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BaoHong Zhao,WeiMing Tian,HaiLan Feng,이인섭,FuZhai Cui 한국물리학회 2005 Current Applied Physics Vol.5 No.5
The aim of this study is to test the adhesion of human gingival broblasts (HGFs) and epithelial cells (HGEs) to titanium surfaceby RGD grafting for dental implant, and to obtain an eective perimucosal seal of soft tissue to the implant. RGD peptides werecovalently attached to the titanium surface by CDI activation method to improve the adhesion of gingival cells to the titanium den-tal implants. HGFs and HGEs were inoculated on commercially pure (CP) titanium and RGD-grafted titanium. The number ofattached and proliferated cells was quantied by morphometric analysis using immunouorescence. The results showed that the bio-active peptide RGD was grafted on CP titanium by CDI activation method. The RGD grafting exhibited that the number ofattached and proliferated broblasts and epithelial cells were higher than that on CP titanium. The RGD-grafting is advantageous. to gingival cells adherence to the surface of titanium implant.