Vacuum Hot-pressed and Sintered Technology of Silver Matrix Composite Electrical Contact Materials

Gu Lin,Guo Hui-Jin,Chen Li-Jun,Wang Fan 한국분말야금학회 2006 한국분말야금학회 학술대회논문집 Vol.2006 No.1

Refining drug administration in a murine model of acute infection with Trypanosoma cruzi

Julián Ernesto Nicolás Gulin,Margarita Bisio,Facundo García-Bournissen 한국실험동물학회 2020 Laboratory Animal Research Vol.36 No.4

Background: In animal research, “refinement” refers to modifications of husbandry or experimental procedures to enhance animal well-being and minimize or eliminate pain and distress. Evaluation of drug efficacy in mice models, such as those used to study Trypanosoma cruzi infection, require prolonged drug administration by the oral route (e.g. for 20 consecutive days). However, the orogastric gavage method can lead to significant discomfort, upper digestive or respiratory tract lesions, aspiration pneumonia and even accidental death. The aim of this work was to evaluate the effect of two administration methods (conventional oral gavage vs. a refined method using a disposable tip and automatic pipette) on the efficacy of benznidazole in a murine model of T. cruzi infection. Results: Both administration methods led to a rapid and persistent reduction in parasitaemia. Absence of T. cruzi DNA (evaluated by real-time PCR) in blood, cardiac and skeletal muscle confirmed that treatment efficacy was not influenced by the administration method used. Conclusions: The proposed refined method for long-term oral drug administration may be a suitable strategy for assessing drug efficacy in mice models of Chagas disease and can be applied to similar murine infection models to reduce animal discomfort.

An Alternative to Sea-Sun-Sand Tourism

Sedef DOGANER,Gulin BEYHAN 세계문화관광학회 2008 Conference Proceedings Vol.9 No.0

In the late 1970s Cohen argued that attention was being overly focused on tourism's negative effects. After that, several types of non-mass tourism such as 'alternative tourism' and 'ecotourism' were advocated as being less damaging to society and environment. In recent years, rural tourism has attracted a steadily increasing level of research attention, stimulated by two factors. First, tourism demand for rural areas is growing. Second, rural tourism has arrived on the political-economic agenda, the hope being that tourism business can alleviate the consequences of a decline in traditional means of rural employment. Varying degrees of rural areas tend to have four main qualities: relatively low physical densities of people, buildings and activities; less social and cultural heterogeneity; less economic diversity; and a comparative physical isolation from general economic, social and political networks. With the aim of improving the possibilities of alternative tourism in Antalya and accelerating the progress in rural areas by means of tourism, mountain villages are attempted to be brought in tourism guaranteed that all its local, social and cultural values kept. Mountain villages were settled by means of an architectural concern that gives priority to natural conditions and that is conscious of human-centered value judgments. By means of this study, necessity of regional protection that covers all the local, social and cultural entities is emphasized, and the importance of involvement within tourism in order to accelerate regional development is discussed.

Responses of Soil Physico-Chemical Properties, Ryegrass Growth And Uptake of Nutrients and Heavy Metals to Dairy Manure Amendment in a Mudflat Soil

Yanchao Bai,Gulin Huang,Wengang Zuo,Xiaowen Zhu,Xiaocheng Ying,Ke Feng,Yuhua Shan 한국토양비료학회 2014 한국토양비료학회 학술발표회 초록집 Vol.2014 No.6

Motor-Unit Number Estimation Is Sensitive in Detecting Motor Nerve Involvement in Patients with Carpal Tunnel Syndrome

Orhan Yilmaz,Gulin Sunter,Celal Salcini,Pınar Kahraman Koytak,Tulin Tanridag,Onder Us,Kayihan Uluc 대한신경과학회 2016 Journal of Clinical Neurology Vol.12 No.2

Background and Purpose We compared the motor-unit number estimation (MUNE) findings in patients who presented with signs and/or findings associated with carpal tunnel syndrome (CTS) and healthy controls, with the aim of determining if motor-unit loss occurs during the clinically silent period and if there is a correlation between clinical and MUNE findings in CTS patients. Methods The study investigated 60 hands of 35 patients with clinical CTS and 60 hands of 34 healthy controls. Routine median and ulnar nerve conduction studies and MUNE analysis according to the multipoint stimulation method were performed. Results The most common electrophysiological abnormality was reduced conduction velocity in the median sensory nerve (100% of the hands). The MUNE value was significantly lower for the patient group than for the control group (p=0.0001). ROC analysis showed that a MUNE value of 121 was the optimal cutoff for differentiating between patients and controls, with a sensitivity of 63.3% and a specificity of 68.3%. MUNE values were lower in patients with complaints of numbness, pain, and weakness in the median nerve territory (p<0.05, for all comparisons), and lower in patients with hypoesthesia than in patients with normal neurological findings (p=0.023). Conclusions The MUNE technique is sensitive in detecting motor nerve involvement in CTS patients who present with sensorial findings, and it may be useful in detecting the loss of motor units during the early stages of CTS. Larger-scale prospective clinical trials assessing the effect of early intervention on the outcome of these patients would help in confirming the possible benefit of detecting subclinical motor-unit loss in CTS.

