立安散이 Angiogenesis 抑制棋戰에 미치는 影響

李紀龍,崔昇勳,安圭錫 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1

This experimental study waas carried out to evaluate the effect of Yipahnasn on angiogenic inhibition mechanism. This study investigates the effects of Yipahnsan on angiogenic inhibition mechanism evaluate cell adhesive inhibition effect, DNA fragmantation analysis, nuclear condensation assay, FACScan analysis, angiogenic lumen formation assay, immunocytochemistry analysis, RT-PCR cor mRNA expression, western blot analysis, confocal analysis for Ca^2+influx. The results were wummarized as follows: 1. The cell adhesive inhibition ability was strongly increased from 5ug/ml on ECV304 cell line and ECVPAR cell line. 2. YY water extract caused G_0/G_1 arrest peak to existed on the ECV304 cell line. 3. YY water extract caused inhibition of proliferation and inducement of apoptosis on the collagen coated plate in ECV304 cell line. 4. YY water extract inhibited the lumen formation on the matrigel coated plate in ECV304 cell line. 5. YY water extract inhibited the expressions of LFA-1 and ELAM-1 on ECV304 cell line and ECVPAR cell line. 6. YY water extract inhibited the expressions of MMP-9 and uPA on ECV304 cell line and ECVPAR cell line. 7. YY water extract inhibited the expressions of integrin α_vβ_3 on ECV304 cell line and ECVPAR cell line. 8. YY water extract dereased the change of Ca^2+ in intracellular on ECV304 cell line and ECVPAR cell line. According to the results, Yipahnsan showed to be a key antagonist of integrin α_vβ_3 and to be induction of apoptosts by p53 through flow cytometry. This report also demonstrated that expressions of MMP-9 and uPA were blocked under the angiogenesis model. Thus, we suggested that Yipahnsan blocks angiogenesis by inducing apoptosis in ECV304 and ECVPAR cell lines, and another oriental herbal medicine that treats qi-stagnation and hlood-stasis type also has angiogenic inhibition effects.

자산감액 손실 현황과 회계규정의 개선방안

박기석,이태정,현수룡 한국세무회계학회 2004 세무회계연구 Vol.14 No.-

본 연구는 우리나라 기업회계기준과 해석 등에 산재된 자산감액손실 관련 회계규정을 검토하고 상장기업의 자산감액손실의 현황과 특징을 살펴봄으로써 문제점과 해결방안을 제시하고자 하였다. 연구결과 자산감액회계는 일부 특정 기업의 재무상태와 일부 계정과목에 중대한 영향을 미치고 있으며, 자산감액손실을 계상하는 기업이 증가추세에 있는 것으로 나타났다. 그러나 현행 회계기준은 감액손실의 인식과 환입에 대하여 재법적인 내용만 담고 있을 뿐이며 실무 적용에 있어서의 구체적인 지침은 마련되어 있지 않은 것으로 나타났으며, 토론서 제16호는 현행 기업회계기준의 문제점을 상당히 개선하고 있는 것으로 보이지만 실무 적용을 위한 구체적인 지침을 제시하지 못하고 있다. 따라서, 향후 자산감액손실에 대한 회계처리기준을 정립하기 위해서는 첫째, 자산의 구분과 적용범위, 사용가치의 추정방법, 감액손실의 추정방법 등에 대한 구체적인 실무지침을 제시하여야 할 것이며, 둘째, 자산감액손실의 엄격한 인식기준과 상장기업의 감액손실 공시의 적시성을 확보, 이익관리의 수단으로 악용 가능성 방지를 위한 관련 법규 등의 개정 등이 검토되어야 할 것이다.

