Multimodal Treatment Strategies in Esophagogastric Junction Cancer: a Western Perspective

Goetze, Thorsten Oliver,Al-Batran, Salah-Eddin,Berlth, Felix,Hoelscher, Arnulf Heinrich The Korean Gastric Cancer Association 2019 Journal of gastric cancer Vol.19 No.2

Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperative context, which might have beneficial outcomes, especially in patients with EGJ cancer. However, it is difficult to recruit patients for trials, exclusively for EGJ cancers; therefore, the results have to be carefully reviewed before establishing a standard protocol. Trastuzumab was the first drug for targeted therapy that was positively evaluated for this tumor entity, and there are several ongoing trials investigating more targeted drugs in order to customize effective therapies based on tissue characteristics. The current study reviews the multimodal treatment concept for EGJ cancers in the West and summarizes the latest reports.

Acoustic Monitoring and Localization for Social Care

Goetze, Stefan,Schroder, Jens,Gerlach, Stephan,Hollosi, Danilo,Appell, Jens-E.,Wallhoff, Frank Korean Institute of Information Scientists and Eng 2012 Journal of Computing Science and Engineering Vol.6 No.1

Increase in the number of older people due to demographic changes poses great challenges to the social healthcare systems both in the Western and as well as in the Eastern countries. Support for older people by formal care givers leads to enormous temporal and personal efforts. Therefore, one of the most important goals is to increase the efficiency and effectiveness of today's care. This can be achieved by the use of assistive technologies. These technologies are able to increase the safety of patients or to reduce the time needed for tasks that do not relate to direct interaction between the care giver and the patient. Motivated by this goal, this contribution focuses on applications of acoustic technologies to support users and care givers in ambient assisted living (AAL) scenarios. Acoustic sensors are small, unobtrusive and can be added to already existing care or living environments easily. The information gathered by the acoustic sensors can be analyzed to calculate the position of the user by localization and the context by detection and classification of acoustic events in the captured acoustic signal. By doing this, possibly dangerous situations like falls, screams or an increased amount of coughs can be detected and appropriate actions can be initialized by an intelligent autonomous system for the acoustic monitoring of older persons. The proposed system is able to reduce the false alarm rate compared to other existing and commercially available approaches that basically rely only on the acoustic level. This is due to the fact that it explicitly distinguishes between the various acoustic events and provides information on the type of emergency that has taken place. Furthermore, the position of the acoustic event can be determined as contextual information by the system that uses only the acoustic signal. By this, the position of the user is known even if she or he does not wear a localization device such as a radio-frequency identification (RFID) tag.

Acoustic Monitoring and Localization for Social Care

Stefan Goetze,Jens Schroder,Stephan Gerlach,Danilo Hollosi,Jens-E. Appell,Frank Wallhoff 한국정보과학회 2012 Journal of Computing Science and Engineering Vol.6 No.1

Increase in the number of older people due to demographic changes poses great challenges to the social healthcare systems both in the Western and as well as in the Eastern countries. Support for older people by formal care givers leads to enormous temporal and personal efforts. Therefore, one of the most important goals is to increase the efficiency and effectiveness of today’s care. This can be achieved by the use of assistive technologies. These technologies are able to increase the safety of patients or to reduce the time needed for tasks that do not relate to direct interaction between the care giver and the patient. Motivated by this goal, this contribution focuses on applications of acoustic technologies to support users and care givers in ambient assisted living (AAL) scenarios. Acoustic sensors are small, unobtrusive and can be added to already existing care or living environments easily. The information gathered by the acoustic sensors can be analyzed to calculate the position of the user by localization and the context by detection and classification of acoustic events in the captured acoustic signal. By doing this, possibly dangerous situations like falls, screams or an increased amount of coughs can be detected and appropriate actions can be initialized by an intelligent autonomous system for the acoustic monitoring of older persons. The proposed system is able to reduce the false alarm rate compared to other existing and commercially available approaches that basically rely only on the acoustic level. This is due to the fact that it explicitly distinguishes between the various acoustic events and provides information on the type of emergency that has taken place. Furthermore, the position of the acoustic event can be determined as contextual information by the system that uses only the acoustic signal. By this, the position of the user is known even if she or he does not wear a localization device such as a radio-frequency identification (RFID) tag.

Multimodal Treatment Strategies in Esophagogastric Junction Cancer: a Western Perspective

Thorsten Oliver Goetze,Salah-Eddin Al-Batran,Felix Berlth,Arnulf Heinrich Hoelscher 대한위암학회 2019 Journal of gastric cancer Vol.19 No.2

Esophagogastric junction (EGJ) cancer is a solid tumor entity with rapidly increasing incidence in the Western countries. Given the high proportion of advanced cancers in the West, treatment strategies routinely employed include surgery and chemotherapy perioperatively, and chemoradiation in neoadjuvant settings. Neoadjuvant chemoradiation and perioperative chemotherapy are mostly performed in esophageal cancer that extends to the EGJ and gastric as well as EGJ cancers, respectively. Recent trials have tried to combine both strategies in a perioperative context, which might have beneficial outcomes, especially in patients with EGJ cancer. However, it is difficult to recruit patients for trials, exclusively for EGJ cancers; therefore, the results have to be carefully reviewed before establishing a standard protocol. Trastuzumab was the first drug for targeted therapy that was positively evaluated for this tumor entity, and there are several ongoing trials investigating more targeted drugs in order to customize effective therapies based on tissue characteristics. The current study reviews the multimodal treatment concept for EGJ cancers in the West and summarizes the latest reports.