Silver nanoparticles in endodontics: recent developments and applications

Oncu Aysenur,Huang Yan,Amasya Gulin,Sevimay Fatma Semra,Orhan Kaan,Celikten Berkan 대한치과보존학회 2021 Restorative Dentistry & Endodontics Vol.46 No.3

The elimination of endodontic biofilms and the maintenance of a leak-proof canal filling are key aspects of successful root canal treatment. Several materials have been introduced to treat endodontic disease, although treatment success is limited by the features of the biomaterials used. Silver nanoparticles (AgNPs) have been increasingly considered in dental applications, especially endodontics, due to their high antimicrobial activity. For the present study, an electronic search was conducted using MEDLINE (PubMed), the Cochrane Central Register of Controlled Trials (CENTRAL), Google Scholar, and EMBASE. This review provides insights into the unique characteristics of AgNPs, including their chemical, physical, and antimicrobial properties; limitations; and potential uses. Various studies involving different application methods of AgNPs were carefully examined. Based on previous clinical studies, the synthesis, means of obtaining, usage conditions, and potential cytotoxicity of AgNPs were evaluated. The findings indicate that AgNPs are effective antimicrobial agents for the elimination of endodontic biofilms.

V2O5-TiO2 heterostructural semiconductors: Synthesis and photocatalytic elimination of organic contaminant

Meltem Isleyen,Eda Sinirtas Ilkme,Gulin Selda Pozan Soylu 한국화학공학회 2017 Korean Journal of Chemical Engineering Vol.34 No.6

V2O5-TiO2 binary oxide catalysts were successfully prepared with different wt% V2O5 loading by solid state mechanical mixing (SSDMMix), and these nanocomposites were modified with hexadecyltrimethylammonium bromide (HTAB) and cetyl trimethylammonium bromide (CTAB) and polyvinyl alcohol (PVA) as surfactant. The resulting catalysts were characterized by X-ray diffraction (XRD), diffuse reflectance spectroscopy (DRS), scanning electron microscopy (SEM), Braun-Emmet-Teller (BET) analysis of surface area techniques. The photocatalytic activities of all samples were evaluated by degradation of 4-chlorophenol (4CP) in aqueous solution under UV irradiation. 50 wt% V2O5-TiO2 photocatalyst exhibited much higher photocatalytic activity than pure V2O5, TiO2 and P-25. The interaction between V2O5 and TiO2 affected the photocatalytic efficiency of binary oxide catalysts. In addition, CTAB and HTABassisted samples significantly enhanced the efficiency of 50V2O5-TiO2 binary oxide catalyst. The highest percentage of 4-chlorophenol degradation (100%) and highest reaction rate (1.69mg L−1 min−1) were obtained in 30 minutes with (50V2O5-TiO2)-CTAB catalyst. It is concluded that the addition of surfactant to binary oxide remarkably enhanced the photocatalytic activity by modifying the optical and electronic properties of V2O5 and TiO2.

Clinical Factors Related with Helicobacter Pylori Infection - Is there an Association with Gastric Cancer History in First-Degree Family Members?

Demirel, Busra B.,Akkas, Burcu Esen,Vural, Gulin Ucmak Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.3

Background: The aim of this study was to assess clinical factors associated with Helicobacter pylori positivity and to evaluate the incidence of gastric carcinoma in first-degree family members of infected patients. A total of 580 patients (mean age:$38{\pm}17$) with gastrointestinal complaints underwent C-14 urea breath test (UBT). Patients were grouped as: Group-1, untreated patients (n:384); and Group-2, patients who previously treated with eradication triple therapy (n:196). C-14 UBT was performed 1-2 months after the completion of eradication therapy. Associations of H pylori positivity with age, gender, ABO and Rhesus groups, smoking, dietary habits, and history of gastric cancer in first-degree family members were evaluated. The frequency of H pylori positivity was significantly higher in group-1 (58%) compared to group-2 (20%), p=0.001. There were no correlations between H pylori positivity and age, gender, ABO groups, Rhesus subgroups, smoking and dietary habits in both patient groups. The frequency of gastric cancer in family members was significantly higher in patients with H pylori infection among group-1, compared to infected patients among group-2 (56% vs. 28.6% respectively, p=0.03). We observed a significant association between H pylori positivity and the presence of gastric cancer in first-degree relatives of group-1 patients. Our results provide some confirmation of the presence of a link between gastric cancer development and H pylori. C-14 UBT is a sensitive, reliable and a widely recommended test for the detection of H pylori infection and recurrence. We suggest that detection and eradication of H pylori may contribute to a reduced risk of gastric cancer in the family members of infected patients.