The Application of CLT in Improving the Extensive Reading Course for English Major in China

( Guan Nan ) 현대영미어문학회 2019 현대영미어문학회 추계학술대회 발표논문집 Vol.2019 No.-

Having worked in college for many years, the researcher was motivated to explore into the reading problems in order to discover an effective method for reading teaching and learning. Too much interference of mother tongue, total absence of reading activities and lack of good reading habits are main factors for the poor reading ability of students. The paper starts by pinpointing the disadvantages of traditional teaching methods in extensive reading course (ERC) and probes communicative language teaching (CLT) theoretically. It then analyzes the basic information of ERC, discusses the concrete application of CLT in ERC with a view to pushing for possible improvements in extensive reading teaching in China.

중국의 보장성주택제도에 관한 연구

류관남 ( Guan Nan Liu ),심성훈 ( Sung Hoon Sim ) 국제지역학회 2014 국제지역연구 Vol.18 No.4

주택보장제도는 중국정부가 중ㆍ저소득계층의 주택문제를 보장하기 위한 제도이다. 본 연구는 중국보장성주택제도의 현황, 문제점, 개선방안 등을 중심으로 분석하였다. 분양주택과 대비 되는 보장성주택은 현재 경제실용주택(經濟適用住房), 저가임대주택(廉租房), 공공임대주택 등을 위주로 공급되고 있다. 보장성주택시스템은 이미 기본적인 체계를 갖추고 있으며 중ㆍ저 소득계층의 주택문제를 해결하는데 일조하였다. 그러나 비구체적인 주택건설계획, 자금부족 및 보장대상에 대한 엄격하지 않은 심의, 개발과정에서 개인적 부당이익의 취득 등의 문제점 들이 드러나고 있다. 본 연구는 이러한 보장성주택제도의 문제점에 대하여, 우선 보장성주택에 관한 전반적인 법률 체제의 개선을 제시하고 있다. 특히 이 제도와 관련된 중앙정부 및 지 방정부의 역할 개편 및 보장성주택의 자금공급 등에 관련된 법적 개선이 필요하다. 두 번째로 도시주민 개인정보시스템의 확립을 통하여 효율적으로 보장대상을 관리ㆍ감독하는 것이 필요 하다. 세 번째 개선방안으로는 보장대상의 진입과 탈퇴에 대한 관리ㆍ감독 강화를 들 수 있다. 넷째, 주택공적금제도의 범위를 확대할 필요가 있다. 이를 위하여 저소득계층의 지원에 중점 을 둔 주택준비금 정책이 필요하다. 마지막으로 경제실용주택에 대한 제도 개선 등의 방안이 필요하다. 즉, 공급을 늘리기 위한 정책으로 재정지원 강화, 대체제인 기존주택의 거래활성화 방안, 가격의 인하 등이 필요하다. The problem raised in the housing sector becomes one of the greatest problems in China. A multi-level indemnificatory housing system has been initially established in order to solve the housing problem for the low-income households, and some success has been achieved. However, there are still many inadequacies needed to improve in the construction and maintaining process of indemnificatory housing system. In this context, this paper analyzes the status and problems of urban affordable housing, and provides some suggestions in order to improve the affordable housing system in China. The specific measures for the reform of the system should be considered in many aspects, such as the basic principles, the legal system, credit system, provident fund related to the both affordable housing and low-rent housing.

Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice

Guan Li-Ping,Nan Ji-Xing,Jin Xue-Jun,Jin Qing-Hao,Kwak Kyung Chell,Chai Kyu-yun,Quan Zhe-Shan The Pharmaceutical Society of Korea 2005 Archives of Pharmacal Research Vol.28 No.1

The hepatoprotective effects of chalcone derivatives were evaluated in D-galactosamine/lipopolysaccharide (D-GaIN/LPS)-induced fulminant hepatic failure in mouse. Thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum. Chalcone preparations were injected into mice at 12 hand 1 h before intraperitoneal injection of D-GaIN/LPS. After abdominal administration, changes in AST and ALT between the control and treated groups were observed. Ten of the synthesized chalcone derivatives exhibited inhibitory effects on D-GaIN/LPS-induced levels of AST and ALT in mice. Compounds 2, 3, 8, 9, and 12 markedly reduced serum AST and ALT at 8 h, inhibited hepatocyte necrosis and showed significant hepatoprotective activities. The activity of compound 3 was compared with the bifendate (DDB) through oral administration. Compound 3 showed much higher inhibitory effects than bifendate for decreasing AST and ALT activity. The results indicate that compound 3 has strong hepatoprotective activity through suppression of tumor necrosis factor­alpha (TNF-alpha) preduction, reduction of the histological change in the liver, and attenuated of hepatocyte apoptosis confirmed by DNA fragmentation assay.

