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AUTOMOTIVE WASTE HEAT RECOVERY: WORKING FLUID SELECTION AND RELATED BOUNDARY CONDITIONS
S. GLOVER,R. DOUGLAS,L. GLOVER,G. MCCULLOUGH,S. MCKENNA 한국자동차공학회 2015 International journal of automotive technology Vol.16 No.3
This paper presents the rational for the selection of fluids for use in a model based study of sub and supercritical Waste Heat Recovery (WHR) Organic Rankine Cycle (ORC). The study focuses on multiple vehicle heat sources and the potential of WHR ORC’s for its conversion into useful work. The work presented on fluid selection is generally applicable to any waste heat recovery system, either stationary or mobile and, with careful consideration, is also applicable to single heat sources. The fluid selection process presented reduces the number of potential fluids from over one hundred to a group of under twenty fluids for further refinement in a model based WHR ORC performance study. The selection process uses engineering judgement, legislation and, where applicable, health and safety as fluid selection or de-selection criteria. This paper also investigates and discusses the properties of specific ORC fluids with regard to their impact on the theoretical potential for delivering efficient WHR ORC work output. The paper concludes by looking at potential temperature and pressure WHR ORC limits with regard to fluid properties thereby assisting with the generation of WHR ORC simulation boundary conditions.
Glover, Gary H.,Mueller, Bryon A.,Turner, Jessica A.,van Erp, Theo G.M.,Liu, Thomas T.,Greve, Douglas N.,Voyvodic, James T.,Rasmussen, Jerod,Brown, Gregory G.,Keator, David B.,Calhoun, Vince D.,Lee, H Wiley Subscription Services, Inc., A Wiley Company 2012 JOURNAL OF MAGNETIC RESONANCE IMAGING Vol.36 No.1
<P><B>Abstract</B></P><P>This report provides practical recommendations for the design and execution of multicenter functional MRI (MC‐fMRI) studies based on the collective experience of the Function Biomedical Informatics Research Network (FBIRN). The study was inspired by many requests from the fMRI community to FBIRN group members for advice on how to conduct MC‐fMRI studies. The introduction briefly discusses the advantages and complexities of MC‐fMRI studies. Prerequisites for MC‐fMRI studies are addressed before delving into the practical aspects of carefully and efficiently setting up a MC‐fMRI study. Practical multisite aspects include: (i) establishing and verifying scan parameters including scanner types and magnetic fields, (ii) establishing and monitoring of a scanner quality program, (iii) developing task paradigms and scan session documentation, (iv) establishing clinical and scanner training to ensure consistency over time, (v) developing means for uploading, storing, and monitoring of imaging and other data, (vi) the use of a traveling fMRI expert, and (vii) collectively analyzing imaging data and disseminating results. We conclude that when MC‐fMRI studies are organized well with careful attention to unification of hardware, software and procedural aspects, the process can be a highly effective means for accessing a desired participant demographics while accelerating scientific discovery. J. Magn. Reson. Imaging 2012;36:39–54. © 2012 Wiley Periodicals, Inc.</P>
A Study of the Judgment Accuracy of Repeated /r/ Stimuli by Graduate Clinicians
Lauren Glover,Dennis Ruscello 한국언어재활사협회 2018 Clinical Archives of Communication Disorders Vol.3 No.3
In the field of speech-language pathology, communication disorders are treated with evidence-based methodologies. Treatment in many cases relies on the clinician’s auditory perceptual skills for feedback purposes, so that the client is aware of correct and incorrect responses. It has been reported clinically that repeated listening to a client’s articulatory responses over time may result in auditory perceptual confusions. This clinical hypothesis was studied by examining the integrity of judgement accuracy of repeated /r/ stimuli, which varied as a function of correct and incorrect stimuli. Findings showed no statistically significant evidence of auditory perceptual confusions when subjects listened to and evaluated repeated productions of synthesized /r/, /w/ for /r/substitution, and /r/ distortion embedded in a CV word.
Sidrat Abdullah,Sunish K. Sehgal,Karl D. Glover,Shaukat Ali 한국식물병리학회 2017 Plant Pathology Journal Vol.33 No.3
Rye (Secale cereale L.) serves as an alternative host of Pyrenophora tritici-repentis (PTR) the cause of tan spot on wheat. Rye is cultivated as a forage or cover crop and overlaps with a significant portion of wheat acreage in the U.S. northern Great Plains; however, it is not known whether the rye crop influences the evolution of PTR races. We evaluated a global collection of 211 rye accessions against tan spot and assessed the diversity in PTR population on rye in South Dakota. All the rye genotypes were inoculated with PTR races 1 and 5, and infiltrated with Ptr ToxA and Ptr ToxB, at seedling stage. We observed 21% of the genotypes exhibited susceptibility to race 1, whereas, 39% were susceptible to race 5. All 211 accessions were insensitive to both the Ptr toxins. It indicates that though rye exhibits diversity in reaction to tan spot, it lacks Ptr ToxA and ToxB sensitivity genes. This suggests that unknown toxins or other factors can lead to PTR establishment in rye. We characterized the race structure of 103 PTR isolates recovered from rye in South Dakota. Only 22% of the isolates amplified Ptr ToxA gene and were identified as race 1 based on their phenotypic reaction on the differential set. The remaining 80 isolates were noted to be race 4. Our results show that races 1 and 4 are prevalent on rye in South Dakota with a higher frequency of race 4, suggesting a minimal role of rye in the disease epidemiology.
