Moisture Transport of Three Different Fabric Structures of an Innovative Knit Fabric

Grasso, Maureen M.,Kim, Charles J.,Shin, Jung Sook,Herr, David G. 한국의류학회 2000 한국의류학회지 Vol.24 No.8

Implementation and assessment of advanced failure criteria for composite layered structures in FEMAP

Grasso, Amedeo,Nali, Pietro,Cinefra, Maria Techno-Press 2019 Advances in aircraft and spacecraft science Vol.6 No.1

AMOSC (Automatic Margin Of Safety Calculation) is a SW tool which has been developed to calculate the failure index of layered composite structures by referring to the cutting edge state-of-the-art LaRC05 criterion. The stress field is calculated by a finite element code. AMOSC allows the user to calculate the failure index also by referring to the classical Hoffman criterion (which is commonly applied in the aerospace industry). When developing the code, particular care was devoted to the computational efficiency of the code and to the automatic reporting capability. The tool implemented is an API which has been embedded into Femap Siemens SW custom tools. Then, a user friendly graphical interface has been associated to the API. A number of study-cases have been solved to validate the code and they are illustrated through this work. Moreover, for the same structure, the differences in results produced by passing from Hoffman to LaRC05 criterion have been identified and discussed. A number of additional comparisons have thus been produced between the results obtained by applying the above two criteria. Possible future developments could explore the sensitivity of the failure indexes to a more accurate stress field inputs (e.g. by employing finite elements formulated on the basis of higher order/hierarchical kinematic theories).

MAGNETIC FIELD IN THE LOCAL UNIVERSE AND THE PROPAGATION OF UHECRS

DOLAG KLAUS,GRASSO DARIO,SPRINGEL VOLKER,TKACHEV IGOR The Korean Astronomical Society 2004 Journal of The Korean Astronomical Society Vol.37 No.5

We use simulations of large-scale structure formation to study the build-up of magnetic fields (MFs) in the intergalactic medium. Our basic assumption is that cosmological MFs grow in a magnetohy-drodynamical (MHD) amplification process driven by structure formation out of a magnetic seed field present at high redshift. This approach is motivated by previous simulations of the MFs in galaxy clusters which, under the same hypothesis that we adopt here, succeeded in reproducing Faraday rotation measurements (RMs) in clusters of galaxies. Our ACDM initial conditions for the dark matter density fluctuations have been statistically constrained by the observed large-scale density field within a sphere of 110 Mpc around the Milky Way, based on the IRAS 1.2-Jy all-sky redshift survey. As a result, the positions and masses of prominent galaxy clusters in our simulation coincide closely with their real counterparts in the Local Universe. We find excellent agreement between RMs of our simulated galaxy clusters and observational data. The improved numerical resolution of our simulations compared to previous work also allows us to study the MF in large-scale filaments, sheets and voids. By tracing the propagation of ultra high energy (UHE) protons in the simulated MF we construct full-sky maps of expected deflection angles of protons with arrival energies $E = 10^{20}\;eV$ and $4 {\times} 10^{19}\;eV$, respectively. Accounting only for the structures within 110 Mpc, we find that strong deflections are only produced if UHE protons cross galaxy clusters. The total area on the sky covered by these structures is however very small. Over still larger distances, multiple crossings of sheets and filaments may give rise to noticeable deflections over a significant fraction of the sky; the exact amount and angular distribution depends on the model adopted for the magnetic seed field. Based on our results we argue that over a large fraction of the sky the deflections are likely to remain smaller than the present experimental angular sensitivity. Therefore, we conclude that forthcoming air shower experiments should be able to locate sources of UHE protons and shed more light on the nature of cosmological MFs.

