성장호르몬 분비성 뇌하수체 선종에서 소마토스타틴 수용체 (제2아형, 제5아형), G_i2α 및 Pit-1 유전자 발현

류미숙,양인명,박철영,우정택,김성운,김진우,김영설,최영길,김은희,박승준,김국기 대한내분비학회 2002 Endocrinology and metabolism Vol.17 No.2

Background: Mutation of Gs protein subunit (gsp oncogene), detected in about 30∼40% of growth hormone (GH)-secreting pituitary tumors, is associated with an increased long-acting somatostatin analog octreotide sensitivity. However, the mRNA expression of somatostatin receptor (sst) was not changed in the GH-secreting pituitary tumor, regardless of whether they were gsp oncogene positive or negative. This suggests that the expression of genes coding for G_i2α, Pit-1 and the other factors involved in the regulation of secretory activity in somatotrophs is likely to be altered in gsp oncogene positive tumors. We observed the impact of the gsp oncogene on the expression of the genes coding for Gi2, Pit-1 and sst (2&5) in GH-secreting pituitary tumors. Methods: The GH response to octreotide was examined in 13 acromegalic patients before transsphenoidal adenomectomy. Genomic DNA and RNA were extracted from fresh frozen tumor tissues. PCR was performed to amplify and sequence the region between codon 184 and 251 that includes exons 8 and 9 of the Gs gene. Sst2, sst5, G_i2α and Pit-1 mRNA levels were measured by semi-quantitative RT-PCR. Results: Sst2 and sst5 mRNA transcripts were detected in all tumors (7 gsp +, 6 gsp-). The amount of sst transcripts varied considerably varied between the tumors. There were no significant differences in sex, age, tumor size, grade or basal GH levels. Pit-1 and sst2 mRNA levels were not different. In contrast, G_i2 mRNA levels were significantly higher in gsp (+) while sst5 mRNA levels were higher in gsp (-). Conclusion: These data suggests that gsp oncogene may increase Gi2α levels but decrease sst5 mRNA levels. However, Pit-1 and sst2 mRNA expression may not be affected by gsp oncogene. The increased expression of the G_i2α gene might be an inhibitory compensatory response to the action of gsp oncogene

진동에 의한 혈관 내 폐 보조장치의 산소전달 특성

김기범,권대규,이삼철,김성종,정인수,오인혁,김기주,변윤섭,정경락 한국화학공학회 2004 Korean Chemical Engineering Research(HWAHAK KONGHA Vol.42 No.2

본 연구는 급성호흡부전환자를 치료하기 위하여 사용되고 있는 혈관 내 폐 보조장치의 기체전달을 향상시키기 위하여 중공사막에 진동기법을 사용하여 기체전달을 향상시키고자 시도하였다. 그리고 혈관 내 폐 보조장치를 정맥에 삽입하기 전, 혈관 내 폐 보조장치의 설계조건을 실험적 모델을 통하여 기체전달을 예측할 수 있는 예측식을 만들고자 하였다. 실험결과, 본 연구에서는 진동기법이 기체전달을 향상시키는데 효과적임을 확인할 수 있었다. 뿐만 아니라, 충진율과 가징 주파수의 함수관계를 이용하여 기체전달을 예측 할 수 있었다. 실험에 의하여 얻어진 결과는 예측식에 의하여 얻어진 결과와 유사한 결과를 얻었다. 그러므로 본 연구에서는 충진율과 가진 주파수의 함수를 이용하여 VIVLAD의 기체전달을 예측할 수 있었다. In this paper, we tried to improve gas exchange of the vibrating intravascular lung assist device(VIVLAD) using vibrating method in the hollow fiber membrane, for the patients suffering from acute respiratory distress syndrome(ARDS). And we tried to formularize prediction equations to make a prediction about gas transfer for designing intravenous artificial lung assist device, and designed modules under various conditions were studied through an experimental modeling before inserted the artificial lung assist device into as venous. As a result, we are convinced that vibration method is very useful for the has transfer increasing. Also, we can estimate the gas transfer as a function of the packing density and excited frequencies. The gas transfer obtained from the experiment was similar to that from the prediction equation, confirming the usefulness prediction equation. Therefore, we can estimate the gas transfer of the VIVLAD as a function of the packing density and excited frequencies.