Abdullah, Sidrat,Sehgal, Sunish K.,Glover, Karl D.,Ali, Shaukat The Korean Society of Plant Pathology 2017 Plant Pathology Journal Vol.33 No.3
Rye (Secale cereale L.) serves as an alternative host of Pyrenophora tritici-repentis (PTR) the cause of tan spot on wheat. Rye is cultivated as a forage or cover crop and overlaps with a significant portion of wheat acreage in the U.S. northern Great Plains; however, it is not known whether the rye crop influences the evolution of PTR races. We evaluated a global collection of 211 rye accessions against tan spot and assessed the diversity in PTR population on rye in South Dakota. All the rye genotypes were inoculated with PTR races 1 and 5, and infiltrated with Ptr ToxA and Ptr ToxB, at seedling stage. We observed 21% of the genotypes exhibited susceptibility to race 1, whereas, 39% were susceptible to race 5. All 211 accessions were insensitive to both the Ptr toxins. It indicates that though rye exhibits diversity in reaction to tan spot, it lacks Ptr ToxA and ToxB sensitivity genes. This suggests that unknown toxins or other factors can lead to PTR establishment in rye. We characterized the race structure of 103 PTR isolates recovered from rye in South Dakota. Only 22% of the isolates amplified Ptr ToxA gene and were identified as race 1 based on their phenotypic reaction on the differential set. The remaining 80 isolates were noted to be race 4. Our results show that races 1 and 4 are prevalent on rye in South Dakota with a higher frequency of race 4, suggesting a minimal role of rye in the disease epidemiology.
Gustav Gbeddy,Yaw Adjei-Kyereme,Eric T. Glover,Eric Akortia,Paul Essel,Abdallah M.A. Dawood,Evans Ameho,Emmanuel Aberikae 한국방사성폐기물학회 2023 방사성폐기물학회지 Vol.21 No.3
Evaluating the effectiveness of the radiation protection measures deployed at the Centralized Radioactive Waste Management Facility in Ghana is pivotal to guaranteeing the safety of personnel, public and the environment, thus the need for this study. RadiagemTM 2000 was used in measuring the dose rate of the facility whilst the personal radiation exposure of the personnel from 2011 to 2022 was measured from the thermoluminescent dosimeter badges using Harshaw 6600 Plus Automated TLD Reader. The decay store containing scrap metals from dismantled disused sealed radioactive sources (DSRS), and low-level wastes measured the highest dose rate of 1.06 ± 0.92 µSv·h−1. The range of the mean annual average personnel dose equivalent is 0.41–2.07 mSv. The annual effective doses are below the ICRP limit of 20 mSv. From the multivariate principal component analysis biplot, all the personal dose equivalent formed a cluster, and the cluster is mostly influenced by the radiological data from the outer wall surface of the facility where no DSRS are stored. The personal dose equivalents are not primarily due to the radiation exposures of staff during operations with DSRS at the facility but can be attributed to environmental radiation, thus the current radiation protection measures at the Facility can be deemed as effective.
BACH1/FANCJ Acts with TopBP1 and Participates Early in DNA Replication Checkpoint Control
Gong, Zihua,Kim, Ja-Eun,Leung, Charles Chung Yun,Glover, J.N. Mark,Chen, Junjie Elsevier 2010 Molecular cell Vol.37 No.3
<P><B>Summary</B></P><P>Human TopBP1 plays a critical role in the control of DNA replication checkpoint. In this study, we report a specific interaction between TopBP1 and BACH1/FANCJ, a DNA helicase involved in the repair of DNA crosslinks. The TopBP1/BACH1 interaction is mediated by the very C-terminal tandem BRCT domains of TopBP1 and S phase-specific phosphorylation of BACH1 at Thr 1133 site. Interestingly, we demonstrate that depletion of TopBP1 or BACH1 attenuates the loading of RPA on chromatin. Moreover, both TopBP1 and BACH1 are required for ATR-dependent phosphorylation events in response to replication stress. Taken together, our data suggest that BACH1 has an unexpected early role in replication checkpoint control. A specific interaction between TopBP1 and BACH1 is likely to be required for the extension of single-stranded DNA regions and RPA loading following replication stress, which is a prerequisite for the subsequent activation of replication checkpoint.</P> <P><B>Highlights</B></P><P>► Human TopBP1 interacts with BACH1 in a phosphorylation-dependent manner ► TopBP1 or BACH1 depletion attenuates RPA chromatin loading after replication stress ► Both TopBP1 and BACH1 are required for ATR-dependent replication checkpoint activation</P>