Platform development for multi-physics coupling and uncertainty analysis based on a unified framework

Qian Guan-Hua,Li Ren,Yang Tao,Wang Xu,Zhao Peng-Cheng,Zhao Ya-Nan,Yu Tao 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.5

The multi-physics coupled methodologies that have been widely used to analyze the complex process occurring in nuclear reactors have also been used to the R&D of numerical reactors. The advancement in the field of computer technology has helped in the development of these methodologies. Herein, we report the integration of ADPRES code and RELAP5 code into the SALOME-ICoCo framework to form a multi-physics coupling platform. The platform exploits the supervisor architecture, serial mode, mesh one-to-one correspondence and explicit coupling methods during analysis, and the uncertainty analysis tool URANIE was used. The correctness of the platform was verified through the NEACRP-L-335 benchmark. The results obtained were in accordance with the reference values. The platform could be used to accurately determine the power peak. In addition, design margins could be gained post uncertainty analysis. The initial power, inlet coolant temperature and the mass flow of assembly property significantly influence reactor safety during the rod ejections accident (REA).

Prognostic Value of Serum AFP, AFP-L3, and GP73 in Monitoring Short-term Treatment Response and Recurrence of Hepatocellular Carcinoma after Radiofrequency Ablation

Wang, Nan-Ya,Wang, Cong,Li, Wei,Wang, Guan-Jun,Cui, Guo-Zhen,He, Hua,Zhao, Heng-Jun Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.4

Purpose: Alpha-fetoprotein (AFP), Lens culinaris agglutinin-reactive fraction of AFP (AFP-L3), and Golgi protein 73 (GP73) levels have been widely used as tumor markers for the diagnosis of hepatocellular carcinoma (HCC). The aim of this study was to investigate whether these tumor markers could be used to monitor short-term treatment response and recurrence of HCC in patients undergoing radiofrequency ablation (RFA). Methods: Between July 2012 and July 2013, 53 consecutive patients with newly diagnosed HCC were prospectively enrolled in this study. Among these, 32 patients underwent RFA, after which they were followed up prospectively at the First Hospital of Jilin University in China. Results: AFP, AFP-L3, and GP-73 values pre-RFA were not associated with tumor size, whereas AFP and GP-73 levels tended to be associated with tumor number, the presence of vascular invasion, deterioration of liver function, advanced-stage disease, and a poor performance status. GP-73 levels were dramatically elevated in the patients with hepatitis C-associated HCC. Neither pre-RFA nor 1-month post-RFA tumor marker values were associated with short-term outcome. The short-term recurrence rate of AFP-positive patients measured 1 month post-RFA was obviously higher than that of AFP-negative patients. Conclusions: AFP and GP-73 values were associated with clinical variables representing tumor growth and invasiveness, and the AFP value measured 1 month post-RFA was a strong predictor of short-term recurrence in patients with HCC.

Application of Multilocus Sequence Analysis (MLSA) for Accurate Identification of Legionella spp. Isolated from Municipal Fountains in Chengdu, China, Based on 16S rRNA, mip, and rpoB Genes

Wang Guan,Ying Xu,Da-li Chen,Jia-nan Xu,Yu Tian,Jian-ping Chen 한국미생물학회 2012 The journal of microbiology Vol.50 No.1

Legionellosis (Legionnaires’ disease; LD) is a form of severe pneumonia caused by species of Legionella bacteria. Because inhalation of Legionella-contaminated aerosol is considered the major infection route, routine assessments of potential infection sources such as hot water systems, air-conditioner cooling water, and municipal fountains are of great importance. In this study, we utilized in vitro culture and multilocus sequence analysis (MLSA) targeting 16S rRNA, mip, rpoB, and mip-rpoB concatenation to isolate and identify Legionella spp. from 5 municipal fountains in Chengdu City, Sichuan Province, China. Our results demonstrated that 16S rRNA was useful for initial identification, as it could recognize isolates robustly at the genus level, while the genes mip, rpoB, and mip-rpoB concatenation could confidently discriminate Legionella species. Notably, the three subspecies of L. pneumophila could be distinguished by the analysis based on rpoB. The serotyping result of strain CD-1 was consistent with genetic analysis based on the concatenation of mip and rpoB. Despite regular maintenance and sanitizing methods, 4 of the 5 municipal fountains investigated in this study were positive for Legionella contamination. Thus, regularly scheduled monitoring of municipal fountains is urgently needed as well as vigilant disinfection. Although the application of MLSA for inspection of potential sites of infection in public areas is not standard procedure, further investigations may prove its usefulness.

