Pre- and post-therapy 18F-FDG PET/CT of a patient affected by non-HIV multicentric IgG4-related Castleman disease

Giordano Savelli,Alfredo Muni,Roberta Falchi,Francesca Giuffrida 대한혈액학회 2015 Blood Research Vol.50 No.4

None

Pre- and post-therapy 18F-FDG PET/CT of a patient affected by non-HIV multicentric IgG4-related Castleman disease

Giordano Savelli,Alfredo Muni,Roberta Falchi,Francesca Giuffrida 대한혈액학회 2015 Blood Research Vol.50 No.4

None

Impact of inhibitors of amino acid, protein, and RNA synthesis on C allocation in the diatom Chaetoceros muellerii: a FTIR approach

Giordano, Mario,Norici, Alessandra,Beardall, John The Korean Society of Phycology 2017 ALGAE Vol.32 No.2

Fourier Transform Infrared (FTIR) spectroscopy was used to study carbon allocation patterns in response to N-starvation in the nearly ubiquitous diatom Chaetoceros muellerii. The role of gene expression, protein synthesis and transamination on the organic composition of cells was tested by using specific inhibitors. The results show that inhibition of key processes in algal metabolism influence the macromolecular composition of cells and and prior cell nutritional state can influence a cell's response to changing nutrient availability. The allocation of C can thus lead to different organic composition depending on the nutritional context, with obvious repercussions for the trophic web. This also shows that C allocation in algal cells is highly flexible and that C (and the energy associated with its allocation) can be variably and rapidly partitioned in algal cells in response to relatively short term perturbations. Furthermore, the data confirm and extend the utility of infrared spectroscopy as a probe of the metabolic state of autotrophic cells.

Time Course of Remote Neuropathology Following Diffuse Traumatic Brain Injury in the Male Rat

Giordano Katherine R.,Law L. Matthew,Henderson Jordan,Rowe Rachel K.,Lifshitz Jonathan 한국뇌신경과학회 2022 Experimental Neurobiology Vol.31 No.2

Traumatic brain injury (TBI) can affect different regions throughout the brain. Regions near the site of impact are the most vulnerable to injury. However, damage to distal regions occurs. We investigated progressive neuropathology in the dorsal hippocampus (near the impact) and cerebellum (distal to the impact) after diffuse TBI. Adult male rats were subjected to midline fluid percussion injury or sham injury. Brain tissue was stained by the amino cupric silver stain. Neuropathology was quantified in sub-regions of the dorsal hippocampus at 1, 7, and 28 days post-injury (DPI) and coronal cerebellar sections at 1, 2, and 7 DPI. The highest observed neuropathology in the dentate gyrus occurred at 7 DPI which attenuated by 28 DPI, whereas the highest observed neuropathology was at 1 DPI in the CA3 region. There was no significant neuropathology in the CA1 region at any time point. Neuropathology was increased at 7 DPI in the cerebellum compared to shams and stripes of pathology were observed in the molecular layer perpendicular to the cerebellar cortical surface. Together these data show that diffuse TBI can result in neuropathology across the brain. By describing the time course of pathology in response to TBI, it is possible to build the temporal profile of disease progression. Key words: Traumatic brain injury, Neuropathology, Diffuse axonal injury, Silver stain, Hippocampus, Cerebellum

Eikonal Approach to N = 4 SYM Regge Amplitudes in the AdS/CFT Correspondence

Giordano, M.,Peschanski, R.,Seki, S. Institute of Physics, Jagellonian University 2012 ACTA PHYSICA POLONICA SERIES B Vol.43 No.6

Risk factors for unexpected admission following arthroscopic and open treatment of shoulder instability: a national database study of 11,230 cases

Joshua Giordano,John M. Tarazi,Matthew J. Partan,Randy M. Cohn 대한견주관절학회 2023 대한견주관절의학회지 Vol.26 No.1

Background: Shoulder instability procedures have low morbidity; however, complications can arise that result in readmission to an inpatient healthcare facility. The purpose of this study is to identify the demographics and risk factors associated with unplanned 30-day readmission and reoperation following arthroscopic and open treatment for shoulder instability. Methods: The American College of Surgeons National Surgical Quality Improvement Program (ACS-NSQIP) database was queried to find patients who underwent shoulder instability surgery from 2015 to 2019. Independent sample Student t-tests, chi-square, and (where appropriate) Fisher’s exact tests were used in univariate analyses to identify demographic, lifestyle, and peri-operative variables related to 30-day readmission and reoperation following repair for shoulder instability. Multivariate logistic regression modeling was subsequently performed. Results: Of the 11,230 cases included in our sample, only 0.54% were readmitted, and 0.23% underwent reoperation within the 30-day postoperative period. Multivariate logistic regression modeling confirmed that the following patient variables were associated with statistically significantly increased odds of readmission and reoperation: open repair, congestive heart failure (CHF), and hospital length of stay. Conclusions: Unplanned 30-day readmission and reoperation after shoulder instability surgery is infrequent. Patients with American Society of Anesthesiologists class II, CHF, longer than average hospital length of stay, or an open procedure have higher odds of readmission than patients without those factors. Patients who have CHF, longer than average hospital length of stay, and open surgery have higher odds of reoperation than others. Arthroscopic procedures should be used to manage shoulder instability, if possible. Surgeons should explain the risks and benefits of each intervention taking individual patient risk factors into account because comorbidities can also increase the risk of adverse outcomes. Level of evidence: III

