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Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment
Gotov, Oyuntuya,Battogtokh, Gantumur,Shin, Dongyun,Ko, Young Tag Elsevier 2018 Journal of industrial and engineering chemistry Vol.65 No.-
<P><B>Abstract</B></P> <P>Gold nanoparticles are widely utilized for medical applications such as drug carriers and therapeutic and diagnostic agents due to their small size and great surface area. In the present study, we prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles to selectively deliver cisplatin into a tumor, and obtain synergistic effects using laser treatment. Our prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles were found to have a mean hydrodynamic diameter of approximately 140nm and negative surface charge. The nanoparticles showed greater cytotoxicity than free cisplatin and in vivo antitumor efficacy in tumor models when near infra-red laser was applied. Therefore, this formulation could be applied for combined cancer therapy.</P> <P><B>Graphical abstract</B></P> <P>[DISPLAY OMISSION]</P>
Gotov, Oyuntuya,Battogtokh, Gantumur,Ko, Young Tag American Chemical Society 2018 MOLECULAR PHARMACEUTICS Vol.15 No.10
<P>Gold nanoparticles are commonly used for medical applications such as drug delivery and as therapeutic and diagnostic materials because of their unique properties. In this study, we prepared docetaxel (DTX)-loaded hyaluronic acid-cleavable-peptide-gold nanoparticles for the treatment of cancer by selectively delivering DTX into the tumor and, thus, enhancing the therapeutic effect of DTX; further, we determined synergistic effects of the nanoparticles using laser treatment. The DTX-loaded hyaluronic acid-cleavable-peptide-gold nanoparticles prepared in this study had an average size of 75 nm and negative surface charge. The nanoparticles revealed greater cytotoxicity and higher tumor suppression efficacy in tumor models than free DTX under near-infrared laser irradiation. Therefore, the nanoparticle formulation prepared in this study could be utilized for targeted drug delivery and in combination with other cancer therapies.</P> [FIG OMISSION]</BR>
Hyaluronic acid-coated cisplatin conjugated gold nanoparticles for combined cancer treatment
Oyuntuya Gotov,Gantumur Battogtokh,신동윤,고영탁 한국공업화학회 2018 Journal of Industrial and Engineering Chemistry Vol.65 No.-
Gold nanoparticles are widely utilized for medical applications such as drug carriers and therapeutic and diagnostic agents due to their small size and great surface area. In the present study, we prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles to selectively deliver cisplatin into a tumor, and obtain synergistic effects using laser treatment. Our prepared hyaluronic acid-coated cisplatin conjugated gold nanoparticles were found to have a mean hydrodynamic diameter of approximately 140 nm and negative surface charge. The nanoparticles showed greater cytotoxicity than free cisplatin and in vivo antitumor efficacy in tumor models when near infra-red laser was applied. Therefore, this formulation could be applied for combined cancer therapy.
바톡토흐 간트므르,Oyuntuya Gotov,고영탁 대한약학회 2017 Archives of Pharmacal Research Vol.40 No.3
Gold nanoparticles are promising materials formany applications that include imaging, drug delivery, andphotothermal therapy. However, AuNPs can be unstableand/or toxic. We purposed to improve the stability andreduce toxicity of gold nanorods (AuNR) upon coatingwith biocompatible polymer, chitosan–ceramide (CS–CE),without replacing the original layer, CTAB. CS–CE-coatedAuNR was prepared by simple mixing for 24 h and purifiedby centrifugation. The coating was confirmed by UV–Visabsorption analysis and surface charge and size measurement. We prepared nanorods with CS or CS–CE coating attwo different concentrations (5 and 10% AuNR), theresulting in larger nanorods with a more positive surfacechargethan that of AuNR. We investigated the UV-absorptionand protein adsorption of the polymer coatednanorods. Based on the protein adsorption, AuNR-CS–CEwas found to be more stable under physiological conditionsthan AuNR-CS. The cell internalization assay revealed thatHela cells internalized higher amounts of AuNR-CS–CEthan that of AuNR-CS. Cytotoxicity study revealed thatAuNR-CS–CE has lower toxicity than AuNR against HeLacells. The CS–CE coating improved the stability of AuNRunder physiological conditions via the hydrophobic interactionsbetween the AuNR lipid surface and the ceramideanchor in the CS backbone as well as.