Resveratrol Exerts Dosage-Dependent Effects on the Self-Renewal and Neural Differentiation of hUC-MSCs

Fangxia Guan,Xinxin Wang,Shanshan Ma,Nan Meng,Ning Yao,Kun Zhang,Qinghua Li,Yanting Zhang,Qu Xing,Kang Han,Jishi Song,Bo Yang 한국분자세포생물학회 2016 Molecules and cells Vol.39 No.5

Resveratrol (RES) plays a critical role in the fate of cells and longevity of animals via activation of the sirtuins1 (SIRT1) gene. In the present study, we intend to investigate whether RES could promote the self-renewal and neural-lineage differentiation in human umbilical cord derived MSCs (hUC-MSCs) in vitro at concentrations ranging from 0.1 to 10 M, and whether it exerts the effects by modulating the SIRT1 signaling. Herein, we demonstrated that RES at the concentrations of 0.1, 1 and 2.5 M could promote cell viability and proliferation, mitigate senescence and induce expression of SIRT1 and Proliferating Cell Nuclear Antigen (PCNA) while inhibit the expression of p53 and p16. However, the effects were reversed by 5 and 10 M of RES. Furthermore, RES could promote neural differentiation in a dose-dependent manner as evidenced by morphological changes and expression of neural markers (Nestin, Ⅲ-tubulin and NSE), as well as pro-neural transcription factors Neurogenin (Ngn)1, Ngn2 and Mash1. Taken together, RES exerts a dosage-dependent effect on the self-renewal and neural differentiation of hUC-MSCs via SIRT1 signaling. The current study provides a new strategy to regulate the fate of hUC-MSCs and suggests a more favorable in vitro cell culture conditions for hUC-MSCs-based therapies for some intractable neurological disorders.

Roles of Fibroblast Growth Factor-inducible 14 in Hepatocellular Carcinoma

Li, Nan,Hu, Wen-Jun,Shi, Jie,Xue, Jie,Guo, Wei-Xing,Zhang, Yang,Guan, Dong-Xian,Liu, Shu-Peng,Cheng, Yu-Qiang,Wu, Meng-Chao,Xie, Dong,Liu, Shan-Rong,Cheng, Shu-Qun Asian Pacific Journal of Cancer Prevention 2013 Asian Pacific journal of cancer prevention Vol.14 No.6

The prognostic value of the fibroblast growth factor-inducible 14 (Fn14) expression in hepatocellular carcinoma (HCC) is unknown. Real-time PCR (RT-PCR), western blot assays and immunohistochemistry analysis were here performed in order to compare Fn14 expressios in paired liver samples of HCC and normal liver tissue. Most of the tumor tissues expressed significantly higher levels of Fn14 compared to adjacent non-tumor tissues, with Fn14High accounting for 54.6% (142/260) of all patients. The Pearson ${\chi}^2$ test indicated that Fn14 expression was closely associated with serum alpha fetal protein (AFP) (P=0.002) and tumor number (p=0.019). Univariate and multivariate analyses revealed that along with tumor diameter and portal vein tumor thrombosis (PVTT ) type, Fn14 was an independent prognostic factor for both overall survival (OS) (HR=1.398, p=0.008) and recurrence (HR=1.541, p=0.001) rates. Fn14 overexpression HCC correlated with poor surgical outcome, and this molecule may be a candidate biomarker for prognosis as well as a target for therapy.

Effects of the molecular weight and chemical properties of Schizophyllum commune polysaccharides on their immunomodulatory activity

Ma Nan,Tae Jin Park,Zhang Yu Tong,Khamphone Yelithao,Sang Guan You 한국식품영양과학회 2020 한국식품영양과학회 학술대회발표집 Vol.2020 No.10

Protective Effects of Chalcone Derivatives for Acute Liver Injury in Mice

Li-Ping Guan,Ji-Xing Nan,Xue-Jun Jin,Qing-Hao Jin,곽경철,채규윤,Zhe-Shan Quan 대한약학회 2005 Archives of Pharmacal Research Vol.28 No.1

The hepatoprotective effects of chalcone derivatives were evaluated in D-galactosamine/ lipopolysaccharide (D-GalN/LPS)-induced fulminant hepatic failure in mouse. Thirteen chalcone derivatives were synthesized for study and their hepatoprotective effects were evaluated by assessing aspartate aminotransferase (AST) and alanine aminotransferase (ALT) levels in serum. Chalcone preparations were injected into mice at 12 h and 1 h before intraperitoneal injection of D- GalN/LPS. After abdominal administration, changes in AST and ALT between the control and treated groups were observed. Ten of the synthesized chalcone derivatives exhibited inhibitory effects on D-GalN/LPS-induced levels of AST and ALT in mice. Compounds 2, 3, 8, 9, and 12 markedly reduced serum AST and ALT at 8 h, inhibited hepatocyte necrosis and showed significant hepatoprotective activities. The activity of compound 3 was compared with the bifendate (DDB) through oral administration. Compound 3 showed much higher inhibitory effects than bifendate for decreasing AST and ALT activity. The results indicate that compound 3 has strong hepatoprotective activity through suppression of tumor necrosis factoralpha (TNF-alpha) preduction, reduction of the histological change in the liver, and attenuated of hepatocyte apoptosis confirmed by DNA fragmentation assay.