산업근로자의 식생활 의식행태 조사

김무룡,황연자,차경미,이순자,위광복,남철현,김기열,김홍길 慶山大學校 保健福祉硏究所 1997 保健福祉硏究 Vol.1 No.-

This study was carried out to grasp the awareness and habits of food intake and use the information for health education program in order to help healthy dietary life. The survey was done in cooperation with health manager in industries on 1,200 workers who was selected randomly from 5 types of industries from Sep. 2 to Oct. 31, 1995. The results are summarized as follows: 1) The percentage of subjects who assess themselves "Healthy" was more higher in female, in 20∼29 age group, in single, in daytime workers, in college graduate than other groups respectively. 2) As for the degree of health education satisfaction, 35.5% of the subjects answered "dissatisfaction" 3) As for the exercise, 52.7% exercised for their health and the rate of exercise was more higher in male, in 30 years age group, in single than other groups respectively. 4) The rate of smoking was 57.6% and the rate of drinking alcohol was 47.3%. 5) 92.8% of the subjects got stress everyday and the rate is more higher in female, in less than 19 years old, in single, in longer working duration, in lower income, in high school graduates, in workers of product field line than other groups respectively. 6) As for drinking times of coffee or soft drink, two times per day was 29.5%, more three times per day was 28.0%. As for the eating speed of meal, 46.0% of the subjects answered "fast" and the rate was more higher in male, in 30 years age group, in married group, than other groups respectively. 7) With regard to the level of preference to instant food, 23.1% preferred to take instant food. As for the level of preference to hot and salty food, 28.1% preferred to have hot and salty food. 8) The score of eating behavior was 3.38±32 point to 6 point full marks. 9) With regard to the correlation among related variables, the variables of gender, marital status and working duration had positive relation with the variables of regular meal intake, the preference to food intake between regular meals.

疎風湯의 消炎·鎭痛作用에 관한 硏究

劉善美,林起龍,嚴基鎭,文永熙 조선대학교 약학연구소 1993 藥學硏究誌 Vol.15 No.1

This study was attempted to examine the effect of Sopung-Tang extract(STE) on anti-inflammatory action in rats, analqesic action and the acute, subacute toxicity in mice. In anti-inflammatory activity in rats, STE was shown to have significant preventive effect in the edema induced by Freund's conplete adjuvant and 5% acetic acid. In analgesic activity in mice, STE was shown to have significant analgesic action on the writhing syndrome in mice induced by 0.7% acetic acid. In acute toxicity test in mice, STE showed 10% mortality at 2000㎎/㎏ . and 1200㎎/㎏ i.p. In subacute toxicity test in mice, STE was not showed for 19 days. Serum uric acid in treated by adjuvant method rats were slightly decreaced by comparing with the control group. During the administration of extracts the body weight increased, but the liver and spleen weight was not changed.

大羌活湯의 消炎 鎭痛作用에 관한 硏究

金度植,林起龍,李炳柱,엄기진,文永熙 조선대학교 약학연구소 1992 藥學硏究誌 Vol.14 No.1

Experimental studies were conducted to investigate for the effect of Daeganghwal-Tang(DHT) extract on the anti-inflammatory activity, analgesic activity, subacute toxicity and acute toxicity. The following results have been obtanied ; In the anti-inflammatory activity in rats, DHT extract (300,600㎎/㎏ p.o) was shown remarkable preventive effect in the edema induced by Freund's complete adjuvant and 5% acetic acid. In analgesic activity test in mouse, DHT extract(300,600㎎/㎏ p.o) was shown significant analgegic activity in mouse induced by 0.7% acetic acid. In acute toxicity test in mouse, DHT extract showed10% mortelity at DHT extract 1.200㎎/㎏ i.p. and 2,000㎎/㎏ p.o.. In subacute toxicity test in mouse. DHT extract was not showed toxicity for 19 day. Uric acid in the serum of the treated rats by Freund's complete adjuvant were slightly decreased by comparing with the control group. During the administration of DHT extract, The body weight increased, but the liver and spleen weight was not changed by comparing with the control group. .

