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Molybdenum (Mo) transporter genes in Panicoideae species: a genome-wide evolution study
Bavaresco Lorrayne Guimarães,Silva Silviany Angelica Fernandes,de Souza Silvia Graciele Hülse,Ribas Alessandra Ferreira,Tiago Benedito dos Santos 한국작물학회 2022 Journal of crop science and biotechnology Vol.25 No.3
Molybdenum (Mo) is one important mineral element for plants because it participates actively in many metabolic essential functions like the synthesis of molybdenum cofactor and nitrogen metabolism. Mo is available on soil in an anionic form, and its activity increases with pH elevation. Few studies in the literature reported the identifcation and characterization of Mo transporter genes. Given the above, we describe a comprehensive in silico analysis of Mo transporters in six Panicoideae species. We identifed 15 candidates genes associated with Mo transporters. The subcellular location shows that all predicted genes were present in the plasma membrane. The genomic structure revealed that most of the Mo transporters genes showed no introns, while two sequences of P. virgatum presented one intron. Five conserved motifs and nine putative transmembrane domains were identifed. Phylogenetic analysis revealed two groups (A1 and A2), showing close or conserved phylogenetic relationships. Synteny analysis identifed 45 pairs of syntenic Mo orthologous among the six genomes of Panicoideae species, and purifying selection played a critical role in the evolution of Mo transporter genes. Eforts need to be undertaken to understand and improve molybdenum uptake and utilization in Panicoideae species for the sustainability of these species. This study will serve as a biotechnological basis for the characterization of candidate genes (Mo) involved in the regulation of gene expression under adverse conditions, allowing the development of future strategies to ensure greater sustainability of the important species of Panicoideae.
Pires Michelle Catarina,Barros Guilherme Antonio Moreira de,Fonseca Lucas Guimarães Ferreira,Thom Murilo Moreira,Junior Paulo do Nascimento,Módolo Norma Sueli Pinheiro 사단법인약침학회 2022 Journal of Acupuncture & Meridian Studies Vol.15 No.5
Background: Nausea and vomiting are frequent complications of anesthesia in the postoperative period. Acupuncture at the pericardium point 6 (PC6) is known to be effective in preventing postoperative nausea and vomiting (PONV). Objectives: The objective of the present study is to investigate the effects of acupuncture performed at the PC6 point in the prevention of PONV in women undergoing elective open hysterectomy under general inhalational anesthesia and to assess its association with plasma serotonin levels. Methods: 97 patients undergoing elective open hysterectomy were randomly divided into two groups: acupuncture group (bilateral acupuncture at PC6, n = 49), and a control group (no acupuncture, n = 48). All patients prophylactically received ondansetron and dexamethasone and, as rescue medication, metoclopramide in case of occurrence of PONV. The primary outcome evaluated was occurrence of nausea and vomiting within 24 hours after surgery. Serotonin plasma levels were measured before and after acupuncture prior to anesthesia induction. For the control group, the repeat measurement was performed 30 minutes after admission to the preoperative unit. Results: Acupuncture at PC6 significantly reduced the incidence of nausea (29.2% vs. 6.1%; p < 0.003), and the need of rescue medication (metoclopramide) (33.3% vs. 10.2%; p < 0.006), but not vomiting (4.2 vs. 4.1; p < 0.98). The plasma serotonin levels between control and acupuncture groups did not differ. Conclusion: This study shows that acupuncture at PC6 resulted in a lower incidence of postoperative nausea in patients undergoing hysterectomy.