한국인 및 중국 한족 정신분열병 환자의 5-HT2A 수용체 유전자 -1438A/G 다형성

이장호,이광철,이승부,오용인,최영근,조아랑,정주호,장환일 大韓神經精神醫學會 2005 신경정신의학 Vol.44 No.1

Objectives : The purpose of the present study was to investigate the association between -1438A/G polymorphism of 5-HT2A receptor gene and schizophrenia in Korean and Han Chinese population. Methods : A sample of 184 Korean patients with schizophrenia and 96 Korean healthy normal controls and 96 Han Chinese patients with schizophrenia and 96 Han-Chinese healthy normal controls were genotyped for a single nucleotide polymorphism with in 5-HT2A receptor gene (promoter region, A-1438G) by Msp I Resthction Fragment Length Polymorphism (RFLP). Results : There was no difference in allelic frequencies and genotype frequencies of -1438A/G polymorphism between Korean schizophrenics and controls (p=0.13) and Han Chinese schizophrenics and controls (p=0.40). Also, -1438A/G Poly-morphism did not show ethnical difference between Korean and Han Chinese controls. The Scale for the Assessment of Negative Symptoms (SANS) scores showed no significant differences between genotypes of -1438A/G polymorphism in both of Korean and Han Chinese schizophrenics. Conclusion : These results suggest that -1438A/G polymorphism of the 5-HT2A receptor gene is not causally related to the development of schizophrenia in Korean and Han Chinese population, and there no ethnic difference between Korean and Han Chinese population.

身體 發達 推移에 關한 硏究 : 國民學校 學生들을 中心으로 centering into the primary school pupils

蔣址奎,丁光福,鄭成浩 진주산업대학교 1981 論文集 Vol.19 No.-

In order to study on the transition of the development of body, a comparison of the result of physical examirations of the 68 primary school pupils under the juridiction of the Jinjoo Education Bureau was made, and from which the following conclusion was obtained. 1. For the comparison of boys and girls by age and the year, the incrdase of each age and year, it was developed gradually, and with a little difference between 1975 and 1976, it was revealt that result for 1975 was high. On the other hand, the increase per year has shown a similar increase per year for the result of all sorts excluding the height. Accordingly for the height, it was revealt as the highest increase per yaer. 2. For the comparison of the result of the physique for boys and girls, theheight, the weight and the sitting height have shown that boys were bigger than girls in each year but for only the of age of 11 that were bigger than boys showing a little difference. Especially for the circumference of the chest, it was revealt that the result of the boys has shown the highest difference. 3. In the comparison of the result of test of physique with the national standards for boys, the result of all other sorts excluding the height and the weight of the age of 9. the pupils under the juridiction of the Jinjoo Education. Bureau was superior to that of girls. And for girls, the result was superior to boys as shown for the boys in exception of little years by sorts.

활성탄에 의한 Polysilane의 분자량 조절

천종현,최광진,박동호 인제대학교기초과학연구소 2002 자연과학 Vol.6 No.-

SiC-fiber의 전구체로 쓰이는 polymethylsilane(PMS), polydimethylsilane(PDMS),polyemthylphenylsilane(PMPS)은 Na촉매 하에 dichloro-organosilanes의 탈 염소화 반응으로 합성된다. 유기용매에 잘 녹는 PMPS를 이용하여 온도, 시간, 첨가제의 농도에 따른 수율과 평균분자량을 조사하였으며,고온에서의 잔류량을 확인하였다. PMPS의 합성시간이 증가할수록 수율과 분산도가 증가하였고 평균분자량이 감소하였다. 활성탄을 첨가하여 합성 시 PMPS은 높은 평균 분자량을 가졌다. Na/C=0.05 첨가 시까지 평균 분자량이 높아졌고, 고분자 분산도는 균일했다. Na/C=0.1 첨가 시 분자량과 분산도가 크게 증가했다. PMPS의 고온 잔류량은 활성탄의 첨가량을 많이 하고, 첨가 후 반응 시간을 늘려줄수록 증가하였다. 반응 시 첨가되는 활성탄의 양과 합성시간을 조절함으로 PMPS의 평균 분자량을 조절할 수 있었다. Polymethylsilane(PMS), polydimethylsilane(PDMS),polyemthylphenylsilane(PMPS), which were used as a precursor of SiC-fiber, were synthesized by dehalocoupling were dichloro-organosilanes using Na as a reductant. By using the PMPS which is easily melted at organic solvent, investigated how yield, average molecular weight and remaining quantity in high temperature be influenced by temperature, time and concentration of additive. When reaction time of PMPS became longer, yield and polydispersity were increased and average molecular weight was decreased. synthesis of PMPS with active carborn as an additive showed high average molecular weight was high while polydispersity was regular. In case of Na/C=0.1, average molecular weight and polydispersity was remarkably increased. Residual quantity in high temperature of PMPS was increased in lots of active carborn and long reaction time. Average molecular weight of PMPS can be controlled by reaction time and amount of active carborn added in polymerization.

