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NEM-FEM comparison on porthole die extrusion of AA-6082
Francesco Gagliardi,Iciar Alfaro,Giuseppina Ambrogio,Luigino Filice,Elias Cueto 대한기계학회 2013 JOURNAL OF MECHANICAL SCIENCE AND TECHNOLOGY Vol.27 No.4
Porthole die extrusion is a forming process used to manufacture hollow components with different shapes. This forming process is optimized to improve the welding line quality. Process optimization can be achieved by determining the influences that each process parameter has on the pressure along the welding plane. The construction complexity of the die results in research difficulty from an experimental point of view. Even the finite element method (FEM) presents relevant drawbacks primarily because of numerical codes are not capable of simulating the welding phase. Hence, the natural element method (NEM), which allows the joining phase of free surfaces,presents significant advantages. In this work, experimental results obtained using a flexible porthole die are discussed. A suitable 2D geometry was extracted from the die, and both FEM and NEM were conducted. A good agreement among the numerical results was recorded.
Rosa Gagliardi,Silvia Llambí,M. Victoria Arruga 대한수의학회 2015 Journal of Veterinary Science Vol.16 No.3
The fields of pharmacogenetics and pharmacogenomics have become increasingly promising regarding the clinical application of geneticdata to aid in prevention of adverse reactions. Specific screening tests can predict which animals express modified proteins or genetic sequencesresponsible for adverse effects associated with a drug. Among the genetic variations that have been investigated in dogs, the multidrugresistance gene (MDR) is the best studied. However, other genes such as CYP1A2 and CYP2B11 control the protein syntheses involved inthe metabolism of many drugs. In the present study, the MDR-1, CYP1A2 and CYP2B11 genes were examined to identify SNP polymorphismsassociated with these genes in the following four canine breeds: Uruguayan Cimarron, Border Collie, Labrador Retriever and GermanShepherd. The results revealed that several SNPs of the CYP1A2 and CYP2B11 genes are potential targets for drug sensitivity investigations.
Inventorying Intangible Cultural Heritage on the Web: a Life-cycle Approach
Maria Teresa Artese,Isabella Gagliardi 국립민속박물관 2017 International Journal of Intangible Heritage Vol.12 No.-
According to the 2003 Convention for the Safeguarding of the Intangible Cultural Heritage of UNESCO, creating inventories and making them accessible is a specific obligation for the States Parties. These activities are complex and require methodological tools to integrate the different backgrounds, competencies and skills needed to succeed. In this paper we will present a framework for the complete management of multimedia information systems related to Intangible Cultural Heritage, that we applied to the design and implementation of the Ethnography and Social History Archive of the Lombardy Region in Italy. We describe the characteristics that distinguish our unified approach, within a broader context of the methodological design of web applications, emphasising the innovative features of the online systems developed. We present the environments for managing, searching and browsing ICH data, with a final comparison.
Cissus sicyoides: Analysis of Glycemic Control in Diabetic Rats Through Biomarkers
Salgado, Jocelem Mastrodi,Mansi, Debora Niero,Gagliardi, Antonio The Korean Society of Food Science and Nutrition 2009 Journal of medicinal food Vol.12 No.4
Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicine as a diuretic, anti-influenza, antiinflammatory, anticonvulsion, and hypoglycemic agent. The objective of this study was to analyze the effects of aqueous extracts from the leaves and stem of C. sicyoides L., administered for 60 days, for the control of glycemia in alloxan (monohydrate)-induced diabetic rats, monitored by biomarkers. Data obtained in this study confirmed that C. sicyoides has a hypoglycemic effect on diabetic rats. Administration of its aqueous extracts promoted a 45% decrease in glucose levels after 60 days of administration. Furthermore, indices of hepatic glycogen, blood glucose, C-reactive peptide, and fructosamine were found to be efficient biomarkers to monitor diabetes in rats.