Concurrent SHORT syndrome and 3q duplication syndrome

Boaz, Alexander M.,Grasso, Salvatore A.,DeRogatis, Michael J.,Beesley, Ellis N. Korean Society of Medical Genetics and Genomics 2019 대한의학유전학회지 Vol.16 No.1

SHORT syndrome is an extremely rare congenital condition due to a chromosomal mutation of the PIK3R1 gene found at 5q13.1. SHORT is a mnemonic representing six manifestations of the syndrome: (S) short stature, (H) hyperextensibility of joints and/or inguinal hernia, (O) ocular depression, (R) Rieger anomaly, and (T) teething delay. Other key aspects of this syndrome not found in the mnemonic include lipodystrophy, triangular face with dimpled chin (progeroid facies, commonly referred to as facial gestalt), hearing loss, vision loss, insulin resistance, and intrauterine growth restriction (IUGR). 3q duplication syndrome is rare syndrome that occurs due to a gain of function mutation found at 3q25.31-33 that presents with a wide array of manifestations including internal organ defects, genitourinary malformations, hand and foot deformities, and mental disability. We present a case of a 2 year and 3 month old male with SHORT syndrome and concurrent 3q duplication syndrome. The patient presented at birth with many of the common manifestations of SHORT syndrome such as bossing of frontal bone of skull, triangular shaped face, lipodystrophy, micrognathia, sunken eyes, and thin, wrinkled skin (progeroid appearance). Additionally, he presented with findings associated with 3q duplication syndrome such as cleft palate and cryptorchidism. Although there is no specific treatment for these conditions, pediatricians should focus on referring patients to various specialists in order to treat each individual manifestation.

Double-Face Activity of Resveratrol in Voluntary Runners: Assessment of DNA Damage by Comet Assay

Barbara Tomasello,Salvatore Grasso,Giuseppe Malfa,Stefania Stella,Marco Favetta,Marcella Renis 한국식품영양과학회 2012 Journal of medicinal food Vol.15 No.5

Voluntary runners are subjected to a massive increase in reactive oxygen/nitrogen species production, which can promote different oxidative stress–related diseases such as premature aging, neurodegenerative disorders, and cancer. The aims of this work were to evaluate the following in peripheral blood cells of voluntary runners: (i) DNA status; (ii)susceptibility to the in vitro insult induced by hydrogen peroxide (H2O2) as a breaking agent; (iii) capabilities of 3,5,40-trihydroxystilbene (RESV) in counteracting DNA damage. Twenty-five male voluntary runners were compared with 20sedentary men, as age-matched controls, and DNA status was evaluated with different versions of comet assay: alkaline,neutral, and Fpg enzyme–modified version to measure 8-OH-deoxyguanosine (8-oxo-dG) levels. The H2O2 and/or RESV treatments were performed directly on agarose-embedded cells (atypical comet assay). The results evidenced DNA damage and levels of 8-oxo-dG higher in runners than in sedentary control subjects. The runners’ DNA was more prone to the in vitro–induced oxidative insult (200 lM H2O2) than that of the control group. Resveratrol (100 lM), depending on the individual basal DNA status, was able to switch from antioxidant to pro-oxidant. Our results, on the one hand, validated the proposed in vitro experimental protocol in order to measure individual DNA status. On the other hand, our data point out the importance of monitoring the athletes’ redox status before subjecting them to dietary supplementation treatment.

Nonlinear effects on motions and loads using an iterative time-frequency solver

Bruzzone, Dario,Gironi, C.,Grasso, A. The Society of Naval Architects of Korea 2011 International Journal of Naval Architecture and Oc Vol.3 No.1

A weakly nonlinear seakeeping methodology for predicting motions and loads is presented in this paper. This methodology assumes linear radiation and diffraction forces, calculated in the frequency domain, and fully nonlinear Froude-Krylov and hydrostatic forces, evaluated in the time domain. The particular approach employed here allows to overcome numerical problems connected to the determination of the impulse response functions. The procedure is divided into three consecutive steps: evaluation of dynamic sinkage and trim in calm water that can significantly influence the final results, a linear seakeeping analysis in the frequency domain and a weakly nonlinear simulation. The first two steps are performed employing a three-dimensional Rankine panel method. Nonlinear Froude-Krylov and hydrostatic forces are computed in the time domain by pressure integration on the actual wetted surface at each time step. Although nonlinear forces are evaluated into the time domain, the equations of motion are solved in the frequency domain iteratively passing from the frequency to the time domain until convergence. The containership S175 is employed as a test case for evaluating the capability of this methodology to correctly predict the nonlinear behavior related to wave induced motions and loads in head seas; numerical results are compared with experimental data provided in literature.

