http://chineseinput.net/에서 pinyin(병음)방식으로 중국어를 변환할 수 있습니다.
변환된 중국어를 복사하여 사용하시면 됩니다.
- 中文 을 입력하시려면 zhongwen을 입력하시고 space를누르시면됩니다.
- 北京 을 입력하시려면 beijing을 입력하시고 space를 누르시면 됩니다.
RISS 인기검색어
- 검색키워드
- 저자 : Grecov (검색결과 2 건)
- 무료
- 기관 내 무료
- 유료
-
Rheology of Osteoarthritic Synovial Fluid Mixed with Viscosupplements: A Pilot Study
Dana Grecov,Petcharatana Bhuanantanondh,Ezra Kwok,Pierre Guy 대한의용생체공학회 2011 Biomedical Engineering Letters (BMEL) Vol.1 No.4
Purpose Osteoarthritis (OA) is a degenerative joint disease that is characterized by the breakdown of articular cartilage. Rheology of synovial fluid is of interest because of its significance in joint lubrication. However, there are still many questions related to synovial fluid rheology and its relation with OA. Although viscosupplementation has been used as a treatment for OA for many years, its clinical effect remains controversial. Therefore, the purpose of this study is to determine in vitro the effect of different viscosupplements on the rheological properties of synovial fluid. Methods A detailed rheological characterization of synovial fluid from 26 patients undergoing total knee arthroplasty (TKA) was performed. The rheological properties of the osteoarthritic synovial fluid added with viscosupplements were compared with those of the healthy human synovial fluid in order to assess the restorative effect on naturally occurring synovial fluid within the joint. Furthermore, the stability of rheological properties of synovial fluid mixed with viscosupplements in vitro over 8 weeks was analyzed. Results The addition of a cross-linked viscosupplement to OA synovial fluid was found to be more efficient than linear ones in improving the overall rheological properties of synovial fluid. The findings indicate that the rheological properties of SF mixed with VSs changed over 8 weeks. Conclusions The findings from this study will lead to a better understanding of the role of viscosupplements in joint lubrication and OA.
-
Rheological study of hyaluronic acid derivatives
Michael Chernos,Dana Grecov,Ezra Kwok,Siziwe Bebe,Oladunni Babsola,Tassos Anastassiades 대한의용생체공학회 2017 Biomedical Engineering Letters (BMEL) Vol.7 No.1
The viscoelastic properties of four novel, lowmolecular weight hyaluronic acid derivatives were investigatedand compared to the parent hyaluronic acid compound. Briefly, all derivatives were synthesized by firstdeacetylating the parent hyaluronic acid. One sample wasleft as such, while two others were reacytelated. The finalcompound, of particular interest for its anti-inflammatoryproperties, was butyrylated. The compounds were dissolvedin phosphate buffer solution (PBS) and studied at aconcentration of 5 mg/mL. Shear thinning behaviour wasobserved for all compounds, however, derivative sampleshad a lower viscosity than the parent compound at highshear rates. Viscoelastic properties were also observed todecrease as a result of the derivative preparation method. Itis believed that these changes are primarily caused by adecrease in hyaluronic acid molecular weight. Byincreasing the concentration of the anti-inflammatorycompound, it may be possible to modulate the viscoelasticproperties to more closely resemble those of commercialviscosupplements. As a result, an anti-inflammatoryderivative of hyaluronic acid may potentially improve uponexisting viscosupplements used to treat patients who aresusceptible to flare up.
연관 검색어 추천
이 검색어로 많이 본 자료
활용도 높은 자료
