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Achalasia and Hiatal Hernia: A Rare Association and a Therapeutic Challenge
Georgiana Tutuian,Chloé Leandri,Radu Tutuian,Sophie Scialom,Mahaut Leconte,Anthony Dohan,Romain Coriat,Stanislas Chaussade,Maximilien Barret 대한소화기 기능성질환∙운동학회 2023 Journal of Neurogastroenterology and Motility (JNM Vol.29 No.4
Background/AimsAchalasia and hiatal hernia are rarely associated. The aim of the current study is to explore the clinical and manometric findings in patients with achalasia and hiatal hernia, and to determine if the presence of a hiatal hernia should influence therapeutic management in patients with achalasia. MethodsThis retrospective single center analysis included a group of patients with achalasia and hiatal hernia (study group) and a group of matched patients with achalasia but no hiatal hernia (control group). We recorded demographic, clinical, endoscopic, and manometric parameters and compared initial presentation and treatment outcomes between the groups. ResultsBetween 2015 and 2022, achalasia was diagnosed in 294/1513 (19.4%) patients. Concomitant hiatal hernia was identified in 13/294 (4.4%) patients. Compared to patients with achalasia and no hiatal hernia, patients in the study group had lower Eckardt scores at baseline (5.4 ± 2.0 vs 7.8 ± 2.4; P = 0.005) but similar integrated relaxation pressure. Following treatment, patients in the study and control group had similar clinical success and prevalence of gastroesophageal reflux symptoms. ConclusionsHiatal hernia is rarely associated with achalasia. The presence of a hiatal hernia should not influence treatment decisions in patients with achalasia.
Chemical functionalization and stabilization of type I collagen with organic tanning agents
Madalina Georgiana Albu,Viorica Deselnicu,Ioannis Ioannidis,Dana Deselnicu,Ciprian Chelaru 한국화학공학회 2015 Korean Journal of Chemical Engineering Vol.32 No.2
We investigated the interactions between selected organic tanning agents and type I fibrillar collagen as amodel fibrillar substrate to enable the fast direct evaluation and validation of interpretations of tanning activity. Type Ifibrillar collagen (1%) as gel was used as substrate of tanning and tannic acid, resorcinol- and melamine-formaldehydeand their combination at three concentrations as crosslinking agents (tannins). To evaluate the stability of collagenduring tanning, the crosslinked gels at 2.8, 4.5 and 9.0 pHs were freeze-dried as discs which were characterized by FTIR,shrinkage temperature, enzymatic degradation and optical microscopy, and the results were validated by statisticalanalyses. The best stability was given by combinations between resorcinol- and melamine-formaldehyde at isoelectricpH.
The effect of lavandula essential oils on release of niflumic acid from collagen hydrolysates
Mădălina Georgiana Albu,Laura-Cristina Rusu,Mihaela Violeta Ghica,Durmuș Alpaslan Kaya,Lăcrămioara Popa,Şevket Öztürk,Cristina Dinu-Pîrvu,Ciprian Chelaru,Luminița Albu,Aurelia Meghea,Cornelia Nitipir 한국화학공학회 2016 Korean Journal of Chemical Engineering Vol.33 No.4
The aim of this paper is to design and characterize some drug delivery systems (DDS) based on collagen hydrolysates (H), niflumic acid as a non-steroidal anti-inflammatory model drug and two essential oils of Lavandula officinalis L. (LO) and Lavandula stoechas L. subsp. Stoechas (LS), for use in healing cutaneous wounds with post-lesion inflammatory response. The essential oils are characterized by GC-MS. The wettability capacity of collagen hydrolysate powders was assessed by contact angle measurement. Niflumic acid release was investigated using a modified Franz diffusion cell, and the diffusion coefficient, time-lag and drug flux were determined. The kinetic parameters were found to be influenced by different concentrations and types of essential oils. These therapeutical products, based on collagen hydrolysates and synergistic drug associations, could have potential biomedical application in wound healing treatment.
Law and Order in Cyberspace: A Case Study of Cyberspace Governance in Hong Kong
Dr,Kam C Wong,Georgiana Wong 아시아경찰학회 2003 아시아경찰학회 국제학술회의 Vol.2003 No.-
Hong Kong has been enjoying the benefits brought by the Information Age that has totally changed our private life and business operations. Computer mediated communication has brought people closer in a virtual world surpassing geographical distance, time zone difference, social inhibitions, or cultural barriers. With a high usage and penetration of information technology at households and offices, Hong Kong's economy is increasingly and irreversibly relying on the Internet to operate. At the same time, computers, particularly the Internet, facilitate traditional criminality and bring new crimes of different types. To safeguard the environment for economic restructuring and e-commerce development, the Hong Kong government has made attempts to control computer crime and maintain order in cyberspace. This research project is an attempt to study cyberspace governance and computer crime control in Hong Kong. The report begins with an investigation into the usage of personal computers and penetration of the Internet in the community. It is then followed by an exploration of the nature, prevalence and distribution of computer crime. The article finishes with a comprehensive description and thorough analysis of the approaches adopted by the government in controlling computer crime. Various recommendations in improving cyberspace governance are proposed to foster law and order in cyberspace.
