds were examined and moderate activity was obtained.
Yilmaz, Fuat,Gundogdu, Mehmet Yasar The Korean Society of Rheology 2008 Korea-Australia rheology journal Vol.20 No.4
The purpose of this study is mainly directed towards present of viewpoints on critical and commentary analysis on blood rheology, blood viscosity models, and physiological flow conditions. Understanding these basics is fundamental to meet the need for a sufficient and reliable CFD model of blood. Most of the used viscosity models on this manner have determined from parameter fitting on experimental viscosity data. Availability of experimental data from literature to define viscosity models of CFD analysis should be accurately chosen and treated in order to avoid any errors. Several basic gaps that limit the CFD model results are identified and given opportunities for future research.
B. Gokce,K. Gundogdu,데이비드에스프네스 한국물리학회 2012 THE JOURNAL OF THE KOREAN PHYSICAL SOCIETY Vol.60 No.10
We discuss recent results regarding the effects of strain, carrier type and concentration on the oxidation of H-terminated (111)Si. Second-harmonic-generation data show that this is a two-stage process where the H of the “up” bonds of the outermost Si layer is replaced by OH, followed by O insertion into the “back” bonds. These data provide additional detailed information about both stages. In particular, directional control of the in-plane surface chemistry by using the applied uniaxial stress provides new opportunities for interface control.
Demirci, Elif,Daloglu, Ferah,Gundogdu, Cemal,Calik, Muhammet,Sipal, Sare,Akgun, Metin Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3
Background: Lung cancer is the most frequent cancer among men and second highest among women overall, including in Turkey. Cigarette smoking is the most important etiologic factor for the development of cancer in both men and women. Objective: To determine the lung cancer incidence in Northeastern Anatolia Region of Turkey with a focus on clinical properties, cancer subtypes, the relationships of tumors with cigarette smoking and radiological properties of the lesions. Materials and Methods: In a retrospective study design, 566 lung cancer cases diagnosed at the Pathology Department of Ataturk University in Erzurum over the last seven years extending from January 2006 to June 2012 were investigated. The results were compared with statistical analyses. Results: The most common histopathological subtype of primary bronchogenic carcinoma in our study was found to be the squamous cell carcinoma, 46.1% (261 out of 566), and the second was small cell lung carcinoma 15.7% (89 out of 566). Based on our data, an overall male predominance was noted with a male/female ratio of 6.1/1. While 296 (52.2%) of the patients were found to be smokers at the time of diagnosis, 125 (22.0%) were nonsmokers and 145 (25.6%) were ex-smokers. Smoking status was found to have a strong correlation with primary lung cancer (p<0.05), and there were significant differences between males and females (p<0.001). Conclusion: Although relative prominence of subtypes of lung cancers differ between Turkish and other populations, lung cancer overall remains as an important health problem in Turkey. Our findings stress the critical need for effective cancer prevention programs such as anti-smoking campaigns.