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2-Cinnamoylthiophene에 대한 Cysteine의 반응 Mechanism에 관한 연구
맹주양,鄭昌雄,張聖根 순천향 대학교 1984 논문집 Vol.7 No.2
The kinetics and mechanism of nucleophilic addition of L-Cysteine to 2-Cinnamoylthiophene over wide pH range were presented and analyzed in detail. The rate constants were determined with UV-spectrophotometer in 50% methanol-water solvent at 25℃. The rate equation which can be applid to over wide pH range was obtained k=?? Anaysis of rate constants suggests that below pH 10, the reaction is initiated by the attack of cysteine molecule, and above pH 12.5, deprotonated cysteine ion attack the molecule.
Outcome of Pallidal Deep Brain Stimulation in Meige Syndrome
Ghang, Ju-Young,Lee, Myung-Ki,Jun, Sung-Man,Ghang, Chang-Ghu The Korean Neurosurgical Society 2010 Journal of Korean neurosurgical society Vol.48 No.2
Objective : Meige syndrome is the combination of blepharospasm and oromandibular dystonia. We assessed the surgical results of bilateral globus pallidus internus (GPi) deep brain stimulation (DBS) in patients with medically refractory Meige syndrome. Methods : Eleven patients were retrospectively analyzed with follow-ups of more than 12 months. The mean follow-up period was $23.1{\pm}6.4$ months. The mean age at time of surgery was $58.0{\pm}7.8$ years. The mean duration of symptoms was $8.7 {\pm}7.6$ years. DBS electrodes were placed under local anesthesia using microelectrode recording and stimulation. After $2.4{\pm}1.3$ days of trial tests, the stimulation device was implanted under general anesthesia. Patients were evaluated using the Burke-Fahn-Marsden Dystonia Rating Scale (BFMDRS). Results : BFMDRS total movement scores improved by 59.8%, 63.5%, 74.1%, 74.5%, and 85.5% during the immediate postoperative period of test stimulation, 3, 6, 12, and 24 months (n = 5) after surgery, respectively. The BFMDRS total movement scores were reduced gradually and the results reached statistical significance in the postoperative period (test period, p < 0.001; 3 months, p < 0.001; 6 months, p = 0.003; 12 months, p < 0.001; 24 months, p = 0.042). There was no statistical difference between 12 months and 24 months. BFM subscores improved by 63.3% for the eyes, 80.9% for the mouth, 68.4% for speech/swallowing, and 87.9% for the neck at 12 months after surgery. The adverse effects were insignificant. Conclusion : The bilateral GPi-DBS can be effective for the treatment of intractable Meige syndrome without significant side effects.
Ghang, Ho-Young,Han, Young-Joo,Jeong, Sang-Jin,Bhak, Jong,Lee, Sung-Hoon,Kim, Tae-Hyung,Kim, Chul-Hong,Kim, Sang-Soo,Al-Mulla, Fahd,Youn, Chan-Hyun,Yoo, Hyang-Sook,The HUGO Pan-Asian SNP Consortium, T Korea Genome Organization 2011 Genomics & informatics Vol.9 No.4
In planning a model-based phylogenic study for highly related ethnic data, the SNP marker number is an important factor to determine for relationship inferences. Genotype frequency data, utilizing a sub sampling method, from 63 Pan Asian ethnic groups was used for determining the minimum SNP number required to establish such relationships. Bootstrap random sub-samplings were done from 5.6K PASNPi SNP data. DA distance was calculated and neighbour-joining trees were drawn with every re-sampling data set. Consensus trees were made with the same 100 sub-samples and bootstrap proportions were calculated. The tree consistency to the one obtained from the whole marker set, improved with increasing marker numbers. The bootstrap proportions became reliable when more than 7,000 SNPs were used at a time. Within highly related ethnic groups, the minimum SNPs number for a robust neighbor-joining tree inference was about 7,000 for a 95% bootstrap support.
The Development of Modularized Post Processing GPS Software Receiving Platform using MATLAB Simulink
Ghang-Ho Kim,Hyoung-Min So,Sang-Hoon Jeon,Chang-Don Kee,Youngsu Cho,Wansik Choi 한국항공우주학회 2008 International Journal of Aeronautical and Space Sc Vol.9 No.2
Modularized GPS software defined radio (SDR) has many advantages of applying and modifying algorithm. Hardware based GPS receiver uses many hardware parts (such as RF front, correlators, CPU and other peripherals) that process tracked signal and navigation data to calculate user position, while SDR uses software modules, which run on general purpose CPU platform or embedded DSP. SDR does not have to change hardware part and is not limited by hardware capability when new processing algorithm is applied. The weakness of SDR is that software correlation takes lots of processing time. However, in these days the evolution of processing power of MPU and DSP leads the competitiveness of SDR against the hardware GPS receiver. This paper shows a study of modulization of GPS software platform and it presents development of the GNSS software platform using MATLAB Simulink™. We focus on post processing SDR platform which is usually adapted in research area. The main functions of SDR are GPS signal acquisition, signal tracking, decoding navigation data and calculating stand alone user position from stored data that was down converted and sampled intermediate frequency (IF) data. Each module of SDR platform is categorized by function for applicability for applying for other frequency and GPS signal easily. The developed software platform is tested using stored data which is down-converted and sampled IF data file. The test results present that the software platform calculates user position properly.
Inhibitory Effects of Ramulus Mori Extracts on Melanogenesis
( Ghang-tai Lee ),( Bong-soo Shin ),( Beom-jun Kim ),( Jeong-ha Kim ),( Byoung-kee Jo ) 대한화장품학회 1997 대한화장품학회지 Vol.23 No.2
It has been observed that local increase in melanin synthesis or uneven distribution can cause local hyperpigmentation or spot. Pigmentary disorders are caused by various factors, including inflammation, imbalance of hormones, and genetic disorder[1]. Recently the harmfulness of Ultraviolet(UV) radiation is increasing due to destruction of ozone layer. Excessive exposure to UV radiation caused post-inflammatory pigmentation[2,3]. Most women want to avoid uneven skin pigmentation. To satisfy this desire many cosmetic companies have been developing melanogenesis inhibitors and finding promising active agents for use in cosmetic preparations for skin whitening. In cosmetic preparations, many inhibitors such as kojic acid[4], arbutin[5], ascorbic acid, and licorice extracts6 have been used as whitening purpose. Plant extracts having an inhibitory effect on melanin formation may be a good choice for cosmetic purpose because of their relatively lower side effects. Therefore, we screened 285 plant extracts for their inhibitory activity in tyrosinase[7]. Of the plant extracts, ramulus mori(the young twig of Morus alba L.) extracts showed potent tyrosinase inhibition activity. We also identified the active compound in the extract.