도시열섬현상 저감을 위한 그린네트워크 구축 방안에 관한 연구 : 대구광역시 달서구를 대상으로

김기호,김수봉,정응호 한국환경과학회 2004 한국환경과학회지 Vol.13 No.6

As urbanization has been expanded in Korea, open spaces, such as urban parks and public sites, have been utilized for other uses, and then this bring out environmental changes for the worse. It is expected that these changes become more serious problems due to overpopulation, increasing individualism, and development of transportation. This research base on the consideration of connecting between decreasing urban green spaces and distributed green sites so as to build the substantial plan for the Green Network construction for urban heat island mitigation in Dalseo district, Daegu Metropolitan City. The result were as follow; 1) Connecting existing natural sites to the remained parks green zone made an Ideal form of Green-Network system. 2) Some school sites were selected for usable open spaces in order to build Green-Network system, and the plan connecting together with exist natural sites was suggested. 3) Moreover, the scheme of planting on the road spaces for connecting green spaces was proposed. 4) The devices of planting on the urban riverside for enhancing the role of urban stream to form green network was conceived.

형질전환 제초제저항성 벼 밀양 204호의 농업적 특성

정응기,이기환,원용재,박향미,전남수,최준호,구연충,한창덕,은무영,김태산,남민희 Plant molecular biology and biotechnology research 2005 Plant molecular biology and biotechnology research Vol.2005 No.

This study was conducted to investigated the major characteristics of genetically modified rice of "Milyang 204" originated from Dongjinbyeo compared to a non-transgenic rice varieties Dongjinbyeo and Junambyeo. Basta resistant transgenic rice lines carrying bar gene produced by the Yeongnam Agricultural Research Institute were evaluated for their agronomic characters. The transgenic Japonica rice of "Milyang 204" showed inferior phenotypic traits compared to a non-transgenic rice variety Dongjinbyeo and Junambyeo. On the basis of UPOV (Union Internationale Pour la Protaection des Obtentions Vegetables) and NSMO(National Seed Management Office) the transgenic "Milyang 204" showed difference in some traits out of some agronomic traits, such as leaf color, angle of flag leaf, number of spikelets, culm length, white core and white belly compared to the nontransgenic varieties rice.

대구광역시 중구의 가로수 및 열섬 모자이크 현황 분석

김수봉,정응호,김기호 한국환경과학회 2006 한국환경과학회지 Vol.15 No.4

Bacillus sp. LJ-25가 생성하는 extracellular chitinase의 정제 및 특성

주동식,조덕제,이정석,조만기,이응호 동서대학교부설연구소 1997 연구소 논문집 Vol.2 No.-

The extracellular chitinase from Bacillus sp. LJ-25 was pruified Sephadex G-100 gel filtration, DEAE-Cellulose and CM-Spephadex C25 column chromatography. The pruified chitinase showed a single band on disc and SDS polyacrylamide gel electrophoresis and the molecular weight was estimated to be about 50KDa. The Optimum pH and temperature for the activity of the purified extracellular chitinase were 7.5 and 35℃, respectively. The activity of chitinase was strongly inhibited by metal ions such as Zn²+, Ba²+, Co²+, Mn²+ and Cu²+. The purified chitinase did not hydrolyze N,N??-diacetylchitobiose, N,N, N'-triacetylchitotriose and p-nitrophenol-N-acetyl-β-D-glucosaminide, which are known to be the substrates of exo-type chitinase. The products in hydolysis of colloidal chitin with the chitinase were N-acetylglucosamine, N,N'-diacetylchitobiose and N,N,N'-triacetylchitotriose.

키틴 분해균 Bacillus sp. LJ-25의 분리 및 효소생산 최적화

이정석,주동식,조만기,이응호 동서대학교부설연구소 1997 연구소 논문집 Vol.2 No.-

In order to produce functional chitin oligosaccharides, a chitinolytic becterium was newly screened from the viscera of Korean bony fish, and identified as Bacillus sp. LJ-25. For the production of chitinolytic enzyme, 1.0% nutrient broth and 0.3% colloical chitin was used as nitrogen and carbon source, respectively. The optimal temperature, initial pH and conentration of NaCl for the production of chitinase from Bacillus sp. LJ-25 were 30℃, 6.5-7.0 and 1.0%, rspectively. Chitinolytic activity of Bacillus sp. LJ-25 was increased until the incubation of 168 hours, but after 168 hours, the activity was decreased.