Liver transplantation for non-alcoholic fatty liver disease: indications and post-transplant management

Sara Battistella,Francesca D’Arcangelo,Marco Grasso,Alberto Zanetto,Martina Gambato,Giacomo Germani,Marco Senzolo,Francesco Paolo Russo,Patrizia Burra 대한간학회 2023 Clinical and Molecular Hepatology(대한간학회지) Vol.29 No.-

Non-alcoholic fatty liver disease (NAFLD) is currently the fastest growing indication to liver transplantation (LT) in Western Countries, both for end stage liver disease and hepatocellular carcinoma. NAFLD/non-alcoholic steatohepatitis (NASH) is often expression of a systemic metabolic syndrome; therefore, NAFLD/NASH patients require a multidisciplinary approach for a proper pre-surgical evaluation, which is important to achieve a post-transplant outcome comparable to that of other indications to LT. NAFLD/NASH patients are also at higher risk of post-transplant cardiovascular events, diabetes, dyslipidemia, obesity, renal impairment and recurrent NASH. Lifestyle modifications, included diet and physical activity, are key to improve survival and quality of life after transplantation. A tailored immunosuppressive regimen may be proposed in selected patients. Development of new drugs for the treatment of recurrent NASH is awaited.

Incidence and risk factors for the development of cerebral metastasis in cervical cancer patients

Juliana de Brito Rangel,Alessandra Grasso Giglio,Cristiane Lemos Cardozo,Anke Bergmann,Luiz Claudio Santos Thuler 대한부인종양학회 2022 Journal of Gynecologic Oncology Vol.33 No.5

Objective: Cerebral metastasis (CM) in cervical cancer (CC) cases, although rare, results in high lethality rates. The present study aimed to assess CM incidence in a Brazilian reference CC center and evaluate the risk factors for CM development. Retrospective observational study of patients diagnosed with CC between 2010 and 2017. Methods: Cumulative CM incidence and incidence density were evaluated. Characteristics associated to CM development risks were identified using crude (cOR) or adjusted (aOR) odds ratios. Results: A total of 3,397 patients were included in this study. Patient age ranged from 18 to 101 years, with a mean age of 48.8±14.0. After a mean follow-up time of 3.2±2.1 years, 51 CM cases were identified, resulting in a cumulative incidence of 1.5% (95% confidence intervals [CI]=1.12–1.97) and an incidence density at the end of the 6th year of 27.4 per 1,000 women/ year. Advanced clinical stage (aOR=3.15; 95% CI=1.16–8.58; p=0.025), the presence of previous lung metastasis (aOR=4.04; 95% CI=1.82–8.94; p=0.001) and the adenocarcinoma (aOR=2.90; 95% CI=1.46–5.76; p=0.002), adenosquamous carcinoma (aOR=7.33; 95%CI=2.87–18.73; p<0.001), undifferentiated carcinoma (aOR=14.37; 95% CI=3.77–54.76;p<0.001) and neuroendocrine carcinoma (aOR=21.31; 95% CI=6.65–68.37, p<0.001) histological types were associated with a higher risk for CM development. CM risk was higher in the first years of follow-up, with no cases observed after the 6th year. Conclusion: CC patients in advanced clinical stages, displaying previous lung metastasis and non-squamous histological types are at high risk of developing CM.