최근 Flat Scanner와 기술 동향에 관한 분석

김두식,정기영,유건룡 혜전대학 1998 論文集 Vol.16 No.-

These days, the scanner systems is one of the electronic products which the speed of development is very fast. It has the inseparable relation to computers, its application has extended to INTERNET. In this paper, we research the its internal structure and the field of the related application regarding the color flat scanner system. Specially we have analyzed its architecture in detail; Opto-Mechanical system, Electronic system, Function block diagram, CAL, VIN Test etc., choose the VISTA-T630 model as a sample. Day by day the computer´s function has been elevated, also the processing technology for the graphics become to diversify. Therefore, many kinds of peripherals have appeared, but our realistic given conditions are inclined to the investment for the field of data communications, disregard that on concerning the image capturing equipments. All of technology can not develop suddenly, so we hope to pave the developing way for the field of scanners by this paer.

대학생의 노인복지에 대한 인식도

차병준,김무룡,김기열,차경미,김귀희,김현실,서인선,임상규,이순자,위광복,남철현 慶山大學校 保健福祉硏究所 1999 保健福祉硏究 Vol.2 No.-

The purpose of this study is to grasp the change of consciousness of young people in order to seek new approach of policy for aged era. 1,200 students attending collages and universities in three small or medium sized cities were inquired for 2 months, from October 1 to November 30, 1996. The result is as follows. 1. The characteristic of the respondents of this survey is that they include 72.1% of women, 40.4% of people aged between 20 to 21, and 49.1% of people who do not have any religion. Those who are from big cities and those who are form farming villages or fishing village occupy equally 40.2%, those who reside in that cities for a long period 49.0%, and those who live with their family 60.9%. 2. The family feature of the subject is that 31.5% of them are those whose father is the age of 55 and more than 55, 10% of them are those whose mothers age is so, 33.1% of them have 5 family members, 29.5% of them have the family income of 1,000,000 to 1,490,000 won, 83.9% of them are from middle class, 47.7% of them are the people whose grand parents have passed away, 70.4% of them live apart from their grand parents, and 60.9% of them are second child. 3. 64.0% of males, 70% of respondents who are aged over 24, 58.1% of respondents who are from rural communities, 62.4% of respondents who live in rural area, and 58.3% of respondents who live alone, prefer to live with grand parents, marked higher rate than other groups. The groups whose father and mother are the age of more than 55 marked higher rate of 55.9% and 58% each than any other groups(p<0.05). The groups whose family member is less than three, whose grand parents both have passed away in middle class, who live with their grand parents, and who are second children, give more positive answers than any other groups. 4. Those who are older, who are buddhists, who are from rural area or live in rural area, whose family is small, whose family income is small, who are from lower class and whose grand parents are still alive, shows preference to support their parents after marriage. 5. Females(89.4%), those who are from small or medium sized cities(89%), who live with their family(85.6%), whose father is the age of 55 and more than 55, whose mother is the age of 54 and less than 54, whose family member is 6, who are from middle class, whose grandparents are still alive and who are the eldest child in their family, give more response that they prefer to live apart from their children in their old age than any other groups. 6. What elderly people need most right now is past time(42.3%), and the respondents whose age is 20 to 21, who are buddhists, who are from middle sized cities and live alone, whose parents are the age of more than 55, who have small family income, who live with their grand parents and who are second children show higher level than any other groups. 7. 76.8% of respondents answer that they do not need their parent's fortune, marked still higher rate than the opposite answer. Those who are older, who are buddhists, who are from big cities, who reside in rural area, who live alone and have smaller family, who are in bad family economic conditions and who live with grand parents present higher rate of positive response. 8. 59.3% of respondents reply that they think about death from time to time, and those who are female, who are in the age of 20 to 21, who are christian, who live with their family, whose siblings or other family members offer their education expenses show higher rate than any other groups. 9. 92.3% of respondents answer that the budget for welfare facility for elderly people is very small. The younger the respondents are and the worse economic condition they have among those who live in big cities, the more answered that. 10. 50% of respondents think social security should provide for their old age, and 42.8% of them believe they themselves provide against it. The respondence that social security ought provide for it appeared more among those whose age are over 24, who are female, who reside in rural area, who are christian, who are in bad economic condition, and who ever used medical institutions in recent one month, marked higher level than other groups. 11. The adequate time of retirement is 59.97±5.60 for public officers, the highest and 59.28±6.35 for teachers, the next. 12. 35.2% of respondents reply that the adequate budget for the old age after their retirement at the age of 60 is 220 million won, showed the highest level of respondence. 13. The factors which affect on the old people in the charged welfare facilities are sex(p<0.01), the type of housing(p<0.05) and whole family income(p<0.05). 14. The factors which affect on remarriage are sex(p<0.05) and religion(p<0.05). For varying old population and expanded welfare service for them, government and relevant authority should give more attention to secure the budget, establish effective plans to expand various program and the facilities for elderly people in order that elderly people spend the rest of life time more happily and more fruitfully. To do that, each college and university should open Health courses, and educate and inform about health and welfare.

