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Impact of patient background factors on the treatment efficacy of once-weekly teriparatide
Fumitoshi Omura 대한골다공증학회 2019 Osteoporosis and Sarcopenia Vol.5 No.2
Objectives: The impact of patient background factors on changes in bone mineral density (BMD) and bone metabolic markers after treatment with once-weekly teriparatide (W-TPTD) has not been fully elucidated. To clarify the impact, I performed stratified analysis in addition to the efficacy and safety assessments to analyze treatment data with W-TPTD. Methods: The primary endpoint of the efficacy was the rate of change of the lumbar spine BMD at 18 months after treatment. In the exploratory analysis, bone metabolic markers at baseline were used to divide the patients into 3 groups, by the first tertile and the second tertile. The rate of change in the lumbar spine/femoral neck BMD and bone metabolic markers in each group were analyzed by stratification. Results: The rate of change in the lumbar spine BMD at 18 months was 9.0%, which represented a significant increase. The rate of change in the lumbar spine/femoral neck BMD in each group classified into tertiles by their baseline bone metabolic markers significantly increased, regardless of the type of bone metabolic markers and baseline value. For markers, all groups remained within the range of reference values at 18 months after treatment. Conclusions: I demonstrated that W-TPTD significantly increased the BMD of the lumbar spine and femur, regardless of baseline values of the bone metabolic markers. In addition, W-TPTD was able to normalize bone metabolic markers. I considered that W-TPTD would be useful, independent of bone metabolic markers in patients, as an agent to improve BMD, and be a useful option for the treatment of osteoporosis.
RELATIONS IN THE TAUTOLOGICAL RING BY LOCALIZATION
Sato, Fumitoshi Korean Mathematical Society 2006 대한수학회논문집 Vol.21 No.3
We give a way to obtain formulas for ${\pi}*{\psi}^{\kappa}_{n+1}$ in terms ${\psi}$ and ${\lambda}-classes$ where ${\pi}=\bar M_{g,n+1}{\rightarrow}\bar M_{g,n}(g=0,\;1,\;2)$ by the localization theorem. By using the formulas, we obtain Kontsevich-Manin type reconstruction theorems for $\bar M_{0,\;n}(\mathbb{R^m}),\;\bar M_{1,\;n},\;and\;\bar M_{2,\;n}$. We also (re)produce a lot of well-known relations in tautological rings, such as WDVV equation, the Mumford relations, the string and dilaton equations (g = 0, 1, 2) etc. and new formulas for ${\pi}*({\lambda}_g{\psi}^{\kappa}_{n+1}+...+{\psi}^{g+{\kappa}_{n+1}$.
Steady-State Characteristics of Resonant Switched Capacitor Converter
Masahito Shoyama,Fumitoshi Deriha,Tamotsu Ninomiya 전력전자학회 2004 ICPE(ISPE)논문집 Vol.- No.-
Conventional switched capacitor converters have an inherent drawback that their efficiency is much decreased as the output current is increased. This inherent drawback is due to a periodical forced charging and discharging operation in the internal switched capacitors accompanied by a large capacitor current, so that their efficiency can not be increased by decreasing its internal resistance. As a result, conventional switched capacitor converters have been limited to be used with a very small output current.<br/> To solve this problem we presented a novel switched capacitor converter topology that uses a resonant operation instead of the forced charging and discharging operation. Its advantage over a conventional switched capacitor converter is a high efficiency even in a high output current region. In this paper, the operation analysis and steady-state characteristics are described in detail for a half buck type switched capacitor converter, and they are confirmed by experiments.
Steady-State Characteristics of Resonant Switched Capacitor Converters
Masahito Shoyama,Fumitoshi Deriha,Tamotsu Ninomiya 전력전자학회 2005 JOURNAL OF POWER ELECTRONICS Vol.5 No.3
Conventional switched capacitor converters have an inherent drawback that their efficiency decreases as the output current increases. This inherent drawback is due to a periodical forced charging and discharging operation in the internal switched capacitors accompanied by a large capacitor current. Their efficiency can not be increased by decreasing its internal resistance. As a result, conventional switched capacitor converters have been limited to uses with a very small output current.<br/> To solve this problem we presented a novel switched capacitor converter topology that uses a resonant operation instead of the forced charging and discharging operation. Its advantage over a conventional switched capacitor converter is higher efficiency even in a high output current region. In this paper, the operation analysis and steady-state characteristics are described in detail for a half buck type switched capacitor converter, and they are confirmed by experimentation.