科學性과 歷史性

권기철 중앙대학교 인문과학연구소 2001 人文學硏究 Vol.31 No.-

우리나라 한중콘크리트 적용기간의 변화에 관한 고찰

한민철,김경민,신동안,윤기원,한천구 대한건축학회 2004 대한건축학회 학술발표대회 논문집 - 계획계/구조계 Vol.24 No.1(구조계)

In this paper. variations of the period of cold weather concrete in Korea are discussed based on the climate data of Korean Meteorological Adminstration(KMA). Determination of the period of cold weather concrete with the region is done by following Korean Concrete Institute(KCD, American Concrete Institute(ACD and AIJ(Architectural Institute of Japan(AIJ) specification. Present study is compared with previous study done by the authors. Period of cold weather concrete is found to increase with high altitude and in-land and mountain area. Period of cold weather concrete by present study is shorted compared with that of previous study by about 3~6 days regardless of applied specification. Especially. the period of cold weather concrete at southern region near sea is reduced remarkably compared with that of previous study. This is due the rise of mean air temperature by global warming. In the scope of present study, period of cold weather concrete is provided with table and map diagram.

효율적인 컴포넌트 개발을 위한 확장 객체지향 분석 및 설계

왕기철,박경우,고형대 木浦大學校 情報産業硏究所 1999 情報産業硏究誌 Vol.7 No.-

Component Based Development(CBD) is an emerging paradigm of software development. Its goal is composing an application with plug & play software components on the frameworks. This CBD requires existing software analysis and design approaches to be reconsidered. In this paper. we present the extended method from Object-Oriented Analysis and Design. To provide a clear separation of component specification form its design and implementation. we add interface design step and component implementation design step to the process of Object-Oriented Methodology. To provide a method of tracking each step in the development process, we add "use case-behavior-control object-interface mapping table", "component-interface-implementation class mapping table", and "interface-implementation class-integrated implementation class mapping table" to the Object-Oriented Models. Object-Oriented Models could be easily re-engineered to Component System Models by the proposed method. Component System Models also could be easily back tracked by the proposed method.

온도의 변화에 따른 혐기성산발효의 동역학특성에 관한 연구

차기철 연세대학교 보건과학연구소 1997 보건과학논집 Vol.7 No.-

난포기 및 황체기에 있어서 돼지 난관 협부 평활근의 neurotransmitter들의 수축효과에 대한 estradiol-17β및 progesterone의 영향

이민기,노규진,심철수,남윤정,김주현,최상용 慶尙大學校 1991 論文集 Vol.30 No.2

The effects of estradiol-17β or progesterone on the contractility of neurotransmitters on pig oviductal isthmic smooth muscle were investigated. The motility of the isolated smooth muscle was recorded by using physiological recording system. The results were summarized as follows : 1. The contractility induced by histamine or prostaglandin F2α was depressed by the pretreatment of estradiol-17β but was not by the preteatment of progesterone in follicular or luteal stage. 2. The contractility induced by acetylcholine was depressed un follicular stage but excited in luteal stage by the pretreatment of estradiol-17β or progesterone. 3. The contractility induced by norepinephrine was depressed by the pretreatment of progesterone in follicular stage but was excited by the pretreatment estradiol-17β in luteal stage.

批判理論과 市民哲學 : Frankfurt 學派 社會哲學의 한 연구

權奇哲 中央大學校 人文科學硏究所 1992 人文學硏究 Vol.19 No.-

광역 인터넷망에서 Bandwidth Broker를 이용한 단대단 QoS에 관한 연구

柳基漢,徐榮喆 충주대 2004 産業科學論文集 Vol.12 No.-

Current Internet is based on TCP/IP service that follow lots of packet loss or packet delay through the Internet delivery. And this service can't guarantee user's various QoS requirement well. In this paper, we studied the features of current Internet and lots of effort to support Internet QoS such as DiffServ model using Bandwidth Broker. Finally, we confirm the superiority of improved DiffServ model using Bandwidth Broker and analyze end-to-end traffic characteristics by network simulation results.

VDSL 가입자의 환경에 따른 속도 영향성 검토분석

柳基漢,徐炳喆 충주대 2004 産業科學論文集 Vol.12 No.-

VDSL(Very high-bit rate Digital Subscriber Line) is one of xDSL Technology as well as ADSL(Asymmetric Digital Subscriber Line), and it has the fastest transmitting speed among other xDSLs. According to ANSI Standard, VDSL has 13~52Mbps of downloading speed and 1.6~6.4Mbps of uploading speed in asymmetric service, and in case of symmetric service, it provides 13Mbps and 26Mbps of transmission speed in both way. VDSL basically consists of CO(Central Office), ONU(Optical Network Unit), STU(Subscriber Terminal Unit) at home and optical distribution network. Since optical cable is used from CO to ONU and copper wire line is used other than that line, there happens speed problem which is the biggest problem of subscribers. In this thesis, examined the effect of bridge tab within copper wire line and the specifications of subscribers' PC on data transmission speed. It is shown that the factors to decrease data transmission speed were the number of bridge taps, thickness of wire line and length of transmission line and that OS and hardware specifications of subscribers' PC affected data transmission speed. This study investigated data transmission speed by wiring types of bridge taps within copper wire line at subscribers' house and suggested five models best for subscribers' environment to improve data transmission speed.