早泄의 病理에 關한 文獻的 考察

安圭錫,李紀龍 대한동의병리학회 1993 동의생리병리학회지 Vol.8 No.-

연구배경 : 성문제는 숭고한 목적을 내포한 생활의 일부분을 차지하고 있다. 그러나 일반인은 물론 전문의학자도 이에 관한 문제를 지나친 도덕상의 문제로만 다루는 경향이 있으므로 그 본질에 대한 연구가 다른 분야에 비하여 적다. 본 연구는 성문제 중에서 사춘기 이후의 남성에게 나타나는 早漏에 대하여 精이 충실하거나 感與이 지나쳐서 설정하는 일시적인 생리적 현상보다는 병적인 조루의 병리에 대하여 한·양방 여러 문헌을 중심으로 검토하여 봄으로서 早漏의 치료에 대한 辨證施治의 기초를 제공하기 위하여 시행되었다. 방법 : 한·양방 서적중에서 早漏에 관계된 文獻을 拔萃하여 그 중 早漏를 일으키는 病因 및 病理에 대하여 文獻을 나열하였다. 결과 : 早漏를 일으키는 원인은 명문화쇠, 신기불고, 상화망동, 간기울결로 나눌 수 있었다. 결론 : ① 명문화쇠는 신양허쇠를 말하며 심양허와 신음허를 수반하기도 한다. ② 신기불고는 봉장, 고삽하는 기능이 소실되므로 불능제화한다. ③ 상화망동은 심신불교와 심음허를 상화가 편성하여 일어난다. ④ 간기울결은 장부간의 평형실조에 의한 정신적인 변동으로 일어난다.

猪笭湯이 實驗的 賢贓障碍家兎에 미치는 影響

文永熙,金美淑,李炳柱,林起龍 조선대학교 약학연구소 1991 藥學硏究誌 Vol.13 No.1

This study was attempted to investigate the effect of Jueryeong Tang(JRT) on renal failure of the rabbit treated with folate. Serum creatinine, blood urea nitrogen and serum uric acid in folate-treated rabbits were markedly increased and creatinine clearance was decreased by comparing with the normal group. JRT(900㎎/㎏) given orally produced significant reduction in concentration of both serum creatinine and blood urea nitrogen by comparing with the corresponding folate-treated group. while did increased clearly in creatinine clearance. The morphological changes of arcuate arteries and glomeruli evoked by folate treatment were almost returned to normal state after administration of JRT. (900㎎/㎏). These experimental results suggest that JRT may greatly improve renal failure of the rabbit induced by folate treatment.

청각 자극용 전기자극기 개발

허승덕,정동근,김리석,김광년,강명구,김재룡,김기련 한국음성과학회 2004 음성과학 Vol.11 No.3

This paper introduces a development of an electrical stimulator for auditory stimulation. The electrical stimulator is useful in neurotological diagnosis, audiological evaluation, candidate selection for cochlear implantation, optimal device selection and decision making of MAP strategy for severe-to-profound hearing impaired persons. The development was based on sound parameters of auditory brainstem responses and auditory electrophysiological characteristic such as effective firing of auditory nerve and recording evoked potentials during refractory period of neuron. Besides pulse parameter could adjustable by programming for more varied electrical stimulation evoked response audiometry. Using the electrical stimulator, electrical square pulse was applied to promontory, and electrically evoked auditory brainstem response and electrically middle latency response were successfully recorded in cats.