Cyclophosphamide가 흰쥐 혀침샘의 점액질에 미치는 영향에 대한 조직화학

조운복,정길남,조기진,이응희 釜山大學校 師範大學 科學敎育硏究所 2006 科學敎育硏究報 Vol.33 No.-

항암 및 항종양 치료제인 CP가 흰쥐의 혀 미각샘과 점액샘의 형태 및 그 분비물인 점액질에 미치는 영향을 PAS, AB pH 2.5, AB pH 2.5-PAS, AB pH 1.0, AF pH 1.7-AB pH 2.5 및 HID-AB pH 2.5 염색법으로 연구하였다. 1. CP군의 혀 미각샘의 형태적인 변화는 장액샘꽈리의 위축 및 파괴, 장액세포의 세포질과립의 감소 및 소실, 세포질의 공포변성 그리고 일부 도관상피세포의 점액화였으며, 혀 점액샘의 형태적 변화는 점액샘꽈리의 확장, 융합, 파괴, 점액세포의 세포질과립 감소 및 소실, 세포질의 공포변성 그리고 도관상칙의 현저한 점액화였다. 2. 혀 미각샘의 중성점액질이 대조군에 비해 현저히 감소하였으며 극소수의 미각샘세포에서 산성 점액질이 나타났다. 혀 점액샘의 중성점액질과 산성점액질은 대조군에 비해 다같이 현저히 감소하였고 산성점액질 중 sulfomucin은 현저히 감소하였으나 sialomucin은 다소 증가하는 경향을 나타내었다. The effect of cyclophophamide(CP) on the mucins of rat lingual salivary gland was examined by prelectin histochemical methods. Sprague-Dawley rats weighing about 250-300 gm were divided into control and CP groups. Control group was administrated by only drinking water for one week, CP group which was admirdstrated by 0.04% CP in the drinking water for one week. Mucins properties were stained with PAS, AB pH 2.5, AB pH 2.5-PAS, AB pH 1.0, AF pH 1.7-AB pH 2.5 and HID-AB pH 2.5 methods. 1. For the morphologic changes, the lingual gustatory glands of CP group, compared with the control group, were noted atrophy of serous adrd, decrease and disapperance of zymogen granules and vacuolation tn the serous cell. The mucification of duct cells was appeared in CP group. And the lingual mucous glands of CP group, compared with the control group, showed atrophy of mucous acini, and decrease of mudgen granules in mucous cells. Especially, many enlarged, fused mucous acini, and vacuolated mucous cells were detected. The mucification of duct cells increased very notably in CP group. 2. Neutral mucin of the lingual gustatory gland, and add and neutral mucins of lingual mucous gland decreased very remarkably in CP group compared with the control group. Especially, the decrease of acid mucin was more remarkable than that of neutral mucin in the mucous gland. But, in CP group, the mucous cells which secrete sulfomudn decreased, and the mucous cells which secrete sialomucin increased remarkably.

수용성 키토산 유도체를 이용한 방사성 스트론튬의 시험관내 흡착능 및 마우스내 체외배출 효과

김희경,송해미,조덕제,조만기,이정석,이응호 동서대학교 부설 연구소 1996 연구소 논문집 Vol.1 No.-

키토산은 천연착화제로서 효용가치가 높은 무독성의 천연고분자로서 키틴으로부터 탈아세틸화시킨 유도체이다. 키토산에 인산기을 도입한 Water-solubel phosphorylated Chitosam(WSPC)의 Sr에 대한 시험관내 흡착률은 pH 3에서는 97.8%이었으나, pH 5와 pH 7에서는 모두 100%이었다. WSPC를 농도별(0.01%, 0.1%, 1%)로 희석하여 11주령의 ICR 수컷 마우스의 위내로 투여한 직후 Sr을 같은 경로로 처리한 다음, WSPC의 Sr에 대한 체외 배출효과와 골내 잔존률을 평가하였다. 또한 Sr와 농도별 WSPC 처리후 6일째에 척추, 두개골, 대퇴골, 경골, 치아 및 꼬리뼈 등에 대해 Sr 잔존율을 측정하였다. 0.01-0.1% 사이의 WSPC를 접종한 마우스 투여군이 Sr만 경구 투요한 대조군에 비하여 골조직에 잔존하는 Sr의 침착률이 낮게 나타났다.(P<0.01). 또한 방사성 스트론튬의 분뇨를 �蔥�배출 효과 역시 WSPC 처리군이 대조군에 비해 유의성이 인정되었고(P<0.05), 대체로 WSPC 농도가 높을수록 그 효과는 비례하였다.(P<0.05). 본 실험에 사용된 WSPC는 체내에 유입된 Sr을 제거하는데 효과가 인정되어 방사성 스트론튬의 방어약제중 하나로 활용할 수 있다고 판단되었다.

정신분열병 및 정신분열형 장애에 대한 올란자핀의 효과와 안전성

안용민,강대엽,권준수,김창윤,김철응,반건호,신영민,이기철,이동우,이중서,조현상,채정호,김용식 大韓神經精神醫學會 2001 신경정신의학 Vol.40 No.4

