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AMPK Promotes Aberrant PGC1β Expression To Support Human Colon Tumor Cell Survival
Fisher, Kurt W.,Das, Binita,Kim, Hyun Seok,Clymer, Beth K.,Gehring, Drew,Smith, Deandra R.,Costanzo-Garvey, Diane L.,Fernandez, Mario R.,Brattain, Michael G.,Kelly, David L.,MacMillan, John,White, Mic American Society for Microbiology 2015 Molecular and cellular biology Vol.35 No.22
<P>A major goal of cancer research is the identification of tumor-specific vulnerabilities that can be exploited for the development of therapies that are selectively toxic to the tumor. We show here that the transcriptional coactivators peroxisome proliferator-activated receptor gamma coactivator 1β (PGC1β) and estrogen-related receptor α (ERRα) are aberrantly expressed in human colon cell lines and tumors. With kinase suppressor of Ras 1 (KSR1) depletion as a reference standard, we used <U>fu</U>nctional <U>si</U>gnature <U>on</U>tology (FUSION) analysis to identify the γ1 subunit of AMP-activated protein kinase (AMPK) as an essential contributor to PGC1β expression and colon tumor cell survival. Subsequent analysis revealed that a subunit composition of AMPK (α2β2γ1) is preferred for colorectal cancer cell survival, at least in part, by stabilizing the tumor-specific expression of PGC1β. In contrast, PGC1β and ERRα are not detectable in nontransformed human colon epithelial cells, and depletion of the AMPKγ1 subunit has no effect on their viability. These data indicate that Ras oncogenesis relies on the aberrant activation of a PGC1β-dependent transcriptional pathway via a specific AMPK isoform.</P>
Behavior of exterior reinforced concrete beam-column joints including a new reinforcement
Fisher, Matthew J.,Sezen, Halil Techno-Press 2011 Structural Engineering and Mechanics, An Int'l Jou Vol.40 No.6
Six reinforced concrete beam-column joint specimens were constructed and tested under reverse cyclic loading to failure. The six specimens were divided into three groups, each group representing a different joint design. The main objectives of this study are to investigate the response of joints with three different design, reinforcement detailing and beam strengths, and to evaluate and compare the responses of beam-column joints reinforced with traditional steel rebar and a recently proposed steel reinforcement called prefabricated cage system (PCS). Each of the three test specimen designs included equivalent amount of steel reinforcement and had virtually identical details. The results of the research show that the PCS reinforced joints had a slightly higher strength and significantly larger deformation capacity than the equivalent rebar reinforced joints.
Fisher, L.A.,Huh, H.s. Wayne State University Press] 2016 JOURNAL OF MACROECONOMICS Vol.49 No.-
This paper estimates SVARs for four small and three large economies. Sign restrictions are used to identify all the shocks in the SVARs, while being agnostic about the sign of the response of the real exchange rate to a relative monetary policy shock. The large number of sets of impulse responses to be judged by sign restrictions for either retention or rejection is generated by a newly proposed method which utilizes instrumental variable estimation. The responses show an absence of an exchange rate puzzle in each economy. The peak appreciation following a contractionary monetary policy shock occurs with at most a one quarter delay in the small countries and, for the United States, on impact. For the Euro region and Japan, the peak appreciation is in the long run. There is considerable model uncertainty in the responses.
Low-Temperature Sintering of Barium Calcium Zirconium Titanate Lead-Free Piezoelectric Ceramics
Fisher, John G.,Lee, Dae-Gi,Oh, Jeong-Hyeon,Kim, Ha-Nul,Nguyen, Dieu,Kim, Jee-Hoon,Lee, Jong-Sook,Lee, Ho-Yong The Korean Ceramic Society 2013 한국세라믹학회지 Vol.50 No.2
The need for lead-free piezoceramics has caused a renewal of interest in $BaTiO_3$-based systems. Recently, it was found that ceramics in the $(Ba,Ca)(Zr,Ti)O_3$ system have properties comparable to those of $Pb(Zr,Ti)O_3$. However, these ceramics require rather high sintering temperatures of $1450-1550^{\circ}C$. In this work, the effect of $TiO_2$ and CuO addition on the sintering behavior, microstructure, dielectric and piezoelectric properties of $(Ba_{0.85}Ca_{0.15})(Zr_{0.1}Ti_{0.9})O_3$ (BCTZ) ceramics will be discussed. BCTZ ceramics were prepared by the mixed oxide route and 1 mol % of $TiO_2$ or CuO was added. Undoped and doped ceramics were sintered at $1350^{\circ}C$ for 1-5 h. CuO was found to be a very effective sintering aid, with samples sintered for 1 h at $1350^{\circ}C$ having a bulk density of 95% theoretical density; however the piezoelectric properties were greatly reduced, probably due to the small grain size.
Generation of Finite Inductive, Pseudo Random, Binary Sequences
Fisher, Paul,Aljohani, Nawaf,Baek, Jinsuk Korea Information Processing Society 2017 Journal of information processing systems Vol.13 No.6
This paper introduces a new type of determining factor for Pseudo Random Strings (PRS). This classification depends upon a mathematical property called Finite Induction (FI). FI is similar to a Markov Model in that it presents a model of the sequence under consideration and determines the generating rules for this sequence. If these rules obey certain criteria, then we call the sequence generating these rules FI a PRS. We also consider the relationship of these kinds of PRS's to Good/deBruijn graphs and Linear Feedback Shift Registers (LFSR). We show that binary sequences from these special graphs have the FI property. We also show how such FI PRS's can be generated without consideration of the Hamiltonian cycles of the Good/deBruijn graphs. The FI PRS's also have maximum Shannon entropy, while sequences from LFSR's do not, nor are such sequences FI random.
ON THE COMMUTATIVE PRODUCT OF DISTRIBUTIONS
Fisher Bring,Tas Kenan Korean Mathematical Society 2006 대한수학회지 Vol.43 No.2
The commutative products of the distributions $x^r\;ln^p\;{\mid}x{\mid}\;and\;x^{-r-1}ln^q\;{\mid}x{\mid}$ and of sgn x $x^r\;ln^p\;{\mid}x{\mid}\;and\;sgn\;x\;x^{-r-1}ln^q\;{\mid}x{\mid}$ are evaluated for $r=0,\;\pm1,\;\pm2,...\;and\;p,\;q=0,1,2,....$
SOME RESULTS ON THE COMMUTATIVE PRODUCT OF DISTRIBUTIONS
Fisher, Brian,Nicholas, Joel-D. Korean Mathematical Society 1999 대한수학회보 Vol.36 No.3
The commutative product of the distributions $x^r lnx and $x^{-r-1}$ is evaluated for r=0,1,2,.... The commutative product of the distributions $x^rln(x+i0) and $(x+i0)^{-r-1}$ is also evaluated for r=1,2,.... Further products are deduced.