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Garcia, Manuel,Vocka, Radim,Tuominen, Riku,Gommlich, Andre,Leppanen, Jaakko,Valtavirta, Ville,Imke, Uwe,Ferraro, Diego,Uffelen, Paul Van,Milisdorfer, Lukas,Sanchez-Espinoza, Victor Korean Nuclear Society 2021 Nuclear Engineering and Technology Vol.53 No.10
This work deals with the validation of a high-fidelity multiphysics system coupling the Serpent 2 Monte Carlo neutron transport code with SUBCHANFLOW, a subchannel thermalhydraulics code, and TRANSURANUS, a fuel-performance analysis code. The results for a full-core pin-by-pin burnup calculation for the ninth operating cycle of the Temelín II VVER-1000 plant, which starts from a fresh core, are presented and assessed using experimental data. A good agreement is found comparing the critical boron concentration and a set of pin-level neutron flux profiles against measurements. In addition, the calculated axial and radial power distributions match closely the values reported by the core monitoring system. To demonstrate the modeling capabilities of the three-code coupling, pin-level neutronic, thermalhydraulic and thermomechanic results are shown as well. These studies are encompassed in the final phase of the EU Horizon 2020 McSAFE project, during which the Serpent-SUBCHANFLOW-TRANSURANUS system was developed.
Meza-Espinoza, Libier,Vivar-Vera, Maria de los Angeles,Garcia-Magana, Maria de Lourdes,Sayago-Ayerdi, Sonia G.,Chacon-Lopez, Alejandra,Becerrea-Verdin, Eduardo M.,Montalvo-Gonzalez, Efigenia 한국식품과학회 2018 Food Science and Biotechnology Vol.27 No.2
The enzymatic activity and partial characterization of proteases from Bromelia karatas fruits were evaluated and compared with Bromelia pinguin proteases. The specific activity increased twofold after partial purification in both proteases. Partially purified proteases from Bromelia karatas showed good specific activity at pH 6.0-8.0 and residual activity of 70-100% for 60 min at $37-60^{\circ}C$, similar to Bromelia pinguin proteases. The $K_m$ value of proteases from Bromelia karatas was higher ($253.32{\mu}M$) than that of Bromelia pinguin proteases ($234.94{\mu}M$). The use of specific protease inhibitors indicated the presence of cysteine and serine proteases. Proteases with molecular weight of 66.2-97 and 21-31 kDa were detected. Bromelia karatas proteases registered 73% hydrolysis using a soy protein concentrate, similar to the enzyme activity of Bromelia pinguin proteases and commercial bromelain. These results demonstrate that Bromelia karatas proteases could be a potential alternative protease in the food industry.
Subunit Principle: Key Element for Plantar Reconstruction with Free Sensate Flaps
Blanca Yadira Arambula Sanchez,Daniel De Luna Gallardo,Jaime Aron Garcia-Espinoza,David Flores Soto 대한수부외과학회 2021 대한수부외과학회지 Vol.26 No.1
Purpose: Plantar wounds represent a frequent practice of the plastic and reconstructive surgeon. The uniqueness and high complexity of the microarchitecture and biomechanics of the plantar region explain the complex challenge of its reconstruction. With the advances in microsurgery, including the plantar subunit principle, both applied in the restoration of plantar defects through the use of sensorineural free flaps have allowed an optimal reconstruction. Methods: A descriptive, retrospective study was carried out in a period of time established between January 2016 and January 2019, obtaining a total of 18 patients with plantar defects, reconstructed using sensory free flaps. Tissue stability, recovery of protective sensitivity, early ambulation, and correct use of footwear were evaluated. Results: The most frequent etiology was secondary to oncological resections due to melanoma (n = 12, 66.7%), followed by gunshot wounds (n = 4, 22.2%). Subunit 3 was the most frequently involved in 38.9% (n = 7). In the 88.8% of the cases, was used an anterolateral thigh flap (n = 16) and the lateral antebrachial flap in 22.2% (n = 2). The free flap survival rate was 100%. An average of seven points was obtained at 6 months based on the Semmes-Weinstein test. The mean for the return to their daily activities was 2.5 months. The patients of 94.4% (n = 17) recovered ambulation and could footwear. Conclusion: The reconstruction of plantar defects must have a systematic approached, taking the subunit principle as a central point. The treatment of plantar defects with sensorineural free flaps represent an unprecedented option for optimal reconstruction.