Wong Kam C,Wong Georgiana 아시아경찰학회 2005 Asia Pacific Journal of Police & Criminal Justice Vol.3 No.1
This research project is a first attempt to study cyber space governance and computer crime control in Hong Kong. The report begins with a discussion of the nature, prevalence and distribution of computer crime in Hong Kong. It then embarks on a comprehensive review of Hong Kong Government"s cyber space governance philosophy and computer crime control policy. The article closes with a number of recommendations in improving Hong Kong cyber space governance.
Numerical Investigation of the Pressure-Time Method, Head loss in Developed and Developing Flows
Mehrdad Kalantar Neyestanaki,Georgiana Dunca,Pontus Jonsson,Michel J. Cervantes 한국유체기계학회 2023 International journal of fluid machinery and syste Vol.16 No.4
Hydraulic efficiency is a crucial parameter in estimating the performance of hydraulic turbines. However, the flow rate makes such estimation challenging. Several methods have been developed over the years to measure the flow rate. The pressure-time method is an accurate and inexpensive alternative for flow rate estimation, based on transforming momentum into pressure during the deceleration of a liquid mass. The flow rate is obtained by integrating the differential pressure and the pressure loss history between two cross-sections. In the present work, three-dimensional (3D) computational fluid dynamics (CFD) analyses are performed to investigate in detail the influence of the head loss due to friction over the method accuracy when applied in developing flows. One important novelty of the CFD analyses is the use of the immersed solid method for the valve movement modeling for studying the pressure-time method, which is less expensive and more stable than the dynamic mesh method applied in previous CFD studies. The losses are investigated with the assumptions of constant, quasi-steady and unsteady friction factors and compared with detailed data obtained from CFD simulation. The calculated flow rate is not found to be precisely related to the initial pressure drop based on quasi-steady and unsteady friction factors in developing flows. Therefore, a friction factor correction coefficient is proposed and implemented, decreasing the error. The numerical results are validated with experimental data and compared with the dynamic mesh method.
Clinicopathologic Characteristics of Breast Cancer in Jamaica
Chin, Sheray Nicole,Green, Cheryl,Strachan, Georgiana Gordon,Wharfe, Gilian Asian Pacific Journal of Cancer Prevention 2014 Asian Pacific journal of cancer prevention Vol.15 No.7
Breast cancer is the most common cancer in Jamaican women. This study assessed the clinicopathologic features of cases in a hospital-based specialist clinic in Kingston, Jamaica. A retrospective chart review was performed for the 2-year study period and relevant clinical and surgico-pathologic data were recorded and analyzed. Median age of the 121 breast cancer patients was 52 years (range 22-84, IQR 20) and there was 1 case of male breast cancer. Most patients (65%) were referred from the surgical service after definitive breast cancer surgery, 20% were referred for pre-operative systemic therapy, and 15% had a diagnosis of metastatic disease. The surgico-pathologic group comprised 78 women who were referred for adjuvant therapy. The majority had presented with a palpable breast lump (91%), with median tumour size 3.5cm (range 0.4-13, IQR 4). Most tumours were node positive (56%). Approximately one-third of patients had stage III disease (33%). Most women presented with large palpable tumours and had lymph node involvement confirmed on surgicopathological evaluation, indicative of limited early breast cancer detection. A national screening mammography programme is recommended for detection of earlier lesions. Pre-operative systemic therapy should be considered as an option for eligible patients.
Maria Demeter,Ion Călina,Cătălin Vancea,Murat Şen,Mădălina Georgiana Albu Kaya,Elena Mănăilă,Marius Dumitru,Viorica Meltzer 한국고분자학회 2019 Macromolecular Research Vol.27 No.3
Collagen (C)-poly(N-vinyl-2-pyrrolidone) (PVP) double-network superabsorbent hydrogels were synthesized by e-beam (electron beam) radiation processing, both with the addition of water-soluble cross-linking agents (CA), as well as without CA. The aim of the study was to develop a hydrogel for future application as wound dressings via e-beam radiation cross-linking of two biocompatible polymers. The formation of C-PVP hydrogels was confirmed by Fourier transform infrared (FTIR) spectroscopy and their performance was determined from morphological and rheological experiments, such as sol-gel analysis, swelling capacity, storage (G') and viscous (G'') moduli, cross-linking density, and pore size. Sol-gel analysis was performed in order to determine the gel properties as function of absorbed dose and it was found that the degradation density (p0)/cross-linking density (q0) ratio indicates a negligible contribution of chain scission processes. The rheological data confirmed that the elastic properties were predominant: G' moduli were larger than G'' moduli, as is specific to elastic solids and indicate the formation of a permanent hydrogel network were cross-links are present. Moreover, the swelling studies indicated that the hydrogels have good stability both in deionized water and phosphate-buffered saline (PBS) solution at 37 oC, and superabsorbent properties. The hydrogels network parameters obtained with lower content of CA, could be controlled by changing the absorbed dose.