Remote handling systems for the Selective Production of Exotic Species (SPES) facility

Lilli Giordano,Centofante Lisa,Manzolaro Mattia,Monetti Alberto,Oboe Roberto,Andrighetto Alberto 한국원자력학회 2023 Nuclear Engineering and Technology Vol.55 No.1

The SPES (Selective Production of Exotic Species) facility, currently under development at Legnaro National Laboratories of INFN, aims at the production of intense RIB (Radioactive Ion Beams) employing the Isotope Separation On-Line (ISOL) technique for interdisciplinary research. The radioactive isotopes of interest are produced by the interaction of a multi-foil uranium carbide target with a 40 MeV 200 mA proton beam generated by a cyclotron proton driver. The Target Ion Source (TIS) is the core of the SPES project, here the radioactive nuclei, mainly neutron-rich isotopes, are stopped, extracted, ionized, separated, accelerated and delivered to specific experimental areas. Due to efficiency reasons, the TIS unit needs to be replaced periodically during operation. In this highly radioactive environment, the employment of autonomous systems allows the manipulation, transport, and storage of the TIS unit without the need for human intervention. A dedicated remote handling infrastructure is therefore under development to fulfill the functional and safety requirement of the project. This contribution describes the layout of the SPES target area, where all the remote handling systems operate to grant the smooth operation of the facility avoiding personnel exposure to a high dose rate or contamination issues

A passivity-based decentralized strategy for generalized connectivity maintenance

Robuffo Giordano, Paolo,Franchi, Antonio,Seccos, Christian,Bü,lthoff, Heinrich H SAGE Publications 2013 The International journal of robotics research Vol.32 No.3

<P>The design of decentralized controllers coping with the typical constraints on the inter-robot sensing/communication capabilities represents a promising direction in multi-robot research thanks to the inherent scalability and fault tolerance of these approaches. In these cases, <I>connectivity</I> of the underlying interaction graph plays a fundamental role: it represents a necessary condition for allowing a group or robots to achieve a common task by resorting to only local information. The goal of this paper is to present a novel decentralized strategy able to enforce <I>connectivity maintenance</I> for a group of robots in a flexible way, that is, by granting large freedom to the group internal configuration so as to allow establishment/deletion of interaction links at anytime as long as global connectivity is preserved. A peculiar feature of our approach is that we are able to embed into a <I>unique connectivity preserving action</I> a large number of constraints and requirements for the group: (i) the presence of specific inter-robot sensing/communication models; (ii) group requirements such as formation control; and (iii) individual requirements such as collision avoidance. This is achieved by defining a suitable global potential function of the second smallest eigenvalue λ<SUB>2</SUB> of the graph Laplacian, and by computing, in a decentralized way, a gradient-like controller built on top of this potential. Simulation results obtained with a group of quadrotor unmanned aerial vehicles (UAVs) and unmanned ground vehicles, and experimental results obtained with four quadrotor UAVs, are finally presented to thoroughly illustrate the features of our approach on a concrete case study.</P>

Impact of inhibitors of amino acid, protein, and RNA synthesis on C allocation in the diatom Chaetoceros muellerii: a FTIR approach

Mario Giordano,Alessandra Norici,John Beardall 한국조류학회I 2017 ALGAE Vol.32 No.2

Fourier Transform Infrared (FTIR) spectroscopy was used to study carbon allocation patterns in response to N-starvationin the nearly ubiquitous diatom Chaetoceros muellerii. The role of gene expression, protein synthesis and transaminationon the organic composition of cells was tested by using specific inhibitors. The results show that inhibitionof key processes in algal metabolism influence the macromolecular composition of cells and and prior cell nutritionalstate can influence a cell’s response to changing nutrient availability. The allocation of C can thus lead to different organiccomposition depending on the nutritional context, with obvious repercussions for the trophic web. This also shows thatC allocation in algal cells is highly flexible and that C (and the energy associated with its allocation) can be variably andrapidly partitioned in algal cells in response to relatively short term perturbations. Furthermore, the data confirm andextend the utility of infrared spectroscopy as a probe of the metabolic state of autotrophic cells.

A review of chronic pectoralis major tears: what options are available?

Joshua R. Giordano,Brandon Klein,Benjamin Hershfeld,Joshua Gruber,Robert Trasolini,Randy M. Cohn 대한견주관절의학회 2023 대한견주관절의학회지 Vol.26 No.3

Rupture of the pectoralis major muscle typically occurs in the young, active male. Acute management of these injuries is recommended; however, what if the patient presents with a chronic tear of the pectoralis major? Physical exams and magnetic resonance imaging can help identify the injury and guide the physician with a plan for management. Nonoperative management is feasible, but is recommended for elderly, low-demand patients whose functional goals are minimal. Repair of chronic tears should be reserved for younger, healthier patients with high functional demands. Although operative management provides better functional outcomes, operative treatment of chronic pectoralis tears can be challenging. Tendon retraction, poor tendinous substance and quality of tissue, muscle atrophy, scar formation, and altered anatomy make direct repairs complicated, often necessitating auto- or allograft use. We review the various graft options and fixation methods that can be used when treating patients with chronic pectoralis major tears.