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Effect of high-fat diet on the various morphological parameters of the ovary
Gö,ren Hilal,Topal Fatma,Yü,cel Ferruh,Gü,ler Sabire,Aydar Yü,ksel 대한해부학회 2020 Anatomy & Cell Biology Vol.53 No.1
Increased food consumption rich in fat and carbohydrate and sedentary lifestyle have seriously increased the rates of obesity and obesity-associated diseases in developed countries. Female mice with diet-induced obesity exhibit infertility and thus can serve as a model for human polycystic ovary syndrome. The aim of the present study was to examine how ovary is affected by diet-induced obesity. The effects of high-fat diet (HFD) on ovary morphology in mice fed with HFD were investigated using unbiased stereological methods. The ovary of mice fed with HFD (n=8, C1090-60, Altromine) for 9 weeks, were compared with that of mice fed with standard chow diet (n=8, C1090-10, Altromine). Stereological parameters were obtained in diestrus cycle. The samples were processed through routine and standard paraffin embedding and were serially sectioned in 5-μm thickness then, every 10th section was saved, stained with Crossman’s triple stain for counting and measuring. In all sampled sections mean follicle numbers, diameters, total ovarian volume cortex to medulla ratio (Vv), ovum to cell ratio in secondary follicle were examined in all sampled sections. The present results showed that weight of ovarian and amount of intraperitoneal adipose tissue and the body weight markedly increased in obese mice when compared with control groups. Moreover, follicle numbers (except primordial follicles) and diameters were significantly increased in obese mice. Cortex to medulla ratio (Vv) and ovum to cell ratio in secondary follicle were also considerably different between experimental and the control groups. The present findings indicate that obesity adversely affects overall ovarian morphology.
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Cem Gö tas,Akln Odabasl,Levent Sezera,Filiz Çlnarb,Sule Günerc,Niyazi Eruslua,Necip Ünlü 한양대학교 세라믹연구소 2009 Journal of Ceramic Processing Research Vol.10 No.1
A white-fused low cement refractory castable was prepared from pure refractories that consisted of 77 wt.% white fused alumina, 10 wt.% calcined alumina, 8 wt.% microsilica, 5 wt.% cement and 0.05 wt.% dispersant. Optimum self-leveling flowability was achieved by using 5.6 wt.% water. To determine the effect of the firing temperature on the white-fused low cement refractory castable, studies of apparent porosity (AP), bulk density (BD), water absorption (WA), cold crushing strength (CCS), hardness, X-ray diffraction (XRD) and microstructural-based evaluation using electron probe microanalyser (EPMA) were performed. The present castable heat treated at 1500℃ for 2 h exhibited the following properties: the AP −14%, the BD −3.12 gcm−3, the WA −2.5%, the CCS −2000 kgcm−2 and the hardness −3185 kg㎟. The new white-fused alumina castable presents unique properties that would make it desirable to use in industrial refractory applications. A white-fused low cement refractory castable was prepared from pure refractories that consisted of 77 wt.% white fused alumina, 10 wt.% calcined alumina, 8 wt.% microsilica, 5 wt.% cement and 0.05 wt.% dispersant. Optimum self-leveling flowability was achieved by using 5.6 wt.% water. To determine the effect of the firing temperature on the white-fused low cement refractory castable, studies of apparent porosity (AP), bulk density (BD), water absorption (WA), cold crushing strength (CCS), hardness, X-ray diffraction (XRD) and microstructural-based evaluation using electron probe microanalyser (EPMA) were performed. The present castable heat treated at 1500℃ for 2 h exhibited the following properties: the AP −14%, the BD −3.12 gcm−3, the WA −2.5%, the CCS −2000 kgcm−2 and the hardness −3185 kg㎟. The new white-fused alumina castable presents unique properties that would make it desirable to use in industrial refractory applications.
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Validity and Reliability of the Turkish Version of Generalized Anxiety Disorder Scale-Revised
Anıl Gü,ndü,z,Ibrahim Gü,ndog˘mus,Sencan Sertç,elik,Betü,l Hacer Engin,Aysel I s¸ler,Alis¸an Burak Yas¸ar,Hatice Gö,nü,l,Arif Ç,ipil,Elvan Bas¸ak Usta Gü,ndü,z 대한신경정신의학회 2021 PSYCHIATRY INVESTIGATION Vol.18 No.10
Objective This study aims to assess the psychometric values of the Generalized Anxiety Disorder Scale-Revised (GADS-R) which measures the intensity and duration of worry, various coping and avoidance strategies to cope with worrying, and positive and negative metacognitive beliefs about worrying. Methods 114 patients with generalized anxiety disorder and 198 healthy controls were included in the study. These patients were diagnosed according to DSM-IV TR, and the primary diagnosis of the patients was generalized anxiety disorder which was confirmed via SCID I and II, subsequently. Sociodemographic form, GADS-R total and subscale scores, and Meta-Cognitions Questionnaire-30 (MCQ-30), Beck Depression Inventory (BDI), Beck Anxiety Inventory (BAI), Generalized Anxiety Disorder-7 Scale (GAD-7), and Penn State Worry Questionnaire (PSWQ) were used to assess validity, reliability and cut-off point. Results GADS-R total and subscale scores and MCQ-30, BDI, BAI, GAD-7, and PSWQ were found to be statistically higher in the patients with GAD compared to a healthy control group. GADS-R has five factors and showed relatively acceptable sensitivity and specificity for detecting anxiety disorders at a cut-off point of 1188. Conclusion The GADS-R is a valid and reliable scale that can be used in the Turkish population as an assessment tool.
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