Al₂O₃物性(Ⅰ) : 粉末法에 依한 α-Al₂O₃의 構造解析 The structure analysis of α-Al₂O₃ by powder method

白南柱,朴載昊,陳光守,黃海善 부산대학교 1972 論文集 Vol.13 No.1

The molecular structure of α-Al₂O₃ is well known being already analyzed by the power method of X-Ray. The diffraction angles of X-Ray beam are measured by the intensity distribution of diffraction beam of X-Ray. The structure of α-Al₂O₃ was Supposed to be a rhombohedron and the Miller-index was determined by a axial transformation from rhombohedral system to hexagonal system. As a result of this study, the lattice constant and axial angle were 5.1252±0.0017 Å and 55°17′ respectively, and the chemical unit per unit cell is two.

운동부하양식에 따른 심폐 능력의 비교분석

전태원,우재홍,신창호,이기봉,이광희,박익렬,박성태,강현주 서울대학교 체육연구소 2000 서울大學校 體育硏究所論集 Vol.21 No.1

The purpose of this study this study was to comparative analysis the V02max and HR through arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise and to propose correct data of aerobic ability according to GXT. Subjects for study were 8 healthy male students. The process of the test were performed maximal GXT on arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise and measured V02max, max heart rate and recovery time of 3 VO2 and heart rate respectively. The conclusions were supported by the findings of this study: 1.There were significant differences between test style and V02/kg/min(p<.05). 2.There were significant differences between test style and test stage at heart rate(p<.05) There were no effect of reciprocal action. Therefore, V02/kg/min should be on individual exercise prescription guiedlines for health promotion should be provided proper GXT which are arm ergometer exercise, bicycle ergometer exercise, and treadmill exercise.

<i>Toxoplasma gondii</i> protects against H₂O₂‐induced apoptosis in ARPE‐19 cells through the transcriptional regulation of apoptotic elements and downregulation of the p38 MAPK pathway

Choi, Si‐,Hwan,Park, Sung Jun,Cha, Guang‐,Ho,Quan, Juan Hua,Chang, Nam‐,Sik,Ahn, Myoung‐,Hee,Shin, Dae‐,Whan,Lee, Young‐,Ha Blackwell Publishing Ltd 2011 Acta ophthalmologica Vol.89 No.4

