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- 저자 : González-Valle (검색결과 3 건)
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Serum Sclerostin in Hepatitis C Virus Infected Patients
E. González-Reimers,Javier López-Prieto,Ricardo Pelazas-González,M.Remedios Alemán-Valls,María José de la Vega-Prieto,Carlos Jorge-Ripper,M. Carmen Durán-Castellón,F Santolaria-Fernández 대한골대사학회 2014 대한골대사학회지 Vol.21 No.1
Background: Sclerostin inhibits osteoblast functions, differentiations, and survival rates. As an endogenous inhibitor of the Wnt/β-catenin pathway, the sclerostin should be re-lated to decreased bone masses, although several studies indicate opposite results. Inaddition, it may be related to insulin resistances and carbohydrate metabolisms, a rela-tion shared with other markers of bone metabolisms, such as osteocalcin. Hepatitis C vi-rus (HCV) infected patients may present osteoporosis, and frequently show liver steato-sis, which is a consequence of insulin resistance. The behaviour of sclerostin in these pa-tients is yet unknown. The aim of this work is to analyse the relationships between se-rum sclerostin and osteocalcin levels and bone mineral density (BMD), liver functions,the intensity of liver steatosis and biochemical markers of bone homeostasis and insulinresistance in HCV-infected patients. Methods: Forty HCV patients with 20 years of ageand gender-matching controls were included in this study and underwent bone densi-tometry. Serum sclerostin, osteocalcin, collagen telopeptide, adiponectin, leptin, insulin,resistin, tumor necrosis factor (TNF)-α, and interleukin (IL)-6 were determined. Liver fatwas histomorphometrically assessed. Results: Sclerostin levels were slightly higher inpatients than in controls, and were directly related to BMD at different parts of the skele-ton, also to the serum telopeptide, and to the liver steatosis and TNF-α. On the contrary,osteocalcin showed a significant direct relationship with serum adiponectin, and an in-verse one with IL-6. Conclusions: Serum sclerostin levels were within the normal rangein HCV patients, and correlated directly with BMD and serum telopeptide. In addition,the relationships of sclerostin and osteocalcin with variables associated with insulin re-sistance suggested the role of bones for intermediary metabolisms.
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Chemical, optical and transport characterization of ALD modified nanoporous alumina based structures
A.L. Cuevas,Ma. Valle Martínez de Yuso,L. Gelde,A.S. González,V. Vega,V.M. Prida,J. Benavente 한국공업화학회 2020 Journal of Industrial and Engineering Chemistry Vol.91 No.-
Nanoporous alumina-based structures (NPA-bSs) obtained by anodization of aluminum in sulfuric acidmedium were coated by atomic layer deposition (ALD) of a thin conformal layer of different functionaloxides (Al2O3, TiO2, Fe2O3 or ZnO), leading to samples with similar geometrical parameters but differentsurface materials. Morphological characterization of the NPA-bSs confirms a reduction of about 35% inpore size associated to the presence of the oxides of interest, while chemical surface analysis permits theestimation of cover layer purity and thickness. Additionally, ALD functionalization also modifies optical(band-gap, refractive index and dielectric constant) according to transmittance and spectroscopicellipsometry results for visible and near-infrared regions, as well as electrolyte diffusive transportparameters (effectivefixed charge, ion transport numbers or ionic permselectivity) of the NPA-bSs, bothof which are dependent on the nature of the coating layer. Therefore, the suitability of ALD technique forgeometrical and functional modification of nanoporous structures is demonstrated, thus broadening thepotential application of these NPA-bSs platforms to optical sensing, nanophotonics, biosensing,microfluidics or drug delivery applications.
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Ribociclib-Related Stevens–Johnson Syndrome: Oncologic Awareness, Case Report, and Literature Review
Victoria López-Gómez,Ramón Yarza,Héctor Muñoz-González,Enrique Revilla,Santos Enrech,Olga González-Valle,Pablo Tolosa,Eva Ciruelos 한국유방암학회 2019 Journal of breast cancer Vol.22 No.4
Stevens-Johnson syndrome (SJS) and toxic epidermal necrolysis belong to a severe dermatopathic spectrum that includes frequently fatal mucocutaneous manifestations consisting of whole epidermal necrosis and sloughing with bullous transformation, blistering, and further skin detachment. Notably, cancer patients are at higher risk of developing SJS than the general population as a consequence of both the nature of neoplastic disease and frequent exposure to anticancer drugs. Ribociclib is a newly approved cycline-dependent kinase inhibitor that has been recently associated with a single case of SJS. We hereby present a case of ribociclib-related SJS. Early detection of threatening skin lesions is crucial to permit the immediate discontinuation of ribociclib given the predictable and unacceptable risk level. In cases of established SJS, early aggressive support should be initiated, ribociclib should be abruptly discontinued, and specific treatment based on actual evidence should be started.
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