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Melatonin’s Effect on the Efficacy of Desmopressin in the Treatment of Enuresis
Pietro Ferrara,Annamaria Sbordone,Costanza Cutrona,Francesca Ianniello,Chiara Guadagno,Giacomo Perrone,Antonio Chiaretti,Alberto Verrotti,Vincenzo Di Lazzaro 대한배뇨장애요실금학회 2016 International Neurourology Journal Vol.20 No.3
Purpose: This study aims to evaluate and compare the efficacy of exogenous melatonin associated with desmopressin (dDAVP) and dietary recommendations. Methods: A total of 189 patients were enrolled from the Service of Pediatrics, Campus Bio-Medico University Hospital of Rome, from January 2013 to June 2015. Of the 189 original patients, 153 children, aged between 5 and 14 years (mean age, 8.7 years) were included in the study. After clinical evaluation and a 3-month period of observation without treatment, children were assigned to receive treatment in one of 3 groups: group 1, dDAVP at a dose of 120 mcg a day (Minirin); group 2, dDAVP at a dose of 120 mcg and dietary recommendations; or group 3, dDAVP at a dose of 120 mcg, dietary recommendations, and melatonin at a dose of 1 mg a day (Melamil plus). Each patient was treated for 3 months. Results: After the 3 months of therapy, a desiderable response was achieved in 30 of 51 patients (58.82%) treated with dDAVP, 35 of 53 patients (66.04%) treated with dDAVP and dietary recommendations, and 35 of 49 patients (71.43%) treated with dDAVP, dietary recommendations, and melatonin. Conclusions: Although not statistically significant, the results show that the association between dDAVP treatment with dietary recommendations and melatonin could be considered a safe and effective treatment of NE. Considering that the statistically insignificant results might be due to the small sample size, the study will be continued to increase the number of subjects.
Ida Palazzo,Marialuigia Raimondo,Giovanna Della Porta,Liberata Guadagno,Ernesto Reverchon 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.90 No.-
Supercritical emulsions extraction (SEE-C) technology was used to produce PMMA/diglycidyl ether ofbisphenol A microcapsules acting as a health-monitoring element. A comparison between SEE-C andsolvent evaporation was carried out. Best results were obtained using SEE-C: spherical microcapsuleswith a smooth surface and a mean size of 220 nm, with an encapsulation efficiency up to 79%, wereobtained. SEE-C capsules preserve their stability for the entire time frame analyzed (30 days). Impact tests were carried out on strips of carbonfiber reinforced composites coated with an aqueouspaint in which capsules were previously dispersed: dye leaking associated with capsules breaking wasevidenced.
Pasquale Longobardi,Annaluisa Mariconda,Elisa Calabrese,Marialuigia Raimondo,Carlo Naddeo,Luigi Vertuccio,Salvatore Russo,Generoso Iannuzzo,Liberata Guadagno 한국공업화학회 2017 Journal of Industrial and Engineering Chemistry Vol.54 No.-
A stable initiator for ROMP reactions, suitably designed to be embedded in structural resins, has been synthetized. It rapidly polymerizes cyclic olefins in reactive environments. The thermal stability and chemical inertness towards oxirane rings allow its employment in the form of molecular complex in epoxy precursors thus reducing the amount of initiator in structural self-healing materials of 90% wt/wt, simultaneously preserving the catalytic activity at high temperatures (180–200 C) also in presence of the aromatic primary amine (DDS). NMR and FTIR spectroscopy highlighted a relevant initiator stability able to fulfill industrial requirements. Self-healing efficiency has been found to be 103%.