<P><B>Abstract.</B></P><P><B>Purpose: </B> Toxoplasmosis, which is caused by the protozoan parasite <I>Toxoplasma gondii</I>, can lead to severe visual impairment. <I>T.?gondii</I> inhibits or delays programmed cell death caused by various apoptotic triggers; however, the mechanisms involved in the <I>T</I>.?<I>gondii</I>‐induced suppression of apoptosis in retinal cells have not been analysed in detail.</P><P><B>Methods: </B> We investigated the role of <I>T</I>.<I>?gondii</I> infection in H<SUB>2</SUB>O<SUB>2</SUB>‐induced apoptosis in human retinal pigment epithelial cells (ARPE‐19) by monitoring the activities of apoptosis‐regulating molecules and mitogen‐activated protein kinases (MAPKs), including p38 MAPK. We also examined the gene downstream from p38 MAPK.</P><P><B>Results: </B> <I>T.?gondii</I> infection significantly inhibited the cellular toxicity of H<SUB>2</SUB>O<SUB>2</SUB> (500 μ<SMALL>m</SMALL>) and increased cell viability in a multiplicity of infection (MOI)‐dependent manner by reducing DNA fragmentation and reactive oxygen species (ROS) generation in ARPE‐19 cells. Western blot analysis also showed that <I>T</I>.?<I>gondii</I> infection prevented the host cell expression of pro‐apoptotic factors, such as Bad and Bax, and the activation of caspase‐3. Infection with <I>T</I>.?<I>gondii</I> increased the expression of the anti‐apoptotic factor Bcl‐2 in ARPE‐19 cells under oxidative stress. In accordance with these findings, <I>Toxoplasma</I> infection was protective enough to suppress the phosphorylation of p38 MAPK following H<SUB>2</SUB>O<SUB>2</SUB> treatment. Exposure to H<SUB>2</SUB>O<SUB>2</SUB> increased the expression of heme oxygenase‐1 (HO‐1) in ARPE‐19 cells, and its expression was significantly inhibited in H<SUB>2</SUB>O<SUB>2</SUB>‐treated infected cells.</P><P><B>Conclusion: </B> The protective function of <I>T</I>.?<I>gondii</I> infection against ROS‐induced apoptosis results from changes in the expression of apoptotic molecules and the downregulation of stress‐induced intracellular signalling.</P>

Nonlinear Approximate Indexing for Multimedia Data

Guang-Ho Cha 보안공학연구지원센터 2016 International Journal of Software Engineering and Vol.10 No.11

This paper presents a new nonlinear approximate indexing method for high-dimensional data such as multimedia data. The new indexing method is designed for approximate similarity searches and all the work is performed in the transformed Gaussian space. In this indexing method, we first map the input space into a feature space via the Gaussian mapping, and then compute the top eigenvectors in the Gaussian space to capture the cluster structure based on the eigenvectors. We describe each cluster with a minimal hypersphere containing all objects in the cluster, derive the similarity measure for each cluster individually and construct a bitmap index for each cluster. Finally we transform the nearest neighbor query into the hyper-rectangular range query and search the clusters near the query point. The experimental results for our new indexing method show considerable effectiveness and efficiency.

The Kernel Trick for Content-Based Media Retrieval in Online Social Networks

( Guang-Ho Cha ) 한국정보처리학회 2021 Journal of information processing systems Vol.17 No.5

Nowadays, online or mobile social network services (SNS) are very popular and widely spread in our society and daily lives to instantly share, disseminate, and search information. In particular, SNS such as YouTube, Flickr, Facebook, and Amazon allow users to upload billions of images or videos and also provide a number of multimedia information to users. Information retrieval in multimedia-rich SNS is very useful but challenging task. Content-based media retrieval (CBMR) is the process of obtaining the relevant image or video objects for a given query from a collection of information sources. However, CBMR suffers from the dimensionality curse due to inherent high dimensionality features of media data. This paper investigates the effectiveness of the kernel trick in CBMR, specifically, the kernel principal component analysis (KPCA) for dimensionality reduction. KPCA is a nonlinear extension of linear principal component analysis (LPCA) to discovering nonlinear embeddings using the kernel trick. The fundamental idea of KPCA is mapping the input data into a high-dimensional feature space through a nonlinear kernel function and then computing the principal components on that mapped space. This paper investigates the potential of KPCA in CBMR for feature extraction or dimensionality reduction. Using the Gaussian kernel in our experiments, we compute the principal components of an image dataset in the transformed space and then we use them as new feature dimensions for the image dataset. Moreover, KPCA can be applied to other many domains including CBMR, where LPCA has been used to extract features and where the nonlinear extension would be effective. Our results from extensive experiments demonstrate that the potential of KPCA is very encouraging compared with LPCA in CBMR.

Performance Analysis for Multidimensional Indexing Methods Supporting Sequential Access

Guang-Ho Cha(차광호) 한국정보과학회 2004 한국정보과학회 학술발표논문집 Vol.2004 No.5

Separation Technology, Thermodynamics : Crystallization of acetaminophen micro-particle using supercritical carbon dioxide

( Guang Hua Li ),( Jun Ho Chu ),( Eun Seok Song ),( Kyung Ho Row ),( Kyong Hwan Lee ),( Youn Woo Lee ) 한국화학공학회 2006 Korean Journal of Chemical Engineering Vol.23 No.3