연구목적 : 본 다기관 공동임상연구는 국내 환자를 대상으로 새로운 항정신병약물인 올라자핀의 치료 효과와 안전성을 확인하고자 시행되었다. 방 법 : 1999년 7월부터 2000년 3월까지 국내 10개 병원에 방문한 정신분열병 및 정신분열형 장애 105명을 대상으로 비대조 개방 임상연구를 시행하였다. 중등도 이상의 정신병 증상을 지니거나, 부작용으로 약물교체가 필요한 경우 또는 기분장애 증상의 치료가 필요한 환자를 대상으로 하였다. 2∼7일간의 약물 배설기간 후에 1일 10mg의 올란자핀을 투여하였고, 이후로 3∼7일 간격으로 용량을 조절하여 총 8주간 투여하였다. 치료 효과는 PANSS(Positive and Negative Syndrome Scale), BPRS(Brief Psychiatric Rating Scale), CGI(Clinical Global Impression-Severity), MADRS(Montgomery-Asberg Depression Rating Scale), HAM-A(Hamilton Rating Scale for Anxiety)로 판정하였다. 안전성 평가는 자발적인 이상반응 보고, 활력징후와 혈액 검사 및 SAS(Simpson-Angus Scale), BARS(Barnes Akathisia Rating Scale), AIMS(Abnormal Involuntary Movement Scale)척도를 이용하였다. 결 과 : 105명중에서 85.7%인 90명이 8주간의 치료를 완료하였다. 평균 최빈 용량은 일일 16.1(±4.7)mg이었고, 종료시점에서의 BPRS전체 점수가 기저 상태에 비해 40%이상 감소된 반응군은 69.5%이었다. PANSS의 양성 증후군과 일반정신병리 뿐만 아니라 음성 증후군 소척도에서도 유의한 감소를 보였으며, 이 감소들은 치료 초기부터 나타나서 8주간 지속되었다. 43.8%의 피험자가 중등도 이상의 우울증상을 같이 지니고 있었으며, 올란자핀에 의해 MADRS와 HAM-A가 유의하게 감소하였다. 치료 기간 동안에 활력징후에는 뚜렷한 변화가 없었으나 체중은 8주간 지속적으로 증가하였다. SAS와 AIMS는 감소하였으며, 정좌불능증을 제외한 나머지 추체외로 증상의 발생비율도 낮았다. 임상적인 증상이나 징후를 동반하지 않는 ALT/SGPT의 상승을 보였지만 프로락틴을 포함하는 대부분의 혈액 검사상 뚜렷한 이상 변화는 없었다. 결 론 ; 비록 본 임상연구가 비대조 개방 임상연구로서 많은 제한점을 가지고 있지만, 올란자핀이 기존 약물에 내약성을 보이거나 기분증상을 동반하는 정신병에 치료 효과가 있었다. 그리고 기존 항정신병약물 치료시에 문제가 되었던 추체외로 증상과 고프르로락틴 혈증을 포함하는 대부분의 부작용면에서 안전성을 보여 주었다. Objective : This multicenter clinical trial was carried out to investigate the efficacy and the safety of olanzpine for the treatment of Korean patients. Mothod : 105 patients with schizophrenia and schizophreniform disorder, visited at 10 mental or university hospitals, had received an open and non-comparative treatment with olanzapine for 8 weeks. Patients had psychotic or depressive symptoms with the severity above moderate degree or intolerable side effects to previous antipsychotics. After a wash-out period of 2-7 days, 10mg olanzapine was prescribed initially to all the patients, and then the dosage could be adjusted within the range of 5-20mg/day of olanzapine by 3-7 days. Results : 90(85.7%) of 105 patients completed the 8-weeks trial and the mean modal dose of olanzapine was 16.1(±4.7%)mg/day. At the end of the trial, 73 patients(69.5%) were classified as responder, which was defined as 40% or more improvement in BPRS(Brief Psychiatric Rating Scale) score comparing to baseline. There was a significant reduction in the scores of PANSS(Positive and Negative Syndrome Scale)and subscales including negative symptom scores and CGI. Also weekly analysis showed that the reductions in scores were kept on for the whole period of the trial. 43.8% of all the patients had depressive symptoms at the baseline and total scores of MADRS(Montgomery-Asberg Depression Rating Scale) and HAM-A(Hamilton Rating Scale for Anxiety) were also reduced after the trials. Vital signs revealed no clinically significant changes but continuous weight gain was observed during the treatment with olanzapine. The scores of SAS(Simpson-Angus Scale) and AIMS(Abnormal Involuntary Movement Scale) for assessing the EPS(extrapyramidal symptoms)and tardive dyskinesia respectively were significantly decreased and only a few patients reported EPS as adverse events. Although mild and clinically non-significant of ALT/SGPT was observed, most laboratory parameters including plasma prolactin level showed to significant changes during the trial. Conclusions : Although this trial had many limitations because it was a non-comparative and open study, olanzapine showed high efficacy on the positive, negative and depressive symptoms in schizophrenia and schizophreniform disorder.In addition to that, olanzapine showed a substantially favorable safety profile, such as low incidence of EPS and hyperprolactinemia.

Evaluation of Rice genetic Resources Collected from Northeastern regions of China

Eung Gi Jeong,O Yeong Jeong,Hae Yeong Ryu,Won Ha Yang,Choon Ki Lee 한국육종학회 2007 한국육종학회 학술발표회 발표요지 Vol.39 No.-

Optical Neuro - Computing

Eung Gi Paek 한국광학회 1991 한국광학회지 Vol.2 No.3

In this paper, we riview a new type of optical computing-optical neuro-computing-which was inspired to emulate the computational capability of the human brain. Also, recent activities at Bellcore for the implementation of optical neuro-computers are described.