Andrew J. Muzyk,Jane P. Gagliardi,Gopalkumar Rakesh,Michael R. Jiroutek,Rajiv Radhakrishnan,배치운,Prakash S. Masand,Steven T. Szabo 대한신경정신의학회 2017 PSYCHIATRY INVESTIGATION Vol.14 No.3
Objective: A clinically relevant approach to patient care grounded in neurobiological constructs and evidence based practice which emphasizes a relevant psychopharmacology is needed to optimally train psychiatry residents. Methods: We implemented a biological psychiatry course that now incorporates neurobiology, psychopharmacology, and evidencebased practice in conjunction with a Research Domain Criteria (RDoC) perspective. A survey launched prior to course implementation and following each class session, served as the outcome metric of residents’ attitudes toward the new curriculum and followed a baseline attitudinal survey designed to evaluate the program. Results: Greater than 90% of the psychiatry residents at Duke University who took the attitudinal survey agreed or strongly agreed with needing a course that helped them develop an understanding of neurobiology, psychopharmacology, and evidence-based practice concepts. Most residents also indicated a less than adequate understanding of the neurobiology and psychopharmacology of psychiatric disorders prior to sessions. Conclusion: Our biological psychiatry curriculum was associated with enthusiasm among residents regarding the incorporation of neurobiology, psychopharmacology, and evidence-based practice into course topics and discussions. A biological psychiatry curriculum with integrated neurobiology and psychopharmacology built on an evidence base approach is possible, well-received, and needed in training of future psychiatrists.
Cissus sicyoides: Analysis of Glycemic Control in Diabetic Rats Through Biomarkers
Jocelem Mastrodi Salgado,Débora Niero Mansi,Antonio Gagliardi 한국식품영양과학회 2009 Journal of medicinal food Vol.12 No.4
Diabetes is a chronic degenerative disease with no cure, is found in millions of people worldwide, and can cause life-threatening complications at any age. The plant Cissus sicyoides L. is a runner plant found abundantly in Brazil, especially in the Amazon. Its therapeutic properties are widely used in popular medicine as a diuretic, anti-influenza, anti-inflammatory, anticonvulsion, and hypoglycemic agent. The objective of this study was to analyze the effects of aqueous extracts from the leaves and stem of C. sicyoides L., administered for 60 days, for the control of glycemia in alloxan (monohydrate)-induced diabetic rats, monitored by biomarkers. Data obtained in this study confirmed that C. sicyoides has a hypoglycemic effect on diabetic rats. Administration of its aqueous extracts promoted a 45% decrease in glucose levels after 60 days of administration. Furthermore, indices of hepatic glycogen, blood glucose, C-reactive peptide, and fructosamine were found to be efficient biomarkers to monitor diabetes in rats.
Global Policy Responses to the COVID-19 Pandemic: Results of the ICOH Survey
Rondinone, Bruna M.,Valenti, Antonio,Boccuni, Valeria,Cannone, Erika,Boccuni, Fabio,Gagliardi, Diana,Dionisi, Pierluca,Barillari, Caterina,Iavicoli, Sergio Occupational Safety and Health Research Institute 2022 Safety and health at work Vol.13 No.2
Background: On the basis of its role for the development of occupational health research, information, good practices, the International Commission on Occupational Health (ICOH) launched the present survey to collect information on public health and prevention policies put in place by the governments of the countries in the world to contain the pandemic. Methods: A cross-sectional study was conducted through an online questionnaire focused on COVID-19 data, public health policies, prevention measures, support measures for economy, work, and education, personal protective equipment, intensive care units, contact tracing, return to work, and the role of ICOH against COVID-19. The questionnaire was administered to 113 ICOH National Secretaries and senior OSH experts. Collected data refer to the period ranging from the beginning of the pandemic in each country to June 30, 2020. Results: A total of 73 questionnaires from 73 countries around the world were considered valid, with a 64.6% response rate. Most of the respondents (71.2%) reported that the state of emergency was declared in their country, and 86.1% reported lockdown measures. Most of the respondents (66.7%) affirmed that the use of face masks was compulsory in their country. As for containment measures, 97.2% indicated that mass gatherings (meetings) were limited. Regarding workplace closing, the most affected sector was entertainment (90.1%). Conclusion: The results of this survey are useful to gain a global view on COVID-19 policy responses at country level.