Remodeling of Epidural Fluid Hematoma after Uniportal Lumbar Endoscopic Unilateral Laminotomy with Bilateral Decompression: Comparative Clinical and Radiological Outcomes with a Minimum Follow-up of 2 Years

Wu Pang Hung,Kim Hyeun Sung,Grasso Giovanni,An Jin Woo,Kim Myeonghun,Lee Inkyung,Park Jong Seon,Lee Jun Hyoung,Kang Sangsoo,Lee Jeongshik,Yi Yeonjin,Lee Jun Hyung,Park Jun Hwan,Lim Jae Hyeon,Jang Il-T 대한척추외과학회 2023 Asian Spine Journal Vol.17 No.1

tudy Design: Retrospective cohort study. Purpose: To evaluate the clinical and radiological effects of epidural fluid hematoma in the medium term after lumbar endoscopic decompression. Overview of Literature: There is limited literature comparing the effect of postoperative epidural fluid hematoma after uniportal endoscopic decompression. Methods: Magnetic resonance imaging (MRI) and clinical evaluation were performed for patients with single-level uniportal endoscopic lumbar decompression with a minimum follow-up of 2 years. Results: A total of 126 patients were recruited with a minimum follow-up of 26 months. The incidence of epidural fluid hematoma was 27%. Postoperative MRI revealed a significant improvement in the postoperative dura sac area at postoperative day 1 and at the upper endplate at 6 months in the hematoma cohort (39.69±15.72 and 26.89±16.58 mm2) as compared with the nonhematoma cohort (48.92±21.36 and 35.1±20.44 mm2), respectively (p<0.05); and at the lower endplate on postoperative 1 day in the hematoma cohort (51.18±24.69 mm2) compared to the nonhematoma cohort (63.91±27.92 mm2) (p<0.05). No significant difference was observed in the dura sac area at postoperative 1 year in both cohorts. The hematoma cohort had statistically significant higher postoperative 1-week Visual Analog Scale (VAS; 3.32±0.68) pain and Oswestry Disability Index (ODI; 32.65±5.56) scores than the nonhematoma cohort (2.99±0.50 and 30.02±4.84, respectively; p<0.05). No significant difference was found at the final follow-up VAS, ODI, and MRI dura sac area. Conclusions: Epidural fluid hematoma is a common early postoperative MRI finding in lumbar endoscopic unilateral laminotomy with bilateral decompression. Conservative management is the preferred treatment option for patients who do not have a neurological deficit. Symptoms last only a few days and are self-limiting. A common endpoint is a remodeled fluid hematoma and the subsequent expansion of the dura sac area.

Concurrent SHORT syndrome and 3q duplication syndrome

Alexander M,Boaz,Salvatore A,Grasso,Michael J,DeRogatis,Ellis N,Beesley 대한의학유전학회 2019 대한의학유전학회지 Vol.16 No.1

SHORT syndrome is an extremely rare congenital condition due to a chromosomal mutation of the PIK3R1 gene found at 5q13.1. SHORT is a mnemonic representing six manifestations of the syndrome: (S) short stature, (H) hyperextensibility of joints and/or inguinal hernia, (O) ocular depression, (R) Rieger anomaly, and (T) teething delay. Other key aspects of this syn-drome not found in the mnemonic include lipodystrophy, triangular face with dimpled chin (progeroid facies, commonly re-ferred to as facial gestalt), hearing loss, vision loss, insulin resistance, and intrauterine growth restriction (IUGR). 3q duplication syndrome is rare syndrome that occurs due to a gain of function mutation found at 3q25.31-33 that presents with a wide array of manifestations including internal organ defects, genitourinary malformations, hand and foot deformities, and mental dis-ability. We present a case of a 2 year and 3 month old male with SHORT syndrome and concurrent 3q duplication syndrome. The patient presented at birth with many of the common manifestations of SHORT syndrome such as bossing of frontal bone of skull, triangular shaped face, lipodystrophy, micrognathia, sunken eyes, and thin, wrinkled skin (progeroid appearance). Additionally, he presented with findings associated with 3q duplication syndrome such as cleft palate and cryptorchidism. Al-though there is no specific treatment for these conditions, pediatricians should focus on referring patients to various specialists in order to treat each individual manifestation.