MONARCH 3: Abemaciclib As Initial Therapy for Advanced Breast Cancer

Goetz, Matthew P.,Toi, Masakazu,Campone, Mario Grune & Stratton 2017 Journal of clinical oncology Vol.35 No.32

Cross Feeding in Microbial Populations : Mathematical Modelling of a Commensalistic TwoSystem

Peter Goetz 한국생명과학회 2004 한국생명과학회 심포지움 Vol.43 No.-

Simulating Network Structures Using Bernoulli's Principle

Han, Y.,Goetz, S.J.,Lee, J.,Yoon, S. UNKNOWN 2012 Advances in complex systems Vol.15 No.5

사방정계 $Sr_{0.6}Ca_{0.4}CuO_2$ 화합물의 결정구조해석

Park, H.M.,Goetz, D.,Hahn, Th. 한국결정학회 1996 韓國結晶學會誌 Vol.7 No.1

(Sr1-xCax)CuO2 단결정을 융제법으로 제조하고 단결정 X-선 회절법을 이용하여 그 결정구조를 밝혔다. 이 화합물의 결정축계는 사방정계(orthorhombic system)이며, 공간군은 Cmcm(63), 그리고 격자상수 a, b, c는 각각 3.4645Å, 16.1417Å, 3.8727Å이었다. (Sr1-xCax)CuO2 화합물에서 Sr대신 치환되는 Ca이온의 한계를 구조적인 관점에서 연구하였다. 이를 위해 X-선 회절(CAD4), energy dispersive X-ray fluorescence (EDAX) and electron probe micro-analysis (EPMA) 등을 사용하였다. Ca가 치환됨에 따른 Cu-O 결합길이의 변화로부터 Ca의 치환한계를 결정하였는데 그 한계치는 Xca≒0.73이었다. Sr0.6Ca0.4CuO2 single crystal has been synthesized by flux method and characterized by the single crystal X-ray diffraction. The compound has the orthorhombic system and the space group is Cmcm(63), lattice parameters are a=3.4645Å, b=16.1417Å, c=3.8727Å. In the (Sr1-xCax)CuO2 compound the limit of Ca from substitution for Sr was determined by the change of bond length. For this, X-ray diffraction, scanning electron microscopy (SEM), energy dispersive X-ray fluorescence (EDAX) and electron probe micro-analysis (EPMA) were used. From the change of Cu-O bond length as the Ca substitution, we concluded the limit of Ca incorporation Xca≒0.73.

<i>CYP2D6</i> Genotype and Adjuvant Tamoxifen: Meta-Analysis of Heterogeneous Study Populations

Province, M A,Goetz, M P,Brauch, H,Flockhart, D A,Hebert, J M,Whaley, R,Suman, V J,Schroth, W,Winter, S,Zembutsu, H,Mushiroda, T,Newman, W G,Lee, M-T M,Ambrosone, C B,Beckmann, M W,Choi, J-Y,Dieudonn& C. V. Mosby 2014 Clinical Pharmacology & Therapeutics Vol. No.

<P>The International Tamoxifen Pharmacogenomics Consortium was established to address the controversy regarding cytochrome P450 2D6 (<I>CYP2D6</I>) status and clinical outcomes in tamoxifen therapy. We performed a meta-analysis on data from 4,973 tamoxifen-treated patients (12 globally distributed sites). Using strict eligibility requirements (postmenopausal women with estrogen receptor–positive breast cancer, receiving 20 mg/day tamoxifen for 5 years, criterion 1); CYP2D6 poor metabolizer status was associated with poorer invasive disease–free survival (IDFS: hazard ratio = 1.25; 95% confidence interval = 1.06, 1.47; <I>P</I> = 0.009). However, <I>CYP2D6</I> status was not statistically significant when tamoxifen duration, menopausal status, and annual follow-up were not specified (criterion 2, <I>n</I> = 2,443; <I>P</I> = 0.25) or when no exclusions were applied (criterion 3, <I>n</I> = 4,935; <I>P</I> = 0.38). Although <I>CYP2D6</I> is a strong predictor of IDFS using strict inclusion criteria, because the results are not robust to inclusion criteria (these were not defined <I>a priori</I>), prospective studies are necessary to fully establish the value of <I>CYP2D6</I> genotyping in tamoxifen therapy.</P>

독일사법의 (獨逸私法) 역사

양창수 (역),츠바이게르트쾨츠 (,Z . Goetz ) 한독법률학회 1986 한독법학 Vol.- No.6