국내 레미콘사의 부순모래 사용실태 조사

김기훈,金虎林,金光華,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

Crushed sand is made by crushing the rock artificially. With the wide shortage of natural fine aggregates at all regions in Korea. crushed sand has been increasingly consumed as a alternative aggreagtes of natural sand. But there is insufficient information related to the actual situation on the produce. quality and manufacturing company of crushed sand. In this paper. survey is performed in order to know actual consumption situation of crushed sand through ready mixed concrete company in domestic. The remicon companies using crushed sand were estimated with 55%. According to the using method of crushed sand. most remicon company used fine aggregates by mixing natural sand and crushed sand. It is found that natural sand is replaced by crushed sand by about 20~50%. For quality problems in using crushed sand. grain shape. grade and fine particles shall be improved to meet the quality requirement of remicon and wide application. Therefore. it is found that quality improvement of crushed sand is required.

Polar 변환을 이용한 의료영상에서의 강인한 워터마킹 기법

남기철,김영희,박무훈 국립7개대학공동논문집간행위원회 2003 공업기술연구 Vol.3 No.-

In this paper, we propose a robust watermarking against RST attacks in medical images on the PACS. The proposed scheme modifies and improves Log-Polar Mapping and Fourier Mellin Transform in order to realize and recover serious image degradation and watermark data loss caused by the conversion between cartesian coordinate and log-polar coordinate. We used the radius and theta Look Up Table to solve the realization of the Fourier Mellin Transform, and inserted a watermark into 2D-DFT magnitude using the Spread Spectrum. Experimental results show that this method is robust to rotation attack.

養液裁培에 의한 상추의 物質生産 및 光合成에 特性에 關한 硏究

許煇,柳慶烈,崔基準 충북대학교 농업과학기술연구소 1993 農業科學硏究 Vol.10 No.2

These experiments were carried out for three terms (1st : 5/23-6/28, 2nd : 8/14-9/l9, 3rd : 9/20-l1/11) to investigate the rate of Dry Matter Production and Photosynthesis of hydroponically cultivated lettuce. The results were obtained as follows : 1.The number of Lettuce leaf in each culturing term was higher in the third term than in others and the emergence rate of the 1st term was the factest one. 2.Among the terms, the photosynthetic activity was in its highest in the 1st term. Progressing curve of photosynthesis during the day showed similar patterns but the highest rate of photosynthesis occurred at noon in the first term, 1 P.M. in the second term, and 11 A. M. in the third term. 3.Fresh weight of the 3rd term increased to 158% compared to that of the 1st term. However, that of the 2nd term decreased to 54% and the rate of dry weight and of specific leaf area decreased, too.

立安散이 Angiogenesis 抑制棋戰에 미치는 影響

李紀龍,崔昇勳,安圭錫 대한한방종양학회 1998 대한한방종양학회지 Vol.4 No.1

This experimental study waas carried out to evaluate the effect of Yipahnasn on angiogenic inhibition mechanism. This study investigates the effects of Yipahnsan on angiogenic inhibition mechanism evaluate cell adhesive inhibition effect, DNA fragmantation analysis, nuclear condensation assay, FACScan analysis, angiogenic lumen formation assay, immunocytochemistry analysis, RT-PCR cor mRNA expression, western blot analysis, confocal analysis for Ca^2+influx. The results were wummarized as follows: 1. The cell adhesive inhibition ability was strongly increased from 5ug/ml on ECV304 cell line and ECVPAR cell line. 2. YY water extract caused G_0/G_1 arrest peak to existed on the ECV304 cell line. 3. YY water extract caused inhibition of proliferation and inducement of apoptosis on the collagen coated plate in ECV304 cell line. 4. YY water extract inhibited the lumen formation on the matrigel coated plate in ECV304 cell line. 5. YY water extract inhibited the expressions of LFA-1 and ELAM-1 on ECV304 cell line and ECVPAR cell line. 6. YY water extract inhibited the expressions of MMP-9 and uPA on ECV304 cell line and ECVPAR cell line. 7. YY water extract inhibited the expressions of integrin α_vβ_3 on ECV304 cell line and ECVPAR cell line. 8. YY water extract dereased the change of Ca^2+ in intracellular on ECV304 cell line and ECVPAR cell line. According to the results, Yipahnsan showed to be a key antagonist of integrin α_vβ_3 and to be induction of apoptosts by p53 through flow cytometry. This report also demonstrated that expressions of MMP-9 and uPA were blocked under the angiogenesis model. Thus, we suggested that Yipahnsan blocks angiogenesis by inducing apoptosis in ECV304 and ECVPAR cell lines, and another oriental herbal medicine that treats qi-stagnation and hlood-stasis type also has angiogenic inhibition effects.

Tubulin Polymerization에 대한 Colchicine의 영향

최병훈,권기량,임규,황병두 충남대학교 의과대학 지역사회의학연구소 1990 충남의대잡지 Vol.17 No.2

Although the inhibition of microtubule assembly by colchicine is well established, the paradoxical effect of colchicine in the centriole, cilia and basal body is not clear. The microtubule(MADBP^+) was prepared from rabbit brain through 2 cycles of glycerol-and GTP-mediated polymerization and the tubulin without DNA binding protein(MADBP^-) was prepared from MADBP^+ using double strand DNA column chromatography and the properties of these tubulin preparation were compared with those of MADBP^+. The time course of tubulin polymerization was different, with MADBP^+ being sigmoidal and MADBP^- being hyperbolic. MADBP^+ polymerization could be inhibited by colchicine, whereas MADBP^- polymerization could not. There was little difference in colchicine binding activity between MADBP^+ and MADBP^- and the initial binding velocity of MADBP^- was faster than MADBP^-. From the above results, the possible existence of colchicine sensitive protein among microtubule associated DNA binding proteins was discussed.

설갑상선 : 1 예 보고 A Case Report

한기석,배일헌,차상훈,김성진,박길선 충북대학교 의과대학 충북대학교 의학연구소 2003 忠北醫大學術誌 Vol.13 No.2

갑상선 조직 전체가 설기저부에 발생한 이소성 설갑상선 증례를 경험하였기에 그 방사선학적 소견을 문헌고찰과 함께 보고하고자 한다. 증례는 59세 여자 환자로 40 일전부터 발생한 음성 변화를 주소로 내원하였다. 이학적 검사에서 설 기지부 중앙에 회백색의 격막에 둘러 쌓인 3 cm 가량의 종괴가 있었으며, 종괴는 내장으로 돌출하여 구인두를 막고 있었다. 경부 전산화 단층촬영 측면 정찰 촬영에서, 설 기저부에 후방으로 돌출하여 구인두를 막고 있는 경계가 분명한 연부조직 종괴가 보였으며, 전산화 단층촬영 동맥기와 정맥기에 주변의 혈관과 비슷한 강하고 균일한 조영증강을 보이는 장경 2.5 cm의 원형 종괴가 있었다. 또한 갑상선이 있어야 할 경부 전방 공간에서 정상 갑상선 조직은 전혀 보이지 않았다. 설 기저부의 종괴에서 생검을 시행하였으며 병리 검사에서 갑상선 조직으로 진단되어 설갑상선으로 확진되었다. The authors report a case of ectopic thyroid that whole thyroid tissue was replaced by lingual thyroid. A 59-year-old female presented with dysphonia duration of 40 days. On physical examination, there was a 3 cm sized well encapsulated whitish mass protruding to oral cavity in milline of tongue to base. Computerized tomography of neck revealed homogeneously enhancing well marginated 2.5 cm sized round mass in the cecum of tongue base on arterial and venous phase. And there was no normal thyroid gland in lower anterior neck.

MEMS 관성센서를 이용한 차량 자세인지 시스템

이정훈,김기택 강원대학교 정보통신연구소 2008 정보통신논문지 Vol.12 No.-

This study has shown the system acquiring information of vehicle posture and rotational direction to be used by the interlock with GPS Navigation system with MEMS inertial sensor(acceleration sensor and angular velocity sensor) and geomagnetic sensor. By using acceleration sensor like accelerometer this study was to know whether the vehicle was moving upward or downward by acquiring the information of pitch for vehicle during driving. Based on this information this was used to judge it fast whether the vehicle enter to elevated highway, uphill road, and downhill. In addition, this study has shown that it could acquire information of vehicle's rotational direction(yaw) and of moving direction by using the accelerometer and geomagnetic sensor. On the basis of it this study could find the escape of route fast during moving vehicle. When it uses various MEMS sensors, it can be more intelligent and effective navigation than the system using existing GPS only. Accordingly, this study was to suggest methods of sensing, data acquisition, data processing, and simulation for sensors.

인슐린 비의존형 당뇨병 환자에서 24시간 혈압 변동 및 요중 알부민 배설량에 관한 연구

주기산,안기완,정종훈,배학연,홍순표 조선대학교 1995 The Medical Journal of Chosun University Vol.20 No.1

Recently, blood pressure(BP) starts to increase in close relationship to development of persistent microalbuminuria in diabetes. Thus, author studied 24-hour BP changes in diabetics compared to the those in nondiabetics and the changes of urinary albumin excretion (UAE) according to 24-hour BP changes in diabetics with microalbuminuria. Twenty-four-hour ambulatory blood pressure monitoring(ABPPM) was performed in 38 NIDDM patients(18 normotensives and 20 hypertensives) and in 37 control subjects without diabetes(18 normotensives and 19 hypertensives) . Also 24-hour ABPM was performed in 38 diabetics (20 microalbuminurit and 18 normoalbuminuric). The analysis of individual recordings allowed us to detect an impaired circadian pattern(the disappearance of the nocturnal BP decrease or a paradoxical BP increase) in 30% of the normotensive and 31% of the hypertensive diabetics. Twenty-four-hour ABPM(night systolic/diastolic ±SD mmHg) was significantly higher in microabluminuric(124.2 ±11.4/75.1±8.2 mmHg) than in normoalbuminuric subject, (114.0±7.6/64.6±6.6 mmHg, p<0.05). This study suggests that not only awaking BP but also especially day-night minimum SBP decrease are highly responsible for the renal impairment in NIDDM patients, unrelation to hypertension. Thus. ABPM reflects the association between UAE and blood pressure in diabetics more precisely than clinical measurements. and a significant correlation exists between rate of increase in Urinary albumin excretion and blood pressure in diabetics.

인공 치아우식 발생 모델에서 디지털 방사선 공제술을 이용한 인접면 치아우식증의 진단

박정훈,최용석,황의환,이기자,최삼진,박영호,김경숙,진현석,홍경원,오범석,박헌국 대한구강악안면방사선학회 2009 Imaging Science in Dentistry Vol.39 No.1

Purpose : The purpose of the experiment was to evaluating the diagnostic ability of dental caries detection using digital subtraction in the artificial caries activity model. Materials and Methods : Digital radiographies of five teeth with 8 proximal surfaces were obtained by CCD sensor (Kodak RVG 6100 using a size #2). The digital radiographic images and subtraction images from artificial proximal caries were examined and interpreted. In this study, we proposed novel caries detection method which could diagnose the dental proximal caries from single digital radiographic image. Results : In artificial caries activity model, the range of lesional depth was 572-1,374 μm and the range of lesional area was 36.95-138.52mm². The lesional depth and the area were significantly increased with demineralization time (p<0.001). Furthermore, the proximal caries detection using digital subtraction radiography showed high detection rate compared to the proximal caries examination using simple digital radiograph. Conclusion : The results demonstrated that the digital subtraction radiography from single radiographic image of artificial caries was highly efficient in the detection of dental caries compared to the data from simple digital radiograph.

Clozapine이 백서의 억제된 자발적 교대 행동에 미치는 영향

천강훈,이기철,이정호,최영민,전성일,정홍경,류정환,최미 大韓神經精神醫學會 1998 신경정신의학 Vol.37 No.5

연구목적 : 강박장애의 생물학적 원인론중 세로토닌-도파민 상호작용 가설에 적합한 5-HT₂ 수용체와 도파민 D₂수용체를 동시에 차단하는 약물의 일종인 cloazpine과 세라토닌 재흡수 차단약물인 clomipramine, 그리고 도파민 D₂수용체 차단 약물인 haloperidol을 실험백서의 강박장애 동물모형에 투여하여 자발적 교대 행동에 미치는 영향을 비교, 측정하였다. 그 결과로서 1) 세라토닌 수용체와 도파민 수용체를 동시에 차단하는 약물의 효과를 확인하고, 2) 세라토닌과 도파민 수용체 동시차단 약물의 효과가 확인되면 임상적으로 기존의 세라토닌 재흡수 차단약물에 반응을 보이지 않는 강박장애 환자 치료에 세라토닌 수용체와 도파민 수용체를 동시에 차단하는 비전형적인 항정신병 약물들이 강박장애의 치료에 유용하게 사용될 수 있는 가능성을 제시하고자 하였다. 실험재료 및 연구방법 : 실험동물은 동일한 배에서 출생한 수컷 Spraque-Dawley 백서를 사용하였다. 자발적 교대 행동(spontaneous alternation behaviour : 이하 SAB)을 시험하기 위해 SAB의 기준치를 구하고 난 후, SAB을 차단하기 위한 방법으로 비선택적 세라토닌 순응제인 5-MeODMT(5-methoxy-N, N-dimethyltrytamine)를 투여하였다. 실험백서들을 clomipramine(5㎎/㎏), clozapine(10㎎/㎏), clozapine(20㎎/㎏), haloperidol(0.1㎎/㎏), 그리고 saline(0.2cc) 투여군으로 나누고 21일에 걸쳐서 복강내 주사하였다. 실험약물 투여가 끝난 다음날인 22일째에 5-MeODMT(5-methoxy-N, N-dimethyltryptamine : 1.25㎎/㎏/IP)를 각각의 실험동물군에게 투여하고 실험약물의 만성투여가 5-MeODMT 투여로 억제되는 SAB을 얼마나 호전시키는 지를 측정하였다. 모든 자료는 SPSS for window 7.5으로 통계처리 하였다. SAB의 기준치 5-MeODMT 투여로 억제되는 SAB의 효과, 실험약물의 만성투여에 따른 SAB의 변화는 일원분산분석을 사용하였으며, 사후검증은 Scheffe 검증을 적용하였다. 각 군내에서 기준치와 5-MeODMT 투여로 억제되는 SAB의 변화, 그리고 실험약물의 만성투여에 따른 SAB의 변화는 다중변량분석을 시행하였다. 결과 및 결론 : 역구결과 실험동물은 T-형 미로의 SAB에서 평균 1.33±0.36회의 훈련 기준치를 보였다. 5-MeODMT 주사후 , 실험동물의 SAB치는 3.12±0.63회를 보여 강박행동이 유발하였다. 21일간의 실험약물 투여후, 22일째에 5-MeODMT 주사에 대한 SAB의 반응은 clozapine 투여군과 clomipramine 투여군이 halo-peridol 투여군과 saline 투여군에 비하여 유의하게 낮은 수치를 보여 5-MeODMT투여로 억제된 SAB을 호전시키는 소견을 나타냈다. 각 실험동물군 내에서 각각의 SAB 훈련 기준치와 실험약물 투여 전후에 5-MeODMT 투여로 인한 SAB을 비교한 바, clomipramine 투여군은 약물투여 전에 5-MeODMT로 억제된 SAB이 약물투여후 의미있게 호전되었다. 한편, clozapine 투여군도 약물 투여전에 5-MeODMT로 억제된 SAB가 약물투여후 의미있게 호전되었으며, 이런 SAB의 호전은 clomipramine 투여군보다 우수하였다. 이상의 연구결과로 보아, 강박장애의 생물학적 병리론을 이해하는데 있어 세라토닌-도파민 상호작용 가설이 의미가 있음을 추정할 수 있었다. 향후, 강박장애의 임상치료에서 전형적인 SSRIs 치료에 반응치 않는 환자들에게 세라토닌-도파민 동시차단제인 비전형적인 약물의 단독투여를 시행하는 후속연구를 기대해 본다. Objectives : This study was designed to evaluate the role of the 5-HT₂and dopamine D₂antagonist on spontaneous alteration behaviour which is an animal modal of obsessive-compulsive disorder in rat. On the basis of serotonin-dopamine interaction hypothesis, the effect of clozapine was evaluated by applying the suppressed spontaneous alternation behaviour model. Methods : The apparatus for spontaneous alternation behaviour was a black plexiglas T-maze with distinctive black and white goal boxes. Black guillotine doors separated the start box and the goal boxes from the main body of the T-maze. Small cups of chocolate milk were placed in the corners of both goal boxes. At 24 hours prior to experiment, rats(Spraque-Dawley) food-deprived. The food-deprived rats were put into T-maze, in which both goal boxes were baited with small amounts of chocolate milk. Each rat was given 2 set of 7 trials during which it was placed in the start box and allowed to choose one of the goal boxes for each time. The mean number of choices until the occurrence of spontaneous alternation behaviour were checked. After baseline of the number of choices of spontaneous alternation behaviour was stabilized, the spontaneous alternation was disrupted by nonselective 5-HT agonist, 5-MeODMT(1.25mg/Kg/IP), The experimental animals were stratified into 5 groups :clomipramine(5mg/Kg/IP), clozapine(10mg/Kg/IP), clozapine(20mg/Kg/IP), haloperidol(0.1mg/Kg /IP), and saline(0.2cc/IP) control groups. They all went through 21 days fo treatment(intraperitoneal). The protective effects against the 5-MeODMT-induced disruption of spontaneous alternation behaviour were evaluated on the next day of drug treatment in each group. Results : 1) SAB was suppressed by 5-MeODMT injection. 2) After 21 days of the drug treatment, the clozapine and the clomipramine groups showed significant difference from the haloperidol and the saline control groups in the reversal of 5-MeODMT-induced suppression of spontaneous alternation behaviour. 3) The clozapine (20mg/kg/IP) group was superior to the clomipramine group in the protective effect of 5-MeODMT-induced suppression of spontaneous alternation behaviour. Conclusion : In clinical situation, the we think that atypical antipsychotic drugs those acting as serotonin and dopamine receptor antagonist with no extrapyramidal side effect can be beneficial to improve the symptoms